LeishMANIAdb
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MFS general substrate transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS general substrate transporter
Gene product:
major facilitator superfamily, putative
Species:
Leishmania major
UniProt:
Q4Q6J1_LEIMA
TriTrypDb:
LmjF.31.0720 , LMJLV39_310013000 * , LMJSD75_310012700 *
Length:
979

Annotations

LeishMANIAdb annotations

Part of a gigantic, highly expanded family of Kinetoplastid transporters. Most similar to plant nodulins and animal monocarboxylate transporters.. Likely one of the main nutrient transporters in Kinetoplastida.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

Q4Q6J1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6J1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 6
GO:0022857 transmembrane transporter activity 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 131 135 PF00656 0.789
CLV_C14_Caspase3-7 145 149 PF00656 0.542
CLV_C14_Caspase3-7 427 431 PF00656 0.747
CLV_C14_Caspase3-7 509 513 PF00656 0.872
CLV_C14_Caspase3-7 534 538 PF00656 0.808
CLV_C14_Caspase3-7 599 603 PF00656 0.733
CLV_MEL_PAP_1 27 33 PF00089 0.637
CLV_NRD_NRD_1 151 153 PF00675 0.475
CLV_NRD_NRD_1 370 372 PF00675 0.379
CLV_NRD_NRD_1 40 42 PF00675 0.687
CLV_NRD_NRD_1 471 473 PF00675 0.598
CLV_NRD_NRD_1 677 679 PF00675 0.551
CLV_NRD_NRD_1 894 896 PF00675 0.722
CLV_NRD_NRD_1 920 922 PF00675 0.474
CLV_NRD_NRD_1 933 935 PF00675 0.443
CLV_PCSK_KEX2_1 13 15 PF00082 0.670
CLV_PCSK_KEX2_1 151 153 PF00082 0.474
CLV_PCSK_KEX2_1 369 371 PF00082 0.379
CLV_PCSK_KEX2_1 42 44 PF00082 0.663
CLV_PCSK_KEX2_1 470 472 PF00082 0.587
CLV_PCSK_KEX2_1 677 679 PF00082 0.551
CLV_PCSK_KEX2_1 894 896 PF00082 0.722
CLV_PCSK_KEX2_1 920 922 PF00082 0.474
CLV_PCSK_KEX2_1 933 935 PF00082 0.443
CLV_PCSK_PC1ET2_1 13 15 PF00082 0.670
CLV_PCSK_PC1ET2_1 369 371 PF00082 0.379
CLV_PCSK_PC1ET2_1 42 44 PF00082 0.663
CLV_PCSK_PC7_1 466 472 PF00082 0.449
CLV_PCSK_SKI1_1 137 141 PF00082 0.590
CLV_PCSK_SKI1_1 154 158 PF00082 0.345
CLV_PCSK_SKI1_1 189 193 PF00082 0.651
CLV_PCSK_SKI1_1 303 307 PF00082 0.579
CLV_PCSK_SKI1_1 345 349 PF00082 0.451
CLV_PCSK_SKI1_1 771 775 PF00082 0.546
CLV_PCSK_SKI1_1 941 945 PF00082 0.535
DEG_COP1_1 788 796 PF00400 0.490
DEG_SCF_SKP2-CKS1_1 397 404 PF00560 0.523
DEG_SPOP_SBC_1 542 546 PF00917 0.818
DOC_ANK_TNKS_1 405 412 PF00023 0.451
DOC_CKS1_1 884 889 PF01111 0.411
DOC_MAPK_gen_1 151 157 PF00069 0.651
DOC_MAPK_gen_1 369 377 PF00069 0.651
DOC_MAPK_gen_1 444 452 PF00069 0.727
