J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q6L2_LEIMA

TriTrypDb:

LmjF.31.0510 , LMJLV39_310010600 , LMJSD75_310010300

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q6L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6L2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.754
CLV_C14_Caspase3-7	413	417	PF00656	0.532
CLV_NRD_NRD_1	225	227	PF00675	0.402
CLV_NRD_NRD_1	26	28	PF00675	0.379
CLV_NRD_NRD_1	299	301	PF00675	0.248
CLV_NRD_NRD_1	304	306	PF00675	0.227
CLV_NRD_NRD_1	403	405	PF00675	0.286
CLV_NRD_NRD_1	492	494	PF00675	0.393
CLV_PCSK_KEX2_1	26	28	PF00082	0.379
CLV_PCSK_KEX2_1	396	398	PF00082	0.324
CLV_PCSK_KEX2_1	402	404	PF00082	0.269
CLV_PCSK_KEX2_1	463	465	PF00082	0.434
CLV_PCSK_KEX2_1	492	494	PF00082	0.438
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.348
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.374
CLV_PCSK_SKI1_1	108	112	PF00082	0.360
CLV_PCSK_SKI1_1	26	30	PF00082	0.463
CLV_PCSK_SKI1_1	305	309	PF00082	0.298
CLV_PCSK_SKI1_1	364	368	PF00082	0.440
CLV_PCSK_SKI1_1	406	410	PF00082	0.374
CLV_PCSK_SKI1_1	492	496	PF00082	0.455
CLV_PCSK_SKI1_1	526	530	PF00082	0.286
DEG_APCC_DBOX_1	525	533	PF00400	0.523
DEG_COP1_1	349	358	PF00400	0.730
DEG_Nend_Nbox_1	1	3	PF02207	0.499
DOC_CYCLIN_yClb5_NLxxxL_5	409	415	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.524
DOC_MAPK_gen_1	542	551	PF00069	0.525
DOC_PP1_RVXF_1	524	531	PF00149	0.572
DOC_USP7_MATH_1	251	255	PF00917	0.760
DOC_USP7_MATH_1	294	298	PF00917	0.553
DOC_USP7_UBL2_3	227	231	PF12436	0.614
DOC_WW_Pin1_4	292	297	PF00397	0.415
DOC_WW_Pin1_4	532	537	PF00397	0.619
DOC_WW_Pin1_4	582	587	PF00397	0.674
DOC_WW_Pin1_4	71	76	PF00397	0.747
DOC_WW_Pin1_4	81	86	PF00397	0.749
LIG_14-3-3_CanoR_1	213	222	PF00244	0.491
LIG_14-3-3_CanoR_1	341	345	PF00244	0.450
LIG_Actin_WH2_2	392	408	PF00022	0.519
LIG_APCC_ABBA_1	308	313	PF00400	0.430
LIG_Clathr_ClatBox_1	527	531	PF01394	0.513
LIG_deltaCOP1_diTrp_1	192	202	PF00928	0.545
LIG_deltaCOP1_diTrp_1	467	473	PF00928	0.640
LIG_FHA_1	27	33	PF00498	0.688
LIG_FHA_2	215	221	PF00498	0.552
LIG_FHA_2	239	245	PF00498	0.704
LIG_FHA_2	293	299	PF00498	0.447
LIG_FHA_2	583	589	PF00498	0.668
LIG_GBD_Chelix_1	407	415	PF00786	0.323
LIG_LIR_Gen_1	210	215	PF02991	0.592
LIG_LIR_Gen_1	322	332	PF02991	0.431
LIG_LIR_Gen_1	92	103	PF02991	0.690
LIG_LIR_Nem_3	163	168	PF02991	0.338
LIG_LIR_Nem_3	210	214	PF02991	0.570
LIG_LIR_Nem_3	322	328	PF02991	0.437
LIG_LIR_Nem_3	343	347	PF02991	0.504
LIG_LIR_Nem_3	92	98	PF02991	0.664
LIG_Pex14_2	2	6	PF04695	0.359
LIG_Pex14_2	381	385	PF04695	0.574
LIG_SH2_CRK	168	172	PF00017	0.355
LIG_SH2_CRK	285	289	PF00017	0.447
LIG_SH2_CRK	332	336	PF00017	0.473
LIG_SH2_STAP1	303	307	PF00017	0.513
LIG_SH2_STAP1	470	474	PF00017	0.676
LIG_SH2_STAT5	303	306	PF00017	0.512
LIG_SH2_STAT5	444	447	PF00017	0.531
LIG_SH3_3	313	319	PF00018	0.554
LIG_SH3_3	54	60	PF00018	0.746
LIG_SH3_3	62	68	PF00018	0.730
LIG_SUMO_SIM_anti_2	547	553	PF11976	0.606
MOD_CDK_SPxxK_3	532	539	PF00069	0.617
MOD_CK1_1	183	189	PF00069	0.661
MOD_CK1_1	252	258	PF00069	0.756
MOD_CK1_1	292	298	PF00069	0.518
MOD_CK1_1	468	474	PF00069	0.572
MOD_CK1_1	476	482	PF00069	0.577
MOD_CK1_1	570	576	PF00069	0.699
MOD_CK1_1	81	87	PF00069	0.724
MOD_CK2_1	186	192	PF00069	0.651
MOD_CK2_1	292	298	PF00069	0.459
MOD_CK2_1	35	41	PF00069	0.785
MOD_CK2_1	417	423	PF00069	0.603
MOD_GlcNHglycan	182	185	PF01048	0.425
MOD_GlcNHglycan	244	247	PF01048	0.526
MOD_GlcNHglycan	251	254	PF01048	0.550
MOD_GlcNHglycan	291	294	PF01048	0.283
MOD_GlcNHglycan	419	422	PF01048	0.404
MOD_GlcNHglycan	423	426	PF01048	0.420
MOD_GlcNHglycan	46	49	PF01048	0.615
MOD_GlcNHglycan	475	478	PF01048	0.405
MOD_GlcNHglycan	62	65	PF01048	0.550
MOD_GlcNHglycan	80	83	PF01048	0.561
MOD_GSK3_1	22	29	PF00069	0.619
MOD_GSK3_1	234	241	PF00069	0.652
MOD_GSK3_1	251	258	PF00069	0.796
MOD_GSK3_1	333	340	PF00069	0.538
MOD_GSK3_1	40	47	PF00069	0.630
MOD_GSK3_1	417	424	PF00069	0.613
MOD_GSK3_1	465	472	PF00069	0.548
MOD_GSK3_1	578	585	PF00069	0.627
MOD_N-GLC_1	242	247	PF02516	0.560
MOD_N-GLC_1	319	324	PF02516	0.344
MOD_N-GLC_1	589	594	PF02516	0.440
MOD_NEK2_1	101	106	PF00069	0.620
MOD_NEK2_1	2	7	PF00069	0.391
MOD_NEK2_1	221	226	PF00069	0.598
MOD_NEK2_1	40	45	PF00069	0.793
MOD_NEK2_1	457	462	PF00069	0.548
MOD_NEK2_1	530	535	PF00069	0.562
MOD_NEK2_2	319	324	PF00069	0.482
MOD_PKA_1	26	32	PF00069	0.588
MOD_PKA_2	26	32	PF00069	0.623
MOD_PKA_2	340	346	PF00069	0.563
MOD_Plk_1	319	325	PF00069	0.514
MOD_Plk_1	530	536	PF00069	0.512
MOD_Plk_1	547	553	PF00069	0.573
MOD_Plk_1	96	102	PF00069	0.674
MOD_Plk_2-3	35	41	PF00069	0.610
MOD_Plk_4	35	41	PF00069	0.757
MOD_Plk_4	410	416	PF00069	0.455
MOD_Plk_4	440	446	PF00069	0.517
MOD_Plk_4	465	471	PF00069	0.626
MOD_Plk_4	476	482	PF00069	0.645
MOD_Plk_4	547	553	PF00069	0.575
MOD_ProDKin_1	292	298	PF00069	0.415
MOD_ProDKin_1	532	538	PF00069	0.620
MOD_ProDKin_1	582	588	PF00069	0.675
MOD_ProDKin_1	71	77	PF00069	0.731
MOD_ProDKin_1	81	87	PF00069	0.747
MOD_SUMO_for_1	395	398	PF00179	0.495
MOD_SUMO_rev_2	270	277	PF00179	0.662
TRG_ENDOCYTIC_2	168	171	PF00928	0.355
TRG_ENDOCYTIC_2	284	287	PF00928	0.431
TRG_ENDOCYTIC_2	332	335	PF00928	0.469
TRG_ENDOCYTIC_2	347	350	PF00928	0.582
TRG_ER_diArg_1	402	404	PF00400	0.481
TRG_NES_CRM1_1	373	386	PF08389	0.602
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBU7	Leptomonas seymouri	60%	98%
A0A0S4JJ62	Bodo saltans	31%	100%
A0A1X0NJF9	Trypanosomatidae	42%	100%
A0A1X0NZV2	Trypanosomatidae	43%	100%
A0A3S7X455	Leishmania donovani	93%	99%
A0A422NZZ9	Trypanosoma rangeli	40%	100%
A4HJ29	Leishmania braziliensis	79%	100%
A4I6K8	Leishmania infantum	93%	99%
C9ZN58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZWY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
V5BN17	Trypanosoma cruzi	40%	100%