Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania major

UniProt:

Q4Q6H7_LEIMA

TriTrypDb:

LmjF.31.0860 , LMJLV39_310014500 , LMJSD75_310014200

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6H7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.402
CLV_C14_Caspase3-7	285	289	PF00656	0.570
CLV_C14_Caspase3-7	393	397	PF00656	0.666
CLV_C14_Caspase3-7	414	418	PF00656	0.730
CLV_C14_Caspase3-7	535	539	PF00656	0.623
CLV_C14_Caspase3-7	78	82	PF00656	0.684
CLV_NRD_NRD_1	198	200	PF00675	0.326
CLV_NRD_NRD_1	243	245	PF00675	0.431
CLV_NRD_NRD_1	459	461	PF00675	0.663
CLV_NRD_NRD_1	466	468	PF00675	0.570
CLV_NRD_NRD_1	484	486	PF00675	0.659
CLV_PCSK_KEX2_1	200	202	PF00082	0.328
CLV_PCSK_KEX2_1	54	56	PF00082	0.424
CLV_PCSK_KEX2_1	572	574	PF00082	0.448
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.306
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.401
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.448
CLV_PCSK_PC7_1	196	202	PF00082	0.328
CLV_PCSK_SKI1_1	271	275	PF00082	0.306
CLV_PCSK_SKI1_1	476	480	PF00082	0.630
CLV_PCSK_SKI1_1	54	58	PF00082	0.396
CLV_PCSK_SKI1_1	593	597	PF00082	0.493
DEG_APCC_DBOX_1	270	278	PF00400	0.306
DEG_SCF_FBW7_2	295	302	PF00400	0.563
DOC_CKS1_1	427	432	PF01111	0.754
DOC_CYCLIN_RxL_1	49	58	PF00134	0.501
DOC_MAPK_MEF2A_6	181	188	PF00069	0.256
DOC_MAPK_MEF2A_6	509	518	PF00069	0.639
DOC_PP2B_LxvP_1	102	105	PF13499	0.431
DOC_PP2B_LxvP_1	353	356	PF13499	0.674
DOC_PP2B_LxvP_1	57	60	PF13499	0.561
DOC_PP4_FxxP_1	326	329	PF00568	0.750
DOC_USP7_MATH_1	109	113	PF00917	0.328
DOC_USP7_MATH_1	194	198	PF00917	0.366
DOC_USP7_MATH_1	364	368	PF00917	0.734
DOC_USP7_MATH_1	392	396	PF00917	0.713
DOC_USP7_MATH_1	532	536	PF00917	0.639
DOC_USP7_UBL2_3	461	465	PF12436	0.655
DOC_USP7_UBL2_3	593	597	PF12436	0.546
DOC_USP7_UBL2_3	598	602	PF12436	0.558
DOC_WW_Pin1_4	222	227	PF00397	0.402
DOC_WW_Pin1_4	295	300	PF00397	0.621
DOC_WW_Pin1_4	335	340	PF00397	0.639
DOC_WW_Pin1_4	344	349	PF00397	0.645
DOC_WW_Pin1_4	357	362	PF00397	0.732
DOC_WW_Pin1_4	376	381	PF00397	0.557
DOC_WW_Pin1_4	387	392	PF00397	0.632
DOC_WW_Pin1_4	415	420	PF00397	0.761
DOC_WW_Pin1_4	426	431	PF00397	0.622
DOC_WW_Pin1_4	62	67	PF00397	0.571
DOC_WW_Pin1_4	89	94	PF00397	0.431
LIG_14-3-3_CanoR_1	135	140	PF00244	0.328
LIG_14-3-3_CanoR_1	283	287	PF00244	0.584
LIG_14-3-3_CanoR_1	369	376	PF00244	0.581
LIG_Actin_WH2_2	181	198	PF00022	0.306
LIG_Actin_WH2_2	267	285	PF00022	0.431
LIG_APCC_ABBA_1	251	256	PF00400	0.328
LIG_BH_BH3_1	152	168	PF00452	0.256
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BIR_III_4	439	443	PF00653	0.660
LIG_BRCT_BRCA1_1	300	304	PF00533	0.610
LIG_FHA_1	118	124	PF00498	0.328
LIG_FHA_1	369	375	PF00498	0.592
LIG_FHA_1	48	54	PF00498	0.403
LIG_FHA_1	513	519	PF00498	0.743
LIG_FHA_1	90	96	PF00498	0.431
LIG_FHA_2	15	21	PF00498	0.522
LIG_FHA_2	188	194	PF00498	0.343
LIG_FHA_2	228	234	PF00498	0.349
LIG_LIR_Apic_2	325	329	PF02991	0.720
LIG_LIR_Gen_1	248	259	PF02991	0.331
LIG_LIR_Nem_3	248	254	PF02991	0.331
LIG_LIR_Nem_3	256	262	PF02991	0.324
LIG_LIR_Nem_3	34	40	PF02991	0.386
LIG_LIR_Nem_3	97	102	PF02991	0.328
LIG_MYND_1	329	333	PF01753	0.692
LIG_PCNA_PIPBox_1	247	256	PF02747	0.262
LIG_PCNA_yPIPBox_3	244	254	PF02747	0.262
LIG_PCNA_yPIPBox_3	465	479	PF02747	0.583
LIG_PTB_Apo_2	133	140	PF02174	0.328
LIG_SH2_CRK	279	283	PF00017	0.471
LIG_SH2_NCK_1	259	263	PF00017	0.328
LIG_SH2_STAP1	100	104	PF00017	0.328
LIG_SH2_STAP1	126	130	PF00017	0.328
LIG_SH2_STAT5	16	19	PF00017	0.511
LIG_SH2_STAT5	35	38	PF00017	0.440
LIG_SH3_1	358	364	PF00018	0.676
LIG_SH3_3	143	149	PF00018	0.372
LIG_SH3_3	24	30	PF00018	0.675
LIG_SH3_3	305	311	PF00018	0.704
LIG_SH3_3	358	364	PF00018	0.634
LIG_SH3_CIN85_PxpxPR_1	340	345	PF14604	0.702
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.327
LIG_SUMO_SIM_par_1	183	190	PF11976	0.256
LIG_SUMO_SIM_par_1	209	216	PF11976	0.372
LIG_SUMO_SIM_par_1	38	44	PF11976	0.364
LIG_TRFH_1	376	380	PF08558	0.662
LIG_TYR_ITIM	257	262	PF00017	0.328
LIG_TYR_ITIM	277	282	PF00017	0.258
LIG_WW_3	355	359	PF00397	0.656
MOD_CAAXbox	607	610	PF01239	0.556
MOD_CDC14_SPxK_1	347	350	PF00782	0.591
MOD_CDK_SPK_2	426	431	PF00069	0.700
MOD_CDK_SPK_2	62	67	PF00069	0.605
MOD_CDK_SPxK_1	344	350	PF00069	0.588
MOD_CK1_1	129	135	PF00069	0.499
MOD_CK1_1	151	157	PF00069	0.339
MOD_CK1_1	189	195	PF00069	0.432
MOD_CK1_1	218	224	PF00069	0.415
MOD_CK1_1	260	266	PF00069	0.332
MOD_CK1_1	322	328	PF00069	0.767
MOD_CK1_1	367	373	PF00069	0.740
MOD_CK1_1	62	68	PF00069	0.761
MOD_CK2_1	14	20	PF00069	0.553
MOD_CK2_1	187	193	PF00069	0.343
MOD_CK2_1	227	233	PF00069	0.349
MOD_CK2_1	387	393	PF00069	0.637
MOD_GlcNHglycan	196	199	PF01048	0.422
MOD_GlcNHglycan	230	233	PF01048	0.324
MOD_GlcNHglycan	261	265	PF01048	0.328
MOD_GlcNHglycan	312	315	PF01048	0.595
MOD_GlcNHglycan	321	324	PF01048	0.602
MOD_GlcNHglycan	326	329	PF01048	0.768
MOD_GlcNHglycan	401	404	PF01048	0.749
MOD_GlcNHglycan	405	409	PF01048	0.697
MOD_GlcNHglycan	413	416	PF01048	0.612
MOD_GlcNHglycan	498	501	PF01048	0.676
MOD_GlcNHglycan	525	528	PF01048	0.717
MOD_GlcNHglycan	61	64	PF01048	0.711
MOD_GSK3_1	126	133	PF00069	0.480
MOD_GSK3_1	144	151	PF00069	0.246
MOD_GSK3_1	215	222	PF00069	0.325
MOD_GSK3_1	364	371	PF00069	0.636
MOD_GSK3_1	372	379	PF00069	0.638
MOD_GSK3_1	411	418	PF00069	0.685
MOD_GSK3_1	422	429	PF00069	0.803
MOD_GSK3_1	43	50	PF00069	0.388
MOD_GSK3_1	445	452	PF00069	0.698
MOD_GSK3_1	532	539	PF00069	0.634
MOD_GSK3_1	55	62	PF00069	0.497
MOD_GSK3_1	75	82	PF00069	0.525
MOD_GSK3_1	87	94	PF00069	0.458
MOD_N-GLC_1	135	140	PF02516	0.328
MOD_N-GLC_1	512	517	PF02516	0.520
MOD_N-GLC_2	606	608	PF02516	0.589
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	144	149	PF00069	0.317
MOD_NEK2_1	170	175	PF00069	0.278
MOD_NEK2_1	282	287	PF00069	0.522
MOD_NEK2_1	304	309	PF00069	0.572
MOD_NEK2_1	445	450	PF00069	0.695
MOD_NEK2_1	75	80	PF00069	0.688
MOD_NEK2_2	109	114	PF00069	0.328
MOD_NEK2_2	130	135	PF00069	0.306
MOD_PIKK_1	378	384	PF00454	0.581
MOD_PK_1	158	164	PF00069	0.317
MOD_PK_1	55	61	PF00069	0.548
MOD_PKA_1	596	602	PF00069	0.575
MOD_PKA_2	282	288	PF00069	0.585
MOD_PKA_2	349	355	PF00069	0.615
MOD_PKA_2	368	374	PF00069	0.563
MOD_PKA_2	554	560	PF00069	0.718
MOD_Plk_1	130	136	PF00069	0.323
MOD_Plk_1	14	20	PF00069	0.532
MOD_Plk_1	170	176	PF00069	0.278
MOD_Plk_1	215	221	PF00069	0.398
MOD_Plk_1	43	49	PF00069	0.384
MOD_Plk_1	512	518	PF00069	0.524
MOD_Plk_1	75	81	PF00069	0.642
MOD_Plk_2-3	14	20	PF00069	0.532
MOD_Plk_2-3	215	221	PF00069	0.404
MOD_Plk_2-3	372	378	PF00069	0.678
MOD_Plk_2-3	70	76	PF00069	0.667
MOD_Plk_4	135	141	PF00069	0.321
MOD_Plk_4	151	157	PF00069	0.306
MOD_Plk_4	158	164	PF00069	0.371
MOD_Plk_4	171	177	PF00069	0.233
MOD_Plk_4	304	310	PF00069	0.577
MOD_Plk_4	48	54	PF00069	0.381
MOD_Plk_4	532	538	PF00069	0.637
MOD_ProDKin_1	222	228	PF00069	0.402
MOD_ProDKin_1	295	301	PF00069	0.621
MOD_ProDKin_1	335	341	PF00069	0.642
MOD_ProDKin_1	344	350	PF00069	0.650
MOD_ProDKin_1	357	363	PF00069	0.728
MOD_ProDKin_1	376	382	PF00069	0.559
MOD_ProDKin_1	387	393	PF00069	0.633
MOD_ProDKin_1	415	421	PF00069	0.763
MOD_ProDKin_1	426	432	PF00069	0.621
MOD_ProDKin_1	62	68	PF00069	0.575
MOD_ProDKin_1	89	95	PF00069	0.431
MOD_SUMO_rev_2	462	466	PF00179	0.675
MOD_SUMO_rev_2	469	478	PF00179	0.555
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.440
TRG_ENDOCYTIC_2	259	262	PF00928	0.328
TRG_ENDOCYTIC_2	279	282	PF00928	0.265
TRG_ER_diArg_1	201	204	PF00400	0.427
TRG_NLS_MonoExtC_3	198	203	PF00514	0.372
TRG_NLS_MonoExtC_3	592	597	PF00514	0.502
TRG_NLS_MonoExtN_4	196	203	PF00514	0.306
TRG_NLS_MonoExtN_4	591	597	PF00514	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTB6	Leptomonas seymouri	46%	97%
A0A3Q8IER9	Leishmania donovani	90%	100%
A4HJ62	Leishmania braziliensis	64%	100%
A4I6I0	Leishmania infantum	91%	100%
E9B1N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%