Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania major

UniProt:

Q4Q6N6_LEIMA

TriTrypDb:

LmjF.31.0270 , LMJLV39_310008000 , LMJSD75_310008000

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6N6

Function

Biological processes
Term	Name	Level	Count
GO:0001666	response to hypoxia	3	2
GO:0006950	response to stress	2	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0036293	response to decreased oxygen levels	4	2
GO:0036294	cellular response to decreased oxygen levels	5	2
GO:0042221	response to chemical	2	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0070482	response to oxygen levels	3	2
GO:0070887	cellular response to chemical stimulus	3	2
GO:0071453	cellular response to oxygen levels	4	2
GO:0071456	cellular response to hypoxia	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0005506	iron ion binding	6	5
GO:0008198	ferrous iron binding	7	2
GO:0016491	oxidoreductase activity	2	5
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	5
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	2
GO:0019842	vitamin binding	3	5
GO:0030246	carbohydrate binding	2	5
GO:0031406	carboxylic acid binding	4	5
GO:0031418	L-ascorbic acid binding	3	5
GO:0031543	peptidyl-proline dioxygenase activity	3	2
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0043169	cation binding	3	5
GO:0043177	organic acid binding	3	5
GO:0046872	metal ion binding	4	5
GO:0046914	transition metal ion binding	5	5
GO:0048029	monosaccharide binding	3	5
GO:0051213	dioxygenase activity	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.387
CLV_NRD_NRD_1	160	162	PF00675	0.303
CLV_NRD_NRD_1	256	258	PF00675	0.404
CLV_PCSK_KEX2_1	12	14	PF00082	0.442
CLV_PCSK_KEX2_1	159	161	PF00082	0.302
CLV_PCSK_KEX2_1	18	20	PF00082	0.358
CLV_PCSK_KEX2_1	256	258	PF00082	0.404
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.396
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.273
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.309
CLV_PCSK_SKI1_1	12	16	PF00082	0.413
CLV_PCSK_SKI1_1	133	137	PF00082	0.406
CLV_PCSK_SKI1_1	160	164	PF00082	0.273
CLV_PCSK_SKI1_1	212	216	PF00082	0.327
CLV_PCSK_SKI1_1	309	313	PF00082	0.351
CLV_PCSK_SKI1_1	42	46	PF00082	0.340
CLV_Separin_Metazoa	110	114	PF03568	0.387
DEG_APCC_DBOX_1	308	316	PF00400	0.381
DEG_Nend_UBRbox_2	1	3	PF02207	0.504
DOC_CYCLIN_RxL_1	39	47	PF00134	0.371
DOC_CYCLIN_RxL_1	9	16	PF00134	0.384
DOC_MAPK_gen_1	156	166	PF00069	0.279
DOC_MAPK_gen_1	17	25	PF00069	0.394
DOC_MAPK_gen_1	220	229	PF00069	0.328
DOC_MAPK_gen_1	307	314	PF00069	0.395
DOC_MAPK_MEF2A_6	159	168	PF00069	0.273
DOC_PP4_FxxP_1	185	188	PF00568	0.273
DOC_USP7_MATH_1	131	135	PF00917	0.476
DOC_WW_Pin1_4	57	62	PF00397	0.532
LIG_14-3-3_CanoR_1	133	138	PF00244	0.411
LIG_14-3-3_CanoR_1	160	165	PF00244	0.326
LIG_14-3-3_CanoR_1	256	264	PF00244	0.374
LIG_14-3-3_CterR_2	323	325	PF00244	0.385
LIG_Actin_WH2_2	240	258	PF00022	0.404
LIG_Actin_WH2_2	308	325	PF00022	0.453
LIG_EH1_1	8	16	PF00400	0.286
LIG_FHA_1	125	131	PF00498	0.459
LIG_FHA_1	134	140	PF00498	0.347
LIG_FHA_1	161	167	PF00498	0.273
LIG_FHA_1	196	202	PF00498	0.381
LIG_GBD_Chelix_1	108	116	PF00786	0.373
LIG_GBD_Chelix_1	7	15	PF00786	0.316
LIG_IRF3_LxIS_1	286	291	PF10401	0.385
LIG_LIR_Gen_1	238	247	PF02991	0.436
LIG_LIR_Gen_1	26	36	PF02991	0.346
LIG_LIR_Nem_3	238	244	PF02991	0.413
LIG_LIR_Nem_3	26	31	PF02991	0.361
LIG_MYND_1	184	188	PF01753	0.273
LIG_NRBOX	298	304	PF00104	0.406
LIG_PCNA_PIPBox_1	22	31	PF02747	0.375
LIG_PCNA_yPIPBox_3	17	29	PF02747	0.384
LIG_Pex14_2	225	229	PF04695	0.273
LIG_Pex14_2	97	101	PF04695	0.366
LIG_PTB_Apo_2	95	102	PF02174	0.381
LIG_Rb_LxCxE_1	114	132	PF01857	0.411
LIG_SH2_CRK	151	155	PF00017	0.273
LIG_SH2_GRB2like	151	154	PF00017	0.273
LIG_SH2_NCK_1	151	155	PF00017	0.273
LIG_SH2_SRC	151	154	PF00017	0.273
LIG_SH2_SRC	273	276	PF00017	0.373
LIG_SH2_STAP1	269	273	PF00017	0.319
LIG_SH2_STAP1	81	85	PF00017	0.382
LIG_SH2_STAT5	167	170	PF00017	0.295
LIG_SH2_STAT5	223	226	PF00017	0.381
LIG_SH2_STAT5	28	31	PF00017	0.369
LIG_SH3_1	151	157	PF00018	0.273
LIG_SH3_2	154	159	PF14604	0.273
LIG_SH3_3	151	157	PF00018	0.273
LIG_SUMO_SIM_anti_2	107	114	PF11976	0.380
MOD_CK2_1	288	294	PF00069	0.430
MOD_GlcNHglycan	257	260	PF01048	0.377
MOD_GSK3_1	129	136	PF00069	0.428
MOD_N-GLC_2	117	119	PF02516	0.381
MOD_NEK2_1	215	220	PF00069	0.309
MOD_NEK2_1	255	260	PF00069	0.340
MOD_NEK2_1	288	293	PF00069	0.365
MOD_NEK2_1	7	12	PF00069	0.332
MOD_PKA_1	160	166	PF00069	0.303
MOD_PKA_2	160	166	PF00069	0.303
MOD_PKA_2	255	261	PF00069	0.375
MOD_Plk_1	273	279	PF00069	0.376
MOD_Plk_4	195	201	PF00069	0.330
MOD_ProDKin_1	57	63	PF00069	0.538
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.371
TRG_ENDOCYTIC_2	28	31	PF00928	0.389
TRG_ER_diArg_1	160	162	PF00400	0.302
TRG_ER_diArg_1	210	213	PF00400	0.330
TRG_ER_diArg_1	255	257	PF00400	0.394
TRG_NLS_MonoExtN_4	156	163	PF00514	0.275
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P964	Leptomonas seymouri	78%	100%
A0A0S4KJQ7	Bodo saltans	47%	99%
A0A3Q8ICC7	Leishmania donovani	94%	100%
A4I6C0	Leishmania infantum	94%	100%