Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6G6_LEIMA

TriTrypDb:

LmjF.31.0970 , LMJLV39_310015800 , LMJSD75_310015400

Length:

882

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6G6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	527	531	PF00656	0.779
CLV_C14_Caspase3-7	590	594	PF00656	0.783
CLV_NRD_NRD_1	187	189	PF00675	0.715
CLV_NRD_NRD_1	193	195	PF00675	0.639
CLV_NRD_NRD_1	335	337	PF00675	0.637
CLV_NRD_NRD_1	562	564	PF00675	0.633
CLV_NRD_NRD_1	603	605	PF00675	0.785
CLV_NRD_NRD_1	65	67	PF00675	0.603
CLV_NRD_NRD_1	743	745	PF00675	0.808
CLV_NRD_NRD_1	759	761	PF00675	0.793
CLV_NRD_NRD_1	774	776	PF00675	0.520
CLV_NRD_NRD_1	855	857	PF00675	0.741
CLV_NRD_NRD_1	877	879	PF00675	0.683
CLV_PCSK_KEX2_1	187	189	PF00082	0.709
CLV_PCSK_KEX2_1	193	195	PF00082	0.634
CLV_PCSK_KEX2_1	562	564	PF00082	0.633
CLV_PCSK_KEX2_1	603	605	PF00082	0.758
CLV_PCSK_KEX2_1	65	67	PF00082	0.531
CLV_PCSK_KEX2_1	659	661	PF00082	0.745
CLV_PCSK_KEX2_1	743	745	PF00082	0.808
CLV_PCSK_KEX2_1	759	761	PF00082	0.793
CLV_PCSK_KEX2_1	877	879	PF00082	0.775
CLV_PCSK_PC1ET2_1	659	661	PF00082	0.745
CLV_PCSK_PC7_1	183	189	PF00082	0.704
CLV_PCSK_PC7_1	599	605	PF00082	0.747
CLV_PCSK_SKI1_1	332	336	PF00082	0.547
CLV_PCSK_SKI1_1	358	362	PF00082	0.663
CLV_PCSK_SKI1_1	420	424	PF00082	0.612
CLV_PCSK_SKI1_1	562	566	PF00082	0.604
CLV_PCSK_SKI1_1	575	579	PF00082	0.723
CLV_PCSK_SKI1_1	604	608	PF00082	0.732
CLV_PCSK_SKI1_1	66	70	PF00082	0.627
CLV_PCSK_SKI1_1	744	748	PF00082	0.802
CLV_Separin_Metazoa	477	481	PF03568	0.604
DEG_APCC_DBOX_1	331	339	PF00400	0.541
DEG_APCC_DBOX_1	467	475	PF00400	0.601
DEG_APCC_DBOX_1	65	73	PF00400	0.482
DEG_Nend_UBRbox_3	1	3	PF02207	0.601
DEG_SPOP_SBC_1	397	401	PF00917	0.575
DOC_CKS1_1	712	717	PF01111	0.807
DOC_MAPK_gen_1	336	343	PF00069	0.641
DOC_MAPK_gen_1	468	475	PF00069	0.600
DOC_MAPK_gen_1	856	864	PF00069	0.677
DOC_MAPK_MEF2A_6	282	289	PF00069	0.700
DOC_MAPK_MEF2A_6	468	475	PF00069	0.600
DOC_MAPK_MEF2A_6	856	864	PF00069	0.672
DOC_MAPK_MEF2A_6	866	875	PF00069	0.597
DOC_MAPK_NFAT4_5	468	476	PF00069	0.601
DOC_PP1_RVXF_1	3	9	PF00149	0.727
DOC_PP1_RVXF_1	795	801	PF00149	0.724
DOC_USP7_MATH_1	121	125	PF00917	0.647
DOC_USP7_MATH_1	15	19	PF00917	0.646
DOC_USP7_MATH_1	176	180	PF00917	0.712
DOC_USP7_MATH_1	226	230	PF00917	0.687
DOC_USP7_MATH_1	397	401	PF00917	0.637
DOC_USP7_MATH_1	456	460	PF00917	0.681
DOC_USP7_MATH_1	521	525	PF00917	0.804
DOC_USP7_MATH_1	594	598	PF00917	0.740
DOC_USP7_MATH_1	696	700	PF00917	0.639
DOC_USP7_MATH_1	748	752	PF00917	0.745
DOC_WW_Pin1_4	153	158	PF00397	0.719
DOC_WW_Pin1_4	215	220	PF00397	0.783
DOC_WW_Pin1_4	222	227	PF00397	0.665
DOC_WW_Pin1_4	281	286	PF00397	0.716
DOC_WW_Pin1_4	367	372	PF00397	0.724
DOC_WW_Pin1_4	393	398	PF00397	0.612
DOC_WW_Pin1_4	555	560	PF00397	0.691
DOC_WW_Pin1_4	575	580	PF00397	0.740
DOC_WW_Pin1_4	621	626	PF00397	0.701
DOC_WW_Pin1_4	639	644	PF00397	0.723
DOC_WW_Pin1_4	711	716	PF00397	0.806
DOC_WW_Pin1_4	723	728	PF00397	0.744
LIG_14-3-3_CanoR_1	101	111	PF00244	0.767
LIG_14-3-3_CanoR_1	14	24	PF00244	0.738
LIG_14-3-3_CanoR_1	414	422	PF00244	0.614
LIG_14-3-3_CanoR_1	437	447	PF00244	0.512
LIG_14-3-3_CanoR_1	507	515	PF00244	0.742
LIG_14-3-3_CanoR_1	603	609	PF00244	0.668
LIG_14-3-3_CanoR_1	665	674	PF00244	0.702
LIG_14-3-3_CanoR_1	677	686	PF00244	0.686
LIG_14-3-3_CanoR_1	717	724	PF00244	0.708
LIG_14-3-3_CanoR_1	750	756	PF00244	0.820
LIG_14-3-3_CanoR_1	863	873	PF00244	0.658
LIG_14-3-3_CanoR_1	87	94	PF00244	0.675
LIG_Actin_RPEL_3	475	494	PF02755	0.485
LIG_Actin_WH2_2	436	452	PF00022	0.486
LIG_BIR_III_2	132	136	PF00653	0.718
LIG_BIR_III_2	147	151	PF00653	0.696
LIG_BRCT_BRCA1_1	226	230	PF00533	0.768
LIG_BRCT_BRCA1_1	234	238	PF00533	0.570
LIG_BRCT_BRCA1_1	516	520	PF00533	0.820
LIG_Clathr_ClatBox_1	286	290	PF01394	0.681
LIG_Clathr_ClatBox_1	359	363	PF01394	0.531
LIG_Clathr_ClatBox_1	383	387	PF01394	0.648
LIG_Clathr_ClatBox_1	488	492	PF01394	0.538
LIG_CtBP_PxDLS_1	371	375	PF00389	0.625
LIG_CtBP_PxDLS_1	462	466	PF00389	0.562
LIG_eIF4E_1	483	489	PF01652	0.626
LIG_FHA_1	180	186	PF00498	0.694
LIG_FHA_1	750	756	PF00498	0.672
LIG_FHA_1	8	14	PF00498	0.711
LIG_FHA_1	95	101	PF00498	0.569
LIG_FHA_2	104	110	PF00498	0.627
LIG_FHA_2	509	515	PF00498	0.632
LIG_FHA_2	590	596	PF00498	0.833
LIG_FHA_2	605	611	PF00498	0.743
LIG_FHA_2	687	693	PF00498	0.785
LIG_FHA_2	699	705	PF00498	0.699
LIG_FHA_2	818	824	PF00498	0.696
LIG_FHA_2	90	96	PF00498	0.623
LIG_LIR_Gen_1	105	116	PF02991	0.778
LIG_LIR_Gen_1	385	393	PF02991	0.623
LIG_LIR_Gen_1	469	479	PF02991	0.502
LIG_LIR_Gen_1	610	619	PF02991	0.689
LIG_LIR_Gen_1	635	643	PF02991	0.633
LIG_LIR_Gen_1	78	86	PF02991	0.627
