PhoU domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6P6_LEIMA

TriTrypDb:

LmjF.31.0180 , LMJLV39_310006900 , LMJSD75_310006900

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6P6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.350
CLV_PCSK_SKI1_1	30	34	PF00082	0.409
CLV_PCSK_SKI1_1	59	63	PF00082	0.498
DEG_Nend_UBRbox_2	1	3	PF02207	0.554
LIG_14-3-3_CanoR_1	127	135	PF00244	0.507
LIG_14-3-3_CanoR_1	138	147	PF00244	0.493
LIG_14-3-3_CanoR_1	23	31	PF00244	0.516
LIG_14-3-3_CanoR_1	59	65	PF00244	0.308
LIG_14-3-3_CanoR_1	90	94	PF00244	0.452
LIG_eIF4E_1	129	135	PF01652	0.514
LIG_eIF4E_1	7	13	PF01652	0.428
LIG_FHA_1	123	129	PF00498	0.370
LIG_FHA_1	139	145	PF00498	0.408
LIG_FHA_1	33	39	PF00498	0.453
LIG_FHA_1	60	66	PF00498	0.535
LIG_FHA_1	90	96	PF00498	0.477
LIG_FHA_2	43	49	PF00498	0.572
LIG_FHA_2	75	81	PF00498	0.533
LIG_LIR_Gen_1	14	21	PF02991	0.472
LIG_LIR_Gen_1	22	32	PF02991	0.450
LIG_LIR_Nem_3	14	19	PF02991	0.408
LIG_LIR_Nem_3	22	27	PF02991	0.353
LIG_LIR_Nem_3	77	82	PF02991	0.527
LIG_LIR_Nem_3	92	96	PF02991	0.497
LIG_NRBOX	146	152	PF00104	0.468
LIG_PCNA_PIPBox_1	1	10	PF02747	0.498
LIG_SH2_SRC	72	75	PF00017	0.539
LIG_SH2_STAP1	129	133	PF00017	0.491
LIG_SH2_STAT5	16	19	PF00017	0.432
LIG_SH2_STAT5	7	10	PF00017	0.334
LIG_UBA3_1	27	33	PF00899	0.460
LIG_Vh1_VBS_1	133	151	PF01044	0.474
MOD_CK1_1	22	28	PF00069	0.533
MOD_CK1_1	83	89	PF00069	0.482
MOD_CK2_1	43	49	PF00069	0.580
MOD_GlcNHglycan	24	27	PF01048	0.530
MOD_GlcNHglycan	51	54	PF01048	0.543
MOD_GSK3_1	39	46	PF00069	0.511
MOD_LATS_1	136	142	PF00433	0.512
MOD_NEK2_1	60	65	PF00069	0.379
MOD_PIKK_1	32	38	PF00454	0.394
MOD_PIKK_1	80	86	PF00454	0.539
MOD_PKA_2	137	143	PF00069	0.509
MOD_PKA_2	22	28	PF00069	0.517
MOD_PKA_2	89	95	PF00069	0.448
MOD_Plk_1	42	48	PF00069	0.593
MOD_Plk_2-3	43	49	PF00069	0.573
MOD_Plk_2-3	74	80	PF00069	0.511
MOD_Plk_4	60	66	PF00069	0.497
MOD_Plk_4	74	80	PF00069	0.449
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.505
TRG_ENDOCYTIC_2	16	19	PF00928	0.375
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH9	Leptomonas seymouri	59%	100%
A0A1X0NJ16	Trypanosomatidae	36%	97%
A0A3R7MDS1	Trypanosoma rangeli	42%	96%
A0A3S7X442	Leishmania donovani	89%	100%
A4HIZ3	Leishmania braziliensis	70%	100%
A4I6B0	Leishmania infantum	89%	100%
C9ZN37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	99%
E9B1G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BDZ3	Trypanosoma cruzi	40%	96%