cGMP-dependent protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q6L4_LEIMA

TriTrypDb:

LmjF.31.0490 , LMJLV39_310010400 , LMJSD75_310010100

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q6L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6L4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.583
CLV_C14_Caspase3-7	457	461	PF00656	0.716
CLV_C14_Caspase3-7	643	647	PF00656	0.501
CLV_C14_Caspase3-7	734	738	PF00656	0.711
CLV_C14_Caspase3-7	81	85	PF00656	0.831
CLV_NRD_NRD_1	104	106	PF00675	0.637
CLV_NRD_NRD_1	139	141	PF00675	0.502
CLV_NRD_NRD_1	485	487	PF00675	0.762
CLV_NRD_NRD_1	517	519	PF00675	0.581
CLV_PCSK_FUR_1	810	814	PF00082	0.506
CLV_PCSK_KEX2_1	103	105	PF00082	0.637
CLV_PCSK_KEX2_1	139	141	PF00082	0.502
CLV_PCSK_KEX2_1	210	212	PF00082	0.661
CLV_PCSK_KEX2_1	380	382	PF00082	0.703
CLV_PCSK_KEX2_1	485	487	PF00082	0.762
CLV_PCSK_KEX2_1	517	519	PF00082	0.620
CLV_PCSK_KEX2_1	812	814	PF00082	0.503
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.541
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.727
CLV_PCSK_PC1ET2_1	812	814	PF00082	0.521
CLV_PCSK_PC7_1	100	106	PF00082	0.667
CLV_PCSK_PC7_1	513	519	PF00082	0.559
CLV_PCSK_SKI1_1	139	143	PF00082	0.456
CLV_PCSK_SKI1_1	380	384	PF00082	0.581
CLV_PCSK_SKI1_1	508	512	PF00082	0.469
CLV_PCSK_SKI1_1	656	660	PF00082	0.373
DEG_Kelch_Keap1_1	602	607	PF01344	0.501
DEG_SPOP_SBC_1	34	38	PF00917	0.715
DEG_SPOP_SBC_1	641	645	PF00917	0.407
DOC_CKS1_1	168	173	PF01111	0.397
DOC_CYCLIN_yCln2_LP_2	794	800	PF00134	0.446
DOC_MAPK_gen_1	422	431	PF00069	0.632
DOC_MAPK_gen_1	536	544	PF00069	0.348
DOC_MAPK_gen_1	810	817	PF00069	0.510
DOC_PP1_RVXF_1	801	807	PF00149	0.499
DOC_PP2B_LxvP_1	623	626	PF13499	0.430
DOC_PP2B_LxvP_1	784	787	PF13499	0.455
DOC_PP4_FxxP_1	40	43	PF00568	0.735
DOC_PP4_FxxP_1	48	51	PF00568	0.641
DOC_USP7_MATH_1	179	183	PF00917	0.584
DOC_USP7_MATH_1	244	248	PF00917	0.688
DOC_USP7_MATH_1	35	39	PF00917	0.710
DOC_USP7_MATH_1	384	388	PF00917	0.600
DOC_USP7_MATH_1	49	53	PF00917	0.732
DOC_USP7_MATH_1	574	578	PF00917	0.790
DOC_USP7_MATH_1	632	636	PF00917	0.426
DOC_USP7_MATH_1	640	644	PF00917	0.485
DOC_USP7_MATH_1	67	71	PF00917	0.654
DOC_USP7_MATH_1	735	739	PF00917	0.660
DOC_USP7_MATH_1	787	791	PF00917	0.476
DOC_USP7_MATH_1	9	13	PF00917	0.709
DOC_WW_Pin1_4	167	172	PF00397	0.529
DOC_WW_Pin1_4	175	180	PF00397	0.612
DOC_WW_Pin1_4	245	250	PF00397	0.591
DOC_WW_Pin1_4	279	284	PF00397	0.538
