Endoplasmic_Reticulum-Golgi_Inediate_Compartment_(ERGIC )/Endoplasmic_reticulum_vesicle_transporter_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative

Species:

Leishmania major

UniProt:

Q4Q6N5_LEIMA

TriTrypDb:

LmjF.31.0280 , LMJLV39_310008100 , LMJSD75_310008100

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	3
GO:0016020	membrane	2	12
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	3
GO:0030135	coated vesicle	7	3
GO:0031410	cytoplasmic vesicle	6	3
GO:0031982	vesicle	4	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0097708	intracellular vesicle	5	3
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q6N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6N5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.467
CLV_NRD_NRD_1	198	200	PF00675	0.492
CLV_NRD_NRD_1	2	4	PF00675	0.391
CLV_NRD_NRD_1	311	313	PF00675	0.403
CLV_NRD_NRD_1	314	316	PF00675	0.412
CLV_NRD_NRD_1	324	326	PF00675	0.436
CLV_PCSK_FUR_1	312	316	PF00082	0.407
CLV_PCSK_FUR_1	322	326	PF00082	0.381
CLV_PCSK_KEX2_1	198	200	PF00082	0.450
CLV_PCSK_KEX2_1	2	4	PF00082	0.371
CLV_PCSK_KEX2_1	313	315	PF00082	0.408
CLV_PCSK_KEX2_1	324	326	PF00082	0.436
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.279
CLV_PCSK_SKI1_1	2	6	PF00082	0.334
CLV_PCSK_SKI1_1	65	69	PF00082	0.431
CLV_PCSK_SKI1_1	92	96	PF00082	0.518
DEG_APCC_DBOX_1	198	206	PF00400	0.250
DEG_Nend_UBRbox_1	1	4	PF02207	0.650
DOC_CKS1_1	23	28	PF01111	0.517
DOC_CYCLIN_RxL_1	62	71	PF00134	0.189
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.245
DOC_PP1_RVXF_1	76	82	PF00149	0.318
DOC_USP7_MATH_1	119	123	PF00917	0.366
DOC_USP7_MATH_1	154	158	PF00917	0.374
DOC_USP7_MATH_1	246	250	PF00917	0.323
DOC_WW_Pin1_4	19	24	PF00397	0.518
DOC_WW_Pin1_4	266	271	PF00397	0.276
DOC_WW_Pin1_4	334	339	PF00397	0.544
DOC_WW_Pin1_4	57	62	PF00397	0.278
LIG_14-3-3_CanoR_1	198	203	PF00244	0.318
LIG_14-3-3_CanoR_1	92	101	PF00244	0.303
LIG_Actin_WH2_2	303	319	PF00022	0.500
LIG_EH1_1	296	304	PF00400	0.350
LIG_FHA_1	147	153	PF00498	0.398
LIG_FHA_1	228	234	PF00498	0.248
LIG_FHA_1	33	39	PF00498	0.372
LIG_FHA_1	93	99	PF00498	0.328
LIG_FHA_2	105	111	PF00498	0.455
LIG_FHA_2	227	233	PF00498	0.315
LIG_FHA_2	296	302	PF00498	0.281
LIG_LIR_Apic_2	114	119	PF02991	0.301
LIG_LIR_Apic_2	190	195	PF02991	0.284
LIG_LIR_Gen_1	157	166	PF02991	0.296
LIG_LIR_Gen_1	245	253	PF02991	0.329
LIG_LIR_Nem_3	157	162	PF02991	0.296
LIG_LIR_Nem_3	25	30	PF02991	0.293
LIG_LIR_Nem_3	46	51	PF02991	0.355
LIG_LIR_Nem_3	62	67	PF02991	0.196
LIG_LIR_Nem_3	9	14	PF02991	0.490
LIG_Pex14_2	219	223	PF04695	0.318
LIG_SH2_CRK	116	120	PF00017	0.331
LIG_SH2_CRK	27	31	PF00017	0.451
LIG_SH2_CRK	48	52	PF00017	0.245
LIG_SH2_NCK_1	297	301	PF00017	0.431
LIG_SH2_STAT3	218	221	PF00017	0.261
LIG_SH2_STAT5	123	126	PF00017	0.313
LIG_SH2_STAT5	131	134	PF00017	0.351
LIG_SH2_STAT5	218	221	PF00017	0.269
LIG_SH2_STAT5	244	247	PF00017	0.330
