Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6L6_LEIMA

TriTrypDb:

LmjF.31.0470 , LMJLV39_310010100 , LMJSD75_310009800

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0097196	Shu complex	2	2

Expansion

Sequence features

Q4Q6L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6L6

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003697	single-stranded DNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.543
CLV_PCSK_FUR_1	139	143	PF00082	0.543
CLV_PCSK_KEX2_1	141	143	PF00082	0.533
CLV_PCSK_KEX2_1	24	26	PF00082	0.562
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.538
CLV_PCSK_SKI1_1	174	178	PF00082	0.362
DEG_SCF_FBW7_1	80	86	PF00400	0.467
DOC_CKS1_1	213	218	PF01111	0.487
DOC_CKS1_1	80	85	PF01111	0.386
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.553
DOC_MAPK_DCC_7	114	124	PF00069	0.460
DOC_MAPK_gen_1	114	124	PF00069	0.460
DOC_MAPK_gen_1	139	149	PF00069	0.478
DOC_MAPK_gen_1	171	181	PF00069	0.365
DOC_MAPK_MEF2A_6	117	124	PF00069	0.522
DOC_MAPK_MEF2A_6	142	151	PF00069	0.531
DOC_PP2B_LxvP_1	192	195	PF13499	0.569
DOC_USP7_MATH_1	10	14	PF00917	0.483
DOC_USP7_MATH_1	154	158	PF00917	0.385
DOC_USP7_MATH_1	83	87	PF00917	0.468
DOC_WW_Pin1_4	212	217	PF00397	0.502
DOC_WW_Pin1_4	79	84	PF00397	0.384
LIG_14-3-3_CanoR_1	114	120	PF00244	0.295
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BIR_III_1	1	5	PF00653	0.595
LIG_BIR_III_3	1	5	PF00653	0.595
LIG_BRCT_BRCA1_1	46	50	PF00533	0.343
LIG_Clathr_ClatBox_1	122	126	PF01394	0.309
LIG_eIF4E_1	196	202	PF01652	0.531
LIG_FHA_1	102	108	PF00498	0.365
LIG_FHA_1	114	120	PF00498	0.342
LIG_FHA_1	180	186	PF00498	0.459
LIG_FHA_1	209	215	PF00498	0.411
LIG_FHA_2	168	174	PF00498	0.373
LIG_HOMEOBOX	166	169	PF00046	0.351
LIG_KLC1_Yacidic_2	96	101	PF13176	0.358
LIG_LIR_Gen_1	163	173	PF02991	0.368
LIG_LIR_Gen_1	193	204	PF02991	0.412
LIG_LIR_Gen_1	71	81	PF02991	0.493
LIG_LIR_Gen_1	96	105	PF02991	0.331
LIG_LIR_Nem_3	173	179	PF02991	0.430
LIG_LIR_Nem_3	193	199	PF02991	0.364
LIG_LIR_Nem_3	71	77	PF02991	0.497
LIG_LIR_Nem_3	96	100	PF02991	0.371
LIG_PAM2_1	10	22	PF00658	0.456
LIG_Rb_pABgroove_1	160	168	PF01858	0.258
LIG_SH2_CRK	74	78	PF00017	0.507
LIG_SH2_NCK_1	74	78	PF00017	0.525
LIG_SH2_PTP2	178	181	PF00017	0.300
LIG_SH2_SRC	99	102	PF00017	0.352
LIG_SH2_STAT5	161	164	PF00017	0.487
LIG_SH2_STAT5	178	181	PF00017	0.300
LIG_SH2_STAT5	231	234	PF00017	0.561
LIG_SH2_STAT5	99	102	PF00017	0.334
LIG_SH3_3	129	135	PF00018	0.473
LIG_SH3_3	222	228	PF00018	0.640
LIG_SH3_3	23	29	PF00018	0.547
LIG_SH3_3	74	80	PF00018	0.433
LIG_SUMO_SIM_anti_2	63	68	PF11976	0.366
LIG_SUMO_SIM_par_1	121	128	PF11976	0.314
LIG_TYR_ITSM	70	77	PF00017	0.404
LIG_WW_1	228	231	PF00397	0.471
LIG_WW_3	3	7	PF00397	0.494
MOD_CK1_1	157	163	PF00069	0.408
MOD_CK1_1	85	91	PF00069	0.422
MOD_CK2_1	157	163	PF00069	0.337
MOD_CK2_1	83	89	PF00069	0.435
MOD_Cter_Amidation	139	142	PF01082	0.551
MOD_GlcNHglycan	142	145	PF01048	0.589
MOD_GlcNHglycan	187	190	PF01048	0.489
MOD_GlcNHglycan	208	211	PF01048	0.474
MOD_GlcNHglycan	89	92	PF01048	0.592
MOD_GSK3_1	150	157	PF00069	0.407
MOD_GSK3_1	208	215	PF00069	0.504
MOD_GSK3_1	53	60	PF00069	0.420
MOD_GSK3_1	79	86	PF00069	0.485
MOD_NEK2_1	113	118	PF00069	0.549
MOD_NEK2_1	130	135	PF00069	0.302
MOD_NEK2_1	150	155	PF00069	0.224
MOD_NEK2_1	87	92	PF00069	0.413
MOD_PIKK_1	187	193	PF00454	0.566
MOD_PIKK_1	214	220	PF00454	0.568
MOD_PKA_2	10	16	PF00069	0.644
MOD_PKA_2	113	119	PF00069	0.390
MOD_Plk_1	130	136	PF00069	0.456
MOD_Plk_1	69	75	PF00069	0.589
MOD_Plk_4	157	163	PF00069	0.430
MOD_Plk_4	60	66	PF00069	0.528
MOD_Plk_4	69	75	PF00069	0.330
MOD_ProDKin_1	212	218	PF00069	0.508
MOD_ProDKin_1	79	85	PF00069	0.390
TRG_ENDOCYTIC_2	166	169	PF00928	0.351
TRG_ENDOCYTIC_2	178	181	PF00928	0.301
TRG_ENDOCYTIC_2	196	199	PF00928	0.489
TRG_ENDOCYTIC_2	74	77	PF00928	0.401
TRG_ER_diArg_1	238	241	PF00400	0.518
TRG_ER_diArg_1	24	26	PF00400	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3G7	Leptomonas seymouri	69%	100%
A0A1X0NJ44	Trypanosomatidae	42%	100%
A0A3Q8IIC3	Leishmania donovani	93%	100%
A0A422P024	Trypanosoma rangeli	44%	100%
A4HJ25	Leishmania braziliensis	83%	100%
A4I6E7	Leishmania infantum	93%	100%
C9ZN54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E8NHF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B1J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BN46	Trypanosoma cruzi	48%	100%