PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6G3_LEIMA

TriTrypDb:

LmjF.31.1000 , LMJLV39_310016100 , LMJSD75_310015700

Length:

1117

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	578	582	PF00656	0.646
CLV_C14_Caspase3-7	586	590	PF00656	0.599
CLV_C14_Caspase3-7	653	657	PF00656	0.665
CLV_C14_Caspase3-7	738	742	PF00656	0.647
CLV_C14_Caspase3-7	749	753	PF00656	0.584
CLV_C14_Caspase3-7	777	781	PF00656	0.652
CLV_NRD_NRD_1	1115	1117	PF00675	0.591
CLV_NRD_NRD_1	240	242	PF00675	0.717
CLV_NRD_NRD_1	284	286	PF00675	0.516
CLV_NRD_NRD_1	397	399	PF00675	0.436
CLV_NRD_NRD_1	417	419	PF00675	0.426
CLV_NRD_NRD_1	437	439	PF00675	0.498
CLV_NRD_NRD_1	5	7	PF00675	0.647
CLV_NRD_NRD_1	65	67	PF00675	0.658
CLV_NRD_NRD_1	794	796	PF00675	0.699
CLV_NRD_NRD_1	799	801	PF00675	0.711
CLV_NRD_NRD_1	824	826	PF00675	0.606
CLV_PCSK_FUR_1	3	7	PF00082	0.646
CLV_PCSK_KEX2_1	1032	1034	PF00082	0.505
CLV_PCSK_KEX2_1	199	201	PF00082	0.546
CLV_PCSK_KEX2_1	240	242	PF00082	0.717
CLV_PCSK_KEX2_1	284	286	PF00082	0.516
CLV_PCSK_KEX2_1	396	398	PF00082	0.472
CLV_PCSK_KEX2_1	437	439	PF00082	0.560
CLV_PCSK_KEX2_1	5	7	PF00082	0.679
CLV_PCSK_KEX2_1	65	67	PF00082	0.661
CLV_PCSK_KEX2_1	824	826	PF00082	0.606
CLV_PCSK_PC1ET2_1	1032	1034	PF00082	0.505
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.546
CLV_PCSK_PC7_1	1028	1034	PF00082	0.488
CLV_PCSK_PC7_1	820	826	PF00082	0.611
CLV_PCSK_SKI1_1	1038	1042	PF00082	0.518
CLV_PCSK_SKI1_1	105	109	PF00082	0.464
CLV_PCSK_SKI1_1	132	136	PF00082	0.526
CLV_PCSK_SKI1_1	206	210	PF00082	0.475
CLV_PCSK_SKI1_1	284	288	PF00082	0.508
CLV_PCSK_SKI1_1	355	359	PF00082	0.464
CLV_PCSK_SKI1_1	447	451	PF00082	0.546
CLV_PCSK_SKI1_1	465	469	PF00082	0.304
CLV_PCSK_SKI1_1	507	511	PF00082	0.623
CLV_PCSK_SKI1_1	518	522	PF00082	0.429
CLV_PCSK_SKI1_1	806	810	PF00082	0.780
DEG_APCC_DBOX_1	446	454	PF00400	0.482
DEG_APCC_DBOX_1	513	521	PF00400	0.494
DEG_APCC_DBOX_1	995	1003	PF00400	0.575
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DEG_SCF_FBW7_2	304	311	PF00400	0.661
DEG_SPOP_SBC_1	290	294	PF00917	0.539
DOC_CKS1_1	305	310	PF01111	0.605
DOC_CKS1_1	37	42	PF01111	0.552
DOC_CKS1_1	92	97	PF01111	0.491
DOC_CYCLIN_RxL_1	426	436	PF00134	0.581
DOC_CYCLIN_RxL_1	501	512	PF00134	0.602
DOC_CYCLIN_RxL_1	99	112	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.492
DOC_MAPK_gen_1	1032	1039	PF00069	0.474
DOC_MAPK_gen_1	272	280	PF00069	0.440
DOC_MAPK_gen_1	396	404	PF00069	0.447
DOC_MAPK_gen_1	437	445	PF00069	0.528
DOC_MAPK_gen_1	514	522	PF00069	0.494
DOC_MAPK_MEF2A_6	1032	1041	PF00069	0.523
DOC_PP1_RVXF_1	1036	1042	PF00149	0.514
DOC_PP1_RVXF_1	1105	1111	PF00149	0.425
DOC_PP1_RVXF_1	270	277	PF00149	0.432
DOC_PP1_RVXF_1	445	452	PF00149	0.595
DOC_PP1_RVXF_1	505	512	PF00149	0.501
DOC_PP2B_LxvP_1	443	446	PF13499	0.489
DOC_USP7_MATH_1	15	19	PF00917	0.653
DOC_USP7_MATH_1	228	232	PF00917	0.474
DOC_USP7_MATH_1	290	294	PF00917	0.476
DOC_USP7_MATH_1	314	318	PF00917	0.718
DOC_USP7_MATH_1	473	477	PF00917	0.464
DOC_USP7_MATH_1	565	569	PF00917	0.635
DOC_USP7_MATH_1	590	594	PF00917	0.661
DOC_USP7_MATH_1	649	653	PF00917	0.663
DOC_USP7_MATH_1	791	795	PF00917	0.657
DOC_USP7_MATH_1	867	871	PF00917	0.710
DOC_USP7_MATH_1	882	886	PF00917	0.604
DOC_USP7_MATH_1	914	918	PF00917	0.707
DOC_USP7_UBL2_3	1103	1107	PF12436	0.513
DOC_USP7_UBL2_3	802	806	PF12436	0.677
DOC_USP7_UBL2_3	826	830	PF12436	0.611
DOC_USP7_UBL2_3	9	13	PF12436	0.634
DOC_USP7_UBL2_3	973	977	PF12436	0.657
DOC_WW_Pin1_4	100	105	PF00397	0.396
DOC_WW_Pin1_4	252	257	PF00397	0.616
DOC_WW_Pin1_4	304	309	PF00397	0.687
DOC_WW_Pin1_4	31	36	PF00397	0.618
DOC_WW_Pin1_4	312	317	PF00397	0.609
DOC_WW_Pin1_4	91	96	PF00397	0.480
LIG_14-3-3_CanoR_1	1028	1035	PF00244	0.530
LIG_14-3-3_CanoR_1	241	247	PF00244	0.704
LIG_14-3-3_CanoR_1	366	375	PF00244	0.508
LIG_14-3-3_CanoR_1	421	427	PF00244	0.519
LIG_14-3-3_CanoR_1	472	481	PF00244	0.470
LIG_14-3-3_CanoR_1	529	533	PF00244	0.464
LIG_14-3-3_CanoR_1	572	579	PF00244	0.672
LIG_14-3-3_CanoR_1	674	682	PF00244	0.656
LIG_14-3-3_CanoR_1	754	762	PF00244	0.572
LIG_14-3-3_CanoR_1	996	1000	PF00244	0.581
LIG_Actin_WH2_2	273	290	PF00022	0.435
LIG_Actin_WH2_2	474	489	PF00022	0.456
LIG_BIR_III_4	553	557	PF00653	0.519
LIG_BIR_III_4	581	585	PF00653	0.578
LIG_Clathr_ClatBox_1	358	362	PF01394	0.465
LIG_Clathr_ClatBox_1	467	471	PF01394	0.454
LIG_EH1_1	81	89	PF00400	0.465
LIG_eIF4E_1	102	108	PF01652	0.476
LIG_FHA_1	1021	1027	PF00498	0.522
LIG_FHA_1	1094	1100	PF00498	0.516
LIG_FHA_1	176	182	PF00498	0.477
LIG_FHA_1	316	322	PF00498	0.690
LIG_FHA_1	32	38	PF00498	0.602
LIG_FHA_1	332	338	PF00498	0.488
LIG_FHA_1	426	432	PF00498	0.513
LIG_FHA_1	544	550	PF00498	0.406
LIG_FHA_1	574	580	PF00498	0.656
LIG_FHA_1	583	589	PF00498	0.647
LIG_FHA_1	614	620	PF00498	0.553
LIG_FHA_1	674	680	PF00498	0.773
LIG_FHA_1	928	934	PF00498	0.673
LIG_FHA_2	101	107	PF00498	0.491
LIG_FHA_2	136	142	PF00498	0.541
LIG_FHA_2	170	176	PF00498	0.492
LIG_FHA_2	246	252	PF00498	0.659
LIG_FHA_2	296	302	PF00498	0.654
LIG_FHA_2	648	654	PF00498	0.647
LIG_FHA_2	754	760	PF00498	0.610
LIG_FHA_2	811	817	PF00498	0.567
LIG_FHA_2	914	920	PF00498	0.772
LIG_FHA_2	955	961	PF00498	0.695
LIG_Integrin_RGD_1	689	691	PF01839	0.595
LIG_LIR_Apic_2	51	56	PF02991	0.475
LIG_LIR_Gen_1	178	188	PF02991	0.486
LIG_LIR_Gen_1	661	670	PF02991	0.658
LIG_LIR_Nem_3	227	232	PF02991	0.472
LIG_LIR_Nem_3	267	273	PF02991	0.439
LIG_LIR_Nem_3	329	333	PF02991	0.489
LIG_LIR_Nem_3	373	379	PF02991	0.515
LIG_LIR_Nem_3	54	60	PF02991	0.499
LIG_LIR_Nem_3	661	667	PF02991	0.664
LIG_LIR_Nem_3	734	739	PF02991	0.651
LIG_MYND_3	144	148	PF01753	0.519
LIG_NRBOX	998	1004	PF00104	0.559
LIG_PCNA_PIPBox_1	144	153	PF02747	0.518
LIG_PCNA_PIPBox_1	85	94	PF02747	0.362
LIG_PTB_Apo_2	67	74	PF02174	0.523
LIG_PTB_Phospho_1	67	73	PF10480	0.523
LIG_SH2_CRK	271	275	PF00017	0.433
LIG_SH2_CRK	376	380	PF00017	0.541
LIG_SH2_CRK	53	57	PF00017	0.434
LIG_SH2_NCK_1	376	380	PF00017	0.504
LIG_SH2_NCK_1	53	57	PF00017	0.434
LIG_SH2_STAP1	109	113	PF00017	0.393
LIG_SH2_STAP1	60	64	PF00017	0.538
LIG_SH2_STAP1	73	77	PF00017	0.382
LIG_SH2_STAT3	60	63	PF00017	0.541
LIG_SH2_STAT5	102	105	PF00017	0.551
LIG_SH2_STAT5	333	336	PF00017	0.453
LIG_SH2_STAT5	485	488	PF00017	0.675
LIG_SH2_STAT5	53	56	PF00017	0.421
LIG_SH3_1	1050	1056	PF00018	0.455
LIG_SH3_1	32	38	PF00018	0.622
LIG_SH3_3	1050	1056	PF00018	0.455
LIG_SH3_3	139	145	PF00018	0.465
LIG_SH3_3	247	253	PF00018	0.638
LIG_SH3_3	302	308	PF00018	0.716
LIG_SH3_3	32	38	PF00018	0.657
LIG_SH3_3	944	950	PF00018	0.654
LIG_SUMO_SIM_anti_2	1086	1091	PF11976	0.532
LIG_SUMO_SIM_par_1	1022	1027	PF11976	0.456
LIG_SUMO_SIM_par_1	276	281	PF11976	0.446
LIG_SUMO_SIM_par_1	428	434	PF11976	0.474
LIG_SUMO_SIM_par_1	466	471	PF11976	0.383
LIG_TRAF2_1	531	534	PF00917	0.408
LIG_TRAF2_1	575	578	PF00917	0.717
LIG_TRAF2_1	659	662	PF00917	0.651
LIG_TRAF2_1	666	669	PF00917	0.571
LIG_TRAF2_1	723	726	PF00917	0.646
LIG_TYR_ITSM	225	232	PF00017	0.469
LIG_WRC_WIRS_1	147	152	PF05994	0.516
LIG_WRC_WIRS_1	177	182	PF05994	0.480
LIG_WRC_WIRS_1	733	738	PF05994	0.566
MOD_CDK_SPK_2	100	105	PF00069	0.506
MOD_CK1_1	1088	1094	PF00069	0.545
MOD_CK1_1	169	175	PF00069	0.483
MOD_CK1_1	231	237	PF00069	0.513
MOD_CK1_1	245	251	PF00069	0.528
MOD_CK1_1	27	33	PF00069	0.672
MOD_CK1_1	537	543	PF00069	0.596
MOD_CK1_1	573	579	PF00069	0.582
MOD_CK1_1	907	913	PF00069	0.666
MOD_CK2_1	100	106	PF00069	0.506
MOD_CK2_1	1019	1025	PF00069	0.565
MOD_CK2_1	198	204	PF00069	0.558
MOD_CK2_1	295	301	PF00069	0.636
MOD_CK2_1	528	534	PF00069	0.614
MOD_CK2_1	565	571	PF00069	0.709
MOD_CK2_1	572	578	PF00069	0.681
MOD_CK2_1	753	759	PF00069	0.703
MOD_CK2_1	810	816	PF00069	0.564
MOD_CK2_1	867	873	PF00069	0.631
MOD_CK2_1	907	913	PF00069	0.647
MOD_CK2_1	954	960	PF00069	0.694
MOD_Cter_Amidation	3	6	PF01082	0.644
MOD_Cter_Amidation	798	801	PF01082	0.629
MOD_Cter_Amidation	822	825	PF01082	0.692
MOD_GlcNHglycan	17	20	PF01048	0.711
MOD_GlcNHglycan	200	203	PF01048	0.534
MOD_GlcNHglycan	26	29	PF01048	0.692
MOD_GlcNHglycan	301	304	PF01048	0.578
MOD_GlcNHglycan	382	385	PF01048	0.570
MOD_GlcNHglycan	539	542	PF01048	0.577
MOD_GlcNHglycan	585	588	PF01048	0.613
MOD_GlcNHglycan	719	722	PF01048	0.577
MOD_GlcNHglycan	909	912	PF01048	0.793
MOD_GlcNHglycan	941	944	PF01048	0.685
MOD_GlcNHglycan	974	977	PF01048	0.748
MOD_GSK3_1	1102	1109	PF00069	0.494
MOD_GSK3_1	166	173	PF00069	0.468
MOD_GSK3_1	224	231	PF00069	0.470
MOD_GSK3_1	27	34	PF00069	0.662
MOD_GSK3_1	291	298	PF00069	0.586
MOD_GSK3_1	299	306	PF00069	0.649
MOD_GSK3_1	331	338	PF00069	0.512
MOD_GSK3_1	425	432	PF00069	0.496
MOD_GSK3_1	471	478	PF00069	0.476
MOD_GSK3_1	539	546	PF00069	0.491
MOD_GSK3_1	613	620	PF00069	0.546
MOD_GSK3_1	639	646	PF00069	0.555
MOD_GSK3_1	83	90	PF00069	0.569
MOD_N-GLC_1	1093	1098	PF02516	0.497
MOD_N-GLC_1	126	131	PF02516	0.447
MOD_N-GLC_1	135	140	PF02516	0.422
MOD_N-GLC_1	366	371	PF02516	0.503
MOD_NEK2_1	1019	1024	PF00069	0.636
MOD_NEK2_1	1026	1031	PF00069	0.526
MOD_NEK2_1	1063	1068	PF00069	0.529
MOD_NEK2_1	1090	1095	PF00069	0.506
MOD_NEK2_1	208	213	PF00069	0.492
MOD_NEK2_1	451	456	PF00069	0.472
MOD_NEK2_1	500	505	PF00069	0.539
MOD_NEK2_1	543	548	PF00069	0.461
MOD_NEK2_1	570	575	PF00069	0.595
MOD_NEK2_1	59	64	PF00069	0.467
MOD_NEK2_1	629	634	PF00069	0.552
MOD_NEK2_1	647	652	PF00069	0.489
MOD_NEK2_1	675	680	PF00069	0.569
MOD_NEK2_1	732	737	PF00069	0.566
MOD_NEK2_1	967	972	PF00069	0.646
MOD_PIKK_1	233	239	PF00454	0.541
MOD_PIKK_1	422	428	PF00454	0.583
MOD_PIKK_1	565	571	PF00454	0.710
MOD_PIKK_1	59	65	PF00454	0.553
MOD_PIKK_1	639	645	PF00454	0.531
MOD_PK_1	83	89	PF00069	0.525
MOD_PKA_1	5	11	PF00069	0.682
MOD_PKA_1	972	978	PF00069	0.664
MOD_PKA_2	1027	1033	PF00069	0.533
MOD_PKA_2	365	371	PF00069	0.583
MOD_PKA_2	471	477	PF00069	0.480
MOD_PKA_2	5	11	PF00069	0.697
MOD_PKA_2	528	534	PF00069	0.459
MOD_PKA_2	673	679	PF00069	0.652
MOD_PKA_2	753	759	PF00069	0.611
MOD_PKA_2	810	816	PF00069	0.548
MOD_PKA_2	995	1001	PF00069	0.589
MOD_PKB_1	3	11	PF00069	0.649
MOD_Plk_1	1085	1091	PF00069	0.532
MOD_Plk_1	126	132	PF00069	0.486
MOD_Plk_1	441	447	PF00069	0.504
MOD_Plk_1	451	457	PF00069	0.425
MOD_Plk_1	570	576	PF00069	0.654
MOD_Plk_1	643	649	PF00069	0.537
MOD_Plk_1	867	873	PF00069	0.669
MOD_Plk_1	890	896	PF00069	0.707
MOD_Plk_1	967	973	PF00069	0.632
MOD_Plk_2-3	1020	1026	PF00069	0.462
MOD_Plk_4	1085	1091	PF00069	0.532
MOD_Plk_4	1106	1112	PF00069	0.469
MOD_Plk_4	146	152	PF00069	0.515
MOD_Plk_4	157	163	PF00069	0.527
MOD_Plk_4	176	182	PF00069	0.341
MOD_Plk_4	539	545	PF00069	0.432
MOD_Plk_4	617	623	PF00069	0.566
MOD_Plk_4	83	89	PF00069	0.518
MOD_ProDKin_1	100	106	PF00069	0.396
MOD_ProDKin_1	252	258	PF00069	0.601
MOD_ProDKin_1	304	310	PF00069	0.689
MOD_ProDKin_1	31	37	PF00069	0.616
MOD_ProDKin_1	312	318	PF00069	0.606
MOD_ProDKin_1	91	97	PF00069	0.489
MOD_SUMO_for_1	746	749	PF00179	0.670
MOD_SUMO_rev_2	191	201	PF00179	0.557
MOD_SUMO_rev_2	849	858	PF00179	0.613
MOD_SUMO_rev_2	859	866	PF00179	0.582
TRG_AP2beta_CARGO_1	661	671	PF09066	0.561
TRG_DiLeu_BaEn_1	204	209	PF01217	0.529
TRG_DiLeu_BaEn_1	534	539	PF01217	0.500
TRG_DiLeu_BaLyEn_6	998	1003	PF01217	0.507
TRG_ENDOCYTIC_2	229	232	PF00928	0.478
TRG_ENDOCYTIC_2	271	274	PF00928	0.433
TRG_ENDOCYTIC_2	376	379	PF00928	0.542
TRG_ER_diArg_1	2	5	PF00400	0.641
TRG_ER_diArg_1	239	241	PF00400	0.653
TRG_ER_diArg_1	396	398	PF00400	0.653
TRG_ER_diArg_1	513	516	PF00400	0.516
TRG_ER_diArg_1	65	67	PF00400	0.655
TRG_ER_diArg_1	797	800	PF00400	0.640
TRG_NES_CRM1_1	512	526	PF08389	0.498
TRG_NLS_MonoExtC_3	799	804	PF00514	0.617
TRG_NLS_MonoExtN_4	793	799	PF00514	0.616
TRG_NLS_MonoExtN_4	824	829	PF00514	0.609
TRG_Pf-PMV_PEXEL_1	1001	1006	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	572	577	PF00026	0.776
TRG_Pf-PMV_PEXEL_1	75	80	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4E0	Leishmania donovani	89%	100%
A4HJ80	Leishmania braziliensis	66%	97%
A4I6M4	Leishmania infantum	89%	100%
E9B1P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%