Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6M6_LEIMA

TriTrypDb:

LmjF.31.0370 , LMJLV39_310009000 , LMJSD75_310009000

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6M6

Function

Could not find GO biological_process term for this entry.

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004497	monooxygenase activity	3	2
GO:0005488	binding	1	2
GO:0005506	iron ion binding	6	2
GO:0016491	oxidoreductase activity	2	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	2
GO:0020037	heme binding	4	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.656
CLV_NRD_NRD_1	21	23	PF00675	0.627
CLV_NRD_NRD_1	25	27	PF00675	0.499
CLV_NRD_NRD_1	33	35	PF00675	0.500
CLV_PCSK_KEX2_1	21	23	PF00082	0.622
CLV_PCSK_KEX2_1	25	27	PF00082	0.510
CLV_PCSK_KEX2_1	33	35	PF00082	0.484
CLV_PCSK_KEX2_1	352	354	PF00082	0.563
CLV_PCSK_KEX2_1	528	530	PF00082	0.477
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.563

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T2	Leptomonas seymouri	45%	100%
A0A3R7MH20	Trypanosoma rangeli	30%	100%
A0A3S7X435	Leishmania donovani	90%	100%
A4HJ12	Leishmania braziliensis	72%	100%
A4I6K2	Leishmania infantum	90%	100%
C9ZJE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B1I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5AYQ1	Trypanosoma cruzi	30%	100%

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