Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6L5_LEIMA

TriTrypDb:

LmjF.31.0480 , LMJLV39_310010300 , LMJSD75_310010000

Length:

473

Annotations

LeishMANIAdb annotations

A small folded protein with a long C-terminal TM segment. Very unclear topology.. Expanded on multiple lineages, especially Strigomonas.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 9
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q6L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6L5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.285
CLV_NRD_NRD_1	256	258	PF00675	0.307
CLV_NRD_NRD_1	26	28	PF00675	0.389
CLV_NRD_NRD_1	440	442	PF00675	0.601
CLV_PCSK_FUR_1	23	27	PF00082	0.382
CLV_PCSK_KEX2_1	214	216	PF00082	0.324
CLV_PCSK_KEX2_1	25	27	PF00082	0.390
CLV_PCSK_KEX2_1	256	258	PF00082	0.307
CLV_PCSK_KEX2_1	281	283	PF00082	0.299
CLV_PCSK_KEX2_1	462	464	PF00082	0.648
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.306
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.285
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.666
CLV_PCSK_SKI1_1	186	190	PF00082	0.289
CLV_PCSK_SKI1_1	309	313	PF00082	0.264
CLV_PCSK_SKI1_1	469	473	PF00082	0.677
CLV_PCSK_SKI1_1	76	80	PF00082	0.227
DEG_APCC_DBOX_1	75	83	PF00400	0.191
DEG_Nend_Nbox_1	1	3	PF02207	0.357
DOC_ANK_TNKS_1	440	447	PF00023	0.377
DOC_CYCLIN_RxL_1	97	105	PF00134	0.329
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.191
DOC_MAPK_gen_1	89	99	PF00069	0.331
DOC_MAPK_MEF2A_6	364	371	PF00069	0.464
DOC_MAPK_MEF2A_6	92	101	PF00069	0.307
DOC_PP2B_LxvP_1	6	9	PF13499	0.191
DOC_PP4_FxxP_1	70	73	PF00568	0.579
DOC_USP7_MATH_1	247	251	PF00917	0.494
DOC_USP7_MATH_1	365	369	PF00917	0.485
DOC_USP7_UBL2_3	214	218	PF12436	0.437
DOC_WW_Pin1_4	111	116	PF00397	0.364
DOC_WW_Pin1_4	120	125	PF00397	0.496
DOC_WW_Pin1_4	26	31	PF00397	0.589
LIG_14-3-3_CanoR_1	128	132	PF00244	0.496
LIG_14-3-3_CanoR_1	220	228	PF00244	0.530
LIG_14-3-3_CanoR_1	25	30	PF00244	0.588
LIG_14-3-3_CanoR_1	270	274	PF00244	0.453
LIG_14-3-3_CanoR_1	31	40	PF00244	0.576
LIG_14-3-3_CanoR_1	64	70	PF00244	0.617
LIG_14-3-3_CanoR_1	83	91	PF00244	0.470
LIG_14-3-3_CanoR_1	92	99	PF00244	0.387
LIG_Actin_WH2_2	113	130	PF00022	0.341
LIG_APCC_ABBA_1	330	335	PF00400	0.510
LIG_BRCT_BRCA1_1	298	302	PF00533	0.411
LIG_BRCT_BRCA1_1	367	371	PF00533	0.485
LIG_BRCT_BRCA1_1	416	420	PF00533	0.297
LIG_BRCT_BRCA1_2	416	422	PF00533	0.295
LIG_CaM_IQ_9	206	222	PF13499	0.496
LIG_deltaCOP1_diTrp_1	353	361	PF00928	0.489
LIG_eIF4E_1	184	190	PF01652	0.496
LIG_FHA_1	112	118	PF00498	0.347
LIG_FHA_1	149	155	PF00498	0.533
LIG_FHA_1	183	189	PF00498	0.507
LIG_FHA_1	37	43	PF00498	0.565
LIG_FHA_1	92	98	PF00498	0.354
LIG_FHA_2	191	197	PF00498	0.485
LIG_IRF3_LxIS_1	206	212	PF10401	0.485
LIG_LIR_Apic_2	18	24	PF02991	0.191
LIG_LIR_Apic_2	69	73	PF02991	0.580
LIG_LIR_Gen_1	142	147	PF02991	0.481
LIG_LIR_Gen_1	161	169	PF02991	0.474
LIG_LIR_Gen_1	222	233	PF02991	0.482
LIG_LIR_Nem_3	142	146	PF02991	0.481
LIG_LIR_Nem_3	161	165	PF02991	0.474
LIG_LIR_Nem_3	353	358	PF02991	0.489
LIG_LIR_Nem_3	368	374	PF02991	0.489
LIG_MAD2	100	108	PF02301	0.266
LIG_PCNA_yPIPBox_3	220	233	PF02747	0.473
LIG_Pex14_1	198	202	PF04695	0.496
LIG_Pex14_2	456	460	PF04695	0.402
LIG_SH2_CRK	162	166	PF00017	0.456
LIG_SH2_CRK	174	178	PF00017	0.456
LIG_SH2_CRK	184	188	PF00017	0.496
LIG_SH2_SRC	333	336	PF00017	0.496
LIG_SH2_SRC	374	377	PF00017	0.496
LIG_SH2_STAP1	162	166	PF00017	0.456
