LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
Q4Q6L0_LEIMA
TriTrypDb:
LmjF.31.0530 , LMJLV39_310010800 , LMJSD75_310010500 *
Length:
678

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6L0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6L0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 135 139 PF00656 0.783
CLV_C14_Caspase3-7 379 383 PF00656 0.708
CLV_C14_Caspase3-7 670 674 PF00656 0.673
CLV_NRD_NRD_1 215 217 PF00675 0.744
CLV_NRD_NRD_1 287 289 PF00675 0.641
CLV_NRD_NRD_1 472 474 PF00675 0.828
CLV_NRD_NRD_1 593 595 PF00675 0.592
CLV_PCSK_KEX2_1 215 217 PF00082 0.744
CLV_PCSK_KEX2_1 287 289 PF00082 0.616
CLV_PCSK_KEX2_1 472 474 PF00082 0.828
CLV_PCSK_KEX2_1 593 595 PF00082 0.592
CLV_PCSK_SKI1_1 157 161 PF00082 0.671
CLV_PCSK_SKI1_1 192 196 PF00082 0.740
CLV_PCSK_SKI1_1 281 285 PF00082 0.703
CLV_PCSK_SKI1_1 333 337 PF00082 0.841
CLV_PCSK_SKI1_1 481 485 PF00082 0.672
DEG_APCC_DBOX_1 535 543 PF00400 0.774
DEG_Nend_UBRbox_3 1 3 PF02207 0.755
DEG_SPOP_SBC_1 325 329 PF00917 0.721
DEG_SPOP_SBC_1 492 496 PF00917 0.811
DEG_SPOP_SBC_1 510 514 PF00917 0.535
DOC_CKS1_1 225 230 PF01111 0.734
DOC_CKS1_1 462 467 PF01111 0.769
DOC_CKS1_1 504 509 PF01111 0.615
DOC_CYCLIN_yCln2_LP_2 137 143 PF00134 0.801
DOC_MAPK_gen_1 593 600 PF00069 0.585
DOC_MAPK_gen_1 652 660 PF00069 0.715
DOC_MAPK_MEF2A_6 653 662 PF00069 0.799
DOC_PIKK_1 128 136 PF02985 0.750
DOC_PP2B_LxvP_1 439 442 PF13499 0.690
DOC_PP2B_LxvP_1 508 511 PF13499 0.767
DOC_PP2B_LxvP_1 549 552 PF13499 0.615
DOC_PP4_FxxP_1 15 18 PF00568 0.769
DOC_PP4_FxxP_1 22 25 PF00568 0.666
DOC_PP4_FxxP_1 648 651 PF00568 0.725
DOC_USP7_MATH_1 190 194 PF00917 0.808
DOC_USP7_MATH_1 235 239 PF00917 0.790
DOC_USP7_MATH_1 241 245 PF00917 0.739
DOC_USP7_MATH_1 272 276 PF00917 0.741
DOC_USP7_MATH_1 325 329 PF00917 0.752
DOC_USP7_MATH_1 381 385 PF00917 0.594
DOC_USP7_MATH_1 403 407 PF00917 0.806
DOC_USP7_MATH_1 420 424 PF00917 0.600
DOC_USP7_MATH_1 425 429 PF00917 0.708
DOC_USP7_MATH_1 440 444 PF00917 0.551
DOC_USP7_MATH_1 457 461 PF00917 0.559
DOC_USP7_MATH_1 527 531 PF00917 0.615
DOC_USP7_MATH_1 552 556 PF00917 0.726
DOC_USP7_MATH_1 664 668 PF00917 0.582
DOC_WW_Pin1_4 150 155 PF00397 0.678
DOC_WW_Pin1_4 201 206 PF00397 0.754
DOC_WW_Pin1_4 221 226 PF00397 0.514
DOC_WW_Pin1_4 26 31 PF00397 0.744
DOC_WW_Pin1_4 263 268 PF00397 0.766
DOC_WW_Pin1_4 35 40 PF00397 0.694
DOC_WW_Pin1_4 384 389 PF00397 0.780
DOC_WW_Pin1_4 399 404 PF00397 0.662
DOC_WW_Pin1_4 45 50 PF00397 0.538
DOC_WW_Pin1_4 455 460 PF00397 0.772