DOC_WW_Pin1_4	478	483	PF00397	0.788
DOC_WW_Pin1_4	580	585	PF00397	0.554
LIG_14-3-3_CanoR_1	346	352	PF00244	0.477
LIG_14-3-3_CanoR_1	422	427	PF00244	0.637
LIG_14-3-3_CanoR_1	513	517	PF00244	0.566
LIG_14-3-3_CanoR_1	524	529	PF00244	0.460
LIG_14-3-3_CanoR_1	614	619	PF00244	0.501
LIG_14-3-3_CanoR_1	628	636	PF00244	0.270
LIG_14-3-3_CanoR_1	803	811	PF00244	0.507
LIG_Actin_WH2_2	143	161	PF00022	0.363
LIG_BIR_III_4	567	571	PF00653	0.573
LIG_BRCT_BRCA1_1	181	185	PF00533	0.525
LIG_BRCT_BRCA1_1	281	285	PF00533	0.502
LIG_BRCT_BRCA1_1	36	40	PF00533	0.709
LIG_Clathr_ClatBox_1	543	547	PF01394	0.518
LIG_deltaCOP1_diTrp_1	213	220	PF00928	0.588
LIG_FHA_1	250	256	PF00498	0.462
LIG_FHA_1	388	394	PF00498	0.586
LIG_FHA_1	56	62	PF00498	0.723
LIG_FHA_1	631	637	PF00498	0.376
LIG_FHA_1	696	702	PF00498	0.557
LIG_FHA_1	8	14	PF00498	0.742
LIG_FHA_2	264	270	PF00498	0.543
LIG_FHA_2	37	43	PF00498	0.584
LIG_FHA_2	455	461	PF00498	0.651
LIG_FHA_2	615	621	PF00498	0.501
LIG_FHA_2	697	703	PF00498	0.556
LIG_Integrin_RGD_1	82	84	PF01839	0.794
LIG_IRF3_LxIS_1	450	455	PF10401	0.601
LIG_LIR_Apic_2	37	43	PF02991	0.738
LIG_LIR_Apic_2	47	51	PF02991	0.615
LIG_LIR_Gen_1	133	142	PF02991	0.597
LIG_LIR_Gen_1	182	193	PF02991	0.576
LIG_LIR_Gen_1	282	293	PF02991	0.513
LIG_LIR_Gen_1	319	329	PF02991	0.493
LIG_LIR_Gen_1	672	681	PF02991	0.494
LIG_LIR_Gen_1	789	799	PF02991	0.328
LIG_LIR_Nem_3	133	138	PF02991	0.608
LIG_LIR_Nem_3	182	188	PF02991	0.508
LIG_LIR_Nem_3	282	288	PF02991	0.491
LIG_LIR_Nem_3	672	676	PF02991	0.525
LIG_LIR_Nem_3	789	794	PF02991	0.485
LIG_LIR_Nem_3	808	814	PF02991	0.517
LIG_LIR_Nem_3	91	97	PF02991	0.702
LIG_PCNA_PIPBox_1	261	270	PF02747	0.482
LIG_PCNA_PIPBox_1	281	290	PF02747	0.378
LIG_PCNA_yPIPBox_3	254	268	PF02747	0.504
LIG_Pex14_1	691	695	PF04695	0.457
LIG_Pex14_2	673	677	PF04695	0.486
LIG_Pex14_2	680	684	PF04695	0.502
LIG_Pex14_2	791	795	PF04695	0.475
LIG_REV1ctd_RIR_1	503	512	PF16727	0.344
LIG_SH2_CRK	260	264	PF00017	0.487
LIG_SH2_CRK	811	815	PF00017	0.586
LIG_SH2_PTP2	775	778	PF00017	0.460
LIG_SH2_SRC	268	271	PF00017	0.508
LIG_SH2_STAT3	278	281	PF00017	0.558
LIG_SH2_STAT3	391	394	PF00017	0.507
LIG_SH2_STAT5	227	230	PF00017	0.550
LIG_SH2_STAT5	278	281	PF00017	0.591
LIG_SH2_STAT5	666	669	PF00017	0.417
LIG_SH2_STAT5	692	695	PF00017	0.401
LIG_SH2_STAT5	730	733	PF00017	0.491
LIG_SH2_STAT5	775	778	PF00017	0.413
LIG_SH2_STAT5	801	804	PF00017	0.461
LIG_SH3_3	202	208	PF00018	0.759
LIG_SH3_3	225	231	PF00018	0.557
LIG_SH3_3	390	396	PF00018	0.592
LIG_SH3_3	433	439	PF00018	0.466
LIG_SH3_3	581	587	PF00018	0.611
LIG_SH3_3	794	800	PF00018	0.476
LIG_SUMO_SIM_anti_2	328	333	PF11976	0.497
LIG_SUMO_SIM_anti_2	362	367	PF11976	0.527
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.510
LIG_SUMO_SIM_anti_2	597	605	PF11976	0.430
LIG_SUMO_SIM_par_1	160	166	PF11976	0.458
LIG_SUMO_SIM_par_1	405	412	PF11976	0.528
LIG_SUMO_SIM_par_1	54	63	PF11976	0.681
LIG_SUMO_SIM_par_1	64	70	PF11976	0.732
LIG_TRAF2_1	370	373	PF00917	0.662
LIG_TRFH_1	227	231	PF08558	0.655
LIG_TYR_ITIM	258	263	PF00017	0.419
LIG_TYR_ITIM	773	778	PF00017	0.459
LIG_WRC_WIRS_1	264	269	PF05994	0.601
LIG_WRC_WIRS_1	751	756	PF05994	0.509
MOD_CDK_SPK_2	580	585	PF00069	0.521
MOD_CDK_SPxxK_3	478	485	PF00069	0.713
MOD_CK1_1	109	115	PF00069	0.590
MOD_CK1_1	247	253	PF00069	0.597
MOD_CK1_1	38	44	PF00069	0.783
MOD_CK1_1	387	393	PF00069	0.538
MOD_CK1_1	481	487	PF00069	0.807
MOD_CK1_1	512	518	PF00069	0.520
MOD_CK1_1	583	589	PF00069	0.557
MOD_CK1_1	631	637	PF00069	0.387
MOD_CK1_1	675	681	PF00069	0.349
MOD_CK1_1	750	756	PF00069	0.538
MOD_CK1_1	790	796	PF00069	0.397
MOD_CK2_1	422	428	PF00069	0.564
MOD_CK2_1	441	447	PF00069	0.593
MOD_CK2_1	49	55	PF00069	0.809
MOD_CK2_1	614	620	PF00069	0.430
MOD_CK2_1	696	702	PF00069	0.558
MOD_GlcNHglycan	108	111	PF01048	0.716
MOD_GlcNHglycan	29	33	PF01048	0.780
MOD_GlcNHglycan	306	310	PF01048	0.644
MOD_GlcNHglycan	325	328	PF01048	0.505
MOD_GlcNHglycan	411	414	PF01048	0.538
MOD_GlcNHglycan	42	46	PF01048	0.718
MOD_GlcNHglycan	572	575	PF01048	0.740
MOD_GlcNHglycan	577	580	PF01048	0.671
MOD_GlcNHglycan	594	597	PF01048	0.411
MOD_GlcNHglycan	630	633	PF01048	0.501
MOD_GlcNHglycan	677	680	PF01048	0.501
MOD_GlcNHglycan	69	72	PF01048	0.645
MOD_GlcNHglycan	733	736	PF01048	0.710
MOD_GlcNHglycan	737	740	PF01048	0.731
MOD_GSK3_1	106	113	PF00069	0.663
MOD_GSK3_1	175	182	PF00069	0.641
MOD_GSK3_1	245	252	PF00069	0.560
MOD_GSK3_1	301	308	PF00069	0.528
MOD_GSK3_1	323	330	PF00069	0.541
MOD_GSK3_1	34	41	PF00069	0.758
MOD_GSK3_1	342	349	PF00069	0.550
MOD_GSK3_1	376	383	PF00069	0.718
MOD_GSK3_1	452	459	PF00069	0.641
MOD_GSK3_1	474	481	PF00069	0.797
MOD_GSK3_1	485	492	PF00069	0.648
MOD_GSK3_1	51	58	PF00069	0.737
MOD_GSK3_1	570	577	PF00069	0.802
MOD_GSK3_1	592	599	PF00069	0.430
MOD_GSK3_1	610	617	PF00069	0.357
MOD_GSK3_1	628	635	PF00069	0.252
MOD_GSK3_1	731	738	PF00069	0.683
MOD_GSK3_1	746	753	PF00069	0.384
MOD_LATS_1	418	424	PF00433	0.623
MOD_N-GLC_1	452	457	PF02516	0.669
MOD_N-GLC_1	695	700	PF02516	0.545
MOD_NEK2_1	263	268	PF00069	0.527
MOD_NEK2_1	323	328	PF00069	0.445
MOD_NEK2_1	452	457	PF00069	0.652
MOD_NEK2_1	651	656	PF00069	0.448
MOD_NEK2_2	632	637	PF00069	0.229
MOD_NMyristoyl	1	7	PF02799	0.682
MOD_PIKK_1	277	283	PF00454	0.483
MOD_PIKK_1	489	495	PF00454	0.678
MOD_PIKK_1	651	657	PF00454	0.268
MOD_PK_1	422	428	PF00069	0.552
MOD_PKA_1	380	386	PF00069	0.567
MOD_PKA_1	485	491	PF00069	0.702
MOD_PKA_2	380	386	PF00069	0.641
MOD_PKA_2	485	491	PF00069	0.702
MOD_PKA_2	512	518	PF00069	0.605
MOD_PKA_2	610	616	PF00069	0.301
MOD_PKA_2	731	737	PF00069	0.698
MOD_PKA_2	768	774	PF00069	0.383
MOD_PKB_1	420	428	PF00069	0.553
MOD_PKB_1	522	530	PF00069	0.525
MOD_PKB_1	536	544	PF00069	0.510
MOD_Plk_1	153	159	PF00069	0.513
MOD_Plk_1	466	472	PF00069	0.818
MOD_Plk_1	500	506	PF00069	0.500
MOD_Plk_1	55	61	PF00069	0.579
MOD_Plk_1	596	602	PF00069	0.460
MOD_Plk_1	746	752	PF00069	0.649
MOD_Plk_2-3	301	307	PF00069	0.515
MOD_Plk_4	153	159	PF00069	0.557
MOD_Plk_4	327	333	PF00069	0.348
MOD_Plk_4	347	353	PF00069	0.399
MOD_Plk_4	466	472	PF00069	0.734
MOD_Plk_4	538	544	PF00069	0.583
MOD_Plk_4	596	602	PF00069	0.385
MOD_Plk_4	672	678	PF00069	0.486
MOD_Plk_4	717	723	PF00069	0.542
MOD_Plk_4	790	796	PF00069	0.397
MOD_ProDKin_1	167	173	PF00069	0.536
MOD_ProDKin_1	175	181	PF00069	0.614
MOD_ProDKin_1	245	251	PF00069	0.578
MOD_ProDKin_1	279	285	PF00069	0.532
MOD_ProDKin_1	478	484	PF00069	0.788
MOD_ProDKin_1	580	586	PF00069	0.540
TRG_DiLeu_BaEn_4	447	453	PF01217	0.471
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.532
TRG_ENDOCYTIC_2	260	263	PF00928	0.499
TRG_ENDOCYTIC_2	591	594	PF00928	0.501
TRG_ENDOCYTIC_2	690	693	PF00928	0.445
TRG_ENDOCYTIC_2	775	778	PF00928	0.460
TRG_ENDOCYTIC_2	801	804	PF00928	0.553
TRG_ENDOCYTIC_2	811	814	PF00928	0.459
TRG_ER_diArg_1	102	105	PF00400	0.625
TRG_ER_diArg_1	138	140	PF00400	0.505
TRG_ER_diArg_1	485	487	PF00400	0.719
TRG_ER_diArg_1	516	518	PF00400	0.585
TRG_ER_diArg_1	780	783	PF00400	0.480
TRG_NES_CRM1_1	320	335	PF08389	0.383
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T1	Leptomonas seymouri	42%	100%
A0A3R7KL00	Trypanosoma rangeli	24%	76%
A0A3S7X491	Leishmania donovani	88%	100%
A4HJ27	Leishmania braziliensis	64%	97%
A4I6E9	Leishmania infantum	88%	100%
E9B1J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%