Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 4, putative

Species:

Leishmania major

UniProt:

Q4Q6N4_LEIMA

TriTrypDb:

LmjF.31.0290 , LMJLV39_310008200 , LMJSD75_310008200

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005874	microtubule	6	7
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0097542	ciliary tip	2	2
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q6N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6N4

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0007019	microtubule depolymerization	5	2
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	2
GO:0022411	cellular component disassembly	4	2
GO:0031109	microtubule polymerization or depolymerization	4	2
GO:0032984	protein-containing complex disassembly	5	2
GO:0043933	protein-containing complex organization	4	2
GO:0051261	protein depolymerization	6	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097435	supramolecular fiber organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003774	cytoskeletal motor activity	1	7
GO:0003777	microtubule motor activity	2	7
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0005524	ATP binding	5	7
GO:0008017	microtubule binding	5	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0015631	tubulin binding	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	698	702	PF00656	0.725
CLV_NRD_NRD_1	103	105	PF00675	0.807
CLV_NRD_NRD_1	211	213	PF00675	0.411
CLV_NRD_NRD_1	359	361	PF00675	0.428
CLV_NRD_NRD_1	388	390	PF00675	0.393
CLV_NRD_NRD_1	581	583	PF00675	0.742
CLV_NRD_NRD_1	589	591	PF00675	0.711
CLV_NRD_NRD_1	666	668	PF00675	0.816
CLV_NRD_NRD_1	672	674	PF00675	0.744
CLV_NRD_NRD_1	72	74	PF00675	0.791
CLV_PCSK_FUR_1	587	591	PF00082	0.793
CLV_PCSK_FUR_1	70	74	PF00082	0.735
CLV_PCSK_KEX2_1	102	104	PF00082	0.803
CLV_PCSK_KEX2_1	213	215	PF00082	0.411
CLV_PCSK_KEX2_1	359	361	PF00082	0.428
CLV_PCSK_KEX2_1	388	390	PF00082	0.411
CLV_PCSK_KEX2_1	581	583	PF00082	0.742
CLV_PCSK_KEX2_1	587	589	PF00082	0.724
CLV_PCSK_KEX2_1	648	650	PF00082	0.731
CLV_PCSK_KEX2_1	666	668	PF00082	0.819
CLV_PCSK_KEX2_1	72	74	PF00082	0.791
CLV_PCSK_KEX2_1	799	801	PF00082	0.604
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.411
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.703
CLV_PCSK_PC1ET2_1	799	801	PF00082	0.604
CLV_PCSK_PC7_1	584	590	PF00082	0.740
CLV_PCSK_SKI1_1	274	278	PF00082	0.410
CLV_PCSK_SKI1_1	34	38	PF00082	0.720
CLV_PCSK_SKI1_1	452	456	PF00082	0.355
CLV_PCSK_SKI1_1	513	517	PF00082	0.411
CLV_PCSK_SKI1_1	716	720	PF00082	0.783
CLV_PCSK_SKI1_1	775	779	PF00082	0.577
CLV_Separin_Metazoa	480	484	PF03568	0.411
DEG_APCC_DBOX_1	735	743	PF00400	0.633
DOC_ANK_TNKS_1	213	220	PF00023	0.492
DOC_CDC14_PxL_1	122	130	PF14671	0.562
DOC_CYCLIN_RxL_1	449	459	PF00134	0.411
DOC_MAPK_gen_1	201	209	PF00069	0.604
DOC_MAPK_gen_1	322	331	PF00069	0.512
DOC_MAPK_gen_1	467	473	PF00069	0.411
DOC_MAPK_gen_1	671	679	PF00069	0.697
DOC_MAPK_gen_1	703	712	PF00069	0.793
DOC_MAPK_MEF2A_6	203	211	PF00069	0.563
DOC_MAPK_MEF2A_6	230	237	PF00069	0.408
DOC_MAPK_MEF2A_6	274	281	PF00069	0.411
DOC_MAPK_MEF2A_6	324	333	PF00069	0.428
DOC_MAPK_MEF2A_6	401	410	PF00069	0.411
DOC_MAPK_MEF2A_6	532	541	PF00069	0.628
DOC_PP2B_LxvP_1	128	131	PF13499	0.744
DOC_PP2B_LxvP_1	521	524	PF13499	0.629
DOC_PP2B_LxvP_1	537	540	PF13499	0.754
DOC_PP2B_LxvP_1	677	680	PF13499	0.685
DOC_USP7_MATH_1	112	116	PF00917	0.756
DOC_USP7_MATH_1	30	34	PF00917	0.770
DOC_USP7_MATH_1	682	686	PF00917	0.760
DOC_USP7_MATH_1	695	699	PF00917	0.698
DOC_USP7_MATH_1	766	770	PF00917	0.647
DOC_USP7_MATH_1	89	93	PF00917	0.743
DOC_WW_Pin1_4	102	107	PF00397	0.731
DOC_WW_Pin1_4	139	144	PF00397	0.766
DOC_WW_Pin1_4	145	150	PF00397	0.723
DOC_WW_Pin1_4	162	167	PF00397	0.684
DOC_WW_Pin1_4	180	185	PF00397	0.767
DOC_WW_Pin1_4	496	501	PF00397	0.394
DOC_WW_Pin1_4	576	581	PF00397	0.760
DOC_WW_Pin1_4	617	622	PF00397	0.771
DOC_WW_Pin1_4	788	793	PF00397	0.728
DOC_WW_Pin1_4	8	13	PF00397	0.753
DOC_WW_Pin1_4	809	814	PF00397	0.669
LIG_14-3-3_CanoR_1	152	159	PF00244	0.839
LIG_14-3-3_CanoR_1	191	196	PF00244	0.737
LIG_14-3-3_CanoR_1	206	210	PF00244	0.449
LIG_14-3-3_CanoR_1	25	30	PF00244	0.735
LIG_14-3-3_CanoR_1	369	375	PF00244	0.409
LIG_14-3-3_CanoR_1	409	416	PF00244	0.450
LIG_14-3-3_CanoR_1	41	46	PF00244	0.717
LIG_14-3-3_CanoR_1	483	487	PF00244	0.450
LIG_14-3-3_CanoR_1	61	68	PF00244	0.821
LIG_14-3-3_CanoR_1	649	658	PF00244	0.718
LIG_14-3-3_CanoR_1	70	79	PF00244	0.670
LIG_14-3-3_CanoR_1	720	726	PF00244	0.750
LIG_14-3-3_CanoR_1	736	740	PF00244	0.444
LIG_14-3-3_CterR_2	836	840	PF00244	0.707
LIG_Actin_WH2_2	760	777	PF00022	0.550
LIG_BRCT_BRCA1_1	420	424	PF00533	0.286
LIG_CaM_IQ_9	625	640	PF13499	0.605
LIG_Clathr_ClatBox_1	725	729	PF01394	0.513
LIG_EH1_1	270	278	PF00400	0.327
LIG_FHA_1	206	212	PF00498	0.564
LIG_FHA_1	276	282	PF00498	0.424
LIG_FHA_1	417	423	PF00498	0.419
LIG_FHA_1	477	483	PF00498	0.411
LIG_FHA_1	490	496	PF00498	0.411
LIG_FHA_1	650	656	PF00498	0.564
LIG_FHA_1	736	742	PF00498	0.531
LIG_FHA_1	779	785	PF00498	0.496
LIG_FHA_1	82	88	PF00498	0.764
LIG_FHA_1	824	830	PF00498	0.798
LIG_FHA_2	243	249	PF00498	0.512
LIG_FHA_2	262	268	PF00498	0.199
LIG_FHA_2	303	309	PF00498	0.411
LIG_FHA_2	371	377	PF00498	0.450