DOC_WW_Pin1_4 461 466 PF00397 0.632
DOC_WW_Pin1_4 476 481 PF00397 0.812
DOC_WW_Pin1_4 495 500 PF00397 0.815
DOC_WW_Pin1_4 503 508 PF00397 0.750
DOC_WW_Pin1_4 534 539 PF00397 0.741
DOC_WW_Pin1_4 564 569 PF00397 0.800
DOC_WW_Pin1_4 571 576 PF00397 0.747
DOC_WW_Pin1_4 625 630 PF00397 0.662
DOC_WW_Pin1_4 76 81 PF00397 0.764
DOC_WW_Pin1_4 8 13 PF00397 0.635
DOC_WW_Pin1_4 91 96 PF00397 0.540
LIG_14-3-3_CanoR_1 186 190 PF00244 0.689
LIG_14-3-3_CanoR_1 287 297 PF00244 0.768
LIG_14-3-3_CanoR_1 314 322 PF00244 0.675
LIG_14-3-3_CanoR_1 33 38 PF00244 0.636
LIG_14-3-3_CanoR_1 355 363 PF00244 0.645
LIG_14-3-3_CanoR_1 399 403 PF00244 0.657
LIG_14-3-3_CanoR_1 472 482 PF00244 0.775
LIG_14-3-3_CanoR_1 593 600 PF00244 0.735
LIG_14-3-3_CanoR_1 84 93 PF00244 0.741
LIG_APCC_ABBA_1 389 394 PF00400 0.728
LIG_BRCT_BRCA1_1 18 22 PF00533 0.717
LIG_BRCT_BRCA1_1 431 435 PF00533 0.670
LIG_CSL_BTD_1 92 95 PF09270 0.809
LIG_deltaCOP1_diTrp_1 639 648 PF00928 0.595
LIG_FHA_1 114 120 PF00498 0.823
LIG_FHA_1 292 298 PF00498 0.823
LIG_FHA_1 32 38 PF00498 0.620
LIG_FHA_1 356 362 PF00498 0.675
LIG_FHA_1 523 529 PF00498 0.642
LIG_FHA_1 63 69 PF00498 0.754
LIG_FHA_1 9 15 PF00498 0.817
LIG_FHA_2 162 168 PF00498 0.769
LIG_FHA_2 207 213 PF00498 0.641
LIG_LIR_Apic_2 13 18 PF02991 0.771
LIG_LIR_Apic_2 19 25 PF02991 0.678
LIG_LIR_Apic_2 498 504 PF02991 0.602
LIG_LIR_Gen_1 394 403 PF02991 0.615
LIG_LIR_Nem_3 346 350 PF02991 0.829
LIG_LIR_Nem_3 394 400 PF02991 0.616
LIG_LIR_Nem_3 433 439 PF02991 0.740
LIG_Pex14_2 55 59 PF04695 0.691
LIG_SH3_1 501 507 PF00018 0.618
LIG_SH3_2 264 269 PF14604 0.732
LIG_SH3_2 373 378 PF14604 0.745
LIG_SH3_3 219 225 PF00018 0.747
LIG_SH3_3 261 267 PF00018 0.723
LIG_SH3_3 294 300 PF00018 0.848
LIG_SH3_3 337 343 PF00018 0.629
LIG_SH3_3 370 376 PF00018 0.741
LIG_SH3_3 397 403 PF00018 0.789
LIG_SH3_3 496 502 PF00018 0.830
LIG_SH3_3 504 510 PF00018 0.715
LIG_SH3_3 532 538 PF00018 0.736
LIG_SH3_3 562 568 PF00018 0.750
LIG_SH3_3 626 632 PF00018 0.696
LIG_SH3_3 65 71 PF00018 0.823
LIG_SUMO_SIM_par_1 173 180 PF11976 0.711
LIG_SUMO_SIM_par_1 197 204 PF11976 0.664
LIG_TRAF2_1 163 166 PF00917 0.851
LIG_TRAF2_1 450 453 PF00917 0.831
LIG_UBA3_1 643 652 PF00899 0.715
LIG_WRC_WIRS_1 344 349 PF05994 0.826
LIG_WRC_WIRS_1 52 57 PF05994 0.734
LIG_WW_3 311 315 PF00397 0.750
MOD_CDC14_SPxK_1 266 269 PF00782 0.774
MOD_CDC14_SPxK_1 48 51 PF00782 0.826
MOD_CDK_SPK_2 476 481 PF00069 0.812
MOD_CDK_SPxK_1 263 269 PF00069 0.769
MOD_CDK_SPxK_1 45 51 PF00069 0.834