LIG_SH2_STAT5	263	266	PF00017	0.318
LIG_SH2_STAT5	297	300	PF00017	0.359
LIG_SH2_STAT5	50	53	PF00017	0.294
LIG_SH3_3	20	26	PF00018	0.478
LIG_SH3_3	83	89	PF00018	0.352
LIG_SUMO_SIM_anti_2	35	43	PF11976	0.396
LIG_SUMO_SIM_par_1	29	37	PF11976	0.258
LIG_TRFH_1	266	270	PF08558	0.311
LIG_TYR_ITSM	23	30	PF00017	0.389
MOD_CK1_1	122	128	PF00069	0.380
MOD_CK1_1	269	275	PF00069	0.293
MOD_CK1_1	32	38	PF00069	0.460
MOD_CK1_1	49	55	PF00069	0.227
MOD_CK2_1	135	141	PF00069	0.462
MOD_CK2_1	295	301	PF00069	0.375
MOD_GlcNHglycan	127	130	PF01048	0.575
MOD_GlcNHglycan	132	135	PF01048	0.597
MOD_GlcNHglycan	137	140	PF01048	0.626
MOD_GlcNHglycan	183	186	PF01048	0.557
MOD_GlcNHglycan	205	208	PF01048	0.515
MOD_GlcNHglycan	209	212	PF01048	0.521
MOD_GlcNHglycan	318	322	PF01048	0.416
MOD_GlcNHglycan	51	54	PF01048	0.518
MOD_GlcNHglycan	61	64	PF01048	0.518
MOD_GSK3_1	104	111	PF00069	0.378
MOD_GSK3_1	203	210	PF00069	0.397
MOD_GSK3_1	242	249	PF00069	0.271
MOD_GSK3_1	262	269	PF00069	0.310
MOD_GSK3_1	29	36	PF00069	0.328
MOD_GSK3_1	334	341	PF00069	0.554
MOD_GSK3_1	92	99	PF00069	0.291
MOD_N-GLC_1	125	130	PF02516	0.600
MOD_N-GLC_2	288	290	PF02516	0.320
MOD_NEK2_1	262	267	PF00069	0.332
MOD_NEK2_1	79	84	PF00069	0.290
MOD_PKA_1	198	204	PF00069	0.261
MOD_PKA_2	108	114	PF00069	0.372
MOD_PKA_2	198	204	PF00069	0.292
MOD_PKB_1	315	323	PF00069	0.596
MOD_Plk_2-3	104	110	PF00069	0.311
MOD_Plk_4	111	117	PF00069	0.242
MOD_Plk_4	119	125	PF00069	0.283
MOD_Plk_4	246	252	PF00069	0.287
MOD_Plk_4	34	40	PF00069	0.381
MOD_Plk_4	46	52	PF00069	0.280
MOD_Plk_4	96	102	PF00069	0.473
MOD_ProDKin_1	19	25	PF00069	0.518
MOD_ProDKin_1	266	272	PF00069	0.276
MOD_ProDKin_1	334	340	PF00069	0.547
MOD_ProDKin_1	57	63	PF00069	0.278
TRG_DiLeu_BaEn_1	141	146	PF01217	0.245
TRG_ENDOCYTIC_2	244	247	PF00928	0.327
TRG_ENDOCYTIC_2	27	30	PF00928	0.451
TRG_ENDOCYTIC_2	279	282	PF00928	0.318
TRG_ENDOCYTIC_2	48	51	PF00928	0.273
TRG_ER_diArg_1	1	3	PF00400	0.597
TRG_ER_diArg_1	197	199	PF00400	0.292
TRG_ER_diArg_1	312	315	PF00400	0.608
TRG_ER_diArg_1	322	325	PF00400	0.631
TRG_NLS_MonoCore_2	311	316	PF00514	0.471
TRG_NLS_MonoExtC_3	171	176	PF00514	0.273
TRG_NLS_MonoExtC_3	312	317	PF00514	0.476
TRG_NLS_MonoExtN_4	312	317	PF00514	0.476
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T7	Leptomonas seymouri	61%	100%
A0A0N1I377	Leptomonas seymouri	25%	100%
A0A0S4J3I3	Bodo saltans	25%	100%
A0A3Q8IGC2	Leishmania donovani	26%	100%
A0A3S7X427	Leishmania donovani	93%	100%
A4HJ02	Leishmania braziliensis	79%	100%
A4HL28	Leishmania braziliensis	28%	100%
A4I6C1	Leishmania infantum	93%	100%
A4I8K9	Leishmania infantum	26%	100%
E9B1H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B3G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q4N1	Leishmania major	26%	100%
Q4V8Y6	Danio rerio	24%	100%
Q6NS19	Xenopus laevis	24%	100%
Q969X5	Homo sapiens	22%	100%
Q9DC16	Mus musculus	23%	100%