Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6I2_LEIMA

TriTrypDb:

LmjF.31.0810 , LMJLV39_310013800 , LMJSD75_310013500

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

Q4Q6I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	280	282	PF00675	0.484
CLV_NRD_NRD_1	295	297	PF00675	0.325
CLV_NRD_NRD_1	334	336	PF00675	0.328
CLV_NRD_NRD_1	392	394	PF00675	0.418
CLV_PCSK_KEX2_1	280	282	PF00082	0.481
CLV_PCSK_KEX2_1	334	336	PF00082	0.334
CLV_PCSK_KEX2_1	394	396	PF00082	0.415
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.446
CLV_PCSK_PC7_1	330	336	PF00082	0.318
CLV_PCSK_SKI1_1	149	153	PF00082	0.446
CLV_PCSK_SKI1_1	426	430	PF00082	0.246
CLV_PCSK_SKI1_1	463	467	PF00082	0.574
CLV_PCSK_SKI1_1	503	507	PF00082	0.280
CLV_PCSK_SKI1_1	616	620	PF00082	0.359
CLV_PCSK_SKI1_1	70	74	PF00082	0.407
CLV_PCSK_SKI1_1	95	99	PF00082	0.330
DEG_Nend_UBRbox_2	1	3	PF02207	0.660
DOC_MAPK_DCC_7	591	599	PF00069	0.295
DOC_MAPK_gen_1	146	156	PF00069	0.554
DOC_MAPK_gen_1	296	304	PF00069	0.573
DOC_MAPK_HePTP_8	613	625	PF00069	0.308
DOC_MAPK_MEF2A_6	488	495	PF00069	0.538
DOC_MAPK_MEF2A_6	562	569	PF00069	0.279
DOC_MAPK_MEF2A_6	591	599	PF00069	0.284
DOC_MAPK_MEF2A_6	616	625	PF00069	0.474
DOC_MAPK_NFAT4_5	488	496	PF00069	0.523
DOC_PIKK_1	75	82	PF02985	0.583
DOC_PP1_RVXF_1	461	468	PF00149	0.187
DOC_PP1_RVXF_1	501	507	PF00149	0.433
DOC_PP1_RVXF_1	93	100	PF00149	0.511
DOC_PP2B_LxvP_1	254	257	PF13499	0.638
DOC_PP4_FxxP_1	316	319	PF00568	0.592
DOC_USP7_MATH_1	142	146	PF00917	0.502
DOC_USP7_MATH_1	157	161	PF00917	0.593
DOC_USP7_MATH_1	225	229	PF00917	0.664
DOC_USP7_MATH_1	257	261	PF00917	0.720
DOC_USP7_MATH_1	424	428	PF00917	0.577
DOC_USP7_MATH_1	557	561	PF00917	0.448
DOC_USP7_UBL2_3	247	251	PF12436	0.597
DOC_WW_Pin1_4	133	138	PF00397	0.498
DOC_WW_Pin1_4	175	180	PF00397	0.795
DOC_WW_Pin1_4	52	57	PF00397	0.761
DOC_WW_Pin1_4	84	89	PF00397	0.589
LIG_14-3-3_CanoR_1	182	188	PF00244	0.761
LIG_14-3-3_CanoR_1	503	509	PF00244	0.472
LIG_14-3-3_CanoR_1	95	100	PF00244	0.521
LIG_Actin_WH2_2	75	93	PF00022	0.637
LIG_APCC_ABBA_1	617	622	PF00400	0.499
LIG_APCC_ABBAyCdc20_2	616	622	PF00400	0.499
LIG_BH_BH3_1	441	457	PF00452	0.317
LIG_BRCT_BRCA1_1	54	58	PF00533	0.624
LIG_eIF4E_1	113	119	PF01652	0.600
LIG_eIF4E_1	612	618	PF01652	0.522
LIG_FHA_1	119	125	PF00498	0.539
LIG_FHA_1	215	221	PF00498	0.656
LIG_FHA_1	413	419	PF00498	0.546
LIG_FHA_1	475	481	PF00498	0.398
LIG_FHA_1	515	521	PF00498	0.303
LIG_FHA_1	598	604	PF00498	0.416
LIG_FHA_1	96	102	PF00498	0.577
LIG_FHA_2	134	140	PF00498	0.549
LIG_FHA_2	235	241	PF00498	0.734
LIG_FHA_2	257	263	PF00498	0.757
LIG_GBD_Chelix_1	432	440	PF00786	0.406
LIG_LIR_Apic_2	314	319	PF02991	0.580
LIG_LIR_Gen_1	434	445	PF02991	0.344
LIG_LIR_Gen_1	579	589	PF02991	0.331
