Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6M6_LEIMA

TriTrypDb:

LmjF.31.0370 , LMJLV39_310009000 , LMJSD75_310009000

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6M6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004497	monooxygenase activity	3	2
GO:0005488	binding	1	2
GO:0005506	iron ion binding	6	2
GO:0016491	oxidoreductase activity	2	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	2
GO:0020037	heme binding	4	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046906	tetrapyrrole binding	3	2
GO:0046914	transition metal ion binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.656
CLV_NRD_NRD_1	21	23	PF00675	0.627
CLV_NRD_NRD_1	25	27	PF00675	0.499
CLV_NRD_NRD_1	33	35	PF00675	0.500
CLV_PCSK_KEX2_1	21	23	PF00082	0.622
CLV_PCSK_KEX2_1	25	27	PF00082	0.510
CLV_PCSK_KEX2_1	33	35	PF00082	0.484
CLV_PCSK_KEX2_1	352	354	PF00082	0.563
CLV_PCSK_KEX2_1	528	530	PF00082	0.477
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.563
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.473
CLV_PCSK_PC7_1	21	27	PF00082	0.614
CLV_PCSK_PC7_1	524	530	PF00082	0.460
CLV_PCSK_SKI1_1	101	105	PF00082	0.573
CLV_PCSK_SKI1_1	39	43	PF00082	0.615
CLV_PCSK_SKI1_1	586	590	PF00082	0.380
DEG_Nend_UBRbox_1	1	4	PF02207	0.652
DEG_SCF_FBW7_1	497	504	PF00400	0.450
DEG_SPOP_SBC_1	541	545	PF00917	0.303
DEG_SPOP_SBC_1	67	71	PF00917	0.545
DOC_CKS1_1	133	138	PF01111	0.543
DOC_CYCLIN_yClb5_NLxxxL_5	669	678	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	618	621	PF00134	0.459
DOC_MAPK_gen_1	528	535	PF00069	0.624
DOC_MAPK_MEF2A_6	289	297	PF00069	0.381
DOC_PP2B_LxvP_1	13	16	PF13499	0.620
DOC_PP2B_LxvP_1	190	193	PF13499	0.463
DOC_PP2B_LxvP_1	618	621	PF13499	0.463
DOC_PP4_FxxP_1	309	312	PF00568	0.449
DOC_PP4_FxxP_1	617	620	PF00568	0.418
DOC_PP4_MxPP_1	185	188	PF00568	0.614
DOC_USP7_MATH_1	112	116	PF00917	0.721
DOC_USP7_MATH_1	142	146	PF00917	0.617
DOC_USP7_MATH_1	342	346	PF00917	0.733
DOC_USP7_MATH_1	366	370	PF00917	0.495
DOC_USP7_MATH_1	410	414	PF00917	0.671
DOC_USP7_MATH_1	416	420	PF00917	0.588
DOC_USP7_MATH_1	541	545	PF00917	0.328
DOC_USP7_MATH_1	637	641	PF00917	0.454
DOC_USP7_UBL2_3	75	79	PF12436	0.496
DOC_WW_Pin1_4	104	109	PF00397	0.707
DOC_WW_Pin1_4	132	137	PF00397	0.580
DOC_WW_Pin1_4	170	175	PF00397	0.374
DOC_WW_Pin1_4	358	363	PF00397	0.597
DOC_WW_Pin1_4	406	411	PF00397	0.645
DOC_WW_Pin1_4	476	481	PF00397	0.461
DOC_WW_Pin1_4	497	502	PF00397	0.501
DOC_WW_Pin1_4	77	82	PF00397	0.702
LIG_14-3-3_CanoR_1	101	108	PF00244	0.727
LIG_14-3-3_CanoR_1	110	119	PF00244	0.725
LIG_14-3-3_CanoR_1	126	136	PF00244	0.545
LIG_14-3-3_CanoR_1	156	163	PF00244	0.496
LIG_14-3-3_CanoR_1	2	8	PF00244	0.613
LIG_14-3-3_CanoR_1	21	27	PF00244	0.571
LIG_14-3-3_CanoR_1	266	271	PF00244	0.379
LIG_14-3-3_CanoR_1	301	306	PF00244	0.545
LIG_14-3-3_CanoR_1	438	444	PF00244	0.409
LIG_14-3-3_CanoR_1	624	628	PF00244	0.531
LIG_Actin_WH2_2	290	308	PF00022	0.275
LIG_Actin_WH2_2	5	23	PF00022	0.609
LIG_APCC_ABBA_1	293	298	PF00400	0.356
LIG_BRCT_BRCA1_1	202	206	PF00533	0.476
LIG_CtBP_PxDLS_1	174	178	PF00389	0.498
LIG_FHA_1	122	128	PF00498	0.679
LIG_FHA_1	133	139	PF00498	0.547
LIG_FHA_1	2	8	PF00498	0.746
LIG_FHA_1	30	36	PF00498	0.592
LIG_FHA_1	331	337	PF00498	0.400
LIG_FHA_1	448	454	PF00498	0.468
LIG_FHA_1	502	508	PF00498	0.481
LIG_FHA_1	546	552	PF00498	0.439
LIG_FHA_1	58	64	PF00498	0.558
LIG_FHA_2	247	253	PF00498	0.459
LIG_FHA_2	566	572	PF00498	0.476
LIG_IBAR_NPY_1	43	45	PF08397	0.526
LIG_Integrin_isoDGR_2	649	651	PF01839	0.473
LIG_LIR_Apic_2	308	312	PF02991	0.472
LIG_LIR_Gen_1	203	212	PF02991	0.498
LIG_LIR_Gen_1	299	309	PF02991	0.371
LIG_LIR_Gen_1	548	556	PF02991	0.419
LIG_LIR_Nem_3	203	209	PF02991	0.477
LIG_LIR_Nem_3	299	305	PF02991	0.382
LIG_LIR_Nem_3	361	367	PF02991	0.522
LIG_LIR_Nem_3	469	475	PF02991	0.342
LIG_LIR_Nem_3	525	530	PF02991	0.388
LIG_LIR_Nem_3	548	553	PF02991	0.401
LIG_LIR_Nem_3	568	573	PF02991	0.340
LIG_MYND_1	175	179	PF01753	0.503
LIG_MYND_1	616	620	PF01753	0.462
LIG_NRBOX	217	223	PF00104	0.387
LIG_NRBOX	562	568	PF00104	0.426
LIG_Pex14_2	360	364	PF04695	0.460
LIG_PTAP_UEV_1	411	416	PF05743	0.545
LIG_SH2_CRK	242	246	PF00017	0.381
LIG_SH2_CRK	625	629	PF00017	0.507
LIG_SH2_NCK_1	625	629	PF00017	0.507
LIG_SH2_PTP2	550	553	PF00017	0.466
LIG_SH2_STAP1	231	235	PF00017	0.494
LIG_SH2_STAP1	488	492	PF00017	0.431
LIG_SH2_STAT5	200	203	PF00017	0.448
LIG_SH2_STAT5	432	435	PF00017	0.372
LIG_SH2_STAT5	475	478	PF00017	0.336
LIG_SH2_STAT5	50	53	PF00017	0.502
LIG_SH2_STAT5	550	553	PF00017	0.466
LIG_SH2_STAT5	625	628	PF00017	0.336
LIG_SH3_3	130	136	PF00018	0.505
LIG_SH3_3	185	191	PF00018	0.502
LIG_SH3_3	365	371	PF00018	0.373
LIG_SH3_3	38	44	PF00018	0.564
LIG_SH3_3	409	415	PF00018	0.592
LIG_SUMO_SIM_par_1	268	274	PF11976	0.338
LIG_TRAF2_1	327	330	PF00917	0.404
LIG_TRAF2_1	87	90	PF00917	0.562
LIG_TYR_ITIM	623	628	PF00017	0.427
LIG_UBA3_1	197	202	PF00899	0.418
LIG_WRC_WIRS_1	247	252	PF05994	0.334
LIG_WRC_WIRS_1	567	572	PF05994	0.440
LIG_WW_3	186	190	PF00397	0.505
MOD_CDC14_SPxK_1	107	110	PF00782	0.578
MOD_CDK_SPK_2	358	363	PF00069	0.556
MOD_CDK_SPxK_1	104	110	PF00069	0.569
MOD_CK1_1	128	134	PF00069	0.639
MOD_CK1_1	220	226	PF00069	0.434
MOD_CK1_1	274	280	PF00069	0.555
MOD_CK1_1	384	390	PF00069	0.578
MOD_CK1_1	406	412	PF00069	0.545
MOD_CK1_1	464	470	PF00069	0.477
MOD_CK1_1	479	485	PF00069	0.292
MOD_CK1_1	545	551	PF00069	0.335
MOD_CK2_1	111	117	PF00069	0.724
MOD_CK2_1	274	280	PF00069	0.486
MOD_CK2_1	310	316	PF00069	0.435
MOD_CK2_1	384	390	PF00069	0.623
MOD_CK2_1	393	399	PF00069	0.404
MOD_CK2_1	439	445	PF00069	0.442
MOD_CK2_1	516	522	PF00069	0.478
MOD_CK2_1	565	571	PF00069	0.481
MOD_GlcNHglycan	114	117	PF01048	0.727
MOD_GlcNHglycan	119	122	PF01048	0.692
MOD_GlcNHglycan	158	161	PF01048	0.611
MOD_GlcNHglycan	222	225	PF01048	0.367
MOD_GlcNHglycan	256	259	PF01048	0.430
MOD_GlcNHglycan	273	276	PF01048	0.442
MOD_GlcNHglycan	332	336	PF01048	0.498
MOD_GlcNHglycan	368	371	PF01048	0.485
MOD_GlcNHglycan	386	389	PF01048	0.498
MOD_GlcNHglycan	412	415	PF01048	0.616
MOD_GlcNHglycan	418	421	PF01048	0.541
MOD_GlcNHglycan	51	54	PF01048	0.561
MOD_GlcNHglycan	535	538	PF01048	0.571
MOD_GlcNHglycan	639	642	PF01048	0.571
MOD_GlcNHglycan	668	672	PF01048	0.663
MOD_GlcNHglycan	70	73	PF01048	0.489
MOD_GlcNHglycan	85	88	PF01048	0.462
MOD_GSK3_1	117	124	PF00069	0.708
MOD_GSK3_1	128	135	PF00069	0.586
MOD_GSK3_1	271	278	PF00069	0.551
MOD_GSK3_1	296	303	PF00069	0.469
MOD_GSK3_1	384	391	PF00069	0.539
MOD_GSK3_1	406	413	PF00069	0.585
MOD_GSK3_1	447	454	PF00069	0.529
MOD_GSK3_1	461	468	PF00069	0.288
MOD_GSK3_1	497	504	PF00069	0.375
MOD_GSK3_1	541	548	PF00069	0.337
MOD_GSK3_1	633	640	PF00069	0.433
MOD_GSK3_1	66	73	PF00069	0.560
MOD_N-GLC_1	122	127	PF02516	0.541
MOD_N-GLC_1	348	353	PF02516	0.596
MOD_N-GLC_1	381	386	PF02516	0.517
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	111	116	PF00069	0.792
MOD_NEK2_1	127	132	PF00069	0.537
MOD_NEK2_1	20	25	PF00069	0.400
MOD_NEK2_1	245	250	PF00069	0.344
MOD_NEK2_1	296	301	PF00069	0.338
MOD_NEK2_1	381	386	PF00069	0.667
MOD_NEK2_1	403	408	PF00069	0.579
MOD_NEK2_1	465	470	PF00069	0.370
MOD_NEK2_1	8	13	PF00069	0.579
MOD_NEK2_2	246	251	PF00069	0.347
MOD_PKA_2	1	7	PF00069	0.655
MOD_PKA_2	112	118	PF00069	0.739
MOD_PKA_2	125	131	PF00069	0.679
MOD_PKA_2	143	149	PF00069	0.625
MOD_PKA_2	168	174	PF00069	0.551
MOD_PKA_2	20	26	PF00069	0.384
MOD_PKA_2	265	271	PF00069	0.553
MOD_PKA_2	300	306	PF00069	0.463
MOD_PKA_2	384	390	PF00069	0.575
MOD_PKA_2	451	457	PF00069	0.543
MOD_PKA_2	623	629	PF00069	0.510
MOD_PKB_1	154	162	PF00069	0.477
MOD_PKB_1	594	602	PF00069	0.461
MOD_Plk_1	122	128	PF00069	0.601
MOD_Plk_1	287	293	PF00069	0.438
MOD_Plk_1	331	337	PF00069	0.400
MOD_Plk_1	381	387	PF00069	0.452
MOD_Plk_1	652	658	PF00069	0.643
MOD_Plk_1	89	95	PF00069	0.580
MOD_Plk_2-3	14	20	PF00069	0.516
MOD_Plk_4	217	223	PF00069	0.508
MOD_Plk_4	259	265	PF00069	0.433
MOD_Plk_4	266	272	PF00069	0.449
MOD_Plk_4	371	377	PF00069	0.420
MOD_Plk_4	461	467	PF00069	0.521
MOD_Plk_4	623	629	PF00069	0.565
MOD_Plk_4	8	14	PF00069	0.619
MOD_ProDKin_1	104	110	PF00069	0.712
MOD_ProDKin_1	132	138	PF00069	0.579
MOD_ProDKin_1	170	176	PF00069	0.381
MOD_ProDKin_1	358	364	PF00069	0.579
MOD_ProDKin_1	406	412	PF00069	0.651
MOD_ProDKin_1	476	482	PF00069	0.469
MOD_ProDKin_1	497	503	PF00069	0.494
MOD_ProDKin_1	77	83	PF00069	0.694
MOD_SUMO_for_1	201	204	PF00179	0.416
MOD_SUMO_rev_2	31	41	PF00179	0.603
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.375
TRG_DiLeu_BaLyEn_6	549	554	PF01217	0.450
TRG_ENDOCYTIC_2	242	245	PF00928	0.497
TRG_ENDOCYTIC_2	550	553	PF00928	0.495
TRG_ENDOCYTIC_2	574	577	PF00928	0.425
TRG_ENDOCYTIC_2	625	628	PF00928	0.554
TRG_ER_diArg_1	153	156	PF00400	0.569
TRG_ER_diArg_1	20	22	PF00400	0.582
TRG_ER_diArg_1	25	27	PF00400	0.505
TRG_ER_diArg_1	33	36	PF00400	0.559
TRG_ER_diArg_1	405	408	PF00400	0.599
TRG_ER_FFAT_2	48	56	PF00635	0.555
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T2	Leptomonas seymouri	45%	100%
A0A3R7MH20	Trypanosoma rangeli	30%	100%
A0A3S7X435	Leishmania donovani	90%	100%
A4HJ12	Leishmania braziliensis	72%	100%
A4I6K2	Leishmania infantum	90%	100%
C9ZJE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B1I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5AYQ1	Trypanosoma cruzi	30%	100%