Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6L3_LEIMA

TriTrypDb:

LmjF.31.0500 , LMJLV39_310010500 , LMJSD75_310010200

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	600	604	PF00656	0.528
CLV_C14_Caspase3-7	70	74	PF00656	0.580
CLV_NRD_NRD_1	204	206	PF00675	0.645
CLV_NRD_NRD_1	225	227	PF00675	0.548
CLV_NRD_NRD_1	405	407	PF00675	0.702
CLV_NRD_NRD_1	47	49	PF00675	0.593
CLV_NRD_NRD_1	568	570	PF00675	0.609
CLV_PCSK_KEX2_1	204	206	PF00082	0.645
CLV_PCSK_KEX2_1	225	227	PF00082	0.548
CLV_PCSK_KEX2_1	405	407	PF00082	0.704
CLV_PCSK_KEX2_1	47	49	PF00082	0.593
CLV_PCSK_KEX2_1	532	534	PF00082	0.448
CLV_PCSK_KEX2_1	568	570	PF00082	0.624
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.436
CLV_PCSK_PC7_1	221	227	PF00082	0.523
CLV_PCSK_SKI1_1	197	201	PF00082	0.633
CLV_PCSK_SKI1_1	307	311	PF00082	0.530
CLV_PCSK_SKI1_1	317	321	PF00082	0.563
CLV_PCSK_SKI1_1	453	457	PF00082	0.595
CLV_PCSK_SKI1_1	504	508	PF00082	0.528
CLV_PCSK_SKI1_1	631	635	PF00082	0.650
DEG_APCC_DBOX_1	306	314	PF00400	0.495
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.561
DOC_MAPK_gen_1	511	518	PF00069	0.557
DOC_MAPK_gen_1	532	539	PF00069	0.421
DOC_MAPK_MEF2A_6	532	539	PF00069	0.501
DOC_PP2B_LxvP_1	105	108	PF13499	0.515
DOC_USP7_MATH_1	153	157	PF00917	0.573
DOC_USP7_MATH_1	172	176	PF00917	0.667
DOC_USP7_MATH_1	179	183	PF00917	0.613
DOC_USP7_MATH_1	251	255	PF00917	0.771
DOC_USP7_MATH_1	404	408	PF00917	0.698
DOC_USP7_MATH_1	446	450	PF00917	0.622
DOC_USP7_MATH_1	498	502	PF00917	0.599
DOC_USP7_MATH_1	60	64	PF00917	0.704
DOC_USP7_MATH_1	627	631	PF00917	0.642
DOC_USP7_MATH_1	67	71	PF00917	0.606
DOC_USP7_MATH_1	87	91	PF00917	0.632
DOC_USP7_UBL2_3	464	468	PF12436	0.616
DOC_WW_Pin1_4	15	20	PF00397	0.706
DOC_WW_Pin1_4	259	264	PF00397	0.711
DOC_WW_Pin1_4	291	296	PF00397	0.563
DOC_WW_Pin1_4	493	498	PF00397	0.653
LIG_14-3-3_CanoR_1	180	189	PF00244	0.630
LIG_14-3-3_CanoR_1	204	212	PF00244	0.593
LIG_14-3-3_CanoR_1	225	234	PF00244	0.537
LIG_14-3-3_CanoR_1	307	315	PF00244	0.482
LIG_14-3-3_CanoR_1	361	369	PF00244	0.656
LIG_14-3-3_CanoR_1	405	413	PF00244	0.645
LIG_14-3-3_CanoR_1	453	458	PF00244	0.572
LIG_14-3-3_CanoR_1	629	634	PF00244	0.625
LIG_14-3-3_CanoR_1	89	93	PF00244	0.634
LIG_BRCT_BRCA1_1	90	94	PF00533	0.608
LIG_BRCT_BRCA1_2	90	96	PF00533	0.669
LIG_FHA_1	409	415	PF00498	0.639
LIG_FHA_1	427	433	PF00498	0.501
LIG_FHA_1	611	617	PF00498	0.651
LIG_FHA_2	212	218	PF00498	0.544
LIG_FHA_2	236	242	PF00498	0.733
LIG_FHA_2	333	339	PF00498	0.585
LIG_FHA_2	340	346	PF00498	0.495
LIG_FHA_2	510	516	PF00498	0.512
LIG_FHA_2	581	587	PF00498	0.621
LIG_Integrin_RGD_1	398	400	PF01839	0.675
LIG_LIR_Gen_1	128	134	PF02991	0.481
LIG_LIR_Nem_3	128	132	PF02991	0.482
LIG_SH2_SRC	546	549	PF00017	0.481
LIG_SH2_STAP1	100	104	PF00017	0.522
LIG_SH2_STAT5	256	259	PF00017	0.631
LIG_SH2_STAT5	348	351	PF00017	0.541
LIG_SH2_STAT5	509	512	PF00017	0.525
LIG_SH2_STAT5	546	549	PF00017	0.451
LIG_SH2_STAT5	598	601	PF00017	0.529
LIG_SH3_3	147	153	PF00018	0.640
LIG_SH3_3	158	164	PF00018	0.591
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.481
LIG_SUMO_SIM_anti_2	428	434	PF11976	0.646
LIG_SUMO_SIM_par_1	428	434	PF11976	0.547
LIG_SUMO_SIM_par_1	534	540	PF11976	0.492
LIG_TRAF2_1	335	338	PF00917	0.603
LIG_TRAF2_1	472	475	PF00917	0.627
LIG_TRFH_1	320	324	PF08558	0.610
LIG_WW_3	177	181	PF00397	0.544
MOD_CDK_SPK_2	259	264	PF00069	0.686
MOD_CK1_1	103	109	PF00069	0.573
MOD_CK1_1	224	230	PF00069	0.488
MOD_CK1_1	305	311	PF00069	0.529
MOD_CK1_1	357	363	PF00069	0.736
MOD_CK1_1	365	371	PF00069	0.581
MOD_CK1_1	408	414	PF00069	0.672
MOD_CK1_1	423	429	PF00069	0.546
MOD_CK1_1	460	466	PF00069	0.585
MOD_CK1_1	502	508	PF00069	0.538
MOD_CK1_1	576	582	PF00069	0.738
MOD_CK1_1	63	69	PF00069	0.558
MOD_CK1_1	632	638	PF00069	0.646
MOD_CK1_1	80	86	PF00069	0.552
MOD_CK1_1	95	101	PF00069	0.618
MOD_CK2_1	211	217	PF00069	0.634
MOD_CK2_1	26	32	PF00069	0.668
MOD_CK2_1	326	332	PF00069	0.617
MOD_CK2_1	339	345	PF00069	0.555
MOD_CK2_1	580	586	PF00069	0.607
MOD_CK2_1	8	14	PF00069	0.709
MOD_GlcNHglycan	102	105	PF01048	0.590
MOD_GlcNHglycan	139	142	PF01048	0.587
MOD_GlcNHglycan	155	158	PF01048	0.595
MOD_GlcNHglycan	174	177	PF01048	0.679
MOD_GlcNHglycan	183	186	PF01048	0.568
MOD_GlcNHglycan	228	231	PF01048	0.589
MOD_GlcNHglycan	274	277	PF01048	0.585
MOD_GlcNHglycan	3	6	PF01048	0.636
MOD_GlcNHglycan	37	40	PF01048	0.660
MOD_GlcNHglycan	378	381	PF01048	0.673
MOD_GlcNHglycan	400	403	PF01048	0.761
MOD_GlcNHglycan	407	410	PF01048	0.625
MOD_GlcNHglycan	443	446	PF01048	0.701
MOD_GlcNHglycan	501	504	PF01048	0.706
MOD_GlcNHglycan	571	574	PF01048	0.635
MOD_GlcNHglycan	575	578	PF01048	0.606
MOD_GlcNHglycan	589	592	PF01048	0.487
MOD_GlcNHglycan	634	637	PF01048	0.695
MOD_GlcNHglycan	65	68	PF01048	0.626
MOD_GlcNHglycan	69	72	PF01048	0.670
MOD_GlcNHglycan	79	82	PF01048	0.560
MOD_GlcNHglycan	83	86	PF01048	0.524
MOD_GSK3_1	200	207	PF00069	0.620
MOD_GSK3_1	211	218	PF00069	0.525
MOD_GSK3_1	221	228	PF00069	0.451
MOD_GSK3_1	23	30	PF00069	0.774
MOD_GSK3_1	259	266	PF00069	0.746
MOD_GSK3_1	279	286	PF00069	0.324
MOD_GSK3_1	305	312	PF00069	0.525
MOD_GSK3_1	33	40	PF00069	0.649
MOD_GSK3_1	365	372	PF00069	0.582
MOD_GSK3_1	404	411	PF00069	0.698
MOD_GSK3_1	453	460	PF00069	0.556
MOD_GSK3_1	498	505	PF00069	0.523
MOD_GSK3_1	569	576	PF00069	0.668
MOD_GSK3_1	63	70	PF00069	0.529
MOD_GSK3_1	76	83	PF00069	0.641
MOD_GSK3_1	88	95	PF00069	0.594
MOD_N-GLC_1	305	310	PF02516	0.621
MOD_N-GLC_1	332	337	PF02516	0.676
MOD_N-GLC_1	362	367	PF02516	0.600
MOD_N-GLC_1	390	395	PF02516	0.704
MOD_N-GLC_1	453	458	PF02516	0.577
MOD_N-GLC_1	603	608	PF02516	0.571
MOD_N-GLC_1	627	632	PF02516	0.681
MOD_N-GLC_1	67	72	PF02516	0.579
MOD_N-GLC_2	255	257	PF02516	0.621
MOD_NEK2_1	215	220	PF00069	0.422
MOD_NEK2_1	234	239	PF00069	0.613
MOD_NEK2_1	354	359	PF00069	0.546
MOD_NEK2_1	390	395	PF00069	0.629
MOD_NEK2_1	420	425	PF00069	0.618
MOD_NEK2_1	433	438	PF00069	0.561
MOD_NEK2_1	620	625	PF00069	0.628
MOD_NEK2_1	76	81	PF00069	0.664
MOD_NEK2_1	88	93	PF00069	0.593
MOD_PIKK_1	204	210	PF00454	0.624
MOD_PIKK_1	283	289	PF00454	0.394
MOD_PIKK_1	324	330	PF00454	0.576
MOD_PIKK_1	390	396	PF00454	0.700
MOD_PIKK_1	98	104	PF00454	0.671
MOD_PKA_1	204	210	PF00069	0.614
MOD_PKA_1	225	231	PF00069	0.588
MOD_PKA_1	405	411	PF00069	0.657
MOD_PKA_1	569	575	PF00069	0.606
MOD_PKA_2	179	185	PF00069	0.622
MOD_PKA_2	204	210	PF00069	0.614
MOD_PKA_2	224	230	PF00069	0.400
MOD_PKA_2	251	257	PF00069	0.619
MOD_PKA_2	263	269	PF00069	0.688
MOD_PKA_2	404	410	PF00069	0.721
MOD_PKA_2	43	49	PF00069	0.642
MOD_PKA_2	77	83	PF00069	0.603
MOD_PKA_2	88	94	PF00069	0.620
MOD_Plk_1	279	285	PF00069	0.433
MOD_Plk_1	305	311	PF00069	0.616
MOD_Plk_1	365	371	PF00069	0.581
MOD_Plk_1	453	459	PF00069	0.565
MOD_Plk_1	475	481	PF00069	0.601
MOD_Plk_1	514	520	PF00069	0.552
MOD_Plk_1	67	73	PF00069	0.580
MOD_Plk_2-3	332	338	PF00069	0.587
MOD_Plk_2-3	339	345	PF00069	0.520
MOD_Plk_2-3	475	481	PF00069	0.682
MOD_Plk_4	128	134	PF00069	0.456
MOD_Plk_4	211	217	PF00069	0.463
MOD_Plk_4	279	285	PF00069	0.412
MOD_Plk_4	339	345	PF00069	0.712
MOD_Plk_4	95	101	PF00069	0.697
MOD_ProDKin_1	15	21	PF00069	0.706
MOD_ProDKin_1	259	265	PF00069	0.709
MOD_ProDKin_1	291	297	PF00069	0.569
MOD_ProDKin_1	493	499	PF00069	0.650
MOD_SUMO_rev_2	140	150	PF00179	0.637
MOD_SUMO_rev_2	458	466	PF00179	0.593
MOD_SUMO_rev_2	70	77	PF00179	0.607
TRG_DiLeu_BaEn_2	279	285	PF01217	0.423
TRG_ER_diArg_1	404	406	PF00400	0.652
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA33	Leptomonas seymouri	44%	100%
A0A3S7X488	Leishmania donovani	92%	100%
A4HJ28	Leishmania braziliensis	61%	99%
A4I6K7	Leishmania infantum	92%	100%
E9B1K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%