LIG_LIR_LC3C_4	517	521	PF02991	0.273
LIG_LIR_Nem_3	111	116	PF02991	0.603
LIG_LIR_Nem_3	139	143	PF02991	0.556
LIG_LIR_Nem_3	427	432	PF02991	0.339
LIG_LIR_Nem_3	434	440	PF02991	0.322
LIG_LIR_Nem_3	579	585	PF02991	0.317
LIG_LIR_Nem_3	607	612	PF02991	0.337
LIG_LYPXL_SIV_4	611	619	PF13949	0.272
LIG_MAD2	70	78	PF02301	0.546
LIG_NRBOX	435	441	PF00104	0.402
LIG_PCNA_PIPBox_1	348	357	PF02747	0.586
LIG_PCNA_yPIPBox_3	347	355	PF02747	0.601
LIG_Pex14_2	312	316	PF04695	0.559
LIG_Pex14_2	437	441	PF04695	0.407
LIG_Pex14_2	460	464	PF04695	0.338
LIG_PTAP_UEV_1	59	64	PF05743	0.607
LIG_SH2_CRK	352	356	PF00017	0.619
LIG_SH2_CRK	405	409	PF00017	0.620
LIG_SH2_NCK_1	135	139	PF00017	0.609
LIG_SH2_NCK_1	195	199	PF00017	0.643
LIG_SH2_PTP2	115	118	PF00017	0.454
LIG_SH2_STAP1	582	586	PF00017	0.356
LIG_SH2_STAP1	609	613	PF00017	0.414
LIG_SH2_STAT5	115	118	PF00017	0.530
LIG_SH2_STAT5	135	138	PF00017	0.540
LIG_SH2_STAT5	258	261	PF00017	0.620
LIG_SH2_STAT5	291	294	PF00017	0.604
LIG_SH2_STAT5	336	339	PF00017	0.531
LIG_SH2_STAT5	419	422	PF00017	0.593
LIG_SH2_STAT5	444	447	PF00017	0.379
LIG_SH2_STAT5	584	587	PF00017	0.447
LIG_SH2_STAT5	612	615	PF00017	0.461
LIG_SH3_3	151	157	PF00018	0.560
LIG_SH3_3	25	31	PF00018	0.788
LIG_SH3_3	470	476	PF00018	0.493
LIG_SH3_3	57	63	PF00018	0.690
LIG_SUMO_SIM_anti_2	517	523	PF11976	0.421
LIG_SUMO_SIM_anti_2	600	607	PF11976	0.353
LIG_SUMO_SIM_par_1	120	126	PF11976	0.443
LIG_SUMO_SIM_par_1	447	454	PF11976	0.545
LIG_SUMO_SIM_par_1	491	496	PF11976	0.624
LIG_SxIP_EBH_1	416	426	PF03271	0.499
LIG_TRAF2_1	260	263	PF00917	0.818
LIG_TRAF2_1	396	399	PF00917	0.691
LIG_TYR_ITSM	109	116	PF00017	0.344
LIG_UBA3_1	417	422	PF00899	0.449
LIG_UBA3_1	518	524	PF00899	0.299
LIG_WRC_WIRS_1	291	296	PF05994	0.428
LIG_WRC_WIRS_1	457	462	PF05994	0.490
MOD_CDK_SPxxK_3	175	182	PF00069	0.521
MOD_CDK_SPxxK_3	84	91	PF00069	0.450
MOD_CK1_1	120	126	PF00069	0.449
MOD_CK1_1	160	166	PF00069	0.659
MOD_CK1_1	185	191	PF00069	0.742
MOD_CK1_1	427	433	PF00069	0.316
MOD_CK1_1	450	456	PF00069	0.465
MOD_CK2_1	185	191	PF00069	0.668
MOD_CK2_1	234	240	PF00069	0.682
MOD_CK2_1	256	262	PF00069	0.679
MOD_GlcNHglycan	159	162	PF01048	0.718
MOD_GlcNHglycan	187	190	PF01048	0.702
MOD_GlcNHglycan	225	228	PF01048	0.633
MOD_GlcNHglycan	231	234	PF01048	0.705
MOD_GlcNHglycan	282	285	PF01048	0.534
MOD_GlcNHglycan	355	358	PF01048	0.448
MOD_GlcNHglycan	429	432	PF01048	0.400
MOD_GlcNHglycan	559	562	PF01048	0.489
MOD_GSK3_1	118	125	PF00069	0.486
MOD_GSK3_1	183	190	PF00069	0.693
MOD_GSK3_1	214	221	PF00069	0.607
MOD_GSK3_1	225	232	PF00069	0.586
MOD_GSK3_1	236	243	PF00069	0.594
MOD_GSK3_1	427	434	PF00069	0.431
MOD_GSK3_1	50	57	PF00069	0.714
MOD_LATS_1	278	284	PF00433	0.397
MOD_LATS_1	497	503	PF00433	0.273
MOD_N-GLC_1	577	582	PF02516	0.416
MOD_N-GLC_2	566	568	PF02516	0.510
MOD_NEK2_1	109	114	PF00069	0.424
MOD_NEK2_1	118	123	PF00069	0.402
MOD_NEK2_1	223	228	PF00069	0.632
MOD_NEK2_1	229	234	PF00069	0.661
MOD_NEK2_1	282	287	PF00069	0.497
MOD_NEK2_1	295	300	PF00069	0.437
MOD_NEK2_1	411	416	PF00069	0.421
MOD_NEK2_1	418	423	PF00069	0.403
MOD_NEK2_1	435	440	PF00069	0.320
MOD_NEK2_1	456	461	PF00069	0.434
MOD_NEK2_1	468	473	PF00069	0.273
MOD_NEK2_1	484	489	PF00069	0.319
MOD_NEK2_1	569	574	PF00069	0.471
MOD_NEK2_1	597	602	PF00069	0.376
MOD_NEK2_1	604	609	PF00069	0.391
MOD_NEK2_2	424	429	PF00069	0.483
MOD_PIKK_1	31	37	PF00454	0.799
MOD_PKA_1	280	286	PF00069	0.485
MOD_PKA_2	214	220	PF00069	0.638
MOD_PKA_2	280	286	PF00069	0.493
MOD_PKA_2	295	301	PF00069	0.495
MOD_PKA_2	50	56	PF00069	0.577
MOD_Plk_1	173	179	PF00069	0.584
MOD_Plk_1	577	583	PF00069	0.521
MOD_Plk_4	109	115	PF00069	0.440
MOD_Plk_4	125	131	PF00069	0.354
MOD_Plk_4	290	296	PF00069	0.529
MOD_Plk_4	311	317	PF00069	0.453
MOD_Plk_4	431	437	PF00069	0.347
MOD_Plk_4	456	462	PF00069	0.407
MOD_Plk_4	468	474	PF00069	0.336
MOD_Plk_4	514	520	PF00069	0.336
MOD_Plk_4	604	610	PF00069	0.350
MOD_Plk_4	95	101	PF00069	0.356
MOD_ProDKin_1	133	139	PF00069	0.352
MOD_ProDKin_1	175	181	PF00069	0.768
MOD_ProDKin_1	52	58	PF00069	0.722
MOD_ProDKin_1	84	90	PF00069	0.471
MOD_SUMO_rev_2	390	396	PF00179	0.575
MOD_SUMO_rev_2	87	93	PF00179	0.474
TRG_DiLeu_BaEn_1	376	381	PF01217	0.390
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.388
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.381
TRG_ENDOCYTIC_2	113	116	PF00928	0.384
TRG_ENDOCYTIC_2	258	261	PF00928	0.573
TRG_ENDOCYTIC_2	291	294	PF00928	0.481
TRG_ENDOCYTIC_2	313	316	PF00928	0.426
TRG_ENDOCYTIC_2	352	355	PF00928	0.459
TRG_ENDOCYTIC_2	444	447	PF00928	0.346
TRG_ENDOCYTIC_2	582	585	PF00928	0.472
TRG_ENDOCYTIC_2	612	615	PF00928	0.385
TRG_ER_diArg_1	279	281	PF00400	0.589
TRG_ER_diArg_1	333	335	PF00400	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	40%	100%
A0A0N1HRT9	Leptomonas seymouri	37%	100%
A0A0N1P9A0	Leptomonas seymouri	34%	100%
A0A0N1PBU6	Leptomonas seymouri	36%	100%
A0A1X0P9W4	Trypanosomatidae	33%	100%
A0A3Q8IFF3	Leishmania donovani	65%	97%
A0A3Q8ISH4	Leishmania donovani	90%	100%
A0A3R7KFP4	Trypanosoma rangeli	29%	100%
A0A3S7X483	Leishmania donovani	48%	97%
A0A3S7X888	Leishmania donovani	34%	99%
A4HB26	Leishmania braziliensis	34%	98%
A4HJ59	Leishmania braziliensis	41%	96%
A4HJ60	Leishmania braziliensis	55%	99%
A4I6H4	Leishmania infantum	48%	97%
A4I6H5	Leishmania infantum	90%	100%
A4IA83	Leishmania infantum	34%	99%
C9ZM24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	97%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	99%
Q4Q6I3	Leishmania major	51%	100%
V5B5A9	Trypanosoma cruzi	28%	100%