LIG_FHA_2	392	398	PF00498	0.512
LIG_FHA_2	409	415	PF00498	0.232
LIG_FHA_2	441	447	PF00498	0.411
LIG_FHA_2	53	59	PF00498	0.759
LIG_FHA_2	593	599	PF00498	0.601
LIG_FHA_2	614	620	PF00498	0.823
LIG_FHA_2	670	676	PF00498	0.773
LIG_LIR_Gen_1	299	306	PF02991	0.411
LIG_LIR_Gen_1	318	325	PF02991	0.411
LIG_LIR_Gen_1	340	350	PF02991	0.394
LIG_LIR_Gen_1	375	385	PF02991	0.407
LIG_LIR_Gen_1	421	428	PF02991	0.512
LIG_LIR_Nem_3	318	323	PF02991	0.325
LIG_LIR_Nem_3	332	337	PF02991	0.419
LIG_LIR_Nem_3	340	345	PF02991	0.394
LIG_LIR_Nem_3	367	371	PF02991	0.443
LIG_LIR_Nem_3	375	381	PF02991	0.378
LIG_LIR_Nem_3	421	427	PF02991	0.428
LIG_NRBOX	340	346	PF00104	0.411
LIG_Pex14_2	255	259	PF04695	0.512
LIG_PTB_Apo_2	336	343	PF02174	0.411
LIG_PTB_Apo_2	412	419	PF02174	0.450
LIG_PTB_Phospho_1	336	342	PF10480	0.512
LIG_SH2_CRK	342	346	PF00017	0.512
LIG_SH2_SRC	247	250	PF00017	0.450
LIG_SH2_SRC	269	272	PF00017	0.389
LIG_SH2_SRC	312	315	PF00017	0.286
LIG_SH2_STAP1	269	273	PF00017	0.380
LIG_SH2_STAP1	514	518	PF00017	0.411
LIG_SH2_STAT5	253	256	PF00017	0.396
LIG_SH2_STAT5	300	303	PF00017	0.411
LIG_SH2_STAT5	312	315	PF00017	0.411
LIG_SH2_STAT5	337	340	PF00017	0.411
LIG_SH3_1	103	109	PF00018	0.772
LIG_SH3_1	212	218	PF00018	0.492
LIG_SH3_3	103	109	PF00018	0.751
LIG_SH3_3	141	147	PF00018	0.724
LIG_SH3_3	156	162	PF00018	0.706
LIG_SH3_3	212	218	PF00018	0.475
LIG_SH3_3	577	583	PF00018	0.784
LIG_SH3_3	707	713	PF00018	0.696
LIG_SH3_3	807	813	PF00018	0.669
LIG_SH3_CIN85_PxpxPR_1	147	152	PF14604	0.775
LIG_SUMO_SIM_par_1	275	280	PF11976	0.411
LIG_SUMO_SIM_par_1	349	356	PF11976	0.411
LIG_SUMO_SIM_par_1	453	459	PF11976	0.411
LIG_SUMO_SIM_par_1	723	729	PF11976	0.570
LIG_TRAF2_1	134	137	PF00917	0.624
LIG_TRAF2_1	246	249	PF00917	0.411
LIG_TRAF2_1	264	267	PF00917	0.411
LIG_TRAF2_1	373	376	PF00917	0.450
LIG_UBA3_1	454	458	PF00899	0.355
MOD_CDC14_SPxK_1	579	582	PF00782	0.779
MOD_CDK_SPK_2	576	581	PF00069	0.735
MOD_CDK_SPK_2	617	622	PF00069	0.761
MOD_CDK_SPxK_1	576	582	PF00069	0.778
MOD_CDK_SPxxK_3	145	152	PF00069	0.822
MOD_CDK_SPxxK_3	617	624	PF00069	0.772
MOD_CK1_1	105	111	PF00069	0.768
MOD_CK1_1	115	121	PF00069	0.632
MOD_CK1_1	160	166	PF00069	0.703
MOD_CK1_1	185	191	PF00069	0.809
MOD_CK1_1	193	199	PF00069	0.650
MOD_CK1_1	282	288	PF00069	0.485
MOD_CK1_1	296	302	PF00069	0.309
MOD_CK1_1	399	405	PF00069	0.349
MOD_CK1_1	476	482	PF00069	0.411
MOD_CK1_1	499	505	PF00069	0.411
MOD_CK1_1	522	528	PF00069	0.651
MOD_CK1_1	54	60	PF00069	0.751
MOD_CK1_1	568	574	PF00069	0.774
MOD_CK1_1	611	617	PF00069	0.741
MOD_CK1_1	640	646	PF00069	0.818
MOD_CK1_1	811	817	PF00069	0.714
MOD_CK1_1	822	828	PF00069	0.639
MOD_CK2_1	139	145	PF00069	0.780
MOD_CK2_1	242	248	PF00069	0.411
MOD_CK2_1	261	267	PF00069	0.411
MOD_CK2_1	302	308	PF00069	0.411
MOD_CK2_1	329	335	PF00069	0.492
MOD_CK2_1	370	376	PF00069	0.450
MOD_CK2_1	380	386	PF00069	0.418
MOD_CK2_1	391	397	PF00069	0.361
MOD_CK2_1	408	414	PF00069	0.411
MOD_CK2_1	440	446	PF00069	0.411
MOD_CK2_1	52	58	PF00069	0.761
MOD_CK2_1	592	598	PF00069	0.608
MOD_CK2_1	613	619	PF00069	0.733
MOD_CK2_1	669	675	PF00069	0.775
MOD_CK2_1	682	688	PF00069	0.732
MOD_CK2_1	766	772	PF00069	0.628
MOD_DYRK1A_RPxSP_1	180	184	PF00069	0.640
MOD_GlcNHglycan	159	162	PF01048	0.719
MOD_GlcNHglycan	184	187	PF01048	0.766
MOD_GlcNHglycan	256	259	PF01048	0.450
MOD_GlcNHglycan	27	30	PF01048	0.712
MOD_GlcNHglycan	281	284	PF01048	0.424
MOD_GlcNHglycan	295	298	PF01048	0.377
MOD_GlcNHglycan	382	385	PF01048	0.453
MOD_GlcNHglycan	559	562	PF01048	0.697
MOD_GlcNHglycan	645	648	PF01048	0.699
MOD_GlcNHglycan	697	700	PF01048	0.691
MOD_GlcNHglycan	74	77	PF01048	0.719
MOD_GlcNHglycan	764	767	PF01048	0.413
MOD_GlcNHglycan	821	824	PF01048	0.704
MOD_GlcNHglycan	91	94	PF01048	0.734
MOD_GSK3_1	113	120	PF00069	0.745
MOD_GSK3_1	176	183	PF00069	0.746
MOD_GSK3_1	187	194	PF00069	0.683
MOD_GSK3_1	243	250	PF00069	0.450
MOD_GSK3_1	275	282	PF00069	0.512
MOD_GSK3_1	298	305	PF00069	0.411
MOD_GSK3_1	387	394	PF00069	0.387
MOD_GSK3_1	404	411	PF00069	0.263
MOD_GSK3_1	41	48	PF00069	0.705
MOD_GSK3_1	522	529	PF00069	0.597
MOD_GSK3_1	611	618	PF00069	0.768
MOD_GSK3_1	637	644	PF00069	0.825
MOD_GSK3_1	661	668	PF00069	0.651
MOD_GSK3_1	682	689	PF00069	0.651
MOD_GSK3_1	695	702	PF00069	0.589
MOD_GSK3_1	716	723	PF00069	0.696
MOD_GSK3_1	762	769	PF00069	0.508
MOD_GSK3_1	818	825	PF00069	0.763
MOD_LATS_1	39	45	PF00433	0.592
MOD_LATS_1	714	720	PF00433	0.725
MOD_N-GLC_1	450	455	PF02516	0.411
MOD_N-GLC_1	52	57	PF02516	0.761
MOD_N-GLC_1	608	613	PF02516	0.709
MOD_N-GLC_1	638	643	PF02516	0.722
MOD_N-GLC_1	695	700	PF02516	0.737
MOD_N-GLC_2	362	364	PF02516	0.411
MOD_NEK2_1	277	282	PF00069	0.411
MOD_NEK2_1	329	334	PF00069	0.383
MOD_NEK2_1	380	385	PF00069	0.450
MOD_NEK2_1	418	423	PF00069	0.512
MOD_NEK2_1	473	478	PF00069	0.411
MOD_NEK2_1	482	487	PF00069	0.411
MOD_NEK2_1	51	56	PF00069	0.763
MOD_NEK2_1	625	630	PF00069	0.796
MOD_NEK2_1	659	664	PF00069	0.637
MOD_NEK2_1	778	783	PF00069	0.543
MOD_NEK2_1	79	84	PF00069	0.755
MOD_NEK2_2	14	19	PF00069	0.771
MOD_NEK2_2	269	274	PF00069	0.492
MOD_NEK2_2	284	289	PF00069	0.294
MOD_NEK2_2	337	342	PF00069	0.394
MOD_NEK2_2	404	409	PF00069	0.411
MOD_NMyristoyl	1	7	PF02799	0.631
MOD_PIKK_1	625	631	PF00454	0.731
MOD_PIKK_1	661	667	PF00454	0.707