DOC_MAPK_gen_1 524 532 PF00069 0.813
DOC_MAPK_gen_1 785 793 PF00069 0.730
DOC_MAPK_MEF2A_6 370 379 PF00069 0.651
DOC_MAPK_MEF2A_6 524 532 PF00069 0.886
DOC_MAPK_MEF2A_6 588 595 PF00069 0.796
DOC_MAPK_MEF2A_6 899 907 PF00069 0.449
DOC_PP1_RVXF_1 152 158 PF00149 0.579
DOC_PP1_RVXF_1 28 34 PF00149 0.881
DOC_PP2B_LxvP_1 422 425 PF13499 0.546
DOC_PP2B_LxvP_1 576 579 PF13499 0.871
DOC_PP2B_LxvP_1 72 75 PF13499 0.849
DOC_PP2B_LxvP_1 79 82 PF13499 0.736
DOC_PP2B_PxIxI_1 588 594 PF00149 0.783
DOC_PP4_FxxP_1 204 207 PF00568 0.386
DOC_SPAK_OSR1_1 152 156 PF12202 0.651
DOC_USP7_MATH_1 222 226 PF00917 0.546
DOC_USP7_MATH_1 425 429 PF00917 0.681
DOC_USP7_MATH_1 605 609 PF00917 0.743
DOC_USP7_MATH_1 763 767 PF00917 0.442
DOC_USP7_MATH_1 799 803 PF00917 0.445
DOC_USP7_MATH_1 908 912 PF00917 0.445
DOC_USP7_UBL2_3 119 123 PF12436 0.829
DOC_WW_Pin1_4 345 350 PF00397 0.651
DOC_WW_Pin1_4 398 403 PF00397 0.523
DOC_WW_Pin1_4 543 548 PF00397 0.855
DOC_WW_Pin1_4 661 666 PF00397 0.867
DOC_WW_Pin1_4 74 79 PF00397 0.820
DOC_WW_Pin1_4 880 885 PF00397 0.549
LIG_14-3-3_CanoR_1 108 112 PF00244 0.741
LIG_14-3-3_CanoR_1 30 34 PF00244 0.881
LIG_14-3-3_CanoR_1 361 368 PF00244 0.579
LIG_14-3-3_CanoR_1 48 56 PF00244 0.667
LIG_14-3-3_CanoR_1 527 531 PF00244 0.854
LIG_14-3-3_CanoR_1 588 594 PF00244 0.827
LIG_14-3-3_CanoR_1 677 687 PF00244 0.773
LIG_Actin_WH2_2 393 408 PF00022 0.630
LIG_AP2alpha_1 306 310 PF02296 0.422
LIG_APCC_ABBA_1 593 598 PF00400 0.811
LIG_BIR_II_1 1 5 PF00653 0.854
LIG_BRCT_BRCA1_1 836 840 PF00533 0.522
LIG_deltaCOP1_diTrp_1 716 721 PF00928 0.445
LIG_eIF4E_1 714 720 PF01652 0.579
LIG_FHA_1 108 114 PF00498 0.853
LIG_FHA_1 166 172 PF00498 0.445
LIG_FHA_1 24 30 PF00498 0.834
LIG_FHA_1 282 288 PF00498 0.651
LIG_FHA_1 388 394 PF00498 0.546
LIG_FHA_1 414 420 PF00498 0.443
LIG_FHA_1 520 526 PF00498 0.721
LIG_FHA_1 645 651 PF00498 0.795
LIG_FHA_1 689 695 PF00498 0.732
LIG_FHA_1 704 710 PF00498 0.627
LIG_FHA_1 722 728 PF00498 0.445
LIG_FHA_1 786 792 PF00498 0.741
LIG_FHA_1 837 843 PF00498 0.445
LIG_FHA_1 960 966 PF00498 0.769
LIG_FHA_2 10 16 PF00498 0.883
LIG_FHA_2 129 135 PF00498 0.817
LIG_FHA_2 143 149 PF00498 0.551
LIG_FHA_2 346 352 PF00498 0.606
LIG_FHA_2 473 479 PF00498 0.738
LIG_FHA_2 705 711 PF00498 0.621
LIG_FHA_2 843 849 PF00498 0.591
LIG_FHA_2 86 92 PF00498 0.771
LIG_FHA_2 93 99 PF00498 0.813
LIG_IRF3_LxIS_1 160 165 PF10401 0.546
LIG_LIR_Apic_2 213 217 PF02991 0.579
LIG_LIR_Apic_2 478 483 PF02991 0.691
LIG_LIR_Apic_2 681 687 PF02991 0.719
LIG_LIR_Apic_2 697 702 PF02991 0.656
LIG_LIR_Gen_1 296 306 PF02991 0.444
LIG_LIR_Gen_1 308 318 PF02991 0.378
LIG_LIR_Gen_1 711 722 PF02991 0.577
LIG_LIR_LC3C_4 70 74 PF02991 0.755
LIG_LIR_Nem_3 173 178 PF02991 0.445
LIG_LIR_Nem_3 289 293 PF02991 0.445
LIG_LIR_Nem_3 296 301 PF02991 0.445
LIG_LIR_Nem_3 308 313 PF02991 0.379
LIG_LIR_Nem_3 711 717 PF02991 0.618
LIG_LIR_Nem_3 837 843 PF02991 0.522
LIG_NRBOX 229 235 PF00104 0.445
LIG_Pex14_1 718 722 PF04695 0.445
LIG_Pex14_1 871 875 PF04695 0.527
LIG_Pex14_2 153 157 PF04695 0.579
LIG_Pex14_2 204 208 PF04695 0.445
LIG_Pex14_2 235 239 PF04695 0.397
LIG_Pex14_2 298 302 PF04695 0.445
LIG_Pex14_2 306 310 PF04695 0.379
LIG_REV1ctd_RIR_1 303 311 PF16727 0.379
LIG_SH2_CRK 480 484 PF00017 0.700
LIG_SH2_CRK 654 658 PF00017 0.850
LIG_SH2_CRK 684 688 PF00017 0.779
LIG_SH2_CRK 722 726 PF00017 0.546
LIG_SH2_CRK 922 926 PF00017 0.655
LIG_SH2_GRB2like 684 687 PF00017 0.785
LIG_SH2_NCK_1 581 585 PF00017 0.696
LIG_SH2_PTP2 699 702 PF00017 0.711
LIG_SH2_STAP1 262 266 PF00017 0.445
LIG_SH2_STAP1 372 376 PF00017 0.484
LIG_SH2_STAP1 54 58 PF00017 0.873
LIG_SH2_STAP1 777 781 PF00017 0.627
LIG_SH2_STAP1 878 882 PF00017 0.511
LIG_SH2_STAP1 922 926 PF00017 0.701
LIG_SH2_STAT3 362 365 PF00017 0.651
LIG_SH2_STAT5 195 198 PF00017 0.511
LIG_SH2_STAT5 331 334 PF00017 0.457
LIG_SH2_STAT5 337 340 PF00017 0.515
LIG_SH2_STAT5 356 359 PF00017 0.537
LIG_SH2_STAT5 385 388 PF00017 0.434
LIG_SH2_STAT5 395 398 PF00017 0.445
LIG_SH2_STAT5 699 702 PF00017 0.711
LIG_SH2_STAT5 714 717 PF00017 0.529
LIG_SH2_STAT5 722 725 PF00017 0.451
LIG_SH2_STAT5 756 759 PF00017 0.546
LIG_SH2_STAT5 825 828 PF00017 0.506
LIG_SH2_STAT5 841 844 PF00017 0.474
LIG_SH2_STAT5 875 878 PF00017 0.468
LIG_SH2_STAT5 889 892 PF00017 0.466
LIG_SH2_STAT5 904 907 PF00017 0.245
LIG_SH2_STAT5 916 919 PF00017 0.496
LIG_SH3_3 18 24 PF00018 0.837
LIG_SH3_3 547 553 PF00018 0.885
LIG_SH3_3 559 565 PF00018 0.753
LIG_SH3_3 583 589 PF00018 0.748
LIG_SH3_3 72 78 PF00018 0.835
LIG_SH3_3 788 794 PF00018 0.582
LIG_SH3_3 881 887 PF00018 0.416
LIG_SH3_3 932 938 PF00018 0.779
LIG_SUMO_SIM_anti_2 416 422 PF11976 0.422
LIG_SUMO_SIM_anti_2 818 824 PF11976 0.414
LIG_SUMO_SIM_par_1 109 115 PF11976 0.782
LIG_SUMO_SIM_par_1 160 168 PF11976 0.445
LIG_SUMO_SIM_par_1 219 225 PF11976 0.445
LIG_SUMO_SIM_par_1 788 795 PF11976 0.643
LIG_SUMO_SIM_par_1 83 88 PF11976 0.693
LIG_TRAF2_1 445 448 PF00917 0.768
LIG_TRAF2_1 475 478 PF00917 0.760
LIG_TRAF2_1 497 500 PF00917 0.834