LIG_LIR_LC3C_4	859	862	PF02991	0.523
LIG_LIR_Nem_3	105	111	PF02991	0.767
LIG_LIR_Nem_3	385	389	PF02991	0.618
LIG_LIR_Nem_3	416	422	PF02991	0.560
LIG_LIR_Nem_3	469	475	PF02991	0.501
LIG_LIR_Nem_3	610	615	PF02991	0.698
LIG_LIR_Nem_3	635	639	PF02991	0.733
LIG_LIR_Nem_3	78	82	PF02991	0.618
LIG_LYPXL_yS_3	844	847	PF13949	0.748
LIG_MLH1_MIPbox_1	228	232	PF16413	0.568
LIG_NRBOX	470	476	PF00104	0.593
LIG_Pex14_1	16	20	PF04695	0.632
LIG_Pex14_2	796	800	PF04695	0.721
LIG_PTAP_UEV_1	134	139	PF05743	0.763
LIG_RPA_C_Fungi	420	432	PF08784	0.446
LIG_SH2_CRK	261	265	PF00017	0.677
LIG_SH2_CRK	605	609	PF00017	0.748
LIG_SH2_CRK	79	83	PF00017	0.620
LIG_SH2_GRB2like	79	82	PF00017	0.665
LIG_SH2_NCK_1	605	609	PF00017	0.748
LIG_SH2_SRC	79	82	PF00017	0.665
LIG_SH2_STAP1	79	83	PF00017	0.620
LIG_SH2_STAT5	20	23	PF00017	0.653
LIG_SH2_STAT5	391	394	PF00017	0.723
LIG_SH2_STAT5	483	486	PF00017	0.540
LIG_SH2_STAT5	487	490	PF00017	0.521
LIG_SH2_STAT5	846	849	PF00017	0.759
LIG_SH3_2	579	584	PF14604	0.824
LIG_SH3_3	132	138	PF00018	0.722
LIG_SH3_3	363	369	PF00018	0.723
LIG_SH3_3	52	58	PF00018	0.588
LIG_SH3_3	576	582	PF00018	0.815
LIG_SH3_3	721	727	PF00018	0.710
LIG_SUMO_SIM_anti_2	357	363	PF11976	0.534
LIG_SUMO_SIM_par_1	357	363	PF11976	0.534
LIG_SUMO_SIM_par_1	459	467	PF11976	0.694
LIG_TRAF2_1	607	610	PF00917	0.733
LIG_TRAF2_1	618	621	PF00917	0.589
LIG_TRAF2_1	820	823	PF00917	0.700
LIG_WRC_WIRS_1	383	388	PF05994	0.664
LIG_WRC_WIRS_1	633	638	PF05994	0.635
MOD_CDK_SPxK_1	711	717	PF00069	0.753
MOD_CDK_SPxxK_3	281	288	PF00069	0.705
MOD_CDK_SPxxK_3	555	562	PF00069	0.709
MOD_CK1_1	156	162	PF00069	0.782
MOD_CK1_1	179	185	PF00069	0.651
MOD_CK1_1	218	224	PF00069	0.720
MOD_CK1_1	225	231	PF00069	0.745
MOD_CK1_1	370	376	PF00069	0.606
MOD_CK1_1	396	402	PF00069	0.752
MOD_CK1_1	412	418	PF00069	0.630
MOD_CK1_1	438	444	PF00069	0.590
MOD_CK1_1	464	470	PF00069	0.567
MOD_CK1_1	613	619	PF00069	0.704
MOD_CK1_1	635	641	PF00069	0.778
MOD_CK1_1	684	690	PF00069	0.744
MOD_CK1_1	777	783	PF00069	0.584
MOD_CK1_1	833	839	PF00069	0.736
MOD_CK2_1	107	113	PF00069	0.680
MOD_CK2_1	372	378	PF00069	0.634
MOD_CK2_1	382	388	PF00069	0.495
MOD_CK2_1	508	514	PF00069	0.659
MOD_CK2_1	521	527	PF00069	0.686
MOD_CK2_1	604	610	PF00069	0.750
MOD_CK2_1	639	645	PF00069	0.725
MOD_CK2_1	686	692	PF00069	0.638
MOD_CK2_1	817	823	PF00069	0.695
MOD_CK2_1	89	95	PF00069	0.631
MOD_Cter_Amidation	741	744	PF01082	0.753
MOD_DYRK1A_RPxSP_1	575	579	PF00069	0.765
MOD_GlcNHglycan	123	126	PF01048	0.669
MOD_GlcNHglycan	135	138	PF01048	0.693
MOD_GlcNHglycan	139	142	PF01048	0.631
MOD_GlcNHglycan	144	147	PF01048	0.678
MOD_GlcNHglycan	162	165	PF01048	0.578
MOD_GlcNHglycan	208	211	PF01048	0.648
MOD_GlcNHglycan	248	251	PF01048	0.574
MOD_GlcNHglycan	32	35	PF01048	0.735
MOD_GlcNHglycan	324	327	PF01048	0.504
MOD_GlcNHglycan	39	42	PF01048	0.707
MOD_GlcNHglycan	453	457	PF01048	0.587
MOD_GlcNHglycan	459	462	PF01048	0.636
MOD_GlcNHglycan	516	519	PF01048	0.766
MOD_GlcNHglycan	574	578	PF01048	0.811
MOD_GlcNHglycan	612	615	PF01048	0.747
MOD_GlcNHglycan	667	670	PF01048	0.674
MOD_GlcNHglycan	698	701	PF01048	0.627
MOD_GlcNHglycan	727	730	PF01048	0.720
MOD_GlcNHglycan	832	835	PF01048	0.732
MOD_GlcNHglycan	853	856	PF01048	0.577
MOD_GlcNHglycan	866	869	PF01048	0.589
MOD_GSK3_1	103	110	PF00069	0.647
MOD_GSK3_1	121	128	PF00069	0.574
MOD_GSK3_1	133	140	PF00069	0.610
MOD_GSK3_1	152	159	PF00069	0.630
MOD_GSK3_1	214	221	PF00069	0.683
MOD_GSK3_1	222	229	PF00069	0.743
MOD_GSK3_1	239	246	PF00069	0.531
MOD_GSK3_1	393	400	PF00069	0.706
MOD_GSK3_1	409	416	PF00069	0.652
MOD_GSK3_1	452	459	PF00069	0.607
MOD_GSK3_1	498	505	PF00069	0.693
MOD_GSK3_1	589	596	PF00069	0.688
MOD_GSK3_1	620	627	PF00069	0.713
MOD_GSK3_1	635	642	PF00069	0.697
MOD_GSK3_1	677	684	PF00069	0.850
MOD_GSK3_1	706	713	PF00069	0.795
MOD_GSK3_1	744	751	PF00069	0.782
MOD_GSK3_1	800	807	PF00069	0.774
MOD_LATS_1	663	669	PF00433	0.655
MOD_N-GLC_1	438	443	PF02516	0.694
MOD_N-GLC_1	499	504	PF02516	0.567
MOD_N-GLC_1	522	527	PF02516	0.663
MOD_N-GLC_1	777	782	PF02516	0.638
MOD_N-GLC_1	791	796	PF02516	0.653
MOD_NEK2_1	231	236	PF00069	0.641
MOD_NEK2_1	239	244	PF00069	0.622
MOD_NEK2_1	413	418	PF00069	0.603
MOD_NEK2_1	421	426	PF00069	0.533
MOD_NEK2_1	445	450	PF00069	0.644
MOD_NEK2_1	619	624	PF00069	0.780
MOD_NEK2_1	716	721	PF00069	0.850
MOD_NEK2_1	815	820	PF00069	0.695
MOD_NEK2_1	864	869	PF00069	0.713
MOD_NEK2_1	89	94	PF00069	0.702
MOD_NEK2_2	226	231	PF00069	0.577
MOD_NEK2_2	372	377	PF00069	0.478
MOD_NEK2_2	594	599	PF00069	0.737
MOD_NEK2_2	9	14	PF00069	0.761
MOD_OFUCOSY	814	819	PF10250	0.750
MOD_PIKK_1	176	182	PF00454	0.747
MOD_PIKK_1	502	508	PF00454	0.745
MOD_PIKK_1	624	630	PF00454	0.729
MOD_PIKK_1	87	93	PF00454	0.669
MOD_PKA_2	121	127	PF00069	0.786
MOD_PKA_2	37	43	PF00069	0.712
MOD_PKA_2	413	419	PF00069	0.629
MOD_PKA_2	498	504	PF00069	0.634
MOD_PKA_2	583	589	PF00069	0.843
MOD_PKA_2	676	682	PF00069	0.782
MOD_PKA_2	716	722	PF00069	0.750
MOD_PKA_2	749	755	PF00069	0.818
MOD_PKA_2	774	780	PF00069	0.611
MOD_PKB_1	320	328	PF00069	0.497
MOD_PKB_1	433	441	PF00069	0.496
MOD_PKB_1	497	505	PF00069	0.685
MOD_PKB_1	85	93	PF00069	0.629
MOD_Plk_1	290	296	PF00069	0.641
MOD_Plk_1	594	600	PF00069	0.738
MOD_Plk_1	707	713	PF00069	0.765
MOD_Plk_1	94	100	PF00069	0.574
MOD_Plk_2-3	107	113	PF00069	0.776
MOD_Plk_2-3	382	388	PF00069	0.657
MOD_Plk_4	226	232	PF00069	0.655
MOD_Plk_4	243	249	PF00069	0.433
MOD_Plk_4	275	281	PF00069	0.549
MOD_ProDKin_1	153	159	PF00069	0.720
MOD_ProDKin_1	215	221	PF00069	0.780
MOD_ProDKin_1	222	228	PF00069	0.663
MOD_ProDKin_1	281	287	PF00069	0.706
MOD_ProDKin_1	367	373	PF00069	0.720
MOD_ProDKin_1	393	399	PF00069	0.617
MOD_ProDKin_1	555	561	PF00069	0.690
MOD_ProDKin_1	575	581	PF00069	0.733
MOD_ProDKin_1	621	627	PF00069	0.703
MOD_ProDKin_1	639	645	PF00069	0.726
MOD_ProDKin_1	711	717	PF00069	0.808
MOD_ProDKin_1	723	729	PF00069	0.743
MOD_SUMO_rev_2	770	777	PF00179	0.572
TRG_DiLeu_BaEn_2	387	393	PF01217	0.710
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.705
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.541
TRG_ENDOCYTIC_2	108	111	PF00928	0.683
TRG_ENDOCYTIC_2	605	608	PF00928	0.753
TRG_ENDOCYTIC_2	79	82	PF00928	0.622
TRG_ENDOCYTIC_2	844	847	PF00928	0.748
TRG_ER_diArg_1	187	189	PF00400	0.704
TRG_ER_diArg_1	193	195	PF00400	0.629
TRG_ER_diArg_1	319	322	PF00400	0.579
TRG_ER_diArg_1	479	482	PF00400	0.521
TRG_ER_diArg_1	562	564	PF00400	0.633
TRG_ER_diArg_1	603	605	PF00400	0.741
TRG_ER_diArg_1	664	667	PF00400	0.659
TRG_ER_diArg_1	787	790	PF00400	0.744
TRG_ER_diArg_1	877	879	PF00400	0.775
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.703
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.767
TRG_Pf-PMV_PEXEL_1	744	749	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ59	Leptomonas seymouri	32%	100%
A0A3Q8IG32	Leishmania donovani	85%	99%
A4I6M1	Leishmania infantum	85%	99%
E9B1P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%