MOD_PK_1	191	197	PF00069	0.716
MOD_PK_1	41	47	PF00069	0.714
MOD_PK_1	519	525	PF00069	0.589
MOD_PKA_1	72	78	PF00069	0.785
MOD_PKA_2	151	157	PF00069	0.842
MOD_PKA_2	190	196	PF00069	0.655
MOD_PKA_2	205	211	PF00069	0.459
MOD_PKA_2	387	393	PF00069	0.411
MOD_PKA_2	408	414	PF00069	0.450
MOD_PKA_2	440	446	PF00069	0.411
MOD_PKA_2	473	479	PF00069	0.411
MOD_PKA_2	482	488	PF00069	0.411
MOD_PKA_2	60	66	PF00069	0.823
MOD_PKA_2	637	643	PF00069	0.706
MOD_PKA_2	665	671	PF00069	0.806
MOD_PKA_2	71	77	PF00069	0.614
MOD_PKA_2	735	741	PF00069	0.506
MOD_PKB_1	102	110	PF00069	0.734
MOD_PKB_1	180	188	PF00069	0.767
MOD_PKB_1	667	675	PF00069	0.774
MOD_PKB_1	70	78	PF00069	0.737
MOD_Plk_1	242	248	PF00069	0.407
MOD_Plk_1	450	456	PF00069	0.411
MOD_Plk_1	565	571	PF00069	0.755
MOD_Plk_1	57	63	PF00069	0.768
MOD_Plk_2-3	243	249	PF00069	0.411
MOD_Plk_4	117	123	PF00069	0.620
MOD_Plk_4	298	304	PF00069	0.367
MOD_Plk_4	329	335	PF00069	0.492
MOD_Plk_4	337	343	PF00069	0.394
MOD_Plk_4	41	47	PF00069	0.590
MOD_Plk_4	450	456	PF00069	0.411
MOD_Plk_4	489	495	PF00069	0.411
MOD_Plk_4	522	528	PF00069	0.525
MOD_Plk_4	721	727	PF00069	0.734
MOD_Plk_4	759	765	PF00069	0.597
MOD_Plk_4	811	817	PF00069	0.672
MOD_ProDKin_1	102	108	PF00069	0.730
MOD_ProDKin_1	139	145	PF00069	0.770
MOD_ProDKin_1	162	168	PF00069	0.684
MOD_ProDKin_1	180	186	PF00069	0.768
MOD_ProDKin_1	496	502	PF00069	0.394
MOD_ProDKin_1	576	582	PF00069	0.762
MOD_ProDKin_1	617	623	PF00069	0.769
MOD_ProDKin_1	788	794	PF00069	0.730
MOD_ProDKin_1	8	14	PF00069	0.754
MOD_ProDKin_1	809	815	PF00069	0.669
MOD_SUMO_rev_2	698	704	PF00179	0.787
TRG_DiLeu_BaEn_1	376	381	PF01217	0.411
TRG_DiLeu_BaEn_1	688	693	PF01217	0.726
TRG_DiLeu_BaEn_2	116	122	PF01217	0.594
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.676
TRG_ENDOCYTIC_2	300	303	PF00928	0.411
TRG_ENDOCYTIC_2	342	345	PF00928	0.512
TRG_ER_diArg_1	102	104	PF00400	0.803
TRG_ER_diArg_1	211	214	PF00400	0.411
TRG_ER_diArg_1	322	325	PF00400	0.511
TRG_ER_diArg_1	359	361	PF00400	0.411
TRG_ER_diArg_1	580	582	PF00400	0.777
TRG_ER_diArg_1	587	590	PF00400	0.741
TRG_ER_diArg_1	621	624	PF00400	0.774
TRG_ER_diArg_1	666	669	PF00400	0.820
TRG_ER_diArg_1	70	73	PF00400	0.778
TRG_NES_CRM1_1	735	748	PF08389	0.632
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	705	709	PF00026	0.792
TRG_Pf-PMV_PEXEL_1	836	840	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGE8	Leptomonas seymouri	55%	90%
A0A3Q8IG71	Leishmania donovani	91%	100%
A4HJ03	Leishmania braziliensis	69%	95%
A4I6C2	Leishmania infantum	91%	88%
E9B1I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%