Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6J4_LEIMA

TriTrypDb:

LmjF.31.0690 , LMJLV39_310012600 , LMJSD75_310012300

Length:

530

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6J4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.629
CLV_NRD_NRD_1	103	105	PF00675	0.593
CLV_NRD_NRD_1	44	46	PF00675	0.460
CLV_PCSK_KEX2_1	103	105	PF00082	0.593
CLV_PCSK_KEX2_1	44	46	PF00082	0.460
CLV_PCSK_SKI1_1	324	328	PF00082	0.629
CLV_PCSK_SKI1_1	4	8	PF00082	0.447
DEG_APCC_DBOX_1	3	11	PF00400	0.446
DEG_Nend_UBRbox_1	1	4	PF02207	0.443
DEG_SCF_FBW7_1	157	164	PF00400	0.625
DEG_SCF_FBW7_1	233	240	PF00400	0.584
DEG_SCF_FBW7_1	494	501	PF00400	0.676
DOC_CKS1_1	158	163	PF01111	0.675
DOC_CKS1_1	186	191	PF01111	0.676
DOC_CKS1_1	234	239	PF01111	0.600
DOC_CKS1_1	244	249	PF01111	0.632
DOC_CKS1_1	495	500	PF01111	0.675
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.579
DOC_MAPK_DCC_7	149	158	PF00069	0.552
DOC_MAPK_gen_1	2	10	PF00069	0.446
DOC_MAPK_gen_1	299	308	PF00069	0.418
DOC_MAPK_gen_1	351	359	PF00069	0.486
DOC_MAPK_MEF2A_6	149	158	PF00069	0.552
DOC_MAPK_MEF2A_6	2	10	PF00069	0.446
DOC_MAPK_MEF2A_6	347	354	PF00069	0.483
DOC_MAPK_MEF2A_6	62	69	PF00069	0.504
DOC_MAPK_NFAT4_5	347	355	PF00069	0.482
DOC_PP2B_LxvP_1	13	16	PF13499	0.443
DOC_PP2B_LxvP_1	426	429	PF13499	0.576
DOC_PP2B_LxvP_1	430	433	PF13499	0.588
DOC_PP4_FxxP_1	150	153	PF00568	0.434
DOC_PP4_FxxP_1	183	186	PF00568	0.730
DOC_PP4_FxxP_1	231	234	PF00568	0.549
DOC_PP4_MxPP_1	470	473	PF00568	0.729
DOC_SPAK_OSR1_1	149	153	PF12202	0.488
DOC_USP7_MATH_1	19	23	PF00917	0.436
DOC_USP7_MATH_1	225	229	PF00917	0.805
DOC_USP7_MATH_1	237	241	PF00917	0.543
DOC_USP7_MATH_1	248	252	PF00917	0.631
DOC_USP7_MATH_1	270	274	PF00917	0.564
DOC_USP7_MATH_1	47	51	PF00917	0.544
DOC_USP7_MATH_1	498	502	PF00917	0.651
DOC_WW_Pin1_4	15	20	PF00397	0.435
DOC_WW_Pin1_4	157	162	PF00397	0.619
DOC_WW_Pin1_4	167	172	PF00397	0.718
DOC_WW_Pin1_4	185	190	PF00397	0.496
DOC_WW_Pin1_4	233	238	PF00397	0.673
DOC_WW_Pin1_4	243	248	PF00397	0.593
DOC_WW_Pin1_4	364	369	PF00397	0.692
DOC_WW_Pin1_4	494	499	PF00397	0.738
LIG_14-3-3_CanoR_1	103	109	PF00244	0.465
LIG_14-3-3_CanoR_1	23	28	PF00244	0.443
LIG_14-3-3_CanoR_1	347	351	PF00244	0.488
LIG_14-3-3_CanoR_1	44	52	PF00244	0.481
LIG_BIR_III_4	58	62	PF00653	0.624
LIG_BRCT_BRCA1_1	227	231	PF00533	0.727
LIG_CSL_BTD_1	365	368	PF09270	0.694
LIG_FHA_1	103	109	PF00498	0.465
LIG_FHA_1	158	164	PF00498	0.546
LIG_FHA_1	186	192	PF00498	0.590
LIG_FHA_1	244	250	PF00498	0.635
LIG_FHA_1	266	272	PF00498	0.555
LIG_FHA_1	279	285	PF00498	0.322
LIG_FHA_1	391	397	PF00498	0.734
LIG_IRF3_LxIS_1	239	245	PF10401	0.668
LIG_LIR_Apic_2	228	234	PF02991	0.596
LIG_LIR_Apic_2	384	390	PF02991	0.592
LIG_LIR_Gen_1	50	59	PF02991	0.613
LIG_LIR_Gen_1	90	100	PF02991	0.404
LIG_LIR_Nem_3	146	151	PF02991	0.490
LIG_LIR_Nem_3	276	282	PF02991	0.513
LIG_LIR_Nem_3	50	56	PF02991	0.650
LIG_LIR_Nem_3	521	526	PF02991	0.727
LIG_LIR_Nem_3	90	96	PF02991	0.419
LIG_LYPXL_S_1	278	282	PF13949	0.510
LIG_LYPXL_yS_3	279	282	PF13949	0.554
LIG_NRBOX	422	428	PF00104	0.566
LIG_NRP_CendR_1	527	530	PF00754	0.675
LIG_Pex14_1	144	148	PF04695	0.473
LIG_Pex14_2	467	471	PF04695	0.643
LIG_PTB_Apo_2	142	149	PF02174	0.481
LIG_REV1ctd_RIR_1	35	45	PF16727	0.450
LIG_SH2_CRK	187	191	PF00017	0.713
LIG_SH2_CRK	302	306	PF00017	0.483
LIG_SH2_CRK	412	416	PF00017	0.624
LIG_SH2_CRK	526	530	PF00017	0.721
LIG_SH2_CRK	53	57	PF00017	0.610
LIG_SH2_NCK_1	53	57	PF00017	0.610
LIG_SH2_PTP2	64	67	PF00017	0.437
LIG_SH2_PTP2	93	96	PF00017	0.408
LIG_SH2_SRC	29	32	PF00017	0.430
LIG_SH2_SRC	64	67	PF00017	0.437
LIG_SH2_STAP1	53	57	PF00017	0.610
LIG_SH2_STAT3	134	137	PF00017	0.559
LIG_SH2_STAT3	235	238	PF00017	0.659
LIG_SH2_STAT5	187	190	PF00017	0.714
LIG_SH2_STAT5	235	238	PF00017	0.565
LIG_SH2_STAT5	29	32	PF00017	0.430
LIG_SH2_STAT5	406	409	PF00017	0.591
LIG_SH2_STAT5	64	67	PF00017	0.437
LIG_SH2_STAT5	93	96	PF00017	0.431
LIG_SH3_3	13	19	PF00018	0.437
LIG_SH3_3	148	154	PF00018	0.471
LIG_SH3_3	162	168	PF00018	0.646
LIG_SH3_3	183	189	PF00018	0.694
LIG_SH3_3	231	237	PF00018	0.572
LIG_SH3_3	459	465	PF00018	0.640
LIG_SH3_3	485	491	PF00018	0.696
LIG_SH3_3	492	498	PF00018	0.650
LIG_SH3_3	519	525	PF00018	0.665
LIG_SUMO_SIM_anti_2	323	330	PF11976	0.639
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.448
LIG_SUMO_SIM_par_1	280	285	PF11976	0.362
LIG_SUMO_SIM_par_1	323	330	PF11976	0.639
LIG_SUMO_SIM_par_1	5	11	PF11976	0.448
LIG_TYR_ITIM	277	282	PF00017	0.522
LIG_WW_2	189	192	PF00397	0.541
MOD_CDK_SPK_2	161	166	PF00069	0.684
MOD_CK1_1	170	176	PF00069	0.775
MOD_CK1_1	273	279	PF00069	0.541
MOD_CK1_1	372	378	PF00069	0.656
MOD_CK1_1	515	521	PF00069	0.725
MOD_GlcNHglycan	121	124	PF01048	0.621
MOD_GlcNHglycan	172	175	PF01048	0.767
MOD_GlcNHglycan	193	196	PF01048	0.608
MOD_GlcNHglycan	197	200	PF01048	0.613
MOD_GlcNHglycan	219	222	PF01048	0.659
MOD_GlcNHglycan	228	231	PF01048	0.613
MOD_GlcNHglycan	250	253	PF01048	0.722
MOD_GlcNHglycan	258	261	PF01048	0.668
MOD_GlcNHglycan	288	291	PF01048	0.495
MOD_GlcNHglycan	343	346	PF01048	0.524
MOD_GlcNHglycan	383	386	PF01048	0.635
MOD_GlcNHglycan	436	439	PF01048	0.612
MOD_GlcNHglycan	500	503	PF01048	0.716
MOD_GlcNHglycan	53	56	PF01048	0.577
MOD_GSK3_1	103	110	PF00069	0.474
MOD_GSK3_1	11	18	PF00069	0.441
MOD_GSK3_1	115	122	PF00069	0.577
MOD_GSK3_1	157	164	PF00069	0.604
MOD_GSK3_1	19	26	PF00069	0.434
MOD_GSK3_1	191	198	PF00069	0.623
MOD_GSK3_1	213	220	PF00069	0.748
MOD_GSK3_1	233	240	PF00069	0.611
MOD_GSK3_1	286	293	PF00069	0.641
MOD_GSK3_1	374	381	PF00069	0.679
MOD_GSK3_1	39	46	PF00069	0.478
MOD_GSK3_1	442	449	PF00069	0.661
MOD_GSK3_1	47	54	PF00069	0.516
MOD_GSK3_1	494	501	PF00069	0.737
MOD_GSK3_1	509	516	PF00069	0.579
MOD_NEK2_1	108	113	PF00069	0.520
MOD_NEK2_1	193	198	PF00069	0.650
MOD_NEK2_1	242	247	PF00069	0.698
MOD_NEK2_1	286	291	PF00069	0.447
MOD_NEK2_1	396	401	PF00069	0.661
MOD_NEK2_2	466	471	PF00069	0.671
MOD_PIKK_1	47	53	PF00454	0.509
MOD_PIKK_1	515	521	PF00454	0.725
MOD_PKA_1	103	109	PF00069	0.564
MOD_PKA_2	102	108	PF00069	0.458
MOD_PKA_2	265	271	PF00069	0.730
MOD_PKA_2	346	352	PF00069	0.487
MOD_PKA_2	43	49	PF00069	0.459
MOD_Plk_1	372	378	PF00069	0.620
MOD_Plk_1	509	515	PF00069	0.710
MOD_Plk_2-3	135	141	PF00069	0.574
MOD_Plk_4	273	279	PF00069	0.518
MOD_Plk_4	332	338	PF00069	0.582
MOD_Plk_4	442	448	PF00069	0.641
MOD_Plk_4	518	524	PF00069	0.651
MOD_ProDKin_1	15	21	PF00069	0.435
MOD_ProDKin_1	157	163	PF00069	0.625
MOD_ProDKin_1	167	173	PF00069	0.719
MOD_ProDKin_1	185	191	PF00069	0.550
MOD_ProDKin_1	233	239	PF00069	0.674
MOD_ProDKin_1	243	249	PF00069	0.594
MOD_ProDKin_1	364	370	PF00069	0.696
MOD_ProDKin_1	494	500	PF00069	0.737
TRG_DiLeu_BaEn_1	3	8	PF01217	0.445
TRG_DiLeu_BaEn_1	323	328	PF01217	0.633
TRG_DiLeu_BaEn_2	145	151	PF01217	0.441
TRG_ENDOCYTIC_2	279	282	PF00928	0.554
TRG_ENDOCYTIC_2	53	56	PF00928	0.633
TRG_ENDOCYTIC_2	64	67	PF00928	0.437
TRG_ENDOCYTIC_2	93	96	PF00928	0.570
TRG_ER_diArg_1	102	104	PF00400	0.551
TRG_ER_diArg_1	350	353	PF00400	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8K0	Leptomonas seymouri	41%	100%
A0A3Q8ISG1	Leishmania donovani	90%	100%
A4HJ47	Leishmania braziliensis	70%	100%
A4I6G3	Leishmania infantum	90%	100%
E9B1M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%