F-BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q4Q6H8_LEIMA

TriTrypDb:

LmjF.31.0850 , LMJLV39_000019800 , LMJSD75_080013100

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6H8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.402
CLV_NRD_NRD_1	191	193	PF00675	0.373
CLV_NRD_NRD_1	422	424	PF00675	0.474
CLV_PCSK_KEX2_1	191	193	PF00082	0.393
CLV_PCSK_KEX2_1	422	424	PF00082	0.476
CLV_PCSK_SKI1_1	104	108	PF00082	0.441
CLV_PCSK_SKI1_1	117	121	PF00082	0.395
CLV_PCSK_SKI1_1	124	128	PF00082	0.322
DOC_PP4_FxxP_1	7	10	PF00568	0.431
DOC_USP7_MATH_1	115	119	PF00917	0.404
DOC_USP7_MATH_1	138	142	PF00917	0.447
DOC_USP7_MATH_1	160	164	PF00917	0.415
DOC_USP7_MATH_1	22	26	PF00917	0.387
DOC_USP7_MATH_1	248	252	PF00917	0.488
DOC_USP7_MATH_1	309	313	PF00917	0.634
DOC_USP7_MATH_1	429	433	PF00917	0.486
DOC_USP7_MATH_1	53	57	PF00917	0.423
DOC_USP7_UBL2_3	103	107	PF12436	0.471
DOC_USP7_UBL2_3	61	65	PF12436	0.343
DOC_WW_Pin1_4	269	274	PF00397	0.563
DOC_WW_Pin1_4	284	289	PF00397	0.586
DOC_WW_Pin1_4	295	300	PF00397	0.692
DOC_WW_Pin1_4	422	427	PF00397	0.478
LIG_14-3-3_CanoR_1	281	287	PF00244	0.607
LIG_14-3-3_CanoR_1	293	299	PF00244	0.553
LIG_14-3-3_CanoR_1	313	321	PF00244	0.580
LIG_Actin_WH2_2	88	105	PF00022	0.436
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_BRCT_BRCA1_1	47	51	PF00533	0.395
LIG_BRCT_BRCA1_1	55	59	PF00533	0.422
LIG_BRCT_BRCA1_2	55	61	PF00533	0.348
LIG_FHA_1	200	206	PF00498	0.401
LIG_FHA_1	333	339	PF00498	0.682
LIG_FHA_2	207	213	PF00498	0.405
LIG_FHA_2	40	46	PF00498	0.403
LIG_FHA_2	403	409	PF00498	0.473
LIG_FHA_2	58	64	PF00498	0.412
LIG_LIR_Apic_2	6	10	PF02991	0.442
LIG_LIR_Gen_1	172	182	PF02991	0.534
LIG_LIR_Gen_1	48	59	PF02991	0.439
LIG_LIR_Gen_1	86	95	PF02991	0.305
LIG_LIR_Nem_3	118	123	PF02991	0.420
LIG_LIR_Nem_3	172	178	PF02991	0.422
LIG_LIR_Nem_3	25	29	PF02991	0.429
LIG_LIR_Nem_3	352	358	PF02991	0.575
LIG_LIR_Nem_3	48	54	PF02991	0.450
LIG_LIR_Nem_3	86	90	PF02991	0.310
LIG_Pex14_2	171	175	PF04695	0.410
LIG_SH2_CRK	87	91	PF00017	0.342
LIG_SH2_STAT5	193	196	PF00017	0.426
LIG_SH2_STAT5	372	375	PF00017	0.554
LIG_SH2_STAT5	391	394	PF00017	0.494
LIG_SH2_STAT5	67	70	PF00017	0.380
LIG_SH3_1	423	429	PF00018	0.483
LIG_SH3_2	288	293	PF14604	0.526
LIG_SH3_3	285	291	PF00018	0.568
LIG_SH3_3	296	302	PF00018	0.650
LIG_SH3_3	383	389	PF00018	0.750
LIG_SH3_3	423	429	PF00018	0.519
LIG_SH3_3	92	98	PF00018	0.385
LIG_TRAF2_2	10	15	PF00917	0.385
LIG_UBA3_1	33	38	PF00899	0.405
LIG_UBA3_1	75	79	PF00899	0.293
LIG_WRC_WIRS_1	23	28	PF05994	0.382
LIG_WRC_WIRS_1	371	376	PF05994	0.561
LIG_WW_1	369	372	PF00397	0.551
LIG_WW_3	290	294	PF00397	0.589
MOD_CK1_1	149	155	PF00069	0.531
MOD_CK1_1	184	190	PF00069	0.372
MOD_CK1_1	243	249	PF00069	0.464
MOD_CK1_1	272	278	PF00069	0.603
MOD_CK1_1	380	386	PF00069	0.556
MOD_CK1_1	415	421	PF00069	0.448
MOD_CK1_1	430	436	PF00069	0.486
MOD_CK2_1	102	108	PF00069	0.584
MOD_CK2_1	115	121	PF00069	0.404
MOD_CK2_1	166	172	PF00069	0.384
MOD_CK2_1	211	217	PF00069	0.399
MOD_CK2_1	229	235	PF00069	0.417
MOD_CK2_1	341	347	PF00069	0.637
MOD_CK2_1	39	45	PF00069	0.404
MOD_CK2_1	402	408	PF00069	0.459
MOD_CK2_1	57	63	PF00069	0.545
MOD_CK2_1	74	80	PF00069	0.409
MOD_GlcNHglycan	116	120	PF01048	0.456
MOD_GlcNHglycan	231	234	PF01048	0.392
MOD_GlcNHglycan	26	29	PF01048	0.406
MOD_GlcNHglycan	315	318	PF01048	0.567
MOD_GlcNHglycan	343	346	PF01048	0.563
MOD_GlcNHglycan	383	386	PF01048	0.575
MOD_GlcNHglycan	416	420	PF01048	0.445
MOD_GSK3_1	181	188	PF00069	0.326
MOD_GSK3_1	24	31	PF00069	0.422
MOD_GSK3_1	240	247	PF00069	0.424
MOD_GSK3_1	265	272	PF00069	0.603
MOD_GSK3_1	280	287	PF00069	0.670
MOD_GSK3_1	309	316	PF00069	0.699
MOD_GSK3_1	320	327	PF00069	0.555
MOD_GSK3_1	337	344	PF00069	0.567
MOD_GSK3_1	377	384	PF00069	0.580
MOD_GSK3_1	398	405	PF00069	0.461
MOD_GSK3_1	408	415	PF00069	0.508
MOD_GSK3_1	53	60	PF00069	0.427
MOD_N-GLC_2	262	264	PF02516	0.510
MOD_NEK2_1	102	107	PF00069	0.407
MOD_NEK2_1	144	149	PF00069	0.465
MOD_NEK2_1	265	270	PF00069	0.585
MOD_NEK2_1	282	287	PF00069	0.610
MOD_PIKK_1	248	254	PF00454	0.537
MOD_PIKK_1	356	362	PF00454	0.567
MOD_PKA_2	229	235	PF00069	0.417
MOD_PKA_2	280	286	PF00069	0.617
MOD_PKA_2	294	300	PF00069	0.533
MOD_Plk_1	115	121	PF00069	0.573
MOD_Plk_1	415	421	PF00069	0.436
MOD_Plk_2-3	74	80	PF00069	0.366
MOD_Plk_4	200	206	PF00069	0.400
MOD_Plk_4	377	383	PF00069	0.547
MOD_ProDKin_1	269	275	PF00069	0.564
MOD_ProDKin_1	284	290	PF00069	0.586
MOD_ProDKin_1	295	301	PF00069	0.690
MOD_ProDKin_1	422	428	PF00069	0.481
MOD_SUMO_for_1	113	116	PF00179	0.398
TRG_DiLeu_BaEn_1	86	91	PF01217	0.300
TRG_DiLeu_BaEn_3	172	178	PF01217	0.318
TRG_ENDOCYTIC_2	193	196	PF00928	0.432
TRG_ENDOCYTIC_2	87	90	PF00928	0.369
TRG_ER_diArg_1	190	192	PF00400	0.386
TRG_ER_diArg_1	292	295	PF00400	0.596
TRG_NLS_MonoExtN_4	122	128	PF00514	0.402
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S1	Leptomonas seymouri	50%	95%
A0A3Q8IG21	Leishmania donovani	85%	100%
A0A3Q8IIE7	Leishmania donovani	81%	100%
A4H6C6	Leishmania braziliensis	23%	100%
A4HJ56	Leishmania braziliensis	64%	100%
A4I6H9	Leishmania infantum	86%	100%
E9AHL0	Leishmania infantum	82%	100%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
E9B1N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q6I6	Leishmania major	93%	100%
Q4QI82	Leishmania major	24%	100%