Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q6G4_LEIMA

TriTrypDb:

LmjF.31.0990 , LMJLV39_310016000 , LMJSD75_310015600

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6G4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.645
CLV_NRD_NRD_1	164	166	PF00675	0.608
CLV_NRD_NRD_1	193	195	PF00675	0.611
CLV_NRD_NRD_1	196	198	PF00675	0.615
CLV_NRD_NRD_1	264	266	PF00675	0.619
CLV_NRD_NRD_1	319	321	PF00675	0.637
CLV_NRD_NRD_1	346	348	PF00675	0.643
CLV_NRD_NRD_1	364	366	PF00675	0.777
CLV_NRD_NRD_1	368	370	PF00675	0.716
CLV_PCSK_FUR_1	194	198	PF00082	0.566
CLV_PCSK_FUR_1	262	266	PF00082	0.613
CLV_PCSK_FUR_1	317	321	PF00082	0.709
CLV_PCSK_FUR_1	343	347	PF00082	0.659
CLV_PCSK_KEX2_1	162	164	PF00082	0.625
CLV_PCSK_KEX2_1	192	194	PF00082	0.618
CLV_PCSK_KEX2_1	196	198	PF00082	0.610
CLV_PCSK_KEX2_1	211	213	PF00082	0.586
CLV_PCSK_KEX2_1	264	266	PF00082	0.614
CLV_PCSK_KEX2_1	268	270	PF00082	0.605
CLV_PCSK_KEX2_1	317	319	PF00082	0.702
CLV_PCSK_KEX2_1	342	344	PF00082	0.640
CLV_PCSK_KEX2_1	345	347	PF00082	0.619
CLV_PCSK_KEX2_1	364	366	PF00082	0.775
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.606
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.618
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.586
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.645
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.640
CLV_PCSK_PC7_1	158	164	PF00082	0.651
CLV_PCSK_PC7_1	260	266	PF00082	0.690
CLV_PCSK_SKI1_1	115	119	PF00082	0.489
CLV_PCSK_SKI1_1	223	227	PF00082	0.699
CLV_PCSK_SKI1_1	269	273	PF00082	0.623
CLV_PCSK_SKI1_1	322	326	PF00082	0.651
CLV_PCSK_SKI1_1	84	88	PF00082	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.545
DEG_SCF_FBW7_1	255	261	PF00400	0.535
DEG_SPOP_SBC_1	183	187	PF00917	0.609
DEG_SPOP_SBC_1	93	97	PF00917	0.494
DOC_CDC14_PxL_1	103	111	PF14671	0.375
DOC_CKS1_1	255	260	PF01111	0.535
DOC_CYCLIN_RxL_1	111	120	PF00134	0.478
DOC_MAPK_gen_1	161	171	PF00069	0.615
DOC_MAPK_gen_1	192	203	PF00069	0.637
DOC_MAPK_gen_1	317	328	PF00069	0.579
DOC_MAPK_gen_1	367	377	PF00069	0.645
DOC_MAPK_gen_1	91	100	PF00069	0.568
DOC_MAPK_MEF2A_6	162	171	PF00069	0.610
DOC_USP7_MATH_1	206	210	PF00917	0.642
DOC_USP7_MATH_1	384	388	PF00917	0.657
DOC_USP7_MATH_1	393	397	PF00917	0.532
DOC_USP7_MATH_1	82	86	PF00917	0.543
DOC_USP7_MATH_1	93	97	PF00917	0.356
DOC_USP7_UBL2_3	162	166	PF12436	0.624
DOC_USP7_UBL2_3	188	192	PF12436	0.665
DOC_USP7_UBL2_3	207	211	PF12436	0.507
DOC_WW_Pin1_4	133	138	PF00397	0.617
DOC_WW_Pin1_4	254	259	PF00397	0.537
DOC_WW_Pin1_4	294	299	PF00397	0.683
LIG_14-3-3_CanoR_1	12	19	PF00244	0.457
LIG_14-3-3_CanoR_1	199	204	PF00244	0.627
LIG_14-3-3_CanoR_1	262	272	PF00244	0.765
LIG_14-3-3_CanoR_1	345	353	PF00244	0.628
LIG_14-3-3_CanoR_1	44	53	PF00244	0.450
LIG_14-3-3_CanoR_1	70	77	PF00244	0.536
LIG_14-3-3_CanoR_1	94	99	PF00244	0.488
LIG_Actin_WH2_2	69	86	PF00022	0.533
LIG_BRCT_BRCA1_1	349	353	PF00533	0.635
LIG_BRCT_BRCA1_1	47	51	PF00533	0.503
LIG_CAP-Gly_1	400	405	PF01302	0.643
LIG_FHA_1	178	184	PF00498	0.591
LIG_FHA_1	295	301	PF00498	0.552
LIG_FHA_1	37	43	PF00498	0.574
LIG_FHA_1	93	99	PF00498	0.497
LIG_FHA_2	111	117	PF00498	0.378
LIG_FHA_2	143	149	PF00498	0.694
LIG_FHA_2	224	230	PF00498	0.699
LIG_FHA_2	265	271	PF00498	0.584
LIG_FHA_2	283	289	PF00498	0.638
LIG_FHA_2	290	296	PF00498	0.508
LIG_FHA_2	331	337	PF00498	0.637
LIG_LIR_Gen_1	54	61	PF02991	0.456
LIG_LIR_Nem_3	54	60	PF02991	0.496
LIG_PDZ_Class_2	400	405	PF00595	0.693
LIG_Rb_pABgroove_1	112	120	PF01858	0.451
LIG_SH2_STAP1	9	13	PF00017	0.405
LIG_SH3_1	252	258	PF00018	0.626
LIG_SH3_2	255	260	PF14604	0.685
LIG_SH3_3	134	140	PF00018	0.657
LIG_SH3_3	164	170	PF00018	0.636
LIG_SH3_3	252	258	PF00018	0.676
LIG_SH3_3	326	332	PF00018	0.578
LIG_SH3_4	391	398	PF00018	0.618
LIG_WRC_WIRS_1	57	62	PF05994	0.403
MOD_CDK_SPxK_1	254	260	PF00069	0.531
MOD_CK1_1	21	27	PF00069	0.613
MOD_CK1_1	227	233	PF00069	0.654
MOD_CK1_1	279	285	PF00069	0.570
MOD_CK1_1	34	40	PF00069	0.443
MOD_CK2_1	110	116	PF00069	0.483
MOD_CK2_1	14	20	PF00069	0.454
MOD_CK2_1	142	148	PF00069	0.750
MOD_CK2_1	264	270	PF00069	0.588
MOD_CK2_1	289	295	PF00069	0.625
MOD_CK2_1	330	336	PF00069	0.654
MOD_CK2_1	384	390	PF00069	0.709
MOD_Cter_Amidation	163	166	PF01082	0.590
MOD_Cter_Amidation	194	197	PF01082	0.593
MOD_Cter_Amidation	262	265	PF01082	0.692
MOD_Cter_Amidation	343	346	PF01082	0.642
MOD_Cter_Amidation	362	365	PF01082	0.754
MOD_GlcNHglycan	119	122	PF01048	0.544
MOD_GlcNHglycan	130	133	PF01048	0.446
MOD_GlcNHglycan	14	17	PF01048	0.495
MOD_GlcNHglycan	215	218	PF01048	0.691
MOD_GlcNHglycan	219	222	PF01048	0.648
MOD_GlcNHglycan	235	239	PF01048	0.468
MOD_GlcNHglycan	347	350	PF01048	0.590
MOD_GlcNHglycan	361	364	PF01048	0.591
MOD_GlcNHglycan	72	75	PF01048	0.482
MOD_GlcNHglycan	79	82	PF01048	0.520
MOD_GSK3_1	14	21	PF00069	0.447
MOD_GSK3_1	213	220	PF00069	0.705
MOD_GSK3_1	223	230	PF00069	0.630
MOD_GSK3_1	24	31	PF00069	0.653
MOD_GSK3_1	254	261	PF00069	0.559
MOD_GSK3_1	279	286	PF00069	0.566
MOD_GSK3_1	330	337	PF00069	0.655
MOD_GSK3_1	345	352	PF00069	0.556
MOD_GSK3_1	94	101	PF00069	0.525
MOD_NEK2_1	117	122	PF00069	0.576
MOD_NEK2_1	18	23	PF00069	0.446
MOD_NEK2_1	2	7	PF00069	0.653
MOD_NEK2_1	213	218	PF00069	0.699
MOD_NEK2_1	378	383	PF00069	0.703
MOD_NEK2_1	68	73	PF00069	0.402
MOD_NEK2_1	76	81	PF00069	0.501
MOD_NEK2_2	36	41	PF00069	0.490
MOD_PIKK_1	378	384	PF00454	0.702
MOD_PK_1	94	100	PF00069	0.474
MOD_PKA_1	264	270	PF00069	0.607
MOD_PKA_1	345	351	PF00069	0.602
MOD_PKA_1	359	365	PF00069	0.586
MOD_PKA_2	107	113	PF00069	0.492
MOD_PKA_2	213	219	PF00069	0.623
MOD_PKA_2	24	30	PF00069	0.620
MOD_PKA_2	263	269	PF00069	0.636
MOD_PKA_2	277	283	PF00069	0.455
MOD_PKA_2	345	351	PF00069	0.646
MOD_PKA_2	93	99	PF00069	0.549
MOD_PKB_1	197	205	PF00069	0.627
MOD_PKB_1	262	270	PF00069	0.608
MOD_PKB_1	343	351	PF00069	0.651
MOD_Plk_1	230	236	PF00069	0.657
MOD_Plk_2-3	330	336	PF00069	0.654
MOD_Plk_4	14	20	PF00069	0.435
MOD_Plk_4	82	88	PF00069	0.526
MOD_ProDKin_1	133	139	PF00069	0.622
MOD_ProDKin_1	254	260	PF00069	0.540
MOD_ProDKin_1	294	300	PF00069	0.686
MOD_SUMO_rev_2	135	143	PF00179	0.545
MOD_SUMO_rev_2	85	93	PF00179	0.457
TRG_ER_diArg_1	193	196	PF00400	0.611
TRG_ER_diArg_1	212	215	PF00400	0.651
TRG_ER_diArg_1	259	262	PF00400	0.632
TRG_ER_diArg_1	317	320	PF00400	0.693
TRG_ER_diArg_1	343	346	PF00400	0.705
TRG_ER_diArg_1	364	367	PF00400	0.713
TRG_NLS_Bipartite_1	192	214	PF00514	0.675
TRG_NLS_MonoCore_2	164	169	PF00514	0.579
TRG_NLS_MonoExtC_3	160	165	PF00514	0.599
TRG_NLS_MonoExtC_3	191	196	PF00514	0.584
TRG_NLS_MonoExtC_3	209	214	PF00514	0.700
TRG_NLS_MonoExtC_3	341	346	PF00514	0.633
TRG_NLS_MonoExtN_4	158	165	PF00514	0.602
TRG_NLS_MonoExtN_4	207	214	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIK0	Leptomonas seymouri	36%	97%
A0A3S7X4A5	Leishmania donovani	84%	97%
A4HJ79	Leishmania braziliensis	59%	96%
A4I6M3	Leishmania infantum	84%	97%
E9B1P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%