Putative lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative lipase

Gene product:

lipase, putative

Species:

Leishmania major

UniProt:

Q4Q6I0_LEIMA

TriTrypDb:

LmjF.31.0830 , LMJLV39_310014100 , LMJSD75_310013800

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 9
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q6I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6I0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004806	triglyceride lipase activity	5	12
GO:0016298	lipase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0052689	carboxylic ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.443
CLV_C14_Caspase3-7	32	36	PF00656	0.320
CLV_C14_Caspase3-7	46	50	PF00656	0.413
CLV_NRD_NRD_1	143	145	PF00675	0.435
CLV_PCSK_KEX2_1	143	145	PF00082	0.426
CLV_PCSK_SKI1_1	187	191	PF00082	0.237
DOC_CYCLIN_yCln2_LP_2	113	119	PF00134	0.173
DOC_PP4_FxxP_1	201	204	PF00568	0.293
DOC_USP7_MATH_1	194	198	PF00917	0.401
DOC_USP7_MATH_1	278	282	PF00917	0.447
DOC_USP7_MATH_1	36	40	PF00917	0.401
DOC_USP7_MATH_1	52	56	PF00917	0.349
DOC_USP7_MATH_1	64	68	PF00917	0.498
LIG_14-3-3_CanoR_1	100	110	PF00244	0.314
LIG_14-3-3_CanoR_1	193	199	PF00244	0.216
LIG_14-3-3_CanoR_1	226	234	PF00244	0.301
LIG_14-3-3_CanoR_1	236	245	PF00244	0.503
LIG_APCC_ABBA_1	154	159	PF00400	0.411
LIG_BRCT_BRCA1_1	241	245	PF00533	0.539
LIG_EH1_1	67	75	PF00400	0.290
LIG_FHA_1	278	284	PF00498	0.437
LIG_FHA_1	32	38	PF00498	0.259
LIG_FHA_1	69	75	PF00498	0.345
LIG_FHA_2	102	108	PF00498	0.216
LIG_FHA_2	44	50	PF00498	0.268
LIG_HP1_1	194	198	PF01393	0.216
LIG_LIR_Apic_2	200	204	PF02991	0.322
LIG_LIR_Gen_1	138	146	PF02991	0.307
LIG_LIR_Gen_1	159	164	PF02991	0.283
LIG_LIR_Gen_1	242	253	PF02991	0.474
LIG_LIR_Nem_3	138	142	PF02991	0.307
LIG_LIR_Nem_3	159	163	PF02991	0.314
LIG_LIR_Nem_3	242	248	PF02991	0.420
LIG_LIR_Nem_3	287	292	PF02991	0.325
LIG_PDZ_Class_2	303	308	PF00595	0.444
LIG_PTB_Apo_2	205	212	PF02174	0.301
LIG_PTB_Apo_2	41	48	PF02174	0.252
LIG_PTB_Apo_2	62	69	PF02174	0.379
LIG_PTB_Phospho_1	41	47	PF10480	0.250
LIG_REV1ctd_RIR_1	187	193	PF16727	0.216
LIG_SH2_CRK	160	164	PF00017	0.250
LIG_SH2_GRB2like	42	45	PF00017	0.245
LIG_SH2_NCK_1	42	46	PF00017	0.397
LIG_SH2_PTP2	85	88	PF00017	0.243
LIG_SH2_SRC	42	45	PF00017	0.454
LIG_SH2_SRC	47	50	PF00017	0.287
LIG_SH2_STAT5	139	142	PF00017	0.396
LIG_SH2_STAT5	199	202	PF00017	0.319
LIG_SH2_STAT5	253	256	PF00017	0.454
LIG_SH2_STAT5	291	294	PF00017	0.380
LIG_SH2_STAT5	85	88	PF00017	0.484
LIG_SH3_3	188	194	PF00018	0.390
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.469
LIG_SUMO_SIM_par_1	194	200	PF11976	0.432
LIG_TRAF2_1	104	107	PF00917	0.216
LIG_WRC_WIRS_1	198	203	PF05994	0.322
MOD_CK1_1	197	203	PF00069	0.427
MOD_CK1_1	220	226	PF00069	0.334
MOD_CK1_1	239	245	PF00069	0.364
MOD_CK1_1	268	274	PF00069	0.426
MOD_CK1_1	4	10	PF00069	0.643
MOD_CK2_1	101	107	PF00069	0.380
MOD_GlcNHglycan	101	104	PF01048	0.268
MOD_GlcNHglycan	122	125	PF01048	0.217
MOD_GlcNHglycan	239	242	PF01048	0.529
MOD_GlcNHglycan	254	257	PF01048	0.322
MOD_GlcNHglycan	27	30	PF01048	0.490
MOD_GlcNHglycan	296	299	PF01048	0.447
MOD_GlcNHglycan	89	94	PF01048	0.434
MOD_GSK3_1	25	32	PF00069	0.418
MOD_GSK3_1	268	275	PF00069	0.513
MOD_GSK3_1	43	50	PF00069	0.280
MOD_GSK3_1	64	71	PF00069	0.407
MOD_LATS_1	224	230	PF00433	0.216
MOD_N-GLC_1	43	48	PF02516	0.425
MOD_NEK2_1	135	140	PF00069	0.337
MOD_NEK2_1	189	194	PF00069	0.232
MOD_NEK2_1	225	230	PF00069	0.388
MOD_NEK2_1	237	242	PF00069	0.433
MOD_NEK2_1	68	73	PF00069	0.387
MOD_NEK2_1	99	104	PF00069	0.335
MOD_NEK2_2	194	199	PF00069	0.216
MOD_PIKK_1	101	107	PF00454	0.389
MOD_PIKK_1	29	35	PF00454	0.310
MOD_PK_1	69	75	PF00069	0.297
MOD_PKA_2	142	148	PF00069	0.245
MOD_PKA_2	220	226	PF00069	0.349
MOD_PKA_2	294	300	PF00069	0.417
MOD_PKA_2	99	105	PF00069	0.301
MOD_Plk_1	43	49	PF00069	0.433
MOD_Plk_4	194	200	PF00069	0.389
MOD_Plk_4	69	75	PF00069	0.325
TRG_ENDOCYTIC_2	139	142	PF00928	0.327
TRG_ENDOCYTIC_2	160	163	PF00928	0.435
TRG_ENDOCYTIC_2	85	88	PF00928	0.391
TRG_ER_diArg_1	142	144	PF00400	0.426
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.173

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D0	Leptomonas seymouri	31%	86%
A0A0S4IJE8	Bodo saltans	30%	94%
A0A0S4J5D7	Bodo saltans	34%	99%
A0A0S4JTA1	Bodo saltans	32%	100%
A0A1X0NH29	Trypanosomatidae	35%	100%
A0A1X0NZH3	Trypanosomatidae	33%	73%
A0A1X0P001	Trypanosomatidae	35%	90%
A0A3Q8IFI3	Leishmania donovani	33%	84%
A0A3Q8IG97	Leishmania donovani	89%	100%
A0A3S7X4C1	Leishmania donovani	38%	100%
A2QSY5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	100%
A4HJN0	Leishmania braziliensis	34%	83%
A4HLK7	Leishmania braziliensis	39%	92%
A4I6H7	Leishmania infantum	89%	100%
A4I6H8	Leishmania infantum	38%	100%
A4I752	Leishmania infantum	33%	84%
B8NIB8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	25%	100%
C9ZME7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	84%
E9B246	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	85%
O42807	Aspergillus niger	26%	100%
O59952	Thermomyces lanuginosus	30%	100%
P19515	Rhizomucor miehei	30%	85%
P61869	Penicillium cyclopium	28%	100%
P61870	Penicillium camembertii	28%	100%
Q0CBM7	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	26%	100%
Q2UNW5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	25%	100%
Q4Q615	Leishmania major	32%	100%
Q9BHD5	Leishmania major	35%	100%
V5B761	Trypanosoma cruzi	30%	100%