NLE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD repeat protein

Species:

Leishmania major

UniProt:

Q4Q6P4_LEIMA

TriTrypDb:

LmjF.31.0200 , LMJLV39_310007100 , LMJSD75_310007100

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q6P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.568
CLV_C14_Caspase3-7	254	258	PF00656	0.465
CLV_MEL_PAP_1	310	316	PF00089	0.360
CLV_NRD_NRD_1	121	123	PF00675	0.407
CLV_NRD_NRD_1	210	212	PF00675	0.589
CLV_PCSK_KEX2_1	121	123	PF00082	0.407
CLV_PCSK_KEX2_1	212	214	PF00082	0.542
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.542
CLV_PCSK_PC7_1	117	123	PF00082	0.502
CLV_PCSK_SKI1_1	307	311	PF00082	0.349
DOC_CDC14_PxL_1	1	9	PF14671	0.523
DOC_MAPK_gen_1	295	302	PF00069	0.547
DOC_MAPK_MEF2A_6	295	302	PF00069	0.547
DOC_PP2B_LxvP_1	22	25	PF13499	0.457
DOC_PP4_FxxP_1	76	79	PF00568	0.426
DOC_USP7_MATH_1	185	189	PF00917	0.474
DOC_USP7_MATH_1	204	208	PF00917	0.379
DOC_USP7_MATH_1	223	227	PF00917	0.449
DOC_USP7_MATH_1	270	274	PF00917	0.471
DOC_USP7_MATH_1	33	37	PF00917	0.614
DOC_USP7_MATH_1	359	363	PF00917	0.571
DOC_USP7_MATH_1	413	417	PF00917	0.543
DOC_USP7_MATH_1	422	426	PF00917	0.318
DOC_USP7_MATH_1	72	76	PF00917	0.327
DOC_USP7_UBL2_3	208	212	PF12436	0.644
DOC_USP7_UBL2_3	386	390	PF12436	0.412
DOC_WW_Pin1_4	132	137	PF00397	0.366
DOC_WW_Pin1_4	29	34	PF00397	0.542
DOC_WW_Pin1_4	360	365	PF00397	0.419
LIG_14-3-3_CanoR_1	121	130	PF00244	0.400
LIG_14-3-3_CanoR_1	354	358	PF00244	0.319
LIG_14-3-3_CanoR_1	436	445	PF00244	0.390
LIG_APCC_ABBA_1	145	150	PF00400	0.436
LIG_Clathr_ClatBox_1	129	133	PF01394	0.380
LIG_Clathr_ClatBox_1	442	446	PF01394	0.390
LIG_eIF4E_1	110	116	PF01652	0.460
LIG_FHA_1	13	19	PF00498	0.701
LIG_FHA_1	133	139	PF00498	0.406
LIG_FHA_1	251	257	PF00498	0.513
LIG_FHA_1	275	281	PF00498	0.475
LIG_FHA_1	427	433	PF00498	0.346
LIG_FHA_1	438	444	PF00498	0.357
LIG_FHA_1	448	454	PF00498	0.315
LIG_FHA_2	212	218	PF00498	0.567
LIG_FHA_2	299	305	PF00498	0.482
LIG_LIR_Apic_2	64	70	PF02991	0.360
LIG_LIR_Apic_2	73	79	PF02991	0.270
LIG_LIR_Nem_3	113	119	PF02991	0.383
LIG_PTB_Apo_2	128	135	PF02174	0.399
LIG_PTB_Phospho_1	128	134	PF10480	0.400
LIG_SH2_CRK	67	71	PF00017	0.372
LIG_SH2_STAP1	14	18	PF00017	0.518
LIG_SH2_STAP1	171	175	PF00017	0.454
LIG_SH2_STAP1	400	404	PF00017	0.326
LIG_SH2_STAT3	458	461	PF00017	0.501
LIG_SH2_STAT5	110	113	PF00017	0.315
LIG_SH2_STAT5	134	137	PF00017	0.368
LIG_SH2_STAT5	14	17	PF00017	0.672
LIG_SH2_STAT5	458	461	PF00017	0.462
LIG_SH3_3	152	158	PF00018	0.461
LIG_SH3_3	198	204	PF00018	0.427
LIG_SH3_3	2	8	PF00018	0.559
LIG_SUMO_SIM_par_1	440	446	PF11976	0.394
LIG_SUMO_SIM_par_1	450	457	PF11976	0.360
LIG_TRAF2_1	125	128	PF00917	0.415
LIG_WRC_WIRS_1	186	191	PF05994	0.499
LIG_WRC_WIRS_1	299	304	PF05994	0.375
LIG_WRC_WIRS_1	389	394	PF05994	0.422
LIG_WRC_WIRS_1	59	64	PF05994	0.315
MOD_CK1_1	206	212	PF00069	0.623
MOD_CK1_1	238	244	PF00069	0.478
MOD_CK1_1	273	279	PF00069	0.516
MOD_CK1_1	3	9	PF00069	0.534
MOD_CK1_1	312	318	PF00069	0.482
MOD_CK1_1	36	42	PF00069	0.701
MOD_CK1_1	371	377	PF00069	0.459
MOD_CK1_1	416	422	PF00069	0.463
MOD_CK2_1	122	128	PF00069	0.394
MOD_Cter_Amidation	209	212	PF01082	0.706
MOD_GlcNHglycan	223	226	PF01048	0.456
MOD_GlcNHglycan	314	317	PF01048	0.387
MOD_GlcNHglycan	324	327	PF01048	0.315
MOD_GlcNHglycan	370	373	PF01048	0.471
MOD_GlcNHglycan	392	395	PF01048	0.359
MOD_GlcNHglycan	414	418	PF01048	0.584
MOD_GlcNHglycan	465	468	PF01048	0.383
MOD_GlcNHglycan	50	53	PF01048	0.602
MOD_GlcNHglycan	56	59	PF01048	0.459
MOD_GSK3_1	223	230	PF00069	0.394
MOD_GSK3_1	270	277	PF00069	0.533
MOD_GSK3_1	29	36	PF00069	0.677
MOD_GSK3_1	388	395	PF00069	0.302
MOD_GSK3_1	422	429	PF00069	0.350
MOD_GSK3_1	437	444	PF00069	0.322
MOD_GSK3_1	459	466	PF00069	0.409
MOD_GSK3_1	472	479	PF00069	0.384
MOD_GSK3_1	54	61	PF00069	0.445
MOD_N-GLC_1	470	475	PF02516	0.378
MOD_NEK2_1	165	170	PF00069	0.461
MOD_NEK2_1	221	226	PF00069	0.396
MOD_NEK2_1	236	241	PF00069	0.431
MOD_NEK2_1	245	250	PF00069	0.483
MOD_NEK2_1	268	273	PF00069	0.513
MOD_NEK2_1	27	32	PF00069	0.616
MOD_NEK2_1	368	373	PF00069	0.407
MOD_NEK2_1	380	385	PF00069	0.357
MOD_NEK2_1	392	397	PF00069	0.352
MOD_NEK2_1	435	440	PF00069	0.426
MOD_NEK2_1	454	459	PF00069	0.166
MOD_NEK2_1	62	67	PF00069	0.314
MOD_NEK2_2	151	156	PF00069	0.461
MOD_NEK2_2	185	190	PF00069	0.486
MOD_NEK2_2	274	279	PF00069	0.461
MOD_NEK2_2	58	63	PF00069	0.426
MOD_PIKK_1	341	347	PF00454	0.517
MOD_PK_1	227	233	PF00069	0.384
MOD_PKA_1	211	217	PF00069	0.590
MOD_PKA_2	312	318	PF00069	0.377
MOD_PKA_2	353	359	PF00069	0.326
MOD_PKA_2	435	441	PF00069	0.392
MOD_Plk_1	274	280	PF00069	0.475
MOD_Plk_1	426	432	PF00069	0.355
MOD_Plk_1	454	460	PF00069	0.356
MOD_Plk_1	72	78	PF00069	0.315
MOD_Plk_4	111	117	PF00069	0.438
MOD_Plk_4	33	39	PF00069	0.568
MOD_Plk_4	398	404	PF00069	0.390
MOD_Plk_4	416	422	PF00069	0.307
MOD_Plk_4	454	460	PF00069	0.396
MOD_Plk_4	58	64	PF00069	0.315
MOD_ProDKin_1	132	138	PF00069	0.369
MOD_ProDKin_1	29	35	PF00069	0.541
MOD_ProDKin_1	360	366	PF00069	0.408
MOD_SUMO_rev_2	466	473	PF00179	0.410
TRG_ENDOCYTIC_2	400	403	PF00928	0.497
TRG_ER_diArg_1	213	216	PF00400	0.566
TRG_ER_diArg_1	377	380	PF00400	0.368
TRG_NES_CRM1_1	85	98	PF08389	0.334
TRG_NLS_MonoExtC_3	210	215	PF00514	0.549
TRG_NLS_MonoExtN_4	208	215	PF00514	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U0	Leptomonas seymouri	83%	100%
A0A0S4ITM8	Bodo saltans	23%	100%
A0A1X0NJ30	Trypanosomatidae	61%	100%
A0A3S5IQK0	Trypanosoma rangeli	63%	93%
A0A3S7X417	Leishmania donovani	94%	100%
A1CH75	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	24%	99%
A1CXL0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	99%
A1DP19	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	24%	100%
A2QI22	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	99%
A3LQ86	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	22%	100%
A4HIZ5	Leishmania braziliensis	87%	100%
A4I6B2	Leishmania infantum	94%	100%
A4R2Q6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	24%	100%
A5DL92	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	23%	100%
A6R3K5	Ajellomyces capsulatus (strain NAm1 / WU24)	25%	99%
A6S0T8	Botryotinia fuckeliana (strain B05.10)	25%	100%
A7ECP3	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	25%	100%
A7RHG8	Nematostella vectensis	31%	100%
A7TMF9	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	22%	100%
A8IR43	Chlamydomonas reinhardtii	28%	100%
A8PD13	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	25%	100%
A8PT44	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	24%	92%
A8QB65	Brugia malayi	25%	100%
A9UP22	Monosiga brevicollis	26%	100%
B0DWM8	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	27%	100%
B0W517	Culex quinquefasciatus	28%	100%
B0Y5V6	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	24%	99%
B2VZH2	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	27%	100%
B3MJV8	Drosophila ananassae	28%	100%
B3N534	Drosophila erecta	29%	100%
B4GT01	Drosophila persimilis	28%	100%
B4HWV6	Drosophila sechellia	29%	100%
B4JPT9	Drosophila grimshawi	28%	100%
B4KKN1	Drosophila mojavensis	28%	100%
B4LS78	Drosophila virilis	29%	100%
B4MU54	Drosophila willistoni	28%	100%
B4P116	Drosophila yakuba	29%	100%
B4Q9T6	Drosophila simulans	29%	100%
B5DG67	Salmo salar	26%	100%
B7PY76	Ixodes scapularis	24%	100%
C5PFX0	Coccidioides posadasii (strain C735)	24%	100%
C9ZN39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
C9ZVL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9B1G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	89%
F6ZT52	Xenopus tropicalis	25%	100%
G0SC29	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	25%	94%
G0SFB5	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	24%	98%
O74855	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	97%
P0CS42	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	100%
P0CS43	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	100%
P25382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	94%
P61480	Rattus norvegicus	27%	100%
P61964	Homo sapiens	25%	100%
P61965	Mus musculus	25%	100%
P91343	Caenorhabditis elegans	23%	100%
Q0CLJ4	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	100%
Q0UXP3	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	25%	100%
Q0VC24	Bos taurus	28%	100%
Q17BB0	Aedes aegypti	28%	100%
Q1DJF7	Coccidioides immitis (strain RS)	26%	100%
Q28I85	Xenopus tropicalis	27%	100%
Q29KQ0	Drosophila pseudoobscura pseudoobscura	28%	100%
Q2GXT0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	23%	100%
Q2KIG2	Bos taurus	25%	100%
Q2UGK1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q498M4	Rattus norvegicus	25%	100%
Q4ICM0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	21%	100%
Q4V7Z1	Xenopus laevis	24%	100%
Q4WP10	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	99%
Q54W52	Dictyostelium discoideum	24%	100%
Q5APF0	Candida albicans (strain SC5314 / ATCC MYA-2876)	22%	100%
Q5B4R1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	100%
Q5BJ90	Xenopus tropicalis	27%	100%
Q5RD06	Pongo abelii	24%	100%
Q5RE95	Pongo abelii	25%	100%
Q5REE6	Pongo abelii	28%	100%
Q5RF51	Pongo abelii	26%	100%
Q6BLS5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	100%
Q6CU59	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	100%
Q6FKK3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	100%
Q6NX08	Danio rerio	27%	100%
Q756D0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%
Q7QJ33	Anopheles gambiae	29%	100%
Q7T0P4	Xenopus laevis	27%	100%
Q86VZ2	Homo sapiens	25%	100%
Q8H594	Oryza sativa subsp. japonica	27%	100%
Q8TC44	Homo sapiens	25%	100%
Q96DI7	Homo sapiens	27%	100%
Q9C2I5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	22%	100%
Q9D7H2	Mus musculus	24%	100%
Q9GZL7	Homo sapiens	28%	100%
Q9JJA4	Mus musculus	27%	100%
Q9LF27	Arabidopsis thaliana	28%	100%
Q9URY0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9V3J8	Drosophila melanogaster	25%	100%
Q9VKQ3	Drosophila melanogaster	29%	100%
V5AYL2	Trypanosoma cruzi	62%	95%