LeishMANIAdb
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Putative ATP-dependent zinc metallopeptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATP-dependent zinc metallopeptidase
Gene product:
ATP-dependent zinc metallopeptidase, putative
Species:
Leishmania major
UniProt:
Q4Q6J3_LEIMA
TriTrypDb:
LmjF.31.0700 * , LMJLV39_310012700 * , LMJSD75_310012400 *
Length:
885

Annotations

LeishMANIAdb annotations

Homologous to bacterial FtsH and Eukaryotic AFG3 proteins. Probably involved in mitochondrial protein processing.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005745 m-AAA complex 4 2
GO:0032991 protein-containing complex 1 2
GO:0098796 membrane protein complex 2 2
GO:0098798 mitochondrial protein-containing complex 2 2
GO:0098800 inner mitochondrial membrane protein complex 3 2
GO:1902494 catalytic complex 2 2
GO:1905368 peptidase complex 3 2
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

Q4Q6J3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6J3

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 18
GO:0006807 nitrogen compound metabolic process 2 18
GO:0008152 metabolic process 1 18
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 2
GO:0016485 protein processing 5 2
GO:0019538 protein metabolic process 3 18
GO:0022607 cellular component assembly 4 2
GO:0034982 mitochondrial protein processing 6 2
GO:0043170 macromolecule metabolic process 3 18
GO:0043933 protein-containing complex organization 4 2
GO:0044238 primary metabolic process 2 18
GO:0051604 protein maturation 4 2
GO:0065003 protein-containing complex assembly 5 2
GO:0071704 organic substance metabolic process 2 18
GO:0071840 cellular component organization or biogenesis 2 2
GO:1901564 organonitrogen compound metabolic process 3 18
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 19
GO:0003824 catalytic activity 1 19
GO:0004175 endopeptidase activity 4 18
GO:0004176 ATP-dependent peptidase activity 2 18
GO:0004222 metalloendopeptidase activity 5 18
GO:0005488 binding 1 19
GO:0005524 ATP binding 5 19
GO:0008233 peptidase activity 3 18
GO:0008237 metallopeptidase activity 4 18
GO:0016462 pyrophosphatase activity 5 19
GO:0016787 hydrolase activity 2 19
GO:0016817 hydrolase activity, acting on acid anhydrides 3 19
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 19
GO:0016887 ATP hydrolysis activity 7 19
GO:0017076 purine nucleotide binding 4 19
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 19
GO:0030554 adenyl nucleotide binding 5 19
GO:0032553 ribonucleotide binding 3 19
GO:0032555 purine ribonucleotide binding 4 19
GO:0032559 adenyl ribonucleotide binding 5 19
GO:0035639 purine ribonucleoside triphosphate binding 4 19
GO:0036094 small molecule binding 2 19
GO:0043167 ion binding 2 19