LIG_TYR_ITIM 712 717 PF00017 0.503
LIG_TYR_ITIM 720 725 PF00017 0.445
LIG_WRC_WIRS_1 287 292 PF05994 0.445
MOD_CDK_SPK_2 345 350 PF00069 0.484
MOD_CDK_SPxK_1 398 404 PF00069 0.644
MOD_CDK_SPxxK_3 661 668 PF00069 0.786
MOD_CK1_1 100 106 PF00069 0.713
MOD_CK1_1 163 169 PF00069 0.546
MOD_CK1_1 197 203 PF00069 0.546
MOD_CK1_1 608 614 PF00069 0.865
MOD_CK1_1 622 628 PF00069 0.687
MOD_CK1_1 637 643 PF00069 0.591
MOD_CK1_1 666 672 PF00069 0.837
MOD_CK1_1 682 688 PF00069 0.457
MOD_CK1_1 883 889 PF00069 0.609
MOD_CK1_1 911 917 PF00069 0.445
MOD_CK1_1 959 965 PF00069 0.747
MOD_CK2_1 184 190 PF00069 0.484
MOD_CK2_1 33 39 PF00069 0.808
MOD_CK2_1 345 351 PF00069 0.481
MOD_CK2_1 472 478 PF00069 0.663
MOD_CK2_1 537 543 PF00069 0.793
MOD_CK2_1 637 643 PF00069 0.809
MOD_CK2_1 704 710 PF00069 0.501
MOD_CK2_1 92 98 PF00069 0.766
MOD_CK2_1 99 105 PF00069 0.778
MOD_CMANNOS 871 874 PF00535 0.546
MOD_GlcNHglycan 102 105 PF01048 0.783
MOD_GlcNHglycan 196 199 PF01048 0.546
MOD_GlcNHglycan 290 293 PF01048 0.484
MOD_GlcNHglycan 493 498 PF01048 0.757
MOD_GlcNHglycan 500 504 PF01048 0.707
MOD_GlcNHglycan 512 515 PF01048 0.739
MOD_GlcNHglycan 557 560 PF01048 0.848
MOD_GlcNHglycan 665 668 PF01048 0.775
MOD_GlcNHglycan 836 839 PF01048 0.518
MOD_GlcNHglycan 958 961 PF01048 0.761
MOD_GSK3_1 107 114 PF00069 0.711
MOD_GSK3_1 160 167 PF00069 0.546
MOD_GSK3_1 25 32 PF00069 0.729
MOD_GSK3_1 533 540 PF00069 0.795
MOD_GSK3_1 54 61 PF00069 0.850
MOD_GSK3_1 603 610 PF00069 0.761
MOD_GSK3_1 619 626 PF00069 0.763
MOD_GSK3_1 634 641 PF00069 0.652
MOD_GSK3_1 653 660 PF00069 0.655
MOD_GSK3_1 676 683 PF00069 0.641
MOD_GSK3_1 704 711 PF00069 0.507
MOD_GSK3_1 832 839 PF00069 0.445
MOD_GSK3_1 85 92 PF00069 0.717
MOD_GSK3_1 907 914 PF00069 0.445
MOD_N-GLC_1 46 51 PF02516 0.807
MOD_N-GLC_1 622 627 PF02516 0.826
MOD_NEK2_1 162 167 PF00069 0.449
MOD_NEK2_1 235 240 PF00069 0.445
MOD_NEK2_1 286 291 PF00069 0.445
MOD_NEK2_1 29 34 PF00069 0.777
MOD_NEK2_1 293 298 PF00069 0.445
MOD_NEK2_1 318 323 PF00069 0.423
MOD_NEK2_1 572 577 PF00069 0.862
MOD_NEK2_1 676 681 PF00069 0.692
MOD_NEK2_1 708 713 PF00069 0.512
MOD_NEK2_1 721 726 PF00069 0.445
MOD_NEK2_1 732 737 PF00069 0.492
MOD_NEK2_1 834 839 PF00069 0.428
MOD_NEK2_1 907 912 PF00069 0.493
MOD_NEK2_2 170 175 PF00069 0.397
MOD_NEK2_2 184 189 PF00069 0.356
MOD_NEK2_2 25 30 PF00069 0.823
MOD_NEK2_2 526 531 PF00069 0.649
MOD_NEK2_2 589 594 PF00069 0.788
MOD_PIKK_1 165 171 PF00454 0.445
MOD_PIKK_1 361 367 PF00454 0.445
MOD_PIKK_1 48 54 PF00454 0.865
MOD_PIKK_1 519 525 PF00454 0.645
MOD_PIKK_1 634 640 PF00454 0.774
MOD_PK_1 404 410 PF00069 0.319
MOD_PKA_1 470 476 PF00069 0.558
MOD_PKA_1 920 926 PF00069 0.618
MOD_PKA_2 107 113 PF00069 0.688
MOD_PKA_2 29 35 PF00069 0.869
MOD_PKA_2 470 476 PF00069 0.558
MOD_PKA_2 526 532 PF00069 0.682
MOD_PKA_2 676 682 PF00069 0.779
MOD_PKA_2 89 95 PF00069 0.738
MOD_PKA_2 920 926 PF00069 0.618
MOD_PKB_1 359 367 PF00069 0.445
MOD_PKB_1 470 478 PF00069 0.687
MOD_PKB_1 785 793 PF00069 0.656
MOD_Plk_1 189 195 PF00069 0.509
MOD_Plk_1 54 60 PF00069 0.852
MOD_Plk_1 642 648 PF00069 0.664
MOD_Plk_2-3 107 113 PF00069 0.639
MOD_Plk_2-3 430 436 PF00069 0.698
MOD_Plk_2-3 533 539 PF00069 0.765
MOD_Plk_2-3 710 716 PF00069 0.495
MOD_Plk_4 170 176 PF00069 0.453
MOD_Plk_4 189 195 PF00069 0.241
MOD_Plk_4 222 228 PF00069 0.525
MOD_Plk_4 243 249 PF00069 0.445
MOD_Plk_4 293 299 PF00069 0.445
MOD_Plk_4 54 60 PF00069 0.839
MOD_Plk_4 704 710 PF00069 0.498
MOD_Plk_4 787 793 PF00069 0.505
MOD_Plk_4 836 842 PF00069 0.511
MOD_Plk_4 912 918 PF00069 0.481
MOD_ProDKin_1 345 351 PF00069 0.546
MOD_ProDKin_1 398 404 PF00069 0.644
MOD_ProDKin_1 543 549 PF00069 0.832
MOD_ProDKin_1 661 667 PF00069 0.848
MOD_ProDKin_1 74 80 PF00069 0.778
MOD_ProDKin_1 880 886 PF00069 0.686
MOD_SUMO_for_1 445 448 PF00179 0.709
MOD_SUMO_rev_2 36 44 PF00179 0.827
TRG_DiLeu_BaLyEn_6 586 591 PF01217 0.743
TRG_ENDOCYTIC_2 212 215 PF00928 0.388
TRG_ENDOCYTIC_2 254 257 PF00928 0.441
TRG_ENDOCYTIC_2 372 375 PF00928 0.511
TRG_ENDOCYTIC_2 385 388 PF00928 0.355
TRG_ENDOCYTIC_2 654 657 PF00928 0.820
TRG_ENDOCYTIC_2 714 717 PF00928 0.491
TRG_ENDOCYTIC_2 722 725 PF00928 0.445
TRG_ENDOCYTIC_2 748 751 PF00928 0.647
TRG_ENDOCYTIC_2 756 759 PF00928 0.414
TRG_ENDOCYTIC_2 777 780 PF00928 0.498
TRG_ENDOCYTIC_2 904 907 PF00928 0.441
TRG_ENDOCYTIC_2 922 925 PF00928 0.458
TRG_ER_diArg_1 150 152 PF00400 0.591
TRG_ER_diArg_1 342 345 PF00400 0.532
TRG_ER_diArg_1 358 361 PF00400 0.321
TRG_ER_diArg_1 370 372 PF00400 0.445
TRG_ER_diArg_1 458 461 PF00400 0.737
TRG_ER_diArg_1 470 472 PF00400 0.589
TRG_ER_diArg_1 676 678 PF00400 0.704
TRG_ER_diArg_1 920 922 PF00400 0.571
TRG_ER_diArg_1 933 935 PF00400 0.537
TRG_NLS_MonoExtN_4 368 373 PF00514 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NZT1 Trypanosomatidae 37% 100%
A0A3Q8IG09 Leishmania donovani 92% 100%
A4HJ52 Leishmania braziliensis 73% 100%
A4I6G6 Leishmania infantum 93% 100%
E9B1M3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS