Putative nucleolar protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein, putative

Species:

Leishmania major

UniProt:

Q4Q6P5_LEIMA

TriTrypDb:

LmjF.31.0190 , LMJLV39_310007000 , LMJSD75_310007000

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q6P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6P5

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0000470	maturation of LSU-rRNA	9	2
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	2
GO:0031167	rRNA methylation	5	2
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0070475	rRNA base methylation	6	2
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0022613	ribonucleoprotein complex biogenesis	4	10
GO:0042254	ribosome biogenesis	5	10
GO:0044085	cellular component biogenesis	3	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008169	C-methyltransferase activity	5	2
GO:0008173	RNA methyltransferase activity	4	2
GO:0008649	rRNA methyltransferase activity	5	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0009383	rRNA (cytosine-C5-)-methyltransferase activity	6	2
GO:0016434	rRNA (cytosine) methyltransferase activity	6	2
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140102	catalytic activity, acting on a rRNA	4	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.655
CLV_C14_Caspase3-7	450	454	PF00656	0.430
CLV_C14_Caspase3-7	71	75	PF00656	0.792
CLV_NRD_NRD_1	133	135	PF00675	0.496
CLV_NRD_NRD_1	274	276	PF00675	0.215
CLV_NRD_NRD_1	483	485	PF00675	0.224
CLV_NRD_NRD_1	53	55	PF00675	0.671
CLV_NRD_NRD_1	621	623	PF00675	0.688
CLV_NRD_NRD_1	627	629	PF00675	0.685
CLV_PCSK_KEX2_1	132	134	PF00082	0.485
CLV_PCSK_KEX2_1	273	275	PF00082	0.213
CLV_PCSK_KEX2_1	283	285	PF00082	0.213
CLV_PCSK_KEX2_1	482	484	PF00082	0.224
CLV_PCSK_KEX2_1	53	55	PF00082	0.691
CLV_PCSK_KEX2_1	564	566	PF00082	0.630
CLV_PCSK_KEX2_1	580	582	PF00082	0.479
CLV_PCSK_KEX2_1	621	623	PF00082	0.711
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.213
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.213
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.683
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.455
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.701
CLV_PCSK_SKI1_1	133	137	PF00082	0.449
CLV_PCSK_SKI1_1	24	28	PF00082	0.623
CLV_PCSK_SKI1_1	4	8	PF00082	0.599
CLV_PCSK_SKI1_1	40	44	PF00082	0.623
CLV_PCSK_SKI1_1	409	413	PF00082	0.224
CLV_PCSK_SKI1_1	426	430	PF00082	0.213
CLV_PCSK_SKI1_1	445	449	PF00082	0.278
CLV_PCSK_SKI1_1	616	620	PF00082	0.799
CLV_Separin_Metazoa	221	225	PF03568	0.429
DEG_APCC_DBOX_1	223	231	PF00400	0.399
DEG_ODPH_VHL_1	333	344	PF01847	0.413
DOC_CYCLIN_RxL_1	439	453	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.437
DOC_MAPK_gen_1	193	202	PF00069	0.367
DOC_MAPK_gen_1	214	222	PF00069	0.389
DOC_MAPK_gen_1	259	267	PF00069	0.424
DOC_MAPK_gen_1	293	301	PF00069	0.413
DOC_MAPK_gen_1	402	412	PF00069	0.413
DOC_MAPK_gen_1	482	488	PF00069	0.437
DOC_MAPK_gen_1	504	514	PF00069	0.516
DOC_MAPK_gen_1	583	592	PF00069	0.731
DOC_MAPK_MEF2A_6	293	301	PF00069	0.421
DOC_PP2B_LxvP_1	244	247	PF13499	0.437
DOC_PP2B_LxvP_1	412	415	PF13499	0.431
DOC_PP2B_LxvP_1	603	606	PF13499	0.715
DOC_PP4_FxxP_1	495	498	PF00568	0.413
DOC_USP7_MATH_1	22	26	PF00917	0.640
DOC_USP7_MATH_1	323	327	PF00917	0.516
DOC_USP7_MATH_1	557	561	PF00917	0.624
DOC_USP7_MATH_1	76	80	PF00917	0.571
DOC_USP7_MATH_2	290	296	PF00917	0.413
DOC_USP7_UBL2_3	24	28	PF12436	0.660
DOC_USP7_UBL2_3	39	43	PF12436	0.513
DOC_USP7_UBL2_3	619	623	PF12436	0.671
DOC_WW_Pin1_4	155	160	PF00397	0.572
LIG_14-3-3_CanoR_1	266	271	PF00244	0.445
LIG_14-3-3_CanoR_1	284	289	PF00244	0.375
LIG_14-3-3_CanoR_1	374	379	PF00244	0.425
LIG_14-3-3_CanoR_1	439	447	PF00244	0.434
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_BIR_III_4	74	78	PF00653	0.505
LIG_BRCT_BRCA1_1	96	100	PF00533	0.749
LIG_CaM_IQ_9	572	588	PF13499	0.560
LIG_EH1_1	235	243	PF00400	0.417
LIG_FHA_1	197	203	PF00498	0.400
LIG_FHA_1	262	268	PF00498	0.437
LIG_FHA_1	3	9	PF00498	0.484
LIG_FHA_1	30	36	PF00498	0.575
LIG_FHA_1	350	356	PF00498	0.430
LIG_FHA_1	360	366	PF00498	0.464
LIG_FHA_1	386	392	PF00498	0.476
LIG_FHA_1	417	423	PF00498	0.516
LIG_FHA_2	186	192	PF00498	0.423
LIG_FHA_2	391	397	PF00498	0.426
LIG_FHA_2	610	616	PF00498	0.694
LIG_LIR_Gen_1	218	227	PF02991	0.344
LIG_LIR_Gen_1	232	241	PF02991	0.350
LIG_LIR_Gen_1	292	302	PF02991	0.442
LIG_LIR_Gen_1	398	407	PF02991	0.516
LIG_LIR_Gen_1	97	104	PF02991	0.573
LIG_LIR_Nem_3	218	222	PF02991	0.373
LIG_LIR_Nem_3	232	236	PF02991	0.406
LIG_LIR_Nem_3	292	297	PF02991	0.442
LIG_LIR_Nem_3	326	330	PF02991	0.279
LIG_LIR_Nem_3	398	403	PF02991	0.450
LIG_LIR_Nem_3	431	437	PF02991	0.387
LIG_LIR_Nem_3	97	103	PF02991	0.572
LIG_MAD2	13	21	PF02301	0.565
LIG_MAD2	340	348	PF02301	0.413
LIG_PCNA_PIPBox_1	238	247	PF02747	0.321
LIG_REV1ctd_RIR_1	526	536	PF16727	0.424
LIG_SH2_SRC	231	234	PF00017	0.385
LIG_SH2_STAP1	233	237	PF00017	0.328
LIG_SH2_STAP1	400	404	PF00017	0.437
LIG_SH2_STAT3	319	322	PF00017	0.413
LIG_SH2_STAT3	354	357	PF00017	0.413
LIG_SH2_STAT5	219	222	PF00017	0.412
LIG_SH2_STAT5	314	317	PF00017	0.427
LIG_SH2_STAT5	354	357	PF00017	0.413
LIG_SH2_STAT5	460	463	PF00017	0.424
LIG_SH2_STAT5	518	521	PF00017	0.480
LIG_SH3_1	621	627	PF00018	0.568
LIG_SH3_2	624	629	PF14604	0.560
LIG_SH3_3	367	373	PF00018	0.439
LIG_SH3_3	621	627	PF00018	0.568
LIG_SUMO_SIM_anti_2	218	226	PF11976	0.399
LIG_SUMO_SIM_par_1	225	232	PF11976	0.393
LIG_TRAF2_1	170	173	PF00917	0.669
LIG_TRAF2_1	188	191	PF00917	0.330
LIG_TRAF2_1	334	337	PF00917	0.424
LIG_TYR_ITSM	396	403	PF00017	0.467
LIG_UBA3_1	448	456	PF00899	0.464
MOD_CK1_1	427	433	PF00069	0.425
MOD_CK1_1	464	470	PF00069	0.413
MOD_CK1_1	537	543	PF00069	0.523
MOD_CK1_1	558	564	PF00069	0.776
MOD_CK1_1	609	615	PF00069	0.600
MOD_CK2_1	184	190	PF00069	0.452
MOD_CK2_1	395	401	PF00069	0.516
MOD_CK2_1	609	615	PF00069	0.595
MOD_CK2_1	89	95	PF00069	0.708
MOD_Cter_Amidation	619	622	PF01082	0.710
MOD_GlcNHglycan	343	347	PF01048	0.280
MOD_GlcNHglycan	416	419	PF01048	0.272
MOD_GlcNHglycan	449	452	PF01048	0.224
MOD_GlcNHglycan	555	558	PF01048	0.685
MOD_GlcNHglycan	88	94	PF01048	0.731
MOD_GSK3_1	151	158	PF00069	0.577
MOD_GSK3_1	2	9	PF00069	0.642
MOD_GSK3_1	257	264	PF00069	0.526
MOD_GSK3_1	416	423	PF00069	0.430
MOD_GSK3_1	424	431	PF00069	0.413
MOD_GSK3_1	508	515	PF00069	0.497
MOD_GSK3_1	534	541	PF00069	0.468
MOD_GSK3_1	549	556	PF00069	0.547
MOD_GSK3_1	601	608	PF00069	0.620
MOD_N-GLC_1	29	34	PF02516	0.666
MOD_N-GLC_1	77	82	PF02516	0.747
MOD_NEK2_1	183	188	PF00069	0.619
MOD_NEK2_1	237	242	PF00069	0.426
MOD_NEK2_1	257	262	PF00069	0.394
MOD_NEK2_1	342	347	PF00069	0.476
MOD_NEK2_1	359	364	PF00069	0.414
MOD_NEK2_1	385	390	PF00069	0.424
MOD_NEK2_1	447	452	PF00069	0.419
MOD_NEK2_1	512	517	PF00069	0.475
MOD_NEK2_1	536	541	PF00069	0.541
MOD_NEK2_2	22	27	PF00069	0.572
MOD_PIKK_1	438	444	PF00454	0.424
MOD_PK_1	284	290	PF00069	0.364
MOD_PK_1	424	430	PF00069	0.413
MOD_PKA_1	534	540	PF00069	0.374
MOD_PKA_2	260	266	PF00069	0.428
MOD_PKA_2	438	444	PF00069	0.429
MOD_Plk_1	424	430	PF00069	0.413
MOD_Plk_1	94	100	PF00069	0.633
MOD_Plk_2-3	566	572	PF00069	0.501
MOD_Plk_2-3	94	100	PF00069	0.533
MOD_Plk_4	237	243	PF00069	0.429
MOD_Plk_4	323	329	PF00069	0.413
MOD_Plk_4	350	356	PF00069	0.413
MOD_Plk_4	464	470	PF00069	0.413
MOD_ProDKin_1	155	161	PF00069	0.574
MOD_SUMO_for_1	126	129	PF00179	0.437
MOD_SUMO_for_1	206	209	PF00179	0.432
MOD_SUMO_rev_2	120	128	PF00179	0.486
MOD_SUMO_rev_2	545	552	PF00179	0.526
TRG_DiLeu_BaEn_1	218	223	PF01217	0.382
TRG_DiLeu_BaEn_2	231	237	PF01217	0.306
TRG_DiLeu_BaEn_2	248	254	PF01217	0.476
TRG_DiLeu_BaEn_3	471	477	PF01217	0.464
TRG_ENDOCYTIC_2	219	222	PF00928	0.370
TRG_ENDOCYTIC_2	233	236	PF00928	0.353
TRG_ENDOCYTIC_2	400	403	PF00928	0.421
TRG_ENDOCYTIC_2	434	437	PF00928	0.411
TRG_ER_diArg_1	131	134	PF00400	0.486
TRG_ER_diArg_1	481	484	PF00400	0.421
TRG_ER_diArg_1	581	584	PF00400	0.649
TRG_NLS_Bipartite_1	563	584	PF00514	0.661
TRG_NLS_MonoExtC_3	579	585	PF00514	0.719
TRG_NLS_MonoExtC_3	620	625	PF00514	0.672
TRG_NLS_MonoExtN_4	619	625	PF00514	0.702
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.213
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.213

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P967	Leptomonas seymouri	72%	100%
A0A0S4KG56	Bodo saltans	65%	100%
A0A1X0NJV9	Trypanosomatidae	62%	100%
A0A3Q8IJ07	Leishmania donovani	28%	99%
A0A3Q8IJS8	Leishmania donovani	93%	100%
A0A422N5J0	Trypanosoma rangeli	71%	100%
A4HIZ4	Leishmania braziliensis	82%	100%
A4I6B1	Leishmania infantum	93%	100%
C9ZN38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AEB6	Leishmania major	27%	99%
E9AHJ5	Leishmania infantum	27%	99%
E9B1G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q5ZLV4	Gallus gallus	22%	79%
Q8VYM6	Arabidopsis thaliana	46%	94%
Q9FG73	Arabidopsis thaliana	44%	92%
V5BIK5	Trypanosoma cruzi	67%	100%