Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6I3_LEIMA

TriTrypDb:

LmjF.31.0800 , LMJLV39_310013700 , LMJLV39_340036000 , LMJSD75_310013400

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

Q4Q6I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6I3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.810
CLV_C14_Caspase3-7	412	416	PF00656	0.478
CLV_C14_Caspase3-7	520	524	PF00656	0.501
CLV_NRD_NRD_1	124	126	PF00675	0.499
CLV_NRD_NRD_1	241	243	PF00675	0.492
CLV_NRD_NRD_1	256	258	PF00675	0.330
CLV_NRD_NRD_1	295	297	PF00675	0.322
CLV_NRD_NRD_1	353	355	PF00675	0.430
CLV_NRD_NRD_1	509	511	PF00675	0.351
CLV_NRD_NRD_1	547	549	PF00675	0.352
CLV_PCSK_KEX2_1	124	126	PF00082	0.499
CLV_PCSK_KEX2_1	241	243	PF00082	0.491
CLV_PCSK_KEX2_1	295	297	PF00082	0.337
CLV_PCSK_KEX2_1	355	357	PF00082	0.427
CLV_PCSK_KEX2_1	509	511	PF00082	0.270
CLV_PCSK_KEX2_1	547	549	PF00082	0.253
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.449
CLV_PCSK_PC7_1	291	297	PF00082	0.321
CLV_PCSK_SKI1_1	144	148	PF00082	0.410
CLV_PCSK_SKI1_1	218	222	PF00082	0.568
CLV_PCSK_SKI1_1	427	431	PF00082	0.472
CLV_PCSK_SKI1_1	583	587	PF00082	0.601
DEG_APCC_DBOX_1	426	434	PF00400	0.244
DEG_ODPH_VHL_1	554	566	PF01847	0.200
DOC_CDC14_PxL_1	24	32	PF14671	0.483
DOC_CYCLIN_RxL_1	215	223	PF00134	0.607
DOC_MAPK_gen_1	257	265	PF00069	0.572
DOC_MAPK_MEF2A_6	455	463	PF00069	0.367
DOC_PP1_RVXF_1	38	45	PF00149	0.518
DOC_PP2B_LxvP_1	30	33	PF13499	0.615
DOC_PP4_FxxP_1	277	280	PF00568	0.600
DOC_USP7_MATH_1	139	143	PF00917	0.770
DOC_USP7_MATH_1	183	187	PF00917	0.642
DOC_USP7_MATH_1	5	9	PF00917	0.640
LIG_14-3-3_CanoR_1	124	130	PF00244	0.778
LIG_14-3-3_CanoR_1	40	45	PF00244	0.530
LIG_14-3-3_CanoR_1	79	85	PF00244	0.566
LIG_Actin_RPEL_3	503	522	PF02755	0.443
LIG_Actin_WH2_2	20	38	PF00022	0.625
LIG_BH_BH3_1	402	418	PF00452	0.346
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_BIR_III_4	182	186	PF00653	0.691
LIG_EH1_1	113	121	PF00400	0.601
LIG_eIF4E_1	570	576	PF01652	0.473
LIG_FHA_1	199	205	PF00498	0.617
LIG_FHA_1	374	380	PF00498	0.343
LIG_FHA_1	440	446	PF00498	0.436
LIG_FHA_1	456	462	PF00498	0.315
LIG_FHA_1	498	504	PF00498	0.480
LIG_FHA_1	511	517	PF00498	0.533
LIG_FHA_1	559	565	PF00498	0.427
LIG_FHA_1	59	65	PF00498	0.515
LIG_FHA_2	129	135	PF00498	0.652
LIG_FHA_2	193	199	PF00498	0.730
LIG_FHA_2	410	416	PF00498	0.353
LIG_FHA_2	79	85	PF00498	0.555
LIG_GBD_Chelix_1	397	405	PF00786	0.420
LIG_LIR_Apic_2	275	280	PF02991	0.585
LIG_LIR_Gen_1	399	410	PF02991	0.391
LIG_LIR_Gen_1	561	571	PF02991	0.336
LIG_LIR_Nem_3	145	150	PF02991	0.790
LIG_LIR_Nem_3	399	405	PF02991	0.333
LIG_LIR_Nem_3	561	566	PF02991	0.375
LIG_LIR_Nem_3	57	63	PF02991	0.607
LIG_LIR_Nem_3	83	88	PF02991	0.567
LIG_NRBOX	574	580	PF00104	0.433
LIG_PCNA_PIPBox_1	309	318	PF02747	0.580
LIG_PCNA_yPIPBox_3	308	316	PF02747	0.598
LIG_Pex14_2	273	277	PF04695	0.562
LIG_Pex14_2	421	425	PF04695	0.555
LIG_Pex14_2	466	470	PF04695	0.241
LIG_SH2_CRK	313	317	PF00017	0.615
LIG_SH2_CRK	366	370	PF00017	0.525
LIG_SH2_CRK	446	450	PF00017	0.363
LIG_SH2_CRK	60	64	PF00017	0.536
LIG_SH2_GRB2like	76	79	PF00017	0.577
LIG_SH2_PTP2	570	573	PF00017	0.229
LIG_SH2_STAP1	446	450	PF00017	0.244
LIG_SH2_STAT5	252	255	PF00017	0.602
LIG_SH2_STAT5	297	300	PF00017	0.533
LIG_SH2_STAT5	380	383	PF00017	0.400
LIG_SH2_STAT5	543	546	PF00017	0.639
LIG_SH2_STAT5	570	573	PF00017	0.472
LIG_SH2_STAT5	60	63	PF00017	0.547
LIG_SH2_STAT5	76	79	PF00017	0.544
LIG_SH2_STAT5	80	83	PF00017	0.562
LIG_SH3_3	148	154	PF00018	0.644
LIG_SH3_3	186	192	PF00018	0.609
LIG_SH3_3	43	49	PF00018	0.516
LIG_SH3_3	447	453	PF00018	0.343
LIG_SUMO_SIM_anti_2	565	570	PF11976	0.406
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.505
LIG_SUMO_SIM_par_1	393	399	PF11976	0.431
LIG_SUMO_SIM_par_1	404	409	PF11976	0.444
LIG_TRAF2_1	357	360	PF00917	0.694
LIG_TYR_ITIM	444	449	PF00017	0.244
LIG_TYR_ITIM	568	573	PF00017	0.402
LIG_UBA3_1	378	383	PF00899	0.397
LIG_UBA3_1	418	424	PF00899	0.459
LIG_UBA3_1	482	488	PF00899	0.390
LIG_UBA3_1	574	583	PF00899	0.438
LIG_Vh1_VBS_1	390	408	PF01044	0.330
LIG_Vh1_VBS_1	469	487	PF01044	0.200
LIG_WRC_WIRS_1	252	257	PF05994	0.557
LIG_WRC_WIRS_1	418	423	PF05994	0.614
LIG_WRC_WIRS_1	426	431	PF05994	0.452
MOD_CK1_1	128	134	PF00069	0.630
MOD_CK1_1	142	148	PF00069	0.624
MOD_CK1_1	409	415	PF00069	0.473
MOD_CK1_1	497	503	PF00069	0.630
MOD_CK1_1	55	61	PF00069	0.620
MOD_CK1_1	65	71	PF00069	0.560
MOD_CK2_1	192	198	PF00069	0.729
MOD_CK2_1	5	11	PF00069	0.584
MOD_GlcNHglycan	110	113	PF01048	0.629
MOD_GlcNHglycan	136	140	PF01048	0.559
MOD_GlcNHglycan	141	144	PF01048	0.579
MOD_GlcNHglycan	160	164	PF01048	0.609
MOD_GlcNHglycan	243	246	PF01048	0.419
MOD_GlcNHglycan	316	319	PF01048	0.352
MOD_GSK3_1	135	142	PF00069	0.799
MOD_GSK3_1	404	411	PF00069	0.437
MOD_GSK3_1	413	420	PF00069	0.567
MOD_GSK3_1	51	58	PF00069	0.662
MOD_GSK3_1	558	565	PF00069	0.391
MOD_N-GLC_1	484	489	PF02516	0.307
MOD_N-GLC_1	510	515	PF02516	0.303
MOD_N-GLC_2	528	530	PF02516	0.418
MOD_NEK2_1	119	124	PF00069	0.687
MOD_NEK2_1	243	248	PF00069	0.613
MOD_NEK2_1	256	261	PF00069	0.553
MOD_NEK2_1	372	377	PF00069	0.346
MOD_NEK2_1	379	384	PF00069	0.346
MOD_NEK2_1	396	401	PF00069	0.338
MOD_NEK2_1	404	409	PF00069	0.336
MOD_NEK2_1	417	422	PF00069	0.567
MOD_NEK2_1	425	430	PF00069	0.309
MOD_NEK2_1	469	474	PF00069	0.408
MOD_NEK2_1	529	534	PF00069	0.575
MOD_NEK2_1	558	563	PF00069	0.392
MOD_OFUCOSY	512	519	PF10250	0.276
MOD_PK_1	125	131	PF00069	0.596
MOD_PK_1	167	173	PF00069	0.619
MOD_PKA_1	241	247	PF00069	0.587
MOD_PKA_2	241	247	PF00069	0.591
MOD_PKA_2	256	262	PF00069	0.588
MOD_PKA_2	78	84	PF00069	0.545
MOD_Plk_1	135	141	PF00069	0.637
MOD_Plk_1	455	461	PF00069	0.297
MOD_Plk_2-3	105	111	PF00069	0.712
MOD_Plk_4	251	257	PF00069	0.622
MOD_Plk_4	272	278	PF00069	0.571
MOD_Plk_4	396	402	PF00069	0.356
MOD_Plk_4	413	419	PF00069	0.551
MOD_Plk_4	445	451	PF00069	0.403
MOD_Plk_4	455	461	PF00069	0.364
MOD_Plk_4	55	61	PF00069	0.574
MOD_Plk_4	62	68	PF00069	0.549
MOD_SUMO_rev_2	351	357	PF00179	0.663
MOD_SUMO_rev_2	83	91	PF00179	0.578
TRG_DiLeu_BaEn_1	215	220	PF01217	0.740
TRG_DiLeu_BaEn_1	337	342	PF01217	0.523
TRG_DiLeu_BaEn_1	456	461	PF01217	0.290
TRG_DiLeu_BaEn_4	86	92	PF01217	0.644
TRG_DiLeu_LyEn_5	215	220	PF01217	0.581
TRG_ENDOCYTIC_2	252	255	PF00928	0.610
TRG_ENDOCYTIC_2	274	277	PF00928	0.551
TRG_ENDOCYTIC_2	313	316	PF00928	0.567
TRG_ENDOCYTIC_2	446	449	PF00928	0.373
TRG_ENDOCYTIC_2	492	495	PF00928	0.560
TRG_ENDOCYTIC_2	570	573	PF00928	0.416
TRG_ENDOCYTIC_2	60	63	PF00928	0.531
TRG_ENDOCYTIC_2	88	91	PF00928	0.548
TRG_ER_diArg_1	123	125	PF00400	0.728
TRG_ER_diArg_1	240	242	PF00400	0.674
TRG_ER_diArg_1	294	296	PF00400	0.519
TRG_ER_diArg_1	547	549	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	38%	96%
A0A0N1HRT9	Leptomonas seymouri	38%	96%
A0A0N1P9A0	Leptomonas seymouri	34%	95%
A0A0N1PBU6	Leptomonas seymouri	33%	93%
A0A1X0P9W4	Trypanosomatidae	31%	100%
A0A3Q8IFF3	Leishmania donovani	70%	91%
A0A3Q8ISH4	Leishmania donovani	51%	94%
A0A3S7X483	Leishmania donovani	85%	91%
A0A3S7X888	Leishmania donovani	31%	93%
A4HB26	Leishmania braziliensis	34%	92%
A4HJ59	Leishmania braziliensis	47%	90%
A4HJ60	Leishmania braziliensis	43%	93%
A4I6H4	Leishmania infantum	85%	91%
A4I6H5	Leishmania infantum	52%	94%
A4IA83	Leishmania infantum	31%	93%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	91%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	94%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	93%
Q4Q6I2	Leishmania major	51%	100%
V5B5A9	Trypanosoma cruzi	29%	100%