MOD_CDK_SPxxK_3 150 157 PF00069 0.683
MOD_CDK_SPxxK_3 26 33 PF00069 0.610
MOD_CK1_1 120 126 PF00069 0.834
MOD_CK1_1 204 210 PF00069 0.797
MOD_CK1_1 224 230 PF00069 0.498
MOD_CK1_1 328 334 PF00069 0.769
MOD_CK1_1 353 359 PF00069 0.812
MOD_CK1_1 38 44 PF00069 0.787
MOD_CK1_1 380 386 PF00069 0.712
MOD_CK1_1 398 404 PF00069 0.540
MOD_CK1_1 45 51 PF00069 0.707
MOD_CK1_1 458 464 PF00069 0.740
MOD_CK1_1 476 482 PF00069 0.711
MOD_CK1_1 54 60 PF00069 0.625
MOD_CK1_1 555 561 PF00069 0.799
MOD_CK1_1 606 612 PF00069 0.823
MOD_CK1_1 613 619 PF00069 0.552
MOD_CK1_1 62 68 PF00069 0.532
MOD_CK1_1 667 673 PF00069 0.749
MOD_CK1_1 91 97 PF00069 0.732
MOD_CK2_1 109 115 PF00069 0.809
MOD_CK2_1 122 128 PF00069 0.618
MOD_CK2_1 159 165 PF00069 0.774
MOD_CK2_1 206 212 PF00069 0.641
MOD_CK2_1 447 453 PF00069 0.834
MOD_CK2_1 534 540 PF00069 0.777
MOD_DYRK1A_RPxSP_1 399 403 PF00069 0.734
MOD_GlcNHglycan 143 146 PF01048 0.741
MOD_GlcNHglycan 161 164 PF01048 0.547
MOD_GlcNHglycan 18 21 PF01048 0.737
MOD_GlcNHglycan 181 184 PF01048 0.535
MOD_GlcNHglycan 242 246 PF01048 0.831
MOD_GlcNHglycan 247 250 PF01048 0.744
MOD_GlcNHglycan 251 254 PF01048 0.676
MOD_GlcNHglycan 379 382 PF01048 0.805
MOD_GlcNHglycan 383 386 PF01048 0.776
MOD_GlcNHglycan 442 445 PF01048 0.626
MOD_GlcNHglycan 495 498 PF01048 0.770
MOD_GlcNHglycan 514 517 PF01048 0.531
MOD_GlcNHglycan 520 523 PF01048 0.620
MOD_GlcNHglycan 557 560 PF01048 0.661
MOD_GlcNHglycan 616 619 PF01048 0.778
MOD_GlcNHglycan 62 65 PF01048 0.726
MOD_GlcNHglycan 670 673 PF01048 0.691
MOD_GSK3_1 1 8 PF00069 0.662
MOD_GSK3_1 109 116 PF00069 0.816
MOD_GSK3_1 170 177 PF00069 0.754
MOD_GSK3_1 200 207 PF00069 0.798
MOD_GSK3_1 241 248 PF00069 0.812
MOD_GSK3_1 287 294 PF00069 0.692
MOD_GSK3_1 31 38 PF00069 0.798
MOD_GSK3_1 324 331 PF00069 0.787
MOD_GSK3_1 350 357 PF00069 0.812
MOD_GSK3_1 377 384 PF00069 0.727
MOD_GSK3_1 395 402 PF00069 0.657
MOD_GSK3_1 403 410 PF00069 0.725
MOD_GSK3_1 416 423 PF00069 0.706
MOD_GSK3_1 425 432 PF00069 0.620
MOD_GSK3_1 457 464 PF00069 0.743
MOD_GSK3_1 468 475 PF00069 0.782
MOD_GSK3_1 483 490 PF00069 0.689
MOD_GSK3_1 491 498 PF00069 0.636
MOD_GSK3_1 51 58 PF00069 0.562
MOD_GSK3_1 518 525 PF00069 0.568
MOD_GSK3_1 589 596 PF00069 0.753
MOD_GSK3_1 59 66 PF00069 0.674
MOD_GSK3_1 602 609 PF00069 0.649
MOD_GSK3_1 610 617 PF00069 0.712
MOD_GSK3_1 664 671 PF00069 0.803
MOD_GSK3_1 84 91 PF00069 0.820
MOD_N-GLC_1 403 408 PF02516 0.737
MOD_N-GLC_1 473 478 PF02516 0.844
MOD_N-GLC_1 488 493 PF02516 0.796
MOD_N-GLC_1 8 13 PF02516 0.680
MOD_NEK2_1 159 164 PF00069 0.736
MOD_NEK2_1 256 261 PF00069 0.645
MOD_NEK2_1 315 320 PF00069 0.752
MOD_NEK2_1 430 435 PF00069 0.652
MOD_NEK2_1 493 498 PF00069 0.669
MOD_NEK2_1 55 60 PF00069 0.792
MOD_NEK2_1 587 592 PF00069 0.841
MOD_NEK2_1 603 608 PF00069 0.565
MOD_NEK2_2 190 195 PF00069 0.730
MOD_NEK2_2 343 348 PF00069 0.705
MOD_PIKK_1 256 262 PF00454 0.588
MOD_PIKK_1 306 312 PF00454 0.656
MOD_PIKK_1 326 332 PF00454 0.677
MOD_PIKK_1 42 48 PF00454 0.847
MOD_PIKK_1 448 454 PF00454 0.758
MOD_PIKK_1 593 599 PF00454 0.717
MOD_PK_1 33 39 PF00069 0.630
MOD_PKA_1 287 293 PF00069 0.640
MOD_PKA_1 472 478 PF00069 0.829
MOD_PKA_1 593 599 PF00069 0.585
MOD_PKA_2 120 126 PF00069 0.834
MOD_PKA_2 16 22 PF00069 0.790
MOD_PKA_2 185 191 PF00069 0.691
MOD_PKA_2 287 293 PF00069 0.792
MOD_PKA_2 354 360 PF00069 0.751
MOD_PKA_2 377 383 PF00069 0.737
MOD_PKA_2 398 404 PF00069 0.629
MOD_PKA_2 468 474 PF00069 0.685
MOD_PKA_2 593 599 PF00069 0.702
MOD_PKA_2 664 670 PF00069 0.686
MOD_Plk_1 359 365 PF00069 0.770
MOD_Plk_1 39 45 PF00069 0.620
MOD_Plk_1 395 401 PF00069 0.771
MOD_Plk_1 416 422 PF00069 0.777
MOD_Plk_1 488 494 PF00069 0.794
MOD_Plk_1 610 616 PF00069 0.704
MOD_Plk_2-3 161 167 PF00069 0.772
MOD_Plk_4 10 16 PF00069 0.843
MOD_Plk_4 55 61 PF00069 0.807
MOD_Plk_4 552 558 PF00069 0.763
MOD_Plk_4 603 609 PF00069 0.787
MOD_Plk_4 63 69 PF00069 0.686
MOD_ProDKin_1 150 156 PF00069 0.680
MOD_ProDKin_1 201 207 PF00069 0.757
MOD_ProDKin_1 221 227 PF00069 0.509
MOD_ProDKin_1 26 32 PF00069 0.745
MOD_ProDKin_1 263 269 PF00069 0.769
MOD_ProDKin_1 35 41 PF00069 0.694
MOD_ProDKin_1 384 390 PF00069 0.778
MOD_ProDKin_1 399 405 PF00069 0.664
MOD_ProDKin_1 45 51 PF00069 0.538
MOD_ProDKin_1 455 461 PF00069 0.773
MOD_ProDKin_1 476 482 PF00069 0.806
MOD_ProDKin_1 495 501 PF00069 0.819
MOD_ProDKin_1 503 509 PF00069 0.749
MOD_ProDKin_1 534 540 PF00069 0.748
MOD_ProDKin_1 564 570 PF00069 0.801
MOD_ProDKin_1 571 577 PF00069 0.747
MOD_ProDKin_1 625 631 PF00069 0.661
MOD_ProDKin_1 76 82 PF00069 0.766
MOD_ProDKin_1 8 14 PF00069 0.637
MOD_ProDKin_1 91 97 PF00069 0.542
MOD_SUMO_rev_2 153 162 PF00179 0.613
TRG_DiLeu_BaEn_4 166 172 PF01217 0.840
TRG_ER_diArg_1 214 216 PF00400 0.747
TRG_ER_diArg_1 287 289 PF00400 0.639
TRG_ER_diArg_1 528 531 PF00400 0.775

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ISE9 Leishmania donovani 89% 100%
A4HJ31 Leishmania braziliensis 60% 100%
A4I6L0 Leishmania infantum 90% 100%
E9B1K3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS