Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6G5_LEIMA

TriTrypDb:

LmjF.31.0980 , LMJLV39_310015900 , LMJSD75_310015500

Length:

769

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q6G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6G5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	611	615	PF00656	0.770
CLV_NRD_NRD_1	163	165	PF00675	0.443
CLV_NRD_NRD_1	222	224	PF00675	0.512
CLV_NRD_NRD_1	304	306	PF00675	0.498
CLV_NRD_NRD_1	353	355	PF00675	0.525
CLV_NRD_NRD_1	587	589	PF00675	0.710
CLV_NRD_NRD_1	63	65	PF00675	0.421
CLV_NRD_NRD_1	715	717	PF00675	0.582
CLV_NRD_NRD_1	729	731	PF00675	0.459
CLV_NRD_NRD_1	767	769	PF00675	0.522
CLV_PCSK_KEX2_1	163	165	PF00082	0.431
CLV_PCSK_KEX2_1	222	224	PF00082	0.512
CLV_PCSK_KEX2_1	585	587	PF00082	0.710
CLV_PCSK_KEX2_1	63	65	PF00082	0.421
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.710
CLV_PCSK_SKI1_1	341	345	PF00082	0.531
CLV_PCSK_SKI1_1	427	431	PF00082	0.486
CLV_PCSK_SKI1_1	500	504	PF00082	0.758
CLV_PCSK_SKI1_1	87	91	PF00082	0.422
CLV_PCSK_SKI1_1	98	102	PF00082	0.408
DEG_APCC_DBOX_1	152	160	PF00400	0.495
DEG_APCC_DBOX_1	340	348	PF00400	0.512
DEG_APCC_DBOX_1	760	768	PF00400	0.566
DEG_APCC_DBOX_1	86	94	PF00400	0.392
DEG_COP1_1	614	623	PF00400	0.664
DEG_SCF_FBW7_2	554	560	PF00400	0.722
DOC_CKS1_1	277	282	PF01111	0.600
DOC_CKS1_1	312	317	PF01111	0.531
DOC_CKS1_1	554	559	PF01111	0.763
DOC_CKS1_1	684	689	PF01111	0.625
DOC_CKS1_1	83	88	PF01111	0.460
DOC_CYCLIN_RxL_1	338	346	PF00134	0.590
DOC_MAPK_gen_1	151	159	PF00069	0.421
DOC_MAPK_gen_1	354	361	PF00069	0.439
DOC_MAPK_MEF2A_6	153	161	PF00069	0.418
DOC_MAPK_MEF2A_6	354	361	PF00069	0.439
DOC_MAPK_MEF2A_6	700	709	PF00069	0.461
DOC_PP2B_LxvP_1	203	206	PF13499	0.518
DOC_PP2B_LxvP_1	380	383	PF13499	0.641
DOC_PP2B_LxvP_1	471	474	PF13499	0.539
DOC_PP4_FxxP_1	379	382	PF00568	0.473
DOC_USP7_MATH_1	134	138	PF00917	0.523
DOC_USP7_MATH_1	483	487	PF00917	0.734
DOC_USP7_MATH_1	526	530	PF00917	0.692
DOC_USP7_MATH_1	536	540	PF00917	0.743
DOC_USP7_MATH_1	542	546	PF00917	0.549
DOC_USP7_MATH_1	606	610	PF00917	0.771
DOC_USP7_MATH_1	619	623	PF00917	0.744
DOC_USP7_UBL2_3	171	175	PF12436	0.604
DOC_USP7_UBL2_3	581	585	PF12436	0.746
DOC_WW_Pin1_4	110	115	PF00397	0.591
DOC_WW_Pin1_4	245	250	PF00397	0.651
DOC_WW_Pin1_4	273	278	PF00397	0.495
DOC_WW_Pin1_4	311	316	PF00397	0.579
DOC_WW_Pin1_4	386	391	PF00397	0.590
DOC_WW_Pin1_4	488	493	PF00397	0.671
DOC_WW_Pin1_4	49	54	PF00397	0.637
DOC_WW_Pin1_4	553	558	PF00397	0.704
DOC_WW_Pin1_4	564	569	PF00397	0.702
DOC_WW_Pin1_4	683	688	PF00397	0.608
DOC_WW_Pin1_4	74	79	PF00397	0.480
DOC_WW_Pin1_4	82	87	PF00397	0.418
LIG_14-3-3_CanoR_1	12	19	PF00244	0.407
LIG_14-3-3_CanoR_1	393	397	PF00244	0.471
LIG_14-3-3_CanoR_1	400	409	PF00244	0.452
LIG_14-3-3_CanoR_1	418	428	PF00244	0.336
LIG_14-3-3_CanoR_1	485	493	PF00244	0.797
LIG_14-3-3_CanoR_1	535	544	PF00244	0.515
LIG_14-3-3_CanoR_1	694	698	PF00244	0.704
LIG_14-3-3_CanoR_1	708	713	PF00244	0.505
LIG_14-3-3_CanoR_1	761	765	PF00244	0.506
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BIR_III_2	614	618	PF00653	0.666
LIG_BRCT_BRCA1_1	362	366	PF00533	0.538
LIG_CaM_NSCaTE_8	238	245	PF13499	0.496
LIG_Clathr_ClatBox_1	291	295	PF01394	0.483
LIG_deltaCOP1_diTrp_1	406	409	PF00928	0.544
LIG_FHA_1	185	191	PF00498	0.390
LIG_FHA_1	202	208	PF00498	0.428
LIG_FHA_1	265	271	PF00498	0.529
LIG_FHA_1	338	344	PF00498	0.558
LIG_FHA_1	420	426	PF00498	0.502
LIG_FHA_1	463	469	PF00498	0.412
LIG_FHA_1	488	494	PF00498	0.701
LIG_FHA_1	49	55	PF00498	0.675
LIG_FHA_1	5	11	PF00498	0.499
LIG_FHA_1	554	560	PF00498	0.764
LIG_FHA_1	603	609	PF00498	0.635
LIG_FHA_1	733	739	PF00498	0.572
LIG_FHA_1	77	83	PF00498	0.587
LIG_FHA_2	187	193	PF00498	0.465
LIG_FHA_2	3	9	PF00498	0.616
LIG_FHA_2	401	407	PF00498	0.550
LIG_FHA_2	408	414	PF00498	0.547
LIG_LIR_Apic_2	376	382	PF02991	0.556
LIG_LIR_Apic_2	685	691	PF02991	0.625
LIG_LIR_Gen_1	146	154	PF02991	0.450
LIG_LIR_Gen_1	192	202	PF02991	0.394
LIG_LIR_Gen_1	237	246	PF02991	0.424
LIG_LIR_Gen_1	252	261	PF02991	0.342
LIG_LIR_Gen_1	55	65	PF02991	0.567
LIG_LIR_Nem_3	146	150	PF02991	0.413
LIG_LIR_Nem_3	192	197	PF02991	0.399
LIG_LIR_Nem_3	237	241	PF02991	0.409
LIG_LIR_Nem_3	252	256	PF02991	0.346
LIG_LIR_Nem_3	278	284	PF02991	0.512
LIG_LIR_Nem_3	335	339	PF02991	0.580
LIG_LIR_Nem_3	55	60	PF02991	0.559
LIG_NRBOX	306	312	PF00104	0.450
LIG_Pex14_2	725	729	PF04695	0.466
LIG_REV1ctd_RIR_1	723	731	PF16727	0.420
LIG_SH2_CRK	102	106	PF00017	0.492
LIG_SH2_CRK	198	202	PF00017	0.385
LIG_SH2_CRK	253	257	PF00017	0.569
LIG_SH2_CRK	57	61	PF00017	0.562
LIG_SH2_NCK_1	253	257	PF00017	0.528
LIG_SH2_PTP2	147	150	PF00017	0.489
LIG_SH2_STAP1	143	147	PF00017	0.456
LIG_SH2_STAP1	24	28	PF00017	0.547
LIG_SH2_STAP1	339	343	PF00017	0.551
LIG_SH2_STAP1	57	61	PF00017	0.522
LIG_SH2_STAT3	231	234	PF00017	0.465
LIG_SH2_STAT3	436	439	PF00017	0.446
LIG_SH2_STAT5	147	150	PF00017	0.497
LIG_SH2_STAT5	253	256	PF00017	0.568
LIG_SH2_STAT5	339	342	PF00017	0.592
LIG_SH2_STAT5	737	740	PF00017	0.597
LIG_SH3_1	223	229	PF00018	0.565
LIG_SH3_1	274	280	PF00018	0.523
LIG_SH3_3	223	229	PF00018	0.578
LIG_SH3_3	243	249	PF00018	0.293
LIG_SH3_3	274	280	PF00018	0.523
LIG_SH3_3	42	48	PF00018	0.770
LIG_SH3_3	545	551	PF00018	0.779
LIG_SH3_3	562	568	PF00018	0.501
LIG_SH3_3	587	593	PF00018	0.585
LIG_SH3_3	647	653	PF00018	0.743
LIG_SH3_3	654	660	PF00018	0.675
LIG_SH3_3	681	687	PF00018	0.632
LIG_SH3_5	53	57	PF00018	0.551
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.487
LIG_SUMO_SIM_par_1	290	295	PF11976	0.408
LIG_SUMO_SIM_par_1	464	469	PF11976	0.427
LIG_TYR_ITIM	145	150	PF00017	0.438
LIG_UBA3_1	470	475	PF00899	0.583
LIG_UBA3_1	709	717	PF00899	0.604
MOD_CDK_SPK_2	82	87	PF00069	0.446
MOD_CDK_SPxxK_3	110	117	PF00069	0.545
MOD_CDK_SPxxK_3	386	393	PF00069	0.417
MOD_CK1_1	126	132	PF00069	0.557
MOD_CK1_1	146	152	PF00069	0.207
MOD_CK1_1	177	183	PF00069	0.511
MOD_CK1_1	2	8	PF00069	0.633
MOD_CK1_1	244	250	PF00069	0.558
MOD_CK1_1	372	378	PF00069	0.511
MOD_CK1_1	484	490	PF00069	0.751
MOD_CK1_1	600	606	PF00069	0.715
MOD_CK1_1	640	646	PF00069	0.728
MOD_CK1_1	683	689	PF00069	0.615
MOD_CK1_1	711	717	PF00069	0.543
MOD_CK1_1	757	763	PF00069	0.643
MOD_CK1_1	76	82	PF00069	0.599
MOD_CK2_1	12	18	PF00069	0.505
MOD_CK2_1	134	140	PF00069	0.415
MOD_CK2_1	186	192	PF00069	0.424
MOD_CK2_1	2	8	PF00069	0.633
MOD_CK2_1	212	218	PF00069	0.590
MOD_CK2_1	346	352	PF00069	0.505
MOD_CK2_1	400	406	PF00069	0.575
MOD_CK2_1	407	413	PF00069	0.513
MOD_CK2_1	670	676	PF00069	0.477
MOD_CK2_1	742	748	PF00069	0.615
MOD_Cter_Amidation	352	355	PF01082	0.540
MOD_Cter_Amidation	582	585	PF01082	0.755
MOD_Cter_Amidation	586	589	PF01082	0.740
MOD_GlcNHglycan	136	139	PF01048	0.476
MOD_GlcNHglycan	176	179	PF01048	0.559
MOD_GlcNHglycan	33	36	PF01048	0.674
MOD_GlcNHglycan	348	351	PF01048	0.566
MOD_GlcNHglycan	39	42	PF01048	0.685
MOD_GlcNHglycan	475	478	PF01048	0.606
MOD_GlcNHglycan	503	506	PF01048	0.781
MOD_GlcNHglycan	514	517	PF01048	0.735
MOD_GlcNHglycan	545	548	PF01048	0.742
MOD_GlcNHglycan	560	563	PF01048	0.564
MOD_GlcNHglycan	621	624	PF01048	0.613
MOD_GlcNHglycan	744	747	PF01048	0.422
MOD_GSK3_1	123	130	PF00069	0.497
MOD_GSK3_1	173	180	PF00069	0.548
MOD_GSK3_1	241	248	PF00069	0.526
MOD_GSK3_1	37	44	PF00069	0.709
MOD_GSK3_1	419	426	PF00069	0.501
MOD_GSK3_1	481	488	PF00069	0.698
MOD_GSK3_1	560	567	PF00069	0.717
MOD_GSK3_1	598	605	PF00069	0.714
MOD_GSK3_1	615	622	PF00069	0.723
MOD_GSK3_1	708	715	PF00069	0.569
MOD_GSK3_1	73	80	PF00069	0.546
MOD_N-GLC_1	110	115	PF02516	0.411
MOD_N-GLC_1	741	746	PF02516	0.528
MOD_NEK2_1	1	6	PF00069	0.605
MOD_NEK2_1	101	106	PF00069	0.486
MOD_NEK2_1	184	189	PF00069	0.453
MOD_NEK2_1	242	247	PF00069	0.482
MOD_NEK2_1	251	256	PF00069	0.481
MOD_NEK2_1	31	36	PF00069	0.585
MOD_NEK2_1	310	315	PF00069	0.560
MOD_NEK2_1	343	348	PF00069	0.583
MOD_NEK2_1	361	366	PF00069	0.314
MOD_NEK2_1	451	456	PF00069	0.538
MOD_NEK2_1	558	563	PF00069	0.729
MOD_NEK2_1	597	602	PF00069	0.764
MOD_NEK2_2	749	754	PF00069	0.613
MOD_PIKK_1	184	190	PF00454	0.471
MOD_PIKK_1	251	257	PF00454	0.548
MOD_PIKK_1	451	457	PF00454	0.512
MOD_PIKK_1	600	606	PF00454	0.743
MOD_PIKK_1	754	760	PF00454	0.644
MOD_PIKK_1	77	83	PF00454	0.571
MOD_PK_1	324	330	PF00069	0.546
MOD_PKA_1	171	177	PF00069	0.629
MOD_PKA_2	11	17	PF00069	0.606
MOD_PKA_2	212	218	PF00069	0.544
MOD_PKA_2	392	398	PF00069	0.474
MOD_PKA_2	399	405	PF00069	0.452
MOD_PKA_2	484	490	PF00069	0.696
MOD_PKA_2	510	516	PF00069	0.671
MOD_PKA_2	680	686	PF00069	0.517
MOD_PKA_2	693	699	PF00069	0.577
MOD_PKA_2	760	766	PF00069	0.530
MOD_Plk_1	242	248	PF00069	0.555
MOD_Plk_1	294	300	PF00069	0.467
MOD_Plk_1	55	61	PF00069	0.541
MOD_Plk_1	598	604	PF00069	0.802
MOD_Plk_1	749	755	PF00069	0.613
MOD_Plk_2-3	659	665	PF00069	0.637
MOD_Plk_2-3	680	686	PF00069	0.649
MOD_Plk_4	143	149	PF00069	0.460
MOD_Plk_4	186	192	PF00069	0.395
MOD_Plk_4	316	322	PF00069	0.529
MOD_Plk_4	392	398	PF00069	0.453
MOD_Plk_4	41	47	PF00069	0.708
MOD_Plk_4	462	468	PF00069	0.408
MOD_Plk_4	55	61	PF00069	0.460
MOD_Plk_4	64	70	PF00069	0.412
MOD_Plk_4	732	738	PF00069	0.551
MOD_ProDKin_1	110	116	PF00069	0.589
MOD_ProDKin_1	245	251	PF00069	0.651
MOD_ProDKin_1	273	279	PF00069	0.491
MOD_ProDKin_1	311	317	PF00069	0.577
MOD_ProDKin_1	386	392	PF00069	0.582
MOD_ProDKin_1	488	494	PF00069	0.672
MOD_ProDKin_1	49	55	PF00069	0.623
MOD_ProDKin_1	553	559	PF00069	0.707
MOD_ProDKin_1	564	570	PF00069	0.700
MOD_ProDKin_1	683	689	PF00069	0.611
MOD_ProDKin_1	74	80	PF00069	0.479
MOD_ProDKin_1	82	88	PF00069	0.417
MOD_SUMO_for_1	366	369	PF00179	0.511
TRG_DiLeu_BaEn_1	18	23	PF01217	0.532
TRG_DiLeu_BaEn_1	287	292	PF01217	0.498
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.533
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.517
TRG_ENDOCYTIC_2	102	105	PF00928	0.483
TRG_ENDOCYTIC_2	147	150	PF00928	0.446
TRG_ENDOCYTIC_2	198	201	PF00928	0.386
TRG_ENDOCYTIC_2	232	235	PF00928	0.377
TRG_ENDOCYTIC_2	253	256	PF00928	0.568
TRG_ENDOCYTIC_2	57	60	PF00928	0.571
TRG_ER_diArg_1	163	165	PF00400	0.449
TRG_ER_diArg_1	222	224	PF00400	0.592
TRG_ER_diArg_1	521	524	PF00400	0.606
TRG_ER_diArg_1	63	65	PF00400	0.429
TRG_NLS_MonoCore_2	587	592	PF00514	0.721
TRG_NLS_MonoExtC_3	580	585	PF00514	0.716
TRG_NLS_MonoExtN_4	581	588	PF00514	0.688
TRG_NLS_MonoExtN_4	713	720	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	371	376	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD12	Leptomonas seymouri	54%	94%
A0A3S5H7P7	Leishmania donovani	91%	100%
A4HJ78	Leishmania braziliensis	78%	100%
A4I6M2	Leishmania infantum	92%	100%
C9ZTI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A527	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B1P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BCP2	Trypanosoma cruzi	31%	100%