Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6N7_LEIMA

TriTrypDb:

LmjF.31.0260 , LMJLV39_310007900 , LMJSD75_310007900

Length:

294

Annotations

LeishMANIAdb annotations

Apparently a divergent chaperone with distant Eukaryotic affinities. Topology is very unclear. Likely non-TM

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q6N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6N7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.630
CLV_NRD_NRD_1	210	212	PF00675	0.674
CLV_PCSK_KEX2_1	210	212	PF00082	0.666
CLV_PCSK_KEX2_1	94	96	PF00082	0.530
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.437
CLV_PCSK_SKI1_1	167	171	PF00082	0.316
CLV_PCSK_SKI1_1	190	194	PF00082	0.665
CLV_PCSK_SKI1_1	233	237	PF00082	0.650
CLV_PCSK_SKI1_1	52	56	PF00082	0.401
DEG_Nend_UBRbox_1	1	4	PF02207	0.609
DEG_SPOP_SBC_1	89	93	PF00917	0.605
DOC_MAPK_gen_1	241	249	PF00069	0.488
DOC_MAPK_JIP1_4	216	222	PF00069	0.397
DOC_PP1_RVXF_1	165	172	PF00149	0.455
DOC_PP2B_LxvP_1	220	223	PF13499	0.544
DOC_USP7_MATH_1	126	130	PF00917	0.578
DOC_USP7_MATH_1	254	258	PF00917	0.464
DOC_USP7_MATH_1	26	30	PF00917	0.689
DOC_USP7_MATH_1	37	41	PF00917	0.531
DOC_USP7_MATH_1	60	64	PF00917	0.701
DOC_USP7_MATH_1	89	93	PF00917	0.605
LIG_14-3-3_CanoR_1	108	117	PF00244	0.672
LIG_14-3-3_CanoR_1	135	144	PF00244	0.597
LIG_14-3-3_CanoR_1	2	6	PF00244	0.588
LIG_14-3-3_CanoR_1	268	273	PF00244	0.509
LIG_14-3-3_CanoR_1	64	74	PF00244	0.625
LIG_APCC_ABBAyCdc20_2	95	101	PF00400	0.615
LIG_BIR_III_2	59	63	PF00653	0.534
LIG_BRCT_BRCA1_1	145	149	PF00533	0.600
LIG_BRCT_BRCA1_1	2	6	PF00533	0.543
LIG_FHA_1	12	18	PF00498	0.584
LIG_FHA_2	148	154	PF00498	0.613
LIG_FHA_2	30	36	PF00498	0.610
LIG_FHA_2	42	48	PF00498	0.537
LIG_Integrin_RGD_1	283	285	PF01839	0.630
LIG_LIR_Apic_2	138	144	PF02991	0.647
LIG_LIR_Gen_1	178	186	PF02991	0.382
LIG_LIR_Nem_3	178	184	PF02991	0.378
LIG_NRBOX	179	185	PF00104	0.323
LIG_SH2_GRB2like	125	128	PF00017	0.625
LIG_SH2_STAP1	137	141	PF00017	0.659
LIG_SH2_STAT5	113	116	PF00017	0.623
LIG_SH2_STAT5	181	184	PF00017	0.351
LIG_SH2_STAT5	234	237	PF00017	0.374
LIG_SUMO_SIM_anti_2	246	251	PF11976	0.500
LIG_SUMO_SIM_par_1	268	273	PF11976	0.495
LIG_TRAF2_1	150	153	PF00917	0.632
MOD_CK1_1	111	117	PF00069	0.709
MOD_CK1_1	22	28	PF00069	0.536
MOD_CK1_1	257	263	PF00069	0.421
MOD_CK1_1	29	35	PF00069	0.489
MOD_CK1_1	65	71	PF00069	0.778
MOD_CK2_1	147	153	PF00069	0.615
MOD_CK2_1	29	35	PF00069	0.565
MOD_CK2_1	37	43	PF00069	0.572
MOD_GlcNHglycan	104	107	PF01048	0.558
MOD_GlcNHglycan	110	113	PF01048	0.499
MOD_GlcNHglycan	120	123	PF01048	0.470
MOD_GlcNHglycan	137	140	PF01048	0.423
MOD_GlcNHglycan	177	180	PF01048	0.445
MOD_GlcNHglycan	272	275	PF01048	0.704
MOD_GlcNHglycan	69	72	PF01048	0.549
MOD_GSK3_1	143	150	PF00069	0.567
MOD_GSK3_1	195	202	PF00069	0.411
MOD_GSK3_1	22	29	PF00069	0.526
MOD_GSK3_1	268	275	PF00069	0.538
MOD_GSK3_1	37	44	PF00069	0.504
MOD_GSK3_1	60	67	PF00069	0.614
MOD_GSK3_1	7	14	PF00069	0.559
MOD_N-GLC_1	126	131	PF02516	0.430
MOD_N-GLC_1	65	70	PF02516	0.406
MOD_N-GLC_1	78	83	PF02516	0.390
MOD_NEK2_1	1	6	PF00069	0.566
MOD_NEK2_1	270	275	PF00069	0.493
MOD_NEK2_1	7	12	PF00069	0.488
MOD_PK_1	268	274	PF00069	0.430
MOD_PKA_2	1	7	PF00069	0.584
MOD_PKA_2	144	150	PF00069	0.692
MOD_PKA_2	257	263	PF00069	0.397
MOD_PKB_1	188	196	PF00069	0.433
MOD_Plk_4	1	7	PF00069	0.731
MOD_SUMO_rev_2	285	294	PF00179	0.418
TRG_ENDOCYTIC_2	181	184	PF00928	0.291
TRG_ER_diArg_1	187	190	PF00400	0.408
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P346	Leptomonas seymouri	27%	79%
A0A0N1I1W6	Leptomonas seymouri	42%	97%
A0A3Q8IEI2	Leishmania donovani	28%	74%
A0A422P027	Trypanosoma rangeli	28%	97%
A4I4P7	Leishmania infantum	28%	74%
E9AE50	Leishmania major	29%	74%
E9ALN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	74%
E9B1H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
V5BN31	Trypanosoma cruzi	32%	96%