Mevalonate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mevalonate kinase

Gene product:

mevalonate kinase, putative

Species:

Leishmania major

UniProt:

Q4Q6K7_LEIMA

TriTrypDb:

LmjF.31.0560 , LMJLV39_310011100 , LMJSD75_310010800

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0005829	cytosol	2	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	9

Expansion

Sequence features

Q4Q6K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6K7

PDB structure(s): 2hfs_A , 2hfs_B , 2hfu_A , 2hfu_B

Function

Biological processes
Term	Name	Level	Count
GO:0006084	acetyl-CoA metabolic process	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006629	lipid metabolic process	3	11
GO:0006637	acyl-CoA metabolic process	4	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006694	steroid biosynthetic process	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006790	sulfur compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008202	steroid metabolic process	4	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009150	purine ribonucleotide metabolic process	6	11
GO:0009240	isopentenyl diphosphate biosynthetic process	6	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009987	cellular process	1	11
GO:0016125	sterol metabolic process	4	11
GO:0016126	sterol biosynthetic process	5	11
GO:0016310	phosphorylation	5	11
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	6	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0033865	nucleoside bisphosphate metabolic process	5	11
GO:0033875	ribonucleoside bisphosphate metabolic process	6	11
GO:0034032	purine nucleoside bisphosphate metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0035383	thioester metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0046490	isopentenyl diphosphate metabolic process	5	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004496	mevalonate kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.471
CLV_C14_Caspase3-7	297	301	PF00656	0.560
CLV_NRD_NRD_1	168	170	PF00675	0.423
CLV_PCSK_KEX2_1	168	170	PF00082	0.423
CLV_PCSK_KEX2_1	217	219	PF00082	0.556
CLV_PCSK_KEX2_1	71	73	PF00082	0.468
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.556
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.493
CLV_PCSK_SKI1_1	173	177	PF00082	0.411
CLV_PCSK_SKI1_1	18	22	PF00082	0.350
CLV_PCSK_SKI1_1	231	235	PF00082	0.331
CLV_PCSK_SKI1_1	3	7	PF00082	0.568
CLV_PCSK_SKI1_1	304	308	PF00082	0.366
DEG_APCC_DBOX_1	183	191	PF00400	0.407
DOC_MAPK_gen_1	207	216	PF00069	0.393
DOC_MAPK_MEF2A_6	285	292	PF00069	0.471
DOC_PP1_RVXF_1	16	23	PF00149	0.358
DOC_PP1_RVXF_1	175	182	PF00149	0.522
DOC_USP7_MATH_1	111	115	PF00917	0.471
DOC_USP7_MATH_1	293	297	PF00917	0.576
DOC_USP7_MATH_1	4	8	PF00917	0.578
DOC_USP7_UBL2_3	173	177	PF12436	0.534
DOC_USP7_UBL2_3	8	12	PF12436	0.556
DOC_WW_Pin1_4	147	152	PF00397	0.471
LIG_14-3-3_CanoR_1	121	129	PF00244	0.510
LIG_14-3-3_CanoR_1	318	322	PF00244	0.411
LIG_APCC_ABBA_1	19	24	PF00400	0.342
LIG_APCC_ABBAyCdc20_2	18	24	PF00400	0.343
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_eIF4E_1	16	22	PF01652	0.412
LIG_FHA_1	196	202	PF00498	0.447
LIG_FHA_1	222	228	PF00498	0.529
LIG_FHA_2	130	136	PF00498	0.514
LIG_LIR_Gen_1	221	230	PF02991	0.441
LIG_LIR_Nem_3	160	164	PF02991	0.471
LIG_LIR_Nem_3	174	179	PF02991	0.432
LIG_LIR_Nem_3	221	226	PF02991	0.460
LIG_LIR_Nem_3	272	276	PF02991	0.554
LIG_PDZ_Class_1	324	329	PF00595	0.574
LIG_Pex14_2	22	26	PF04695	0.361
LIG_SH2_CRK	16	20	PF00017	0.431
LIG_SH2_CRK	161	165	PF00017	0.511
LIG_SH2_CRK	273	277	PF00017	0.560
LIG_SH2_GRB2like	220	223	PF00017	0.493
LIG_SH2_STAP1	223	227	PF00017	0.495
LIG_SH2_STAT3	167	170	PF00017	0.356
LIG_SH2_STAT3	319	322	PF00017	0.485
LIG_SH2_STAT3	67	70	PF00017	0.555
LIG_SH2_STAT5	186	189	PF00017	0.387
LIG_SH2_STAT5	223	226	PF00017	0.507
LIG_SH2_STAT5	319	322	PF00017	0.485
LIG_SH2_STAT5	41	44	PF00017	0.360
LIG_SH2_STAT5	67	70	PF00017	0.450
LIG_SH3_3	172	178	PF00018	0.550
LIG_SH3_3	47	53	PF00018	0.549
LIG_SH3_3	59	65	PF00018	0.437
LIG_SH3_3	99	105	PF00018	0.396
LIG_SUMO_SIM_par_1	186	192	PF11976	0.414
LIG_TRAF2_1	132	135	PF00917	0.548
LIG_TYR_ITIM	14	19	PF00017	0.428
MOD_CK1_1	39	45	PF00069	0.438
MOD_CK1_1	7	13	PF00069	0.524
MOD_CK2_1	129	135	PF00069	0.548
MOD_CK2_1	256	262	PF00069	0.471
MOD_GlcNHglycan	106	109	PF01048	0.271
MOD_GlcNHglycan	111	114	PF01048	0.271
MOD_GlcNHglycan	138	141	PF01048	0.280
MOD_GlcNHglycan	151	154	PF01048	0.252
MOD_GlcNHglycan	280	283	PF01048	0.281
MOD_GlcNHglycan	323	326	PF01048	0.475
MOD_GlcNHglycan	89	93	PF01048	0.374
MOD_GSK3_1	117	124	PF00069	0.551
MOD_GSK3_1	221	228	PF00069	0.550
MOD_GSK3_1	262	269	PF00069	0.564
MOD_GSK3_1	317	324	PF00069	0.492
MOD_N-GLC_1	129	134	PF02516	0.304
MOD_N-GLC_1	136	141	PF02516	0.264
MOD_N-GLC_1	194	199	PF02516	0.574
MOD_N-GLC_1	221	226	PF02516	0.481
MOD_NEK2_1	280	285	PF00069	0.479
MOD_OFUCOSY	253	260	PF10250	0.271
MOD_PIKK_1	225	231	PF00454	0.507
MOD_PKA_2	317	323	PF00069	0.413
MOD_Plk_1	136	142	PF00069	0.485
MOD_Plk_1	221	227	PF00069	0.475
MOD_Plk_4	171	177	PF00069	0.417
MOD_Plk_4	262	268	PF00069	0.555
MOD_ProDKin_1	147	153	PF00069	0.471
TRG_ENDOCYTIC_2	16	19	PF00928	0.430
TRG_ENDOCYTIC_2	161	164	PF00928	0.511
TRG_ENDOCYTIC_2	186	189	PF00928	0.379
TRG_ENDOCYTIC_2	223	226	PF00928	0.455
TRG_ENDOCYTIC_2	273	276	PF00928	0.560
TRG_ER_diArg_1	167	169	PF00400	0.394
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE67	Leptomonas seymouri	78%	100%
A0A0S4KH54	Bodo saltans	59%	98%
A0A1D8PEL1	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	76%
A0A1X0NJ39	Trypanosomatidae	62%	100%
A0A3R7M8L1	Trypanosoma rangeli	59%	100%
A0A3S7X459	Leishmania donovani	96%	100%
A4HJ34	Leishmania braziliensis	86%	100%
A4I6L2	Leishmania infantum	97%	100%
A9MTL0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	26%	86%
B4SZH7	Salmonella newport (strain SL254)	26%	86%
B4TC28	Salmonella heidelberg (strain SL476)	26%	86%
B4TQR9	Salmonella schwarzengrund (strain CVM19633)	26%	86%
B5BC50	Salmonella paratyphi A (strain AKU_12601)	26%	86%
B5F052	Salmonella agona (strain SL483)	26%	86%
B5FP41	Salmonella dublin (strain CT_02021853)	26%	86%
B5QX45	Salmonella enteritidis PT4 (strain P125109)	26%	86%
B5R741	Salmonella gallinarum (strain 287/91 / NCTC 13346)	26%	86%
B6YST1	Thermococcus onnurineus (strain NA1)	32%	99%
C0PWW2	Salmonella paratyphi C (strain RKS4594)	26%	86%
C5A7L8	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	34%	99%
C6A3T5	Thermococcus sibiricus (strain DSM 12597 / MM 739)	33%	99%
C9ZN67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B1K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	93%
O27995	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O58107	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	26%	94%
O59291	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	98%
P07277	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	74%
P22713	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	86%
P46086	Arabidopsis thaliana	26%	87%
Q03426	Homo sapiens	27%	83%
Q03PA8	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	25%	85%
Q09780	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	81%
Q50559	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	30%	100%
Q57RI3	Salmonella choleraesuis (strain SC-B67)	26%	86%
Q58487	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	29%	100%
Q5E9T8	Bos taurus	25%	83%
Q5JEK8	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	30%	94%
Q5JJC6	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	34%	98%
Q5PG77	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	26%	86%
Q86AG7	Dictyostelium discoideum	23%	84%
Q8U0F3	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	33%	99%
Q8Z8B0	Salmonella typhi	26%	86%
Q980D2	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	28%	100%
Q9HHB6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	28%	93%
Q9V187	Pyrococcus abyssi (strain GE5 / Orsay)	31%	98%
Q9Y946	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	32%	100%