LIG_SH2_STAP1	174	178	PF00017	0.456
LIG_SH2_STAP1	184	188	PF00017	0.496
LIG_SH2_STAP1	202	206	PF00017	0.496
LIG_SH2_STAP1	333	337	PF00017	0.496
LIG_SH2_STAT5	122	125	PF00017	0.490
LIG_SH2_STAT5	184	187	PF00017	0.538
LIG_SH2_STAT5	32	35	PF00017	0.585
LIG_SH2_STAT5	396	399	PF00017	0.384
LIG_SH2_STAT5	425	428	PF00017	0.399
LIG_SH3_1	364	370	PF00018	0.496
LIG_SH3_3	162	168	PF00018	0.479
LIG_SH3_3	336	342	PF00018	0.464
LIG_SH3_3	364	370	PF00018	0.490
LIG_SUMO_SIM_anti_2	185	194	PF11976	0.489
LIG_SUMO_SIM_par_1	185	194	PF11976	0.489
LIG_TYR_ITIM	172	177	PF00017	0.411
MOD_CDK_SPK_2	26	31	PF00069	0.589
MOD_CDK_SPxxK_3	111	118	PF00069	0.364
MOD_CK1_1	251	257	PF00069	0.535
MOD_CK1_1	291	297	PF00069	0.519
MOD_CK1_1	340	346	PF00069	0.431
MOD_CK1_1	4	10	PF00069	0.189
MOD_CK2_1	446	452	PF00069	0.538
MOD_CK2_1	467	473	PF00069	0.461
MOD_CMANNOS	45	48	PF00535	0.379
MOD_GlcNHglycan	290	293	PF01048	0.265
MOD_GlcNHglycan	295	298	PF01048	0.267
MOD_GlcNHglycan	33	36	PF01048	0.385
MOD_GlcNHglycan	435	438	PF01048	0.621
MOD_GlcNHglycan	70	73	PF01048	0.379
MOD_GlcNHglycan	86	89	PF01048	0.247
MOD_GSK3_1	123	130	PF00069	0.535
MOD_GSK3_1	210	217	PF00069	0.538
MOD_GSK3_1	247	254	PF00069	0.542
MOD_GSK3_1	257	264	PF00069	0.434
MOD_GSK3_1	284	291	PF00069	0.509
MOD_GSK3_1	333	340	PF00069	0.520
MOD_GSK3_1	463	470	PF00069	0.401
MOD_NEK2_1	102	107	PF00069	0.405
MOD_NEK2_1	12	17	PF00069	0.197
MOD_NEK2_1	127	132	PF00069	0.489
MOD_NEK2_1	141	146	PF00069	0.442
MOD_NEK2_1	209	214	PF00069	0.485
MOD_NEK2_1	269	274	PF00069	0.547
MOD_NEK2_1	284	289	PF00069	0.535
MOD_NEK2_1	302	307	PF00069	0.396
MOD_NEK2_1	91	96	PF00069	0.390
MOD_NEK2_2	333	338	PF00069	0.485
MOD_OFUCOSY	11	16	PF10250	0.191
MOD_PIKK_1	141	147	PF00454	0.508
MOD_PIKK_1	219	225	PF00454	0.480
MOD_PIKK_1	63	69	PF00454	0.591
MOD_PK_1	463	469	PF00069	0.424
MOD_PKA_1	214	220	PF00069	0.508
MOD_PKA_1	25	31	PF00069	0.589
MOD_PKA_2	127	133	PF00069	0.501
MOD_PKA_2	214	220	PF00069	0.530
MOD_PKA_2	25	31	PF00069	0.589
MOD_PKA_2	255	261	PF00069	0.541
MOD_PKA_2	269	275	PF00069	0.458
MOD_PKA_2	302	308	PF00069	0.586
MOD_PKA_2	337	343	PF00069	0.494
MOD_PKA_2	36	42	PF00069	0.563
MOD_PKA_2	440	446	PF00069	0.497
MOD_PKA_2	63	69	PF00069	0.615
MOD_PKA_2	91	97	PF00069	0.387
MOD_PKB_1	23	31	PF00069	0.585
MOD_Plk_1	141	147	PF00069	0.480
MOD_Plk_1	333	339	PF00069	0.533
MOD_Plk_1	4	10	PF00069	0.189
MOD_Plk_4	102	108	PF00069	0.343
MOD_Plk_4	36	42	PF00069	0.566
MOD_Plk_4	406	412	PF00069	0.418
MOD_ProDKin_1	111	117	PF00069	0.364
MOD_ProDKin_1	120	126	PF00069	0.496
MOD_ProDKin_1	26	32	PF00069	0.590
MOD_SUMO_rev_2	142	151	PF00179	0.483
TRG_DiLeu_BaEn_1	142	147	PF01217	0.481
TRG_ENDOCYTIC_2	162	165	PF00928	0.456
TRG_ENDOCYTIC_2	174	177	PF00928	0.456
TRG_ENDOCYTIC_2	184	187	PF00928	0.496
TRG_ER_diArg_1	22	25	PF00400	0.571
TRG_ER_diArg_1	256	259	PF00400	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P304	Leptomonas seymouri	26%	100%
A0A0N0P958	Leptomonas seymouri	61%	100%
A0A3Q8IGS5	Leishmania donovani	25%	100%
A0A3S7X466	Leishmania donovani	91%	100%
A4HJ26	Leishmania braziliensis	78%	100%
A4HLE0	Leishmania braziliensis	27%	100%
A4I6E8	Leishmania infantum	91%	100%
A4I8U9	Leishmania infantum	25%	100%
E8NHM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B1J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B3R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q4A6	Leishmania major	26%	100%