GO:0043168 anion binding 3 19
GO:0097159 organic cyclic compound binding 2 19
GO:0097367 carbohydrate derivative binding 2 19
GO:0140096 catalytic activity, acting on a protein 2 18
GO:0140657 ATP-dependent activity 1 18
GO:1901265 nucleoside phosphate binding 3 19
GO:1901363 heterocyclic compound binding 2 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 213 217 PF00656 0.476
CLV_C14_Caspase3-7 431 435 PF00656 0.446
CLV_C14_Caspase3-7 460 464 PF00656 0.474
CLV_C14_Caspase3-7 528 532 PF00656 0.772
CLV_C14_Caspase3-7 751 755 PF00656 0.464
CLV_NRD_NRD_1 421 423 PF00675 0.328
CLV_NRD_NRD_1 469 471 PF00675 0.341
CLV_NRD_NRD_1 48 50 PF00675 0.436
CLV_NRD_NRD_1 585 587 PF00675 0.542
CLV_NRD_NRD_1 781 783 PF00675 0.282
CLV_NRD_NRD_1 825 827 PF00675 0.355
CLV_NRD_NRD_1 880 882 PF00675 0.452
CLV_PCSK_KEX2_1 439 441 PF00082 0.239
CLV_PCSK_KEX2_1 469 471 PF00082 0.264
CLV_PCSK_KEX2_1 48 50 PF00082 0.414
CLV_PCSK_KEX2_1 599 601 PF00082 0.527
CLV_PCSK_KEX2_1 825 827 PF00082 0.355
CLV_PCSK_PC1ET2_1 439 441 PF00082 0.239
CLV_PCSK_PC1ET2_1 599 601 PF00082 0.413
CLV_PCSK_SKI1_1 102 106 PF00082 0.422
CLV_PCSK_SKI1_1 343 347 PF00082 0.340
CLV_PCSK_SKI1_1 379 383 PF00082 0.246
CLV_PCSK_SKI1_1 415 419 PF00082 0.255
CLV_PCSK_SKI1_1 618 622 PF00082 0.403
CLV_PCSK_SKI1_1 747 751 PF00082 0.285
CLV_PCSK_SKI1_1 783 787 PF00082 0.327
CLV_PCSK_SKI1_1 810 814 PF00082 0.253
CLV_PCSK_SKI1_1 825 829 PF00082 0.317
DEG_APCC_DBOX_1 139 147 PF00400 0.450
DEG_Nend_UBRbox_3 1 3 PF02207 0.585
DEG_SCF_FBW7_1 30 37 PF00400 0.701
DEG_SCF_FBW7_1 502 508 PF00400 0.619
DEG_SCF_FBW7_1 521 528 PF00400 0.469
DOC_ANK_TNKS_1 86 93 PF00023 0.609
DOC_CKS1_1 502 507 PF01111 0.619
DOC_CYCLIN_RxL_1 412 420 PF00134 0.469
DOC_CYCLIN_yCln2_LP_2 60 66 PF00134 0.546
DOC_CYCLIN_yCln2_LP_2 811 817 PF00134 0.541
DOC_MAPK_gen_1 314 322 PF00069 0.599
DOC_MAPK_gen_1 422 430 PF00069 0.469
DOC_MAPK_gen_1 469 476 PF00069 0.472
DOC_MAPK_gen_1 492 502 PF00069 0.446
DOC_MAPK_gen_1 750 760 PF00069 0.524
DOC_MAPK_MEF2A_6 140 149 PF00069 0.276
DOC_MAPK_MEF2A_6 717 726 PF00069 0.460
DOC_MAPK_MEF2A_6 753 760 PF00069 0.464
DOC_PP1_RVXF_1 100 107 PF00149 0.575
DOC_PP2B_LxvP_1 372 375 PF13499 0.459
DOC_PP2B_LxvP_1 558 561 PF13499 0.643
DOC_PP2B_LxvP_1 60 63 PF13499 0.713
DOC_USP7_MATH_1 15 19 PF00917 0.673
DOC_USP7_MATH_1 159 163 PF00917 0.451
DOC_USP7_MATH_1 34 38 PF00917 0.588
DOC_USP7_MATH_1 387 391 PF00917 0.450
DOC_USP7_MATH_1 397 401 PF00917 0.450
DOC_USP7_MATH_1 592 596 PF00917 0.756
DOC_USP7_MATH_1 90 94 PF00917 0.632
DOC_USP7_UBL2_3 312 316 PF12436 0.625
DOC_USP7_UBL2_3 339 343 PF12436 0.538
DOC_USP7_UBL2_3 360 364 PF12436 0.625
DOC_USP7_UBL2_3 846 850 PF12436 0.519
DOC_WW_Pin1_4 234 239 PF00397 0.420
DOC_WW_Pin1_4 253 258 PF00397 0.466
DOC_WW_Pin1_4 30 35 PF00397 0.729
DOC_WW_Pin1_4 501 506 PF00397 0.585
DOC_WW_Pin1_4 521 526 PF00397 0.626
LIG_14-3-3_CanoR_1 19 25 PF00244 0.582
LIG_14-3-3_CanoR_1 48 53 PF00244 0.642
LIG_14-3-3_CanoR_1 600 606 PF00244 0.614
LIG_14-3-3_CanoR_1 691 700 PF00244 0.460
LIG_14-3-3_CanoR_1 825 831 PF00244 0.408
LIG_14-3-3_CanoR_1 877 885 PF00244 0.718
LIG_Actin_WH2_2 509 524 PF00022 0.530
LIG_Actin_WH2_2 766 784 PF00022 0.464
LIG_APCC_ABBA_1 188 193 PF00400 0.409
LIG_APCC_ABBAyCdc20_2 425 431 PF00400 0.439
LIG_BIR_III_4 434 438 PF00653 0.446
LIG_BRCT_BRCA1_1 79 83 PF00533 0.567
LIG_FHA_1 150 156 PF00498 0.419
LIG_FHA_1 19 25 PF00498 0.749
LIG_FHA_1 270 276 PF00498 0.306
LIG_FHA_1 344 350 PF00498 0.504
LIG_FHA_1 502 508 PF00498 0.604
LIG_FHA_1 564 570 PF00498 0.734
LIG_FHA_1 807 813 PF00498 0.450
LIG_FHA_1 836 842 PF00498 0.431
LIG_FHA_1 99 105 PF00498 0.749
LIG_FHA_2 235 241 PF00498 0.578
LIG_FHA_2 250 256 PF00498 0.526
LIG_FHA_2 452 458 PF00498 0.454
LIG_FHA_2 522 528 PF00498 0.658
LIG_FHA_2 538 544 PF00498 0.690
LIG_FHA_2 573 579 PF00498 0.736
LIG_FHA_2 746 752 PF00498 0.450
LIG_FHA_2 827 833 PF00498 0.534
LIG_FHA_2 861 867 PF00498 0.450
LIG_Integrin_RGD_1 470 472 PF01839 0.250
LIG_Integrin_RGD_1 529 531 PF01839 0.432
LIG_LIR_Apic_2 134 139 PF02991 0.688
LIG_LIR_Apic_2 799 804 PF02991 0.506
LIG_LIR_Gen_1 141 151 PF02991 0.294
LIG_LIR_Gen_1 166 175 PF02991 0.362
LIG_LIR_Gen_1 18 25 PF02991 0.729
LIG_LIR_Gen_1 185 195 PF02991 0.359
LIG_LIR_Gen_1 356 366 PF02991 0.560
LIG_LIR_Gen_1 400 409 PF02991 0.446
LIG_LIR_Gen_1 80 91 PF02991 0.593
LIG_LIR_Gen_1 863 871 PF02991 0.450
LIG_LIR_Nem_3 141 147 PF02991 0.269
LIG_LIR_Nem_3 166 171 PF02991 0.448
LIG_LIR_Nem_3 18 23 PF02991 0.742
LIG_LIR_Nem_3 185 190 PF02991 0.351
LIG_LIR_Nem_3 330 335 PF02991 0.534
LIG_LIR_Nem_3 356 361 PF02991 0.557
LIG_LIR_Nem_3 400 405 PF02991 0.446
LIG_LIR_Nem_3 80 86 PF02991 0.697
LIG_LIR_Nem_3 863 867 PF02991 0.450
LIG_NRBOX 454 460 PF00104 0.439
LIG_PCNA_PIPBox_1 849 858 PF02747 0.450
LIG_Pex14_1 282 286 PF04695 0.278
LIG_Pex14_2 288 292 PF04695 0.297
LIG_PTAP_UEV_1 552 557 PF05743 0.642
LIG_PTB_Apo_2 739 746 PF02174 0.437
LIG_SH2_CRK 20 24 PF00017 0.735
LIG_SH2_CRK 358 362 PF00017 0.530
LIG_SH2_CRK 789 793 PF00017 0.464
LIG_SH2_GRB2like 184 187 PF00017 0.344
LIG_SH2_SRC 789 792 PF00017 0.506
LIG_SH2_SRC 864 867 PF00017 0.506
LIG_SH2_STAP1 184 188 PF00017 0.353
LIG_SH2_STAP1 20 24 PF00017 0.567
LIG_SH2_STAP1 306 310 PF00017 0.695
LIG_SH2_STAP1 613 617 PF00017 0.564
LIG_SH2_STAP1 635 639 PF00017 0.510
LIG_SH2_STAP1 736 740 PF00017 0.460
LIG_SH2_STAP1 835 839 PF00017 0.477
LIG_SH2_STAP1 864 868 PF00017 0.489
LIG_SH2_STAT5 11 14 PF00017 0.674
LIG_SH2_STAT5 187 190 PF00017 0.340
LIG_SH2_STAT5 198 201 PF00017 0.384
LIG_SH2_STAT5 20 23 PF00017 0.676
LIG_SH2_STAT5 299 302 PF00017 0.633
LIG_SH2_STAT5 358 361 PF00017 0.535
LIG_SH2_STAT5 406 409 PF00017 0.439
LIG_SH2_STAT5 429 432 PF00017 0.439
LIG_SH2_STAT5 739 742 PF00017 0.459
LIG_SH2_STAT5 791 794 PF00017 0.489
LIG_SH2_STAT5 870 873 PF00017 0.541
LIG_SH3_3 499 505 PF00018 0.457
LIG_SH3_3 550 556 PF00018 0.732
LIG_SH3_3 797 803 PF00018 0.489
LIG_SUMO_SIM_anti_2 472 479 PF11976 0.460
LIG_SUMO_SIM_anti_2 837 843 PF11976 0.541
LIG_SUMO_SIM_par_1 837 843 PF11976 0.541
LIG_TRAF2_1 580 583 PF00917 0.766
LIG_TYR_ITIM 862 867 PF00017 0.482
LIG_WRC_WIRS_1 792 797 PF05994 0.464
MOD_CK1_1 10 16 PF00069 0.672
MOD_CK1_1 18 24 PF00069 0.655
MOD_CK1_1 233 239 PF00069 0.570
MOD_CK1_1 35 41 PF00069 0.646
MOD_CK1_1 508 514 PF00069 0.571
MOD_CK1_1 563 569 PF00069 0.775
MOD_CK1_1 607 613 PF00069 0.733
MOD_CK1_1 806 812 PF00069 0.495
MOD_CK1_1 93 99 PF00069 0.767
MOD_CK2_1 253 259 PF00069 0.476
MOD_CK2_1 451 457 PF00069 0.454
MOD_CK2_1 537 543 PF00069 0.699
MOD_CK2_1 577 583 PF00069 0.727
MOD_CK2_1 608 614 PF00069 0.701
MOD_CK2_1 622 628 PF00069 0.570
MOD_CK2_1 670 676 PF00069 0.456
MOD_CK2_1 691 697 PF00069 0.450
MOD_CK2_1 745 751 PF00069 0.450
MOD_Cter_Amidation 467 470 PF01082 0.282
MOD_GlcNHglycan 161 164 PF01048 0.630
MOD_GlcNHglycan 232 235 PF01048 0.621
MOD_GlcNHglycan 34 37 PF01048 0.490
MOD_GlcNHglycan 389 392 PF01048 0.252
MOD_GlcNHglycan 531 534 PF01048 0.569
MOD_GlcNHglycan 588 593 PF01048 0.526
MOD_GlcNHglycan 609 613 PF01048 0.493
MOD_GlcNHglycan 67 72 PF01048 0.518
MOD_GlcNHglycan 731 734 PF01048 0.250
MOD_GlcNHglycan 79 82 PF01048 0.532
MOD_GlcNHglycan 92 95 PF01048 0.506
MOD_GSK3_1 159 166 PF00069 0.430
MOD_GSK3_1 230 237 PF00069 0.508
MOD_GSK3_1 245 252 PF00069 0.499
MOD_GSK3_1 30 37 PF00069 0.745
MOD_GSK3_1 308 315 PF00069 0.661
MOD_GSK3_1 323 330 PF00069 0.618
MOD_GSK3_1 501 508 PF00069 0.621
MOD_GSK3_1 521 528 PF00069 0.613
MOD_GSK3_1 529 536 PF00069 0.688
MOD_GSK3_1 560 567 PF00069 0.702
MOD_GSK3_1 568 575 PF00069 0.698
MOD_GSK3_1 588 595 PF00069 0.789
MOD_GSK3_1 600 607 PF00069 0.738
MOD_GSK3_1 687 694 PF00069 0.572
MOD_GSK3_1 69 76 PF00069 0.660
MOD_GSK3_1 7 14 PF00069 0.663
MOD_GSK3_1 752 759 PF00069 0.455
MOD_GSK3_1 771 778 PF00069 0.488
MOD_GSK3_1 872 879 PF00069 0.635
MOD_GSK3_1 90 97 PF00069 0.698
MOD_N-GLC_1 743 748 PF02516 0.345
MOD_N-GLC_1 806 811 PF02516 0.302
MOD_N-GLC_2 641 643 PF02516 0.291
MOD_N-GLC_2 653 655 PF02516 0.207
MOD_NEK2_1 260 265 PF00069 0.506
MOD_NEK2_1 269 274 PF00069 0.431
MOD_NEK2_1 294 299 PF00069 0.435
MOD_NEK2_1 476 481 PF00069 0.435
MOD_NEK2_1 568 573 PF00069 0.701
MOD_NEK2_1 722 727 PF00069 0.461
MOD_NEK2_1 745 750 PF00069 0.532
MOD_NEK2_1 82 87 PF00069 0.635
MOD_PIKK_1 204 210 PF00454 0.382
MOD_PIKK_1 25 31 PF00454 0.625
MOD_PIKK_1 294 300 PF00454 0.557
MOD_PIKK_1 457 463 PF00454 0.459
MOD_PIKK_1 568 574 PF00454 0.772
MOD_PIKK_1 73 79 PF00454 0.589
MOD_PKA_1 48 54 PF00069 0.668
MOD_PKA_1 599 605 PF00069 0.590
MOD_PKA_2 159 165 PF00069 0.479
MOD_PKA_2 18 24 PF00069 0.728
MOD_PKA_2 356 362 PF00069 0.521
MOD_PKA_2 48 54 PF00069 0.650
MOD_PKA_2 599 605 PF00069 0.590
MOD_PKA_2 637 643 PF00069 0.523
MOD_PKA_2 752 758 PF00069 0.464
MOD_PKA_2 873 879 PF00069 0.577
MOD_PKB_1 689 697 PF00069 0.516
MOD_Plk_1 260 266 PF00069 0.447
MOD_Plk_1 451 457 PF00069 0.447
MOD_Plk_1 564 570 PF00069 0.783
MOD_Plk_1 608 614 PF00069 0.602
MOD_Plk_1 675 681 PF00069 0.506
MOD_Plk_1 806 812 PF00069 0.532
MOD_Plk_2-3 860 866 PF00069 0.450
MOD_Plk_4 149 155 PF00069 0.280
MOD_Plk_4 377 383 PF00069 0.446
MOD_Plk_4 564 570 PF00069 0.719
MOD_Plk_4 7 13 PF00069 0.734
MOD_Plk_4 722 728 PF00069 0.492
MOD_Plk_4 796 802 PF00069 0.506
MOD_Plk_4 826 832 PF00069 0.556
MOD_ProDKin_1 234 240 PF00069 0.422
MOD_ProDKin_1 253 259 PF00069 0.463
MOD_ProDKin_1 30 36 PF00069 0.728
MOD_ProDKin_1 501 507 PF00069 0.586
MOD_ProDKin_1 521 527 PF00069 0.639
MOD_SUMO_for_1 341 344 PF00179 0.539
MOD_SUMO_for_1 573 576 PF00179 0.772
MOD_SUMO_for_1 857 860 PF00179 0.506
MOD_SUMO_rev_2 127 133 PF00179 0.740
MOD_SUMO_rev_2 193 197 PF00179 0.373
MOD_SUMO_rev_2 591 601 PF00179 0.774
MOD_SUMO_rev_2 847 852 PF00179 0.541
TRG_DiLeu_BaEn_2 346 352 PF01217 0.498
TRG_ENDOCYTIC_2 187 190 PF00928 0.301
TRG_ENDOCYTIC_2 198 201 PF00928 0.352
TRG_ENDOCYTIC_2 20 23 PF00928 0.731
TRG_ENDOCYTIC_2 358 361 PF00928 0.552
TRG_ENDOCYTIC_2 406 409 PF00928 0.439
TRG_ENDOCYTIC_2 789 792 PF00928 0.450
TRG_ENDOCYTIC_2 864 867 PF00928 0.489
TRG_ER_diArg_1 412 415 PF00400 0.458
TRG_ER_diArg_1 47 49 PF00400 0.638
TRG_ER_diArg_1 86 89 PF00400 0.701
TRG_ER_diArg_1 99 102 PF00400 0.747
TRG_ER_diLys_1 882 885 PF00400 0.686
TRG_NES_CRM1_1 404 416 PF08389 0.439
TRG_Pf-PMV_PEXEL_1 415 420 PF00026 0.246
TRG_Pf-PMV_PEXEL_1 629 633 PF00026 0.337
TRG_Pf-PMV_PEXEL_1 691 695 PF00026 0.341

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PGD9 Leptomonas seymouri 70% 89%
A0A0S4JGG9 Bodo saltans 30% 100%
A0A0S4JTL4 Bodo saltans 54% 100%
A0A1X0NJP5 Trypanosomatidae 61% 100%
A0A1X0NW32 Trypanosomatidae 32% 100%
A0A3Q8ICE7 Leishmania donovani 95% 100%
A0A3Q8IFG3 Leishmania donovani 32% 100%
A0A3R7L0P7 Trypanosoma rangeli 33% 100%
A0A422NQX8 Trypanosoma rangeli 62% 98%
A4HJ48 Leishmania braziliensis 82% 86%
A4I6G4 Leishmania infantum 95% 100%
A4I809 Leishmania infantum 32% 100%
C9ZN81 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9B1M1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B2S6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
V5B3P7 Trypanosoma cruzi 55% 100%
V5BP04 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS