F-BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6I6_LEIMA

TriTrypDb:

LmjF.31.0770 , LMJLV39_000019800

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6I6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.610
CLV_NRD_NRD_1	191	193	PF00675	0.397
CLV_NRD_NRD_1	68	70	PF00675	0.455
CLV_PCSK_KEX2_1	191	193	PF00082	0.445
CLV_PCSK_KEX2_1	272	274	PF00082	0.670
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.497
CLV_PCSK_SKI1_1	117	121	PF00082	0.456
CLV_PCSK_SKI1_1	124	128	PF00082	0.389
DOC_MAPK_gen_1	155	164	PF00069	0.374
DOC_PP4_FxxP_1	7	10	PF00568	0.433
DOC_USP7_MATH_1	115	119	PF00917	0.391
DOC_USP7_MATH_1	138	142	PF00917	0.475
DOC_USP7_MATH_1	160	164	PF00917	0.563
DOC_USP7_MATH_1	22	26	PF00917	0.529
DOC_USP7_MATH_1	248	252	PF00917	0.534
DOC_USP7_MATH_1	53	57	PF00917	0.503
DOC_USP7_UBL2_3	103	107	PF12436	0.557
DOC_USP7_UBL2_3	61	65	PF12436	0.436
LIG_14-3-3_CanoR_1	285	290	PF00244	0.689
LIG_Actin_WH2_2	88	105	PF00022	0.544
LIG_ActinCP_CPI_1	278	295	PF01115	0.493
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_BRCT_BRCA1_1	47	51	PF00533	0.488
LIG_BRCT_BRCA1_1	55	59	PF00533	0.498
LIG_BRCT_BRCA1_2	55	61	PF00533	0.323
LIG_FHA_1	177	183	PF00498	0.474
LIG_FHA_1	200	206	PF00498	0.538
LIG_FHA_1	284	290	PF00498	0.534
LIG_FHA_2	207	213	PF00498	0.483
LIG_FHA_2	58	64	PF00498	0.462
LIG_LIR_Apic_2	6	10	PF02991	0.445
LIG_LIR_Gen_1	172	182	PF02991	0.422
LIG_LIR_Gen_1	48	59	PF02991	0.486
LIG_LIR_Gen_1	86	95	PF02991	0.289
LIG_LIR_Nem_3	118	123	PF02991	0.482
LIG_LIR_Nem_3	172	178	PF02991	0.431
LIG_LIR_Nem_3	25	29	PF02991	0.551
LIG_LIR_Nem_3	268	274	PF02991	0.545
LIG_LIR_Nem_3	48	54	PF02991	0.472
LIG_LIR_Nem_3	86	90	PF02991	0.306
LIG_Pex14_2	171	175	PF04695	0.436
LIG_SH2_CRK	87	91	PF00017	0.455
LIG_SH2_STAT5	193	196	PF00017	0.449
LIG_SH3_3	288	294	PF00018	0.669
LIG_SH3_3	92	98	PF00018	0.441
LIG_TRAF2_1	214	217	PF00917	0.547
LIG_TRAF2_2	10	15	PF00917	0.391
LIG_UBA3_1	33	38	PF00899	0.448
LIG_UBA3_1	75	79	PF00899	0.289
LIG_WRC_WIRS_1	23	28	PF05994	0.396
MOD_CK1_1	149	155	PF00069	0.511
MOD_CK1_1	184	190	PF00069	0.346
MOD_CK1_1	243	249	PF00069	0.483
MOD_CK1_1	281	287	PF00069	0.660
MOD_CK2_1	102	108	PF00069	0.509
MOD_CK2_1	115	121	PF00069	0.535
MOD_CK2_1	177	183	PF00069	0.374
MOD_CK2_1	211	217	PF00069	0.431
MOD_CK2_1	229	235	PF00069	0.312
MOD_CK2_1	57	63	PF00069	0.473
MOD_CK2_1	74	80	PF00069	0.520
MOD_GlcNHglycan	116	120	PF01048	0.392
MOD_GlcNHglycan	231	234	PF01048	0.513
MOD_GlcNHglycan	26	29	PF01048	0.516
MOD_GSK3_1	177	184	PF00069	0.462
MOD_GSK3_1	24	31	PF00069	0.471
MOD_GSK3_1	240	247	PF00069	0.507
MOD_GSK3_1	279	286	PF00069	0.727
MOD_GSK3_1	53	60	PF00069	0.448
MOD_N-GLC_2	262	264	PF02516	0.472
MOD_NEK2_1	102	107	PF00069	0.488
MOD_NEK2_1	144	149	PF00069	0.504
MOD_NEK2_1	265	270	PF00069	0.626
MOD_NEK2_1	278	283	PF00069	0.544
MOD_NEK2_1	40	45	PF00069	0.498
MOD_PIKK_1	248	254	PF00454	0.508
MOD_PKA_2	229	235	PF00069	0.545
MOD_PKA_2	278	284	PF00069	0.684
MOD_PKB_1	277	285	PF00069	0.489
MOD_Plk_1	115	121	PF00069	0.396
MOD_Plk_2-3	74	80	PF00069	0.359
MOD_Plk_4	200	206	PF00069	0.536
MOD_Plk_4	265	271	PF00069	0.537
MOD_SUMO_for_1	113	116	PF00179	0.612
TRG_DiLeu_BaEn_1	86	91	PF01217	0.283
TRG_DiLeu_BaEn_3	172	178	PF01217	0.302
TRG_ENDOCYTIC_2	193	196	PF00928	0.445
TRG_ENDOCYTIC_2	87	90	PF00928	0.483
TRG_ER_diArg_1	154	157	PF00400	0.312
TRG_ER_diArg_1	190	192	PF00400	0.410
TRG_NLS_MonoExtN_4	122	128	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P348	Leptomonas seymouri	23%	68%
A0A0N0P4S1	Leptomonas seymouri	24%	100%
A0A1X0NK28	Trypanosomatidae	37%	73%
A0A3Q8IG21	Leishmania donovani	82%	71%
A0A3Q8IIE7	Leishmania donovani	78%	95%
A0A3S5H792	Leishmania donovani	25%	100%
A0A3S7WQB3	Leishmania donovani	22%	71%
A0A422NQZ1	Trypanosoma rangeli	33%	72%
A4H6C6	Leishmania braziliensis	24%	76%
A4HBK0	Leishmania braziliensis	23%	100%
A4HJ56	Leishmania braziliensis	69%	68%
A4HTM7	Leishmania infantum	22%	71%
A4HZL5	Leishmania infantum	25%	100%
A4I6H9	Leishmania infantum	83%	71%
E9AHL0	Leishmania infantum	79%	95%
E9AMG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	71%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
E9B1N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	71%
Q4Q6H8	Leishmania major	93%	68%
Q4QCL3	Leishmania major	27%	100%
Q4QI82	Leishmania major	23%	74%