TPR_MLP1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6P1_LEIMA

TriTrypDb:

LmjF.31.0230 , LMJLV39_310007500 , LMJSD75_310007500

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q6P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6P1

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	2
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036159	inner dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0048870	cell motility	2	2
GO:0060285	cilium-dependent cell motility	4	2
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.692
CLV_C14_Caspase3-7	4	8	PF00656	0.596
CLV_C14_Caspase3-7	675	679	PF00656	0.488
CLV_C14_Caspase3-7	821	825	PF00656	0.438
CLV_NRD_NRD_1	148	150	PF00675	0.473
CLV_NRD_NRD_1	184	186	PF00675	0.452
CLV_NRD_NRD_1	211	213	PF00675	0.452
CLV_NRD_NRD_1	339	341	PF00675	0.688
CLV_NRD_NRD_1	350	352	PF00675	0.683
CLV_NRD_NRD_1	474	476	PF00675	0.556
CLV_NRD_NRD_1	48	50	PF00675	0.455
CLV_NRD_NRD_1	618	620	PF00675	0.450
CLV_NRD_NRD_1	682	684	PF00675	0.595
CLV_NRD_NRD_1	721	723	PF00675	0.431
CLV_NRD_NRD_1	738	740	PF00675	0.499
CLV_PCSK_FUR_1	321	325	PF00082	0.671
CLV_PCSK_FUR_1	680	684	PF00082	0.602
CLV_PCSK_KEX2_1	148	150	PF00082	0.562
CLV_PCSK_KEX2_1	184	186	PF00082	0.421
CLV_PCSK_KEX2_1	255	257	PF00082	0.472
CLV_PCSK_KEX2_1	323	325	PF00082	0.631
CLV_PCSK_KEX2_1	339	341	PF00082	0.562
CLV_PCSK_KEX2_1	349	351	PF00082	0.578
CLV_PCSK_KEX2_1	461	463	PF00082	0.645
CLV_PCSK_KEX2_1	47	49	PF00082	0.461
CLV_PCSK_KEX2_1	504	506	PF00082	0.448
CLV_PCSK_KEX2_1	525	527	PF00082	0.537
CLV_PCSK_KEX2_1	587	589	PF00082	0.555
CLV_PCSK_KEX2_1	620	622	PF00082	0.449
CLV_PCSK_KEX2_1	682	684	PF00082	0.587
CLV_PCSK_KEX2_1	738	740	PF00082	0.558
CLV_PCSK_KEX2_1	75	77	PF00082	0.458
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.538
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.669
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.644
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.645
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.448
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.537
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.536
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.557
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.458
CLV_PCSK_SKI1_1	170	174	PF00082	0.499
CLV_PCSK_SKI1_1	23	27	PF00082	0.470
CLV_PCSK_SKI1_1	342	346	PF00082	0.739
CLV_PCSK_SKI1_1	350	354	PF00082	0.542
CLV_PCSK_SKI1_1	525	529	PF00082	0.381
CLV_PCSK_SKI1_1	570	574	PF00082	0.587
CLV_PCSK_SKI1_1	606	610	PF00082	0.597
CLV_PCSK_SKI1_1	621	625	PF00082	0.533
CLV_PCSK_SKI1_1	631	635	PF00082	0.511
CLV_PCSK_SKI1_1	686	690	PF00082	0.582
CLV_PCSK_SKI1_1	722	726	PF00082	0.561
CLV_PCSK_SKI1_1	730	734	PF00082	0.467
CLV_PCSK_SKI1_1	738	742	PF00082	0.492
CLV_PCSK_SKI1_1	846	850	PF00082	0.498
DEG_APCC_DBOX_1	109	117	PF00400	0.550
DEG_APCC_DBOX_1	46	54	PF00400	0.455
DEG_APCC_KENBOX_2	401	405	PF00400	0.548
DEG_APCC_KENBOX_2	802	806	PF00400	0.583
DEG_Nend_UBRbox_3	1	3	PF02207	0.635
DOC_CYCLIN_RxL_1	45	55	PF00134	0.454
DOC_MAPK_gen_1	148	158	PF00069	0.523
DOC_MAPK_gen_1	321	330	PF00069	0.596
DOC_MAPK_gen_1	475	484	PF00069	0.622
DOC_MAPK_gen_1	546	557	PF00069	0.487
DOC_MAPK_gen_1	574	583	PF00069	0.525
DOC_MAPK_gen_1	637	644	PF00069	0.513
DOC_MAPK_gen_1	682	691	PF00069	0.539
DOC_MAPK_MEF2A_6	290	299	PF00069	0.554
DOC_MAPK_MEF2A_6	550	559	PF00069	0.540
DOC_MAPK_MEF2A_6	653	661	PF00069	0.683
DOC_PIKK_1	360	368	PF02985	0.547
DOC_PP1_RVXF_1	46	53	PF00149	0.457
DOC_PP1_RVXF_1	756	763	PF00149	0.574
DOC_USP7_UBL2_3	286	290	PF12436	0.643
DOC_USP7_UBL2_3	546	550	PF12436	0.557
DOC_USP7_UBL2_3	609	613	PF12436	0.464
DOC_USP7_UBL2_3	711	715	PF12436	0.692
LIG_14-3-3_CanoR_1	112	117	PF00244	0.535
LIG_14-3-3_CanoR_1	350	358	PF00244	0.680
LIG_14-3-3_CanoR_1	411	421	PF00244	0.575
LIG_14-3-3_CanoR_1	511	517	PF00244	0.494
LIG_14-3-3_CanoR_1	653	661	PF00244	0.638
LIG_14-3-3_CanoR_1	722	732	PF00244	0.632
LIG_14-3-3_CanoR_1	766	775	PF00244	0.448
LIG_Actin_WH2_2	118	133	PF00022	0.450
LIG_Actin_WH2_2	246	262	PF00022	0.609
LIG_Actin_WH2_2	555	572	PF00022	0.450
LIG_Clathr_ClatBox_1	556	560	PF01394	0.414
LIG_Clathr_ClatBox_1	580	584	PF01394	0.545
LIG_Clathr_ClatBox_1	607	611	PF01394	0.516
LIG_FHA_1	171	177	PF00498	0.509
LIG_FHA_1	195	201	PF00498	0.529
LIG_FHA_1	24	30	PF00498	0.469
LIG_FHA_1	272	278	PF00498	0.671
LIG_FHA_1	413	419	PF00498	0.573
LIG_FHA_1	559	565	PF00498	0.434
LIG_FHA_1	622	628	PF00498	0.552
LIG_FHA_1	65	71	PF00498	0.436
LIG_FHA_1	692	698	PF00498	0.471
LIG_FHA_1	780	786	PF00498	0.548
LIG_FHA_2	130	136	PF00498	0.581
LIG_FHA_2	19	25	PF00498	0.502
LIG_FHA_2	229	235	PF00498	0.503
LIG_FHA_2	278	284	PF00498	0.619
LIG_FHA_2	28	34	PF00498	0.490
LIG_FHA_2	331	337	PF00498	0.689
LIG_FHA_2	343	349	PF00498	0.725
LIG_FHA_2	351	357	PF00498	0.405
LIG_FHA_2	415	421	PF00498	0.555
LIG_FHA_2	469	475	PF00498	0.538
LIG_FHA_2	486	492	PF00498	0.472
LIG_FHA_2	537	543	PF00498	0.539
LIG_FHA_2	580	586	PF00498	0.548
LIG_FHA_2	785	791	PF00498	0.562
LIG_FHA_2	98	104	PF00498	0.555
LIG_Integrin_RGD_1	673	675	PF01839	0.584
LIG_LIR_Gen_1	223	233	PF02991	0.461
LIG_LIR_Gen_1	777	786	PF02991	0.481
LIG_LIR_Nem_3	210	214	PF02991	0.466
LIG_LIR_Nem_3	223	228	PF02991	0.417
LIG_LIR_Nem_3	726	732	PF02991	0.605
LIG_LIR_Nem_3	777	781	PF02991	0.484
LIG_PDZ_Class_3	854	859	PF00595	0.635
LIG_PTB_Apo_2	448	455	PF02174	0.497
LIG_SH2_CRK	211	215	PF00017	0.476
LIG_SH2_NCK_1	778	782	PF00017	0.594
LIG_SH2_SRC	246	249	PF00017	0.500
LIG_SH2_STAP1	795	799	PF00017	0.534
LIG_SH2_STAT3	279	282	PF00017	0.624
LIG_SH2_STAT5	279	282	PF00017	0.624
LIG_SUMO_SIM_anti_2	694	699	PF11976	0.511
LIG_SUMO_SIM_anti_2	813	819	PF11976	0.550
LIG_SUMO_SIM_anti_2	839	846	PF11976	0.596
LIG_SUMO_SIM_par_1	579	585	PF11976	0.546
LIG_SUMO_SIM_par_1	784	792	PF11976	0.568
LIG_SUMO_SIM_par_1	829	834	PF11976	0.595
LIG_TRAF2_1	270	273	PF00917	0.564
LIG_TRAF2_1	280	283	PF00917	0.560
LIG_TRAF2_1	471	474	PF00917	0.552
LIG_TRAF2_1	527	530	PF00917	0.533
LIG_TRAF2_1	582	585	PF00917	0.559
LIG_TRAF2_1	615	618	PF00917	0.470
LIG_UBA3_1	516	525	PF00899	0.545
LIG_UBA3_1	580	587	PF00899	0.548
LIG_UBA3_1	607	613	PF00899	0.455
LIG_UBA3_1	688	693	PF00899	0.587
MOD_CK1_1	317	323	PF00069	0.706
MOD_CK1_1	734	740	PF00069	0.575
MOD_CK1_1	80	86	PF00069	0.594
MOD_CK2_1	18	24	PF00069	0.504
MOD_CK2_1	228	234	PF00069	0.510
MOD_CK2_1	259	265	PF00069	0.598
MOD_CK2_1	27	33	PF00069	0.419
MOD_CK2_1	277	283	PF00069	0.580
MOD_CK2_1	330	336	PF00069	0.690
MOD_CK2_1	342	348	PF00069	0.707
MOD_CK2_1	350	356	PF00069	0.410
MOD_CK2_1	414	420	PF00069	0.571
MOD_CK2_1	468	474	PF00069	0.524
MOD_CK2_1	485	491	PF00069	0.472
MOD_CK2_1	536	542	PF00069	0.581
MOD_CK2_1	579	585	PF00069	0.469
MOD_CK2_1	66	72	PF00069	0.466
MOD_CK2_1	784	790	PF00069	0.564
MOD_CK2_1	97	103	PF00069	0.554
MOD_GlcNHglycan	216	221	PF01048	0.561
MOD_GlcNHglycan	420	424	PF01048	0.485
MOD_GlcNHglycan	512	515	PF01048	0.528
MOD_GlcNHglycan	733	736	PF01048	0.566
MOD_GSK3_1	23	30	PF00069	0.469
MOD_GSK3_1	259	266	PF00069	0.603
MOD_GSK3_1	64	71	PF00069	0.522
MOD_GSK3_1	784	791	PF00069	0.597
MOD_N-GLC_1	18	23	PF02516	0.513
MOD_N-GLC_1	277	282	PF02516	0.626
MOD_N-GLC_1	631	636	PF02516	0.566
MOD_NEK2_1	179	184	PF00069	0.539
MOD_NEK2_1	18	23	PF00069	0.515
MOD_NEK2_1	194	199	PF00069	0.430
MOD_NEK2_1	259	264	PF00069	0.625
MOD_NEK2_1	330	335	PF00069	0.661
MOD_NEK2_1	510	515	PF00069	0.575
MOD_NEK2_1	520	525	PF00069	0.506
MOD_NEK2_1	691	696	PF00069	0.470
MOD_NEK2_1	70	75	PF00069	0.524
MOD_NEK2_1	746	751	PF00069	0.578
MOD_NEK2_1	788	793	PF00069	0.552
MOD_NEK2_1	823	828	PF00069	0.475
MOD_PIKK_1	170	176	PF00454	0.547
MOD_PIKK_1	194	200	PF00454	0.565
MOD_PIKK_1	285	291	PF00454	0.617
MOD_PIKK_1	441	447	PF00454	0.486
MOD_PIKK_1	64	70	PF00454	0.447
MOD_PIKK_1	652	658	PF00454	0.568
MOD_PIKK_1	767	773	PF00454	0.550
MOD_PIKK_1	779	785	PF00454	0.596
MOD_PIKK_1	97	103	PF00454	0.475
MOD_PK_1	112	118	PF00069	0.538
MOD_PK_1	789	795	PF00069	0.532
MOD_PKA_1	350	356	PF00069	0.631
MOD_PKA_2	111	117	PF00069	0.519
MOD_PKA_2	159	165	PF00069	0.441
MOD_PKA_2	317	323	PF00069	0.673
MOD_PKA_2	350	356	PF00069	0.675
MOD_PKA_2	510	516	PF00069	0.571
MOD_PKA_2	652	658	PF00069	0.648
MOD_PKA_2	788	794	PF00069	0.458
MOD_PKA_2	97	103	PF00069	0.499
MOD_PKB_1	110	118	PF00069	0.547
MOD_PKB_1	619	627	PF00069	0.509
MOD_Plk_1	179	185	PF00069	0.536
MOD_Plk_1	271	277	PF00069	0.624
MOD_Plk_1	342	348	PF00069	0.732
MOD_Plk_1	452	458	PF00069	0.521
MOD_Plk_1	631	637	PF00069	0.535
MOD_Plk_1	691	697	PF00069	0.513
MOD_Plk_1	789	795	PF00069	0.532
MOD_Plk_1	80	86	PF00069	0.592
MOD_Plk_1	823	829	PF00069	0.515
MOD_Plk_2-3	332	338	PF00069	0.662
MOD_Plk_2-3	579	585	PF00069	0.507
MOD_Plk_2-3	710	716	PF00069	0.636
MOD_Plk_2-3	77	83	PF00069	0.562
MOD_Plk_2-3	784	790	PF00069	0.525
MOD_Plk_4	823	829	PF00069	0.460
MOD_SUMO_for_1	125	128	PF00179	0.540
MOD_SUMO_for_1	270	273	PF00179	0.525
MOD_SUMO_for_1	358	361	PF00179	0.676
MOD_SUMO_for_1	466	469	PF00179	0.554
MOD_SUMO_for_1	608	611	PF00179	0.465
MOD_SUMO_for_1	689	692	PF00179	0.492
MOD_SUMO_rev_2	128	133	PF00179	0.454
MOD_SUMO_rev_2	162	169	PF00179	0.563
MOD_SUMO_rev_2	469	478	PF00179	0.600
MOD_SUMO_rev_2	541	548	PF00179	0.596
MOD_SUMO_rev_2	616	622	PF00179	0.563
TRG_DiLeu_BaEn_1	618	623	PF01217	0.463
TRG_DiLeu_BaEn_4	473	479	PF01217	0.525
TRG_DiLeu_BaEn_4	755	761	PF01217	0.574
TRG_DiLeu_BaLyEn_6	603	608	PF01217	0.551
TRG_ENDOCYTIC_2	161	164	PF00928	0.583
TRG_ENDOCYTIC_2	211	214	PF00928	0.477
TRG_ENDOCYTIC_2	778	781	PF00928	0.566
TRG_ER_diArg_1	183	185	PF00400	0.517
TRG_ER_diArg_1	47	49	PF00400	0.461
TRG_ER_diArg_1	619	622	PF00400	0.445
TRG_ER_diArg_1	680	683	PF00400	0.592
TRG_NES_CRM1_1	553	565	PF08389	0.564
TRG_NES_CRM1_1	821	836	PF08389	0.592
TRG_NLS_MonoExtC_3	523	529	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	526	530	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	588	593	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	606	611	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	758	763	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	76	81	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP4	Leptomonas seymouri	77%	100%
A0A1X0NJ74	Trypanosomatidae	49%	100%
A0A3Q8IFA9	Leishmania donovani	96%	100%
A0A422MZK1	Trypanosoma rangeli	49%	100%
A4HIZ8	Leishmania braziliensis	87%	100%
A4I6B5	Leishmania infantum	96%	100%
A8IQE0	Chlamydomonas reinhardtii	29%	96%
C9ZN73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D3Z8K2	Rattus norvegicus	30%	92%
E1BM70	Bos taurus	27%	91%
E2R1I5	Canis lupus familiaris	29%	91%
E9B1H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P0CK98	Danio rerio	29%	91%
Q0V9R4	Xenopus tropicalis	31%	91%
Q9D5Y1	Mus musculus	30%	92%
Q9UFE4	Homo sapiens	29%	91%
V5DEU3	Trypanosoma cruzi	50%	100%