Putative amastin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative amastin

Gene product:

amastin, putative

Species:

Leishmania major

UniProt:

Q4Q6L8_LEIMA

TriTrypDb:

LmjF.31.0450 , LMJLV39_310009900 , LMJSD75_080012700

Length:

197

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 189
NetGPI	no	yes: 0, no: 199

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	177
GO:0110165	cellular anatomical entity	1	177

Expansion

Sequence features

Q4Q6L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6L8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	53	55	PF00675	0.565
CLV_PCSK_SKI1_1	65	69	PF00082	0.516
DEG_MDM2_SWIB_1	157	165	PF02201	0.324
DEG_SCF_FBW7_1	32	37	PF00400	0.270
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.434
DOC_MAPK_MEF2A_6	108	116	PF00069	0.584
DOC_MAPK_RevD_3	40	55	PF00069	0.198
DOC_WW_Pin1_4	30	35	PF00397	0.308
LIG_14-3-3_CanoR_1	41	47	PF00244	0.320
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_BRCT_BRCA1_1	144	148	PF00533	0.213
LIG_BRCT_BRCA1_1	92	96	PF00533	0.227
LIG_CORNRBOX	5	13	PF00104	0.219
LIG_FHA_1	119	125	PF00498	0.394
LIG_FHA_1	130	136	PF00498	0.415
LIG_FHA_1	84	90	PF00498	0.303
LIG_FHA_2	23	29	PF00498	0.386
LIG_LIR_Nem_3	105	110	PF02991	0.562
LIG_LIR_Nem_3	152	157	PF02991	0.425
LIG_LIR_Nem_3	93	99	PF02991	0.288
LIG_PCNA_yPIPBox_3	73	82	PF02747	0.211
LIG_Pex14_2	150	154	PF04695	0.369
LIG_Pex14_2	157	161	PF04695	0.423
LIG_Pex14_2	96	100	PF04695	0.445
LIG_SH2_CRK	10	14	PF00017	0.361
LIG_SH2_STAP1	90	94	PF00017	0.220
LIG_SH2_STAT5	103	106	PF00017	0.545
LIG_SH3_3	55	61	PF00018	0.315
LIG_Sin3_3	15	22	PF02671	0.378
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.434
LIG_SUMO_SIM_par_1	161	167	PF11976	0.464
LIG_TRAF2_1	185	188	PF00917	0.647
LIG_TRAF2_1	194	197	PF00917	0.674
LIG_TYR_ITIM	8	13	PF00017	0.433
MOD_GlcNHglycan	104	107	PF01048	0.324
MOD_GlcNHglycan	179	182	PF01048	0.427
MOD_GSK3_1	30	37	PF00069	0.286
MOD_N-GLC_1	142	147	PF02516	0.473
MOD_NEK2_1	129	134	PF00069	0.471
MOD_NEK2_1	22	27	PF00069	0.427
MOD_NEK2_1	42	47	PF00069	0.325
MOD_NEK2_2	83	88	PF00069	0.471
MOD_Plk_1	142	148	PF00069	0.301
MOD_Plk_1	34	40	PF00069	0.332
MOD_Plk_4	42	48	PF00069	0.336
MOD_Plk_4	90	96	PF00069	0.326
MOD_ProDKin_1	30	36	PF00069	0.308
MOD_SUMO_rev_2	187	194	PF00179	0.840
TRG_ENDOCYTIC_2	10	13	PF00928	0.441
TRG_NLS_MonoCore_2	53	58	PF00514	0.213

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	31%	100%
A0A0N0P547	Leptomonas seymouri	36%	100%
A0A0N1HWY5	Leptomonas seymouri	24%	100%
A0A0N1PAD5	Leptomonas seymouri	29%	78%
A0A0N1PDH0	Leptomonas seymouri	33%	98%
A0A0S4J784	Bodo saltans	25%	88%
A0A1X0NQ58	Trypanosomatidae	28%	100%
A0A1X0NUH1	Trypanosomatidae	28%	87%
A0A1X0NVN5	Trypanosomatidae	25%	100%
A0A1X0P988	Trypanosomatidae	31%	100%
A0A381MTA7	Leishmania infantum	43%	100%
A0A381MTB8	Leishmania infantum	41%	100%
A0A381MTC7	Leishmania infantum	40%	96%
A0A381MTN2	Leishmania infantum	39%	100%
A0A381MVY0	Leishmania infantum	41%	100%
A0A3Q8ID16	Leishmania donovani	31%	100%
A0A3Q8IE85	Leishmania donovani	44%	100%
A0A3Q8IEC2	Leishmania donovani	43%	100%
A0A3Q8IEI1	Leishmania donovani	43%	100%
A0A3Q8IF65	Leishmania donovani	75%	100%
A0A3Q8IFB9	Leishmania donovani	30%	97%
A0A3Q8IFH7	Leishmania donovani	40%	96%
A0A3Q8IH65	Leishmania donovani	40%	100%
A0A3Q8IHN2	Leishmania donovani	44%	100%
A0A3Q8IHW7	Leishmania donovani	42%	100%
A0A3Q8IHZ6	Leishmania donovani	43%	93%
A0A3Q8IIH1	Leishmania donovani	40%	100%
A0A3Q8IL03	Leishmania donovani	36%	100%
A0A3Q8IUK8	Leishmania donovani	39%	100%
A0A3Q8IUR5	Leishmania donovani	39%	100%
A0A3S5H662	Leishmania donovani	66%	98%
A0A3S5H663	Leishmania donovani	66%	98%
A0A3S5H665	Leishmania donovani	66%	98%
A0A3S5H666	Leishmania donovani	44%	100%
A0A3S5H667	Leishmania donovani	68%	97%
A0A3S5H7D2	Leishmania donovani	29%	100%
A0A3S5H7L2	Leishmania donovani	44%	96%
A0A3S5H7V9	Leishmania donovani	38%	99%
A0A3S5H7W2	Leishmania donovani	26%	100%
A0A3S5H7W6	Leishmania donovani	39%	99%
A0A3S7WQA0	Leishmania donovani	65%	97%
A0A3S7WQA8	Leishmania donovani	44%	100%
A0A3S7WQC1	Leishmania donovani	42%	100%
A0A3S7X2E6	Leishmania donovani	43%	100%
A0A3S7X357	Leishmania donovani	24%	89%
A0A3S7X453	Leishmania donovani	74%	100%
A0A3S7X472	Leishmania donovani	71%	99%
A0A3S7X7E5	Leishmania donovani	43%	79%
A0A3S7X7M4	Leishmania donovani	43%	93%
A0A3S7X7U1	Leishmania donovani	44%	94%
A0A3S7X7U4	Leishmania donovani	41%	76%
A0A3S7X7W2	Leishmania donovani	35%	94%
A0A3S7X7Y0	Leishmania donovani	37%	100%
A4H595	Leishmania braziliensis	41%	85%
A4H596	Leishmania braziliensis	40%	90%
A4H597	Leishmania braziliensis	42%	85%
A4H5D1	Leishmania braziliensis	45%	100%
A4H5D2	Leishmania braziliensis	38%	100%
A4H5G0	Leishmania braziliensis	43%	100%
A4H5G4	Leishmania braziliensis	39%	94%
A4H5G6	Leishmania braziliensis	37%	89%
A4H5G7	Leishmania braziliensis	40%	90%
A4H5G9	Leishmania braziliensis	45%	100%
A4H5H0	Leishmania braziliensis	45%	100%
A4H5H1	Leishmania braziliensis	43%	100%
A4H5H2	Leishmania braziliensis	44%	100%
A4H5H3	Leishmania braziliensis	38%	95%
A4H6C8	Leishmania braziliensis	42%	99%
A4H7D7	Leishmania braziliensis	44%	100%
A4H9E8	Leishmania braziliensis	47%	94%
A4H9E9	Leishmania braziliensis	42%	100%
A4HAJ4	Leishmania braziliensis	43%	93%
A4HAJ5	Leishmania braziliensis	39%	89%
A4HAJ6	Leishmania braziliensis	42%	85%
A4HAL1	Leishmania braziliensis	42%	100%
A4HAL2	Leishmania braziliensis	27%	100%
A4HAM2	Leishmania braziliensis	40%	100%
A4HAM4	Leishmania braziliensis	39%	100%
A4HAR1	Leishmania braziliensis	40%	100%
A4HAZ8	Leishmania braziliensis	44%	100%
A4HB00	Leishmania braziliensis	38%	100%
A4HB02	Leishmania braziliensis	40%	100%
A4HB47	Leishmania braziliensis	30%	97%
A4HBJ0	Leishmania braziliensis	43%	100%
A4HBJ1	Leishmania braziliensis	40%	100%
A4HBJ2	Leishmania braziliensis	39%	95%
A4HDI3	Leishmania braziliensis	31%	81%
A4HDI4	Leishmania braziliensis	30%	100%
A4HDL3	Leishmania braziliensis	31%	100%
A4HDL4	Leishmania braziliensis	30%	100%
A4HTM3	Leishmania infantum	41%	100%
A4HTM4	Leishmania infantum	45%	100%
A4HTM5	Leishmania infantum	44%	100%
A4I0W4	Leishmania infantum	29%	100%
A4I0W5	Leishmania infantum	31%	100%
A4I4J2	Leishmania infantum	41%	96%
A4I4J3	Leishmania infantum	48%	76%
A4I5B9	Leishmania infantum	24%	89%
A4I6E5	Leishmania infantum	71%	99%
A4I9Q4	Leishmania infantum	40%	100%
A4I9R4	Leishmania infantum	26%	100%
A4I9R5	Leishmania infantum	30%	97%
A4I9R7	Leishmania infantum	45%	100%
A4I9W8	Leishmania infantum	41%	76%
A4I9X0	Leishmania infantum	37%	94%
A4IA59	Leishmania infantum	39%	76%
A4IAL7	Leishmania infantum	41%	100%
A4IAM1	Leishmania infantum	41%	100%
A4IAM2	Leishmania infantum	43%	100%
E8NHC3	Leishmania infantum	67%	98%
E8NHD3	Leishmania infantum	43%	96%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	94%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	95%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	93%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	93%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	93%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	93%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	93%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	96%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	94%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	93%
E9AG81	Leishmania infantum	64%	97%
E9AG82	Leishmania infantum	63%	97%
E9AG83	Leishmania infantum	47%	98%
E9AG85	Leishmania infantum	66%	97%
E9AHI9	Leishmania infantum	42%	100%
E9AHT2	Leishmania infantum	46%	93%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	95%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	77%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	95%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	94%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	89%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	95%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	93%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	99%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	99%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	96%
Q4Q1U9	Leishmania major	43%	100%
Q4Q305	Leishmania major	42%	100%
Q4Q309	Leishmania major	42%	100%
Q4Q313	Leishmania major	42%	100%
Q4Q317	Leishmania major	38%	100%
Q4Q325	Leishmania major	45%	100%
Q4Q327	Leishmania major	42%	99%
Q4Q329	Leishmania major	44%	100%
Q4Q333	Leishmania major	41%	100%
Q4Q335	Leishmania major	43%	100%
Q4Q337	Leishmania major	43%	100%
Q4Q339	Leishmania major	42%	100%
Q4Q341	Leishmania major	47%	99%
Q4Q397	Leishmania major	43%	100%
Q4Q3A7	Leishmania major	27%	100%
Q4Q3A8	Leishmania major	29%	100%
Q4Q3A9	Leishmania major	43%	100%
Q4Q3F7	Leishmania major	44%	100%
Q4Q7L6	Leishmania major	25%	89%
Q4QAK5	Leishmania major	34%	100%
Q4QAK6	Leishmania major	29%	100%
Q4QI84	Leishmania major	44%	100%
Q4QI85	Leishmania major	40%	100%
Q4QI86	Leishmania major	42%	100%
Q4QI87	Leishmania major	40%	100%
Q4QI88	Leishmania major	42%	100%
Q4QI92	Leishmania major	65%	99%
Q4QI93	Leishmania major	65%	99%
Q4QI95	Leishmania major	67%	99%
Q4QI97	Leishmania major	68%	99%
Q4QIA0	Leishmania major	69%	97%
Q4QIA1	Leishmania major	69%	97%