LeishMANIAdb
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Putative sodium stibogluconate resistance protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative sodium stibogluconate resistance protein
Gene product:
sodium stibogluconate resistance protein, putative
Species:
Leishmania major
UniProt:
Q4Q6H0_LEIMA
TriTrypDb:
LmjF.31.0960 , LMJLV39_310015100 , LMJSD75_310014900 , LMJSD75_310015000
Length:
621

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6H0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6H0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 121 125 PF00656 0.853
CLV_C14_Caspase3-7 130 134 PF00656 0.746
CLV_C14_Caspase3-7 246 250 PF00656 0.636
CLV_C14_Caspase3-7 518 522 PF00656 0.642
CLV_NRD_NRD_1 305 307 PF00675 0.690
CLV_NRD_NRD_1 48 50 PF00675 0.480
CLV_NRD_NRD_1 513 515 PF00675 0.715
CLV_NRD_NRD_1 540 542 PF00675 0.745
CLV_NRD_NRD_1 615 617 PF00675 0.619
CLV_PCSK_KEX2_1 48 50 PF00082 0.480
CLV_PCSK_KEX2_1 524 526 PF00082 0.758
CLV_PCSK_KEX2_1 539 541 PF00082 0.515
CLV_PCSK_PC1ET2_1 524 526 PF00082 0.780
CLV_PCSK_PC1ET2_1 539 541 PF00082 0.515
CLV_PCSK_PC7_1 44 50 PF00082 0.463
CLV_PCSK_PC7_1 535 541 PF00082 0.687
CLV_PCSK_SKI1_1 21 25 PF00082 0.605
CLV_PCSK_SKI1_1 231 235 PF00082 0.633
CLV_PCSK_SKI1_1 324 328 PF00082 0.611
CLV_PCSK_SKI1_1 525 529 PF00082 0.714
CLV_PCSK_SKI1_1 535 539 PF00082 0.571
CLV_PCSK_SKI1_1 56 60 PF00082 0.623
DEG_APCC_DBOX_1 353 361 PF00400 0.706
DOC_MAPK_MEF2A_6 146 154 PF00069 0.652
DOC_MAPK_MEF2A_6 553 560 PF00069 0.640
DOC_PP1_RVXF_1 368 375 PF00149 0.708
DOC_PP2B_LxvP_1 478 481 PF13499 0.729
DOC_PP2B_LxvP_1 566 569 PF13499 0.410
DOC_SPAK_OSR1_1 30 34 PF12202 0.592
DOC_USP7_MATH_1 250 254 PF00917 0.687
DOC_USP7_MATH_1 347 351 PF00917 0.635
DOC_USP7_MATH_1 391 395 PF00917 0.634
DOC_USP7_MATH_1 445 449 PF00917 0.594
DOC_USP7_MATH_1 461 465 PF00917 0.485
DOC_USP7_MATH_1 513 517 PF00917 0.697
DOC_USP7_MATH_1 567 571 PF00917 0.523
DOC_USP7_MATH_1 603 607 PF00917 0.574
DOC_USP7_MATH_1 92 96 PF00917 0.669
DOC_USP7_MATH_2 334 340 PF00917 0.658
DOC_USP7_MATH_2 424 430 PF00917 0.655
DOC_WW_Pin1_4 387 392 PF00397 0.675
DOC_WW_Pin1_4 420 425 PF00397 0.712
LIG_14-3-3_CanoR_1 265 270 PF00244 0.652
LIG_14-3-3_CanoR_1 30 39 PF00244 0.636
LIG_14-3-3_CanoR_1 4 9 PF00244 0.775
LIG_14-3-3_CanoR_1 406 410 PF00244 0.598
LIG_14-3-3_CanoR_1 415 421 PF00244 0.665
LIG_14-3-3_CanoR_1 427 431 PF00244 0.555
LIG_14-3-3_CanoR_1 541 549 PF00244 0.607
LIG_Actin_WH2_2 437 455 PF00022 0.655
LIG_AP2alpha_1 50 54 PF02296 0.639
LIG_BRCT_BRCA1_1 267 271 PF00533 0.642
LIG_CSL_BTD_1 388 391 PF09270 0.663
LIG_deltaCOP1_diTrp_1 607 614 PF00928 0.407
LIG_FHA_1 143 149 PF00498 0.687
LIG_FHA_1 180 186 PF00498 0.588
LIG_FHA_1 201 207 PF00498 0.583
LIG_FHA_1 264 270 PF00498 0.663
LIG_FHA_1 402 408 PF00498 0.459
LIG_FHA_1 53 59 PF00498 0.651
LIG_FHA_2 30 36 PF00498 0.637
LIG_FHA_2 406 412 PF00498 0.473
LIG_FHA_2 469 475 PF00498 0.715
LIG_Integrin_RGD_1 122 124 PF01839 0.786
LIG_LIR_Gen_1 174 183 PF02991 0.612
LIG_LIR_Gen_1 226 235 PF02991 0.721
LIG_LIR_Gen_1 298 304 PF02991 0.620
LIG_LIR_Gen_1 605 615 PF02991 0.607
LIG_LIR_Nem_3 149 154 PF02991 0.627
LIG_LIR_Nem_3 163 168 PF02991 0.398
LIG_LIR_Nem_3 17 23 PF02991 0.656
LIG_LIR_Nem_3 174 178 PF02991 0.451
LIG_LIR_Nem_3 226 230 PF02991 0.711
LIG_LIR_Nem_3 298 302 PF02991 0.609
LIG_LIR_Nem_3 464 469 PF02991 0.660
LIG_LIR_Nem_3 583 589 PF02991 0.487
LIG_PCNA_PIPBox_1 594 603 PF02747 0.396
LIG_PCNA_yPIPBox_3 204 217 PF02747 0.415
LIG_Pex14_2 50 54 PF04695 0.639
LIG_SH2_CRK 165 169 PF00017 0.601
LIG_SH2_CRK 20 24 PF00017 0.661
LIG_SH2_CRK 227 231 PF00017 0.689
LIG_SH2_CRK 283 287 PF00017 0.574
LIG_SH2_CRK 291 295 PF00017 0.493
LIG_SH2_CRK 299 303 PF00017 0.455
LIG_SH2_STAP1 143 147 PF00017 0.565
LIG_SH2_STAP1 469 473 PF00017 0.674
LIG_SH2_STAT3 37 40 PF00017 0.640
LIG_SH2_STAT5 175 178 PF00017 0.631
LIG_SH2_STAT5 195 198 PF00017 0.286
LIG_SH2_STAT5 283 286 PF00017 0.595
LIG_SH2_STAT5 291 294 PF00017 0.472
LIG_SH2_STAT5 337 340 PF00017 0.631
LIG_SH2_STAT5 37 40 PF00017 0.640
LIG_SH2_STAT5 432 435 PF00017 0.695
LIG_SH3_3 147 153 PF00018 0.602
LIG_SH3_3 385 391 PF00018 0.705
LIG_SH3_3 439 445 PF00018 0.663
LIG_SH3_3 493 499 PF00018 0.837
LIG_SH3_3 86 92 PF00018 0.777
LIG_SUMO_SIM_anti_2 439 445 PF11976 0.658
LIG_TRAF2_1 25 28 PF00917 0.593
LIG_TRAF2_1 408 411 PF00917 0.528
LIG_TYR_ITIM 18 23 PF00017 0.648
LIG_TYR_ITIM 225 230 PF00017 0.678
LIG_UBA3_1 206 214 PF00899 0.599
LIG_UBA3_1 342 348 PF00899 0.605
LIG_WRC_WIRS_1 371 376 PF05994 0.697
LIG_WRC_WIRS_1 611 616 PF05994 0.416
MOD_CDK_SPxxK_3 420 427 PF00069 0.712
MOD_CK1_1 300 306 PF00069 0.660
MOD_CK1_1 414 420 PF00069 0.685
MOD_CK1_1 516 522 PF00069 0.773
MOD_CK2_1 249 255 PF00069 0.632
MOD_CK2_1 29 35 PF00069 0.632
MOD_CK2_1 405 411 PF00069 0.539
MOD_CK2_1 420 426 PF00069 0.588
MOD_CK2_1 468 474 PF00069 0.683
MOD_Cter_Amidation 46 49 PF01082 0.470
MOD_GlcNHglycan 127 130 PF01048 0.792
MOD_GlcNHglycan 236 239 PF01048 0.731
MOD_GlcNHglycan 384 387 PF01048 0.758
MOD_GlcNHglycan 393 396 PF01048 0.488
MOD_GlcNHglycan 438 441 PF01048 0.471
MOD_GlcNHglycan 492 495 PF01048 0.807
MOD_GlcNHglycan 517 521 PF01048 0.819
MOD_GSK3_1 125 132 PF00069 0.715
MOD_GSK3_1 196 203 PF00069 0.584
MOD_GSK3_1 259 266 PF00069 0.693
MOD_GSK3_1 356 363 PF00069 0.757
MOD_GSK3_1 387 394 PF00069 0.665
MOD_GSK3_1 401 408 PF00069 0.446
MOD_GSK3_1 426 433 PF00069 0.657
MOD_GSK3_1 547 554 PF00069 0.693
MOD_GSK3_1 567 574 PF00069 0.328
MOD_N-GLC_1 411 416 PF02516 0.677
MOD_N-GLC_2 290 292 PF02516 0.532
MOD_NEK2_1 198 203 PF00069 0.597
MOD_NEK2_1 269 274 PF00069 0.609
MOD_NEK2_1 295 300 PF00069 0.635
MOD_NEK2_1 360 365 PF00069 0.719
MOD_NEK2_1 382 387 PF00069 0.739
MOD_NEK2_1 401 406 PF00069 0.370
MOD_NEK2_1 452 457 PF00069 0.644
MOD_NEK2_1 50 55 PF00069 0.638
MOD_NEK2_1 571 576 PF00069 0.584
MOD_NEK2_1 610 615 PF00069 0.407
MOD_NEK2_2 445 450 PF00069 0.587
MOD_NMyristoyl 1 7 PF02799 0.832
MOD_PIKK_1 200 206 PF00454 0.580
MOD_PIKK_1 365 371 PF00454 0.730
MOD_PIKK_1 389 395 PF00454 0.527
MOD_PIKK_1 414 420 PF00454 0.685
MOD_PK_1 105 111 PF00069 0.671
MOD_PK_1 4 10 PF00069 0.832
MOD_PKA_2 29 35 PF00069 0.632
MOD_PKA_2 3 9 PF00069 0.779
MOD_PKA_2 405 411 PF00069 0.602
MOD_PKA_2 414 420 PF00069 0.668
MOD_PKA_2 426 432 PF00069 0.552
MOD_PKA_2 490 496 PF00069 0.802
MOD_PKA_2 513 519 PF00069 0.724
MOD_Plk_1 156 162 PF00069 0.429
MOD_Plk_1 551 557 PF00069 0.663
MOD_Plk_4 171 177 PF00069 0.605
MOD_Plk_4 265 271 PF00069 0.655
MOD_Plk_4 445 451 PF00069 0.582
MOD_Plk_4 567 573 PF00069 0.568
MOD_Plk_4 610 616 PF00069 0.613
MOD_ProDKin_1 387 393 PF00069 0.671
MOD_ProDKin_1 420 426 PF00069 0.714
TRG_DiLeu_BaEn_4 561 567 PF01217 0.363
TRG_DiLeu_BaLyEn_6 163 168 PF01217 0.608
TRG_DiLeu_BaLyEn_6 337 342 PF01217 0.582
TRG_DiLeu_BaLyEn_6 395 400 PF01217 0.662
TRG_DiLeu_BaLyEn_6 532 537 PF01217 0.656
TRG_ENDOCYTIC_2 164 167 PF00928 0.577
TRG_ENDOCYTIC_2 175 178 PF00928 0.454
TRG_ENDOCYTIC_2 195 198 PF00928 0.280
TRG_ENDOCYTIC_2 20 23 PF00928 0.654
TRG_ENDOCYTIC_2 227 230 PF00928 0.694
TRG_ENDOCYTIC_2 282 285 PF00928 0.593
TRG_ENDOCYTIC_2 291 294 PF00928 0.457
TRG_ENDOCYTIC_2 299 302 PF00928 0.412
TRG_ENDOCYTIC_2 469 472 PF00928 0.661
TRG_ER_diArg_1 48 50 PF00400 0.469
TRG_NES_CRM1_1 317 328 PF08389 0.466
TRG_NLS_Bipartite_1 524 543 PF00514 0.735
TRG_NLS_MonoCore_2 537 542 PF00514 0.703
TRG_NLS_MonoExtN_4 535 542 PF00514 0.702
TRG_Pf-PMV_PEXEL_1 166 170 PF00026 0.600

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFG5 Leishmania donovani 88% 100%
A0A3Q8ISI8 Leishmania donovani 87% 100%
A0A3S7X4A3 Leishmania donovani 87% 100%
A4HJ70 Leishmania braziliensis 63% 99%
A4HJ71 Leishmania braziliensis 66% 99%
A4HJ73 Leishmania braziliensis 66% 100%
A4HJW7 Leishmania braziliensis 60% 100%
A4I6I2 Leishmania infantum 88% 94%
A4I6L8 Leishmania infantum 88% 100%
E8NHD1 Leishmania infantum 87% 100%
E8NHD2 Leishmania infantum 86% 100%
E8NHE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E8NHE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9B1P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q6G7 Leishmania major 100% 100%
Q4Q6G8 Leishmania major 95% 100%
Q9BHE5 Leishmania major 95% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS