SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6K1_LEIMA

TriTrypDb:

LmjF.31.0620 , LMJLV39_310011900 , LMJSD75_310011600

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.590
CLV_C14_Caspase3-7	463	467	PF00656	0.707
CLV_C14_Caspase3-7	671	675	PF00656	0.583
CLV_C14_Caspase3-7	787	791	PF00656	0.683
CLV_NRD_NRD_1	113	115	PF00675	0.651
CLV_NRD_NRD_1	148	150	PF00675	0.687
CLV_NRD_NRD_1	154	156	PF00675	0.695
CLV_NRD_NRD_1	184	186	PF00675	0.548
CLV_NRD_NRD_1	34	36	PF00675	0.625
CLV_NRD_NRD_1	622	624	PF00675	0.578
CLV_NRD_NRD_1	735	737	PF00675	0.643
CLV_PCSK_FUR_1	114	118	PF00082	0.530
CLV_PCSK_FUR_1	645	649	PF00082	0.796
CLV_PCSK_KEX2_1	113	115	PF00082	0.682
CLV_PCSK_KEX2_1	116	118	PF00082	0.790
CLV_PCSK_KEX2_1	147	149	PF00082	0.646
CLV_PCSK_KEX2_1	587	589	PF00082	0.485
CLV_PCSK_KEX2_1	622	624	PF00082	0.595
CLV_PCSK_KEX2_1	647	649	PF00082	0.742
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.602
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.663
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.485
CLV_PCSK_PC1ET2_1	647	649	PF00082	0.765
CLV_PCSK_SKI1_1	155	159	PF00082	0.658
CLV_PCSK_SKI1_1	185	189	PF00082	0.488
CLV_PCSK_SKI1_1	221	225	PF00082	0.641
CLV_PCSK_SKI1_1	415	419	PF00082	0.553
CLV_PCSK_SKI1_1	459	463	PF00082	0.682
CLV_PCSK_SKI1_1	609	613	PF00082	0.567
CLV_PCSK_SKI1_1	784	788	PF00082	0.586
DEG_APCC_KENBOX_2	657	661	PF00400	0.655
DEG_Nend_UBRbox_2	1	3	PF02207	0.812
DEG_SCF_FBW7_2	171	177	PF00400	0.666
DEG_SCF_FBW7_2	725	732	PF00400	0.655
DEG_SPOP_SBC_1	778	782	PF00917	0.532
DOC_CKS1_1	171	176	PF01111	0.621
DOC_CKS1_1	44	49	PF01111	0.538
DOC_CYCLIN_RxL_1	233	245	PF00134	0.684
DOC_MAPK_FxFP_2	81	84	PF00069	0.690
DOC_MAPK_gen_1	357	365	PF00069	0.723
DOC_MAPK_RevD_3	723	737	PF00069	0.681
DOC_PP1_RVXF_1	236	243	PF00149	0.566
DOC_PP4_FxxP_1	443	446	PF00568	0.547
DOC_PP4_FxxP_1	81	84	PF00568	0.690
DOC_SPAK_OSR1_1	238	242	PF12202	0.650
DOC_USP7_MATH_1	130	134	PF00917	0.646
DOC_USP7_MATH_1	157	161	PF00917	0.698
DOC_USP7_MATH_1	206	210	PF00917	0.812
DOC_USP7_MATH_1	212	216	PF00917	0.704
DOC_USP7_MATH_1	293	297	PF00917	0.576
DOC_USP7_MATH_1	302	306	PF00917	0.534
DOC_USP7_MATH_1	379	383	PF00917	0.726
DOC_USP7_MATH_1	405	409	PF00917	0.689
DOC_USP7_MATH_1	455	459	PF00917	0.559
DOC_USP7_MATH_1	460	464	PF00917	0.617
DOC_USP7_MATH_1	468	472	PF00917	0.629
DOC_USP7_MATH_1	503	507	PF00917	0.678
DOC_USP7_MATH_1	512	516	PF00917	0.642
DOC_USP7_MATH_1	532	536	PF00917	0.577
DOC_USP7_MATH_1	581	585	PF00917	0.682
DOC_USP7_MATH_1	678	682	PF00917	0.768
DOC_USP7_MATH_1	7	11	PF00917	0.498
DOC_USP7_MATH_1	710	714	PF00917	0.492
DOC_USP7_MATH_1	778	782	PF00917	0.732
DOC_USP7_MATH_2	657	663	PF00917	0.585
DOC_USP7_UBL2_3	152	156	PF12436	0.676
DOC_USP7_UBL2_3	411	415	PF12436	0.776
DOC_WW_Pin1_4	102	107	PF00397	0.711
DOC_WW_Pin1_4	170	175	PF00397	0.717
DOC_WW_Pin1_4	202	207	PF00397	0.765
DOC_WW_Pin1_4	265	270	PF00397	0.730
DOC_WW_Pin1_4	403	408	PF00397	0.658
DOC_WW_Pin1_4	43	48	PF00397	0.586
DOC_WW_Pin1_4	572	577	PF00397	0.735
DOC_WW_Pin1_4	679	684	PF00397	0.697
DOC_WW_Pin1_4	725	730	PF00397	0.650
DOC_WW_Pin1_4	795	800	PF00397	0.605
LIG_14-3-3_CanoR_1	277	283	PF00244	0.645
LIG_14-3-3_CanoR_1	362	366	PF00244	0.751
LIG_14-3-3_CanoR_1	380	385	PF00244	0.695
LIG_14-3-3_CanoR_1	389	393	PF00244	0.713
LIG_14-3-3_CanoR_1	483	492	PF00244	0.579
LIG_14-3-3_CanoR_1	536	542	PF00244	0.494
LIG_14-3-3_CanoR_1	588	593	PF00244	0.637
LIG_14-3-3_CanoR_1	622	628	PF00244	0.444
LIG_14-3-3_CanoR_1	690	695	PF00244	0.586
LIG_14-3-3_CanoR_1	711	715	PF00244	0.459
LIG_14-3-3_CanoR_1	79	84	PF00244	0.683
LIG_14-3-3_CanoR_1	807	813	PF00244	0.563
LIG_APCC_ABBA_1	727	732	PF00400	0.665
LIG_BRCT_BRCA1_1	457	461	PF00533	0.514
LIG_BRCT_BRCA1_1	712	716	PF00533	0.509
LIG_BRCT_BRCA1_1	763	767	PF00533	0.664
LIG_deltaCOP1_diTrp_1	74	83	PF00928	0.659
LIG_FHA_1	133	139	PF00498	0.610
LIG_FHA_1	166	172	PF00498	0.719
LIG_FHA_1	335	341	PF00498	0.706
LIG_FHA_1	536	542	PF00498	0.607
LIG_FHA_2	106	112	PF00498	0.584
LIG_FHA_2	138	144	PF00498	0.613
LIG_FHA_2	298	304	PF00498	0.804
LIG_FHA_2	325	331	PF00498	0.799
LIG_FHA_2	362	368	PF00498	0.700
LIG_FHA_2	419	425	PF00498	0.569
LIG_FHA_2	565	571	PF00498	0.767
LIG_FHA_2	669	675	PF00498	0.744
LIG_FHA_2	785	791	PF00498	0.679
LIG_LIR_Gen_1	18	28	PF02991	0.630
LIG_LIR_Gen_1	317	328	PF02991	0.788
LIG_LIR_Gen_1	525	533	PF02991	0.468
LIG_LIR_Gen_1	713	723	PF02991	0.568
LIG_LIR_Gen_1	728	738	PF02991	0.472
LIG_LIR_Gen_1	743	752	PF02991	0.463
LIG_LIR_Gen_1	801	810	PF02991	0.615
LIG_LIR_Nem_3	18	24	PF02991	0.632
LIG_LIR_Nem_3	219	223	PF02991	0.734
LIG_LIR_Nem_3	27	33	PF02991	0.378
LIG_LIR_Nem_3	317	323	PF02991	0.776
LIG_LIR_Nem_3	518	523	PF02991	0.495
LIG_LIR_Nem_3	525	531	PF02991	0.441
LIG_LIR_Nem_3	614	618	PF02991	0.580
LIG_LIR_Nem_3	713	719	PF02991	0.555
LIG_LIR_Nem_3	728	733	PF02991	0.499
LIG_LIR_Nem_3	743	748	PF02991	0.440
LIG_LIR_Nem_3	75	81	PF02991	0.596
LIG_Pex14_1	744	748	PF04695	0.494
LIG_SH2_CRK	320	324	PF00017	0.794
LIG_SH2_CRK	37	41	PF00017	0.571
LIG_SH2_CRK	615	619	PF00017	0.561
LIG_SH2_CRK	625	629	PF00017	0.384
LIG_SH2_GRB2like	37	40	PF00017	0.604
LIG_SH2_NCK_1	320	324	PF00017	0.794
LIG_SH2_NCK_1	625	629	PF00017	0.500
LIG_SH2_PTP2	21	24	PF00017	0.629
LIG_SH2_SRC	21	24	PF00017	0.588
LIG_SH2_SRC	37	40	PF00017	0.563
LIG_SH2_STAP1	413	417	PF00017	0.676
LIG_SH2_STAP1	436	440	PF00017	0.610
LIG_SH2_STAT5	21	24	PF00017	0.588
LIG_SH2_STAT5	227	230	PF00017	0.564
LIG_SH2_STAT5	275	278	PF00017	0.543
LIG_SH2_STAT5	594	597	PF00017	0.608
LIG_SH3_3	168	174	PF00018	0.636
LIG_SH3_3	19	25	PF00018	0.581
LIG_SH3_3	225	231	PF00018	0.609
LIG_SH3_3	41	47	PF00018	0.601
LIG_SH3_3	526	532	PF00018	0.465
LIG_SH3_3	553	559	PF00018	0.720
LIG_SH3_3	81	87	PF00018	0.669
LIG_SUMO_SIM_par_1	133	140	PF11976	0.609
LIG_SUMO_SIM_par_1	336	341	PF11976	0.678
LIG_SxIP_EBH_1	715	724	PF03271	0.594
LIG_TYR_ITIM	19	24	PF00017	0.634
LIG_TYR_ITIM	318	323	PF00017	0.789
LIG_WRC_WIRS_1	800	805	PF05994	0.630
MOD_CDK_SPK_2	170	175	PF00069	0.679
MOD_CK1_1	119	125	PF00069	0.655
MOD_CK1_1	229	235	PF00069	0.649
MOD_CK1_1	268	274	PF00069	0.679
MOD_CK1_1	305	311	PF00069	0.781
MOD_CK1_1	506	512	PF00069	0.693
MOD_CK1_1	515	521	PF00069	0.504
MOD_CK1_1	535	541	PF00069	0.601
MOD_CK1_1	571	577	PF00069	0.714
MOD_CK1_1	626	632	PF00069	0.545
MOD_CK1_1	681	687	PF00069	0.715
MOD_CK1_1	717	723	PF00069	0.536
MOD_CK1_1	773	779	PF00069	0.691
MOD_CK1_1	82	88	PF00069	0.634
MOD_CK2_1	105	111	PF00069	0.592
MOD_CK2_1	297	303	PF00069	0.780
MOD_CK2_1	324	330	PF00069	0.722
MOD_CK2_1	361	367	PF00069	0.687
MOD_CK2_1	564	570	PF00069	0.783
MOD_CK2_1	574	580	PF00069	0.747
MOD_CK2_1	795	801	PF00069	0.552
MOD_CMANNOS	449	452	PF00535	0.659
MOD_GlcNHglycan	121	124	PF01048	0.669
MOD_GlcNHglycan	159	163	PF01048	0.723
MOD_GlcNHglycan	168	171	PF01048	0.716
MOD_GlcNHglycan	208	211	PF01048	0.747
MOD_GlcNHglycan	228	231	PF01048	0.545
MOD_GlcNHglycan	244	247	PF01048	0.533
MOD_GlcNHglycan	258	261	PF01048	0.718
MOD_GlcNHglycan	278	281	PF01048	0.411
MOD_GlcNHglycan	295	298	PF01048	0.560
MOD_GlcNHglycan	306	310	PF01048	0.704
MOD_GlcNHglycan	385	388	PF01048	0.740
MOD_GlcNHglycan	394	397	PF01048	0.632
MOD_GlcNHglycan	403	406	PF01048	0.568
MOD_GlcNHglycan	47	50	PF01048	0.701
MOD_GlcNHglycan	486	489	PF01048	0.525
MOD_GlcNHglycan	505	508	PF01048	0.702
MOD_GlcNHglycan	510	513	PF01048	0.714
MOD_GlcNHglycan	544	547	PF01048	0.464
MOD_GlcNHglycan	552	556	PF01048	0.599
MOD_GlcNHglycan	570	573	PF01048	0.680
MOD_GlcNHglycan	59	62	PF01048	0.620
MOD_GlcNHglycan	628	631	PF01048	0.489
MOD_GlcNHglycan	642	645	PF01048	0.667
MOD_GlcNHglycan	756	759	PF01048	0.707
MOD_GlcNHglycan	763	766	PF01048	0.567
MOD_GlcNHglycan	772	775	PF01048	0.393
MOD_GSK3_1	102	109	PF00069	0.567
MOD_GSK3_1	112	119	PF00069	0.632
MOD_GSK3_1	132	139	PF00069	0.558
MOD_GSK3_1	166	173	PF00069	0.681
MOD_GSK3_1	202	209	PF00069	0.745
MOD_GSK3_1	212	219	PF00069	0.458
MOD_GSK3_1	293	300	PF00069	0.736
MOD_GSK3_1	334	341	PF00069	0.720
MOD_GSK3_1	379	386	PF00069	0.670
MOD_GSK3_1	388	395	PF00069	0.647
MOD_GSK3_1	401	408	PF00069	0.681
MOD_GSK3_1	455	462	PF00069	0.683
MOD_GSK3_1	466	473	PF00069	0.742
MOD_GSK3_1	508	515	PF00069	0.677
MOD_GSK3_1	531	538	PF00069	0.610
MOD_GSK3_1	564	571	PF00069	0.707
MOD_GSK3_1	626	633	PF00069	0.452
MOD_GSK3_1	659	666	PF00069	0.766
MOD_GSK3_1	710	717	PF00069	0.508
MOD_GSK3_1	773	780	PF00069	0.665
MOD_GSK3_1	795	802	PF00069	0.626
MOD_N-GLC_1	542	547	PF02516	0.482
MOD_N-GLC_1	659	664	PF02516	0.793
MOD_N-GLC_1	668	673	PF02516	0.732
MOD_N-GLC_1	761	766	PF02516	0.676
MOD_N-GLC_1	91	96	PF02516	0.745
MOD_N-GLC_2	699	701	PF02516	0.457
MOD_NEK2_1	112	117	PF00069	0.601
MOD_NEK2_1	136	141	PF00069	0.479
MOD_NEK2_1	314	319	PF00069	0.640
MOD_NEK2_1	366	371	PF00069	0.596
MOD_NEK2_1	484	489	PF00069	0.597
MOD_NEK2_1	551	556	PF00069	0.553
MOD_NEK2_1	561	566	PF00069	0.646
MOD_NEK2_1	595	600	PF00069	0.504
MOD_NEK2_1	702	707	PF00069	0.504
MOD_NEK2_1	738	743	PF00069	0.465
MOD_NEK2_1	91	96	PF00069	0.741
MOD_NEK2_2	537	542	PF00069	0.542
MOD_PIKK_1	372	378	PF00454	0.791
MOD_PIKK_1	595	601	PF00454	0.521
MOD_PIKK_1	717	723	PF00454	0.572
MOD_PKA_1	116	122	PF00069	0.784
MOD_PKA_1	411	417	PF00069	0.736
MOD_PKA_2	112	118	PF00069	0.719
MOD_PKA_2	276	282	PF00069	0.542
MOD_PKA_2	361	367	PF00069	0.746
MOD_PKA_2	379	385	PF00069	0.700
MOD_PKA_2	388	394	PF00069	0.683
MOD_PKA_2	498	504	PF00069	0.523
MOD_PKA_2	535	541	PF00069	0.601
MOD_PKA_2	581	587	PF00069	0.517
MOD_PKA_2	689	695	PF00069	0.612
MOD_PKA_2	710	716	PF00069	0.470
MOD_PKB_1	688	696	PF00069	0.646
MOD_PKB_1	77	85	PF00069	0.693
MOD_Plk_1	212	218	PF00069	0.569
MOD_Plk_1	338	344	PF00069	0.637
MOD_Plk_1	366	372	PF00069	0.632
MOD_Plk_1	436	442	PF00069	0.684
MOD_Plk_1	551	557	PF00069	0.590
MOD_Plk_1	630	636	PF00069	0.499
MOD_Plk_1	738	744	PF00069	0.465
MOD_Plk_1	91	97	PF00069	0.752
MOD_Plk_2-3	668	674	PF00069	0.583
MOD_Plk_4	132	138	PF00069	0.630
MOD_Plk_4	361	367	PF00069	0.693
MOD_Plk_4	380	386	PF00069	0.757
MOD_Plk_4	388	394	PF00069	0.776
MOD_Plk_4	512	518	PF00069	0.617
MOD_Plk_4	524	530	PF00069	0.540
MOD_Plk_4	581	587	PF00069	0.673
MOD_Plk_4	623	629	PF00069	0.460
MOD_Plk_4	740	746	PF00069	0.580
MOD_ProDKin_1	102	108	PF00069	0.698
MOD_ProDKin_1	170	176	PF00069	0.716
MOD_ProDKin_1	202	208	PF00069	0.766
MOD_ProDKin_1	265	271	PF00069	0.730
MOD_ProDKin_1	403	409	PF00069	0.658
MOD_ProDKin_1	43	49	PF00069	0.591
MOD_ProDKin_1	572	578	PF00069	0.733
MOD_ProDKin_1	679	685	PF00069	0.696
MOD_ProDKin_1	725	731	PF00069	0.654
MOD_ProDKin_1	795	801	PF00069	0.601
MOD_SUMO_for_1	174	177	PF00179	0.724
MOD_SUMO_rev_2	251	258	PF00179	0.677
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.692
TRG_ENDOCYTIC_2	21	24	PF00928	0.645
TRG_ENDOCYTIC_2	320	323	PF00928	0.795
TRG_ENDOCYTIC_2	37	40	PF00928	0.341
TRG_ENDOCYTIC_2	615	618	PF00928	0.529
TRG_ENDOCYTIC_2	625	628	PF00928	0.429
TRG_ER_diArg_1	112	114	PF00400	0.663
TRG_ER_diArg_1	622	624	PF00400	0.595
TRG_NLS_MonoExtN_4	412	419	PF00514	0.551
TRG_NLS_MonoExtN_4	645	651	PF00514	0.697
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T0	Leptomonas seymouri	47%	99%
A0A1X0NK18	Trypanosomatidae	26%	100%
A0A3R7NKJ0	Trypanosoma rangeli	27%	100%
A0A3S7X461	Leishmania donovani	89%	100%
A4HJ41	Leishmania braziliensis	73%	100%
A4I6F6	Leishmania infantum	89%	100%
C9ZN74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B1L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%