RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6G0_LEIMA

TriTrypDb:

LmjF.31.1030 , LMJLV39_310016500 , LMJSD75_310016100

Length:

902

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6G0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.613
CLV_C14_Caspase3-7	27	31	PF00656	0.630
CLV_C14_Caspase3-7	307	311	PF00656	0.384
CLV_C14_Caspase3-7	551	555	PF00656	0.645
CLV_NRD_NRD_1	161	163	PF00675	0.548
CLV_NRD_NRD_1	254	256	PF00675	0.275
CLV_NRD_NRD_1	405	407	PF00675	0.636
CLV_NRD_NRD_1	769	771	PF00675	0.440
CLV_PCSK_FUR_1	855	859	PF00082	0.483
CLV_PCSK_KEX2_1	254	256	PF00082	0.275
CLV_PCSK_KEX2_1	305	307	PF00082	0.403
CLV_PCSK_KEX2_1	405	407	PF00082	0.551
CLV_PCSK_KEX2_1	641	643	PF00082	0.434
CLV_PCSK_KEX2_1	769	771	PF00082	0.440
CLV_PCSK_KEX2_1	857	859	PF00082	0.422
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.403
CLV_PCSK_PC1ET2_1	641	643	PF00082	0.395
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.422
CLV_PCSK_SKI1_1	563	567	PF00082	0.467
CLV_PCSK_SKI1_1	776	780	PF00082	0.386
CLV_PCSK_SKI1_1	809	813	PF00082	0.409
CLV_PCSK_SKI1_1	858	862	PF00082	0.426
CLV_PCSK_SKI1_1	865	869	PF00082	0.415
DEG_APCC_DBOX_1	775	783	PF00400	0.384
DEG_SPOP_SBC_1	757	761	PF00917	0.520
DEG_SPOP_SBC_1	839	843	PF00917	0.457
DOC_CKS1_1	330	335	PF01111	0.562
DOC_CYCLIN_RxL_1	195	205	PF00134	0.312
DOC_CYCLIN_yClb5_NLxxxL_5	639	648	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	519	522	PF00134	0.606
DOC_MAPK_gen_1	254	260	PF00069	0.475
DOC_MAPK_gen_1	855	862	PF00069	0.454
DOC_MAPK_MEF2A_6	776	785	PF00069	0.383
DOC_PP1_RVXF_1	856	863	PF00149	0.445
DOC_PP2B_LxvP_1	519	522	PF13499	0.610
DOC_PP4_FxxP_1	518	521	PF00568	0.693
DOC_PP4_FxxP_1	718	721	PF00568	0.559
DOC_USP7_MATH_1	187	191	PF00917	0.474
DOC_USP7_MATH_1	213	217	PF00917	0.495
DOC_USP7_MATH_1	311	315	PF00917	0.461
DOC_USP7_MATH_1	385	389	PF00917	0.582
DOC_USP7_MATH_1	435	439	PF00917	0.607
DOC_USP7_MATH_1	460	464	PF00917	0.700
DOC_USP7_MATH_1	529	533	PF00917	0.563
DOC_USP7_MATH_1	542	546	PF00917	0.450
DOC_USP7_MATH_1	55	59	PF00917	0.545
DOC_USP7_MATH_1	609	613	PF00917	0.481
DOC_USP7_MATH_1	748	752	PF00917	0.647
DOC_USP7_MATH_1	757	761	PF00917	0.468
DOC_USP7_MATH_1	82	86	PF00917	0.630
DOC_USP7_MATH_1	839	843	PF00917	0.527
DOC_USP7_MATH_1	89	93	PF00917	0.567
DOC_USP7_MATH_2	13	19	PF00917	0.561
DOC_USP7_UBL2_3	172	176	PF12436	0.489
DOC_WW_Pin1_4	103	108	PF00397	0.596
DOC_WW_Pin1_4	120	125	PF00397	0.541
DOC_WW_Pin1_4	329	334	PF00397	0.615
DOC_WW_Pin1_4	336	341	PF00397	0.591
DOC_WW_Pin1_4	351	356	PF00397	0.519
DOC_WW_Pin1_4	362	367	PF00397	0.596
DOC_WW_Pin1_4	392	397	PF00397	0.645
DOC_WW_Pin1_4	438	443	PF00397	0.602
DOC_WW_Pin1_4	445	450	PF00397	0.580
DOC_WW_Pin1_4	467	472	PF00397	0.617
DOC_WW_Pin1_4	492	497	PF00397	0.545
DOC_WW_Pin1_4	5	10	PF00397	0.572
LIG_14-3-3_CanoR_1	622	629	PF00244	0.391
LIG_14-3-3_CanoR_1	642	651	PF00244	0.256
LIG_14-3-3_CanoR_1	689	696	PF00244	0.581
LIG_14-3-3_CanoR_1	865	874	PF00244	0.374
LIG_BIR_III_2	287	291	PF00653	0.436
LIG_BIR_III_2	646	650	PF00653	0.423
LIG_BIR_III_4	585	589	PF00653	0.357
LIG_BRCT_BRCA1_1	486	490	PF00533	0.532
LIG_eIF4E_1	777	783	PF01652	0.381
LIG_FHA_1	187	193	PF00498	0.482
LIG_FHA_1	194	200	PF00498	0.424
LIG_FHA_1	392	398	PF00498	0.603
LIG_FHA_1	419	425	PF00498	0.690
LIG_FHA_1	475	481	PF00498	0.562
LIG_FHA_1	614	620	PF00498	0.480
LIG_FHA_2	305	311	PF00498	0.588
LIG_FHA_2	493	499	PF00498	0.585
LIG_FHA_2	528	534	PF00498	0.571
LIG_FHA_2	551	557	PF00498	0.448
LIG_FHA_2	707	713	PF00498	0.507
LIG_FHA_2	867	873	PF00498	0.443
LIG_FHA_2	9	15	PF00498	0.522
LIG_LIR_Apic_2	151	155	PF02991	0.594
LIG_LIR_Apic_2	390	396	PF02991	0.627
LIG_LIR_Apic_2	517	521	PF02991	0.662
LIG_LIR_Gen_1	113	119	PF02991	0.601
LIG_LIR_Gen_1	220	226	PF02991	0.503
LIG_LIR_Gen_1	33	42	PF02991	0.646
LIG_LIR_Gen_1	450	461	PF02991	0.624
LIG_LIR_Gen_1	885	893	PF02991	0.376
LIG_LIR_Nem_3	113	117	PF02991	0.601
LIG_LIR_Nem_3	170	174	PF02991	0.482
LIG_LIR_Nem_3	220	224	PF02991	0.503
LIG_LIR_Nem_3	313	318	PF02991	0.443
LIG_LIR_Nem_3	33	37	PF02991	0.605
LIG_LIR_Nem_3	450	456	PF02991	0.624
LIG_LIR_Nem_3	693	699	PF02991	0.624
LIG_LIR_Nem_3	712	718	PF02991	0.566
LIG_LIR_Nem_3	771	777	PF02991	0.404
LIG_LIR_Nem_3	78	83	PF02991	0.676
LIG_LIR_Nem_3	834	840	PF02991	0.453
LIG_LIR_Nem_3	861	866	PF02991	0.373
LIG_LIR_Nem_3	885	891	PF02991	0.423
LIG_NRBOX	592	598	PF00104	0.395
LIG_PAM2_1	351	363	PF00658	0.614
LIG_PCNA_yPIPBox_3	272	285	PF02747	0.437
LIG_Pex14_1	236	240	PF04695	0.503
LIG_Pex14_2	863	867	PF04695	0.406
LIG_PTB_Apo_2	700	707	PF02174	0.526
LIG_PTB_Phospho_1	700	706	PF10480	0.527
LIG_SH2_CRK	114	118	PF00017	0.671
LIG_SH2_CRK	152	156	PF00017	0.597
LIG_SH2_CRK	837	841	PF00017	0.432
LIG_SH2_GRB2like	315	318	PF00017	0.444
LIG_SH2_NCK_1	801	805	PF00017	0.377
LIG_SH2_SRC	372	375	PF00017	0.584
LIG_SH2_SRC	41	44	PF00017	0.595
LIG_SH2_STAP1	32	36	PF00017	0.610
LIG_SH2_STAP1	801	805	PF00017	0.377
LIG_SH2_STAT5	150	153	PF00017	0.603
LIG_SH2_STAT5	159	162	PF00017	0.559
LIG_SH2_STAT5	221	224	PF00017	0.503
LIG_SH2_STAT5	372	375	PF00017	0.632
LIG_SH2_STAT5	4	7	PF00017	0.620
LIG_SH2_STAT5	41	44	PF00017	0.644
LIG_SH2_STAT5	777	780	PF00017	0.382
LIG_SH3_3	121	127	PF00018	0.624
LIG_SH3_3	19	25	PF00018	0.517
LIG_SH3_3	261	267	PF00018	0.611
LIG_SH3_3	327	333	PF00018	0.529
LIG_SH3_3	344	350	PF00018	0.615
LIG_SH3_3	468	474	PF00018	0.682
LIG_SH3_5	155	159	PF00018	0.575
LIG_SH3_5	449	453	PF00018	0.618
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.361
LIG_SUMO_SIM_par_1	394	402	PF11976	0.539
LIG_SUMO_SIM_par_1	592	598	PF11976	0.361
LIG_TRAF2_1	175	178	PF00917	0.485
LIG_TRAF2_1	709	712	PF00917	0.510
LIG_TRAF2_1	788	791	PF00917	0.399
LIG_TRFH_1	518	522	PF08558	0.661
LIG_UBA3_1	297	305	PF00899	0.418
LIG_UBA3_1	632	641	PF00899	0.336
LIG_WRC_WIRS_1	453	458	PF05994	0.624
MOD_CDK_SPxxK_3	351	358	PF00069	0.616
MOD_CDK_SPxxK_3	5	12	PF00069	0.571
MOD_CK1_1	106	112	PF00069	0.732
MOD_CK1_1	3	9	PF00069	0.592
MOD_CK1_1	381	387	PF00069	0.551
MOD_CK1_1	399	405	PF00069	0.778
MOD_CK1_1	413	419	PF00069	0.685
MOD_CK1_1	422	428	PF00069	0.764
MOD_CK1_1	438	444	PF00069	0.518
MOD_CK1_1	44	50	PF00069	0.536
MOD_CK1_1	467	473	PF00069	0.609
MOD_CK1_1	505	511	PF00069	0.754
MOD_CK1_1	758	764	PF00069	0.504
MOD_CK2_1	253	259	PF00069	0.312
MOD_CK2_1	492	498	PF00069	0.584
MOD_CK2_1	589	595	PF00069	0.384
MOD_CK2_1	706	712	PF00069	0.612
MOD_CK2_1	720	726	PF00069	0.629
MOD_CK2_1	728	734	PF00069	0.558
MOD_CK2_1	757	763	PF00069	0.504
MOD_CK2_1	785	791	PF00069	0.353
MOD_CK2_1	866	872	PF00069	0.362
MOD_GlcNHglycan	19	22	PF01048	0.604
MOD_GlcNHglycan	255	258	PF01048	0.312
MOD_GlcNHglycan	274	277	PF01048	0.423
MOD_GlcNHglycan	334	337	PF01048	0.647
MOD_GlcNHglycan	380	383	PF01048	0.793
MOD_GlcNHglycan	415	418	PF01048	0.666
MOD_GlcNHglycan	421	424	PF01048	0.709
MOD_GlcNHglycan	43	46	PF01048	0.614
MOD_GlcNHglycan	437	440	PF01048	0.556
MOD_GlcNHglycan	462	465	PF01048	0.711
MOD_GlcNHglycan	487	490	PF01048	0.670
MOD_GlcNHglycan	512	515	PF01048	0.665
MOD_GlcNHglycan	550	553	PF01048	0.628
MOD_GlcNHglycan	611	614	PF01048	0.528
MOD_GlcNHglycan	676	679	PF01048	0.576
MOD_GlcNHglycan	746	749	PF01048	0.735
MOD_GlcNHglycan	760	763	PF01048	0.400
MOD_GlcNHglycan	798	801	PF01048	0.420
MOD_GlcNHglycan	815	818	PF01048	0.521
MOD_GlcNHglycan	851	854	PF01048	0.740
MOD_GlcNHglycan	89	92	PF01048	0.604
MOD_GSK3_1	106	113	PF00069	0.549
MOD_GSK3_1	202	209	PF00069	0.312
MOD_GSK3_1	332	339	PF00069	0.677
MOD_GSK3_1	381	388	PF00069	0.611
MOD_GSK3_1	392	399	PF00069	0.771
MOD_GSK3_1	4	11	PF00069	0.558
MOD_GSK3_1	406	413	PF00069	0.705
MOD_GSK3_1	415	422	PF00069	0.631
MOD_GSK3_1	434	441	PF00069	0.508
MOD_GSK3_1	443	450	PF00069	0.628
MOD_GSK3_1	451	458	PF00069	0.555
MOD_GSK3_1	460	467	PF00069	0.575
MOD_GSK3_1	485	492	PF00069	0.574
MOD_GSK3_1	542	549	PF00069	0.465
MOD_GSK3_1	609	616	PF00069	0.543
MOD_GSK3_1	680	687	PF00069	0.591
MOD_GSK3_1	744	751	PF00069	0.631
MOD_GSK3_1	753	760	PF00069	0.579
MOD_GSK3_1	849	856	PF00069	0.695
MOD_GSK3_1	89	96	PF00069	0.762
MOD_N-GLC_1	120	125	PF02516	0.686
MOD_N-GLC_1	228	233	PF02516	0.312
MOD_N-GLC_1	492	497	PF02516	0.524
MOD_N-GLC_1	642	647	PF02516	0.384
MOD_N-GLC_1	744	749	PF02516	0.567
MOD_N-GLC_2	831	833	PF02516	0.433
MOD_NEK2_1	138	143	PF00069	0.716
MOD_NEK2_1	193	198	PF00069	0.405
MOD_NEK2_1	243	248	PF00069	0.312
MOD_NEK2_1	253	258	PF00069	0.312
MOD_NEK2_1	548	553	PF00069	0.588
MOD_NEK2_1	576	581	PF00069	0.415
MOD_NEK2_1	690	695	PF00069	0.617
MOD_NEK2_1	823	828	PF00069	0.535
MOD_NEK2_2	586	591	PF00069	0.350
MOD_PIKK_1	447	453	PF00454	0.604
MOD_PIKK_1	576	582	PF00454	0.436
MOD_PIKK_1	621	627	PF00454	0.404
MOD_PIKK_1	93	99	PF00454	0.663
MOD_PKA_2	253	259	PF00069	0.312
MOD_PKA_2	621	627	PF00069	0.401
MOD_PKA_2	688	694	PF00069	0.580
MOD_PKB_1	561	569	PF00069	0.456
MOD_Plk_1	451	457	PF00069	0.621
MOD_Plk_1	47	53	PF00069	0.607
MOD_Plk_1	563	569	PF00069	0.454
MOD_Plk_1	858	864	PF00069	0.415
MOD_Plk_2-3	110	116	PF00069	0.656
MOD_Plk_2-3	30	36	PF00069	0.655
MOD_Plk_2-3	410	416	PF00069	0.550
MOD_Plk_4	202	208	PF00069	0.312
MOD_Plk_4	311	317	PF00069	0.425
MOD_Plk_4	542	548	PF00069	0.397
MOD_Plk_4	701	707	PF00069	0.629
MOD_Plk_4	720	726	PF00069	0.616
MOD_ProDKin_1	103	109	PF00069	0.593
MOD_ProDKin_1	120	126	PF00069	0.543
MOD_ProDKin_1	329	335	PF00069	0.618
MOD_ProDKin_1	336	342	PF00069	0.591
MOD_ProDKin_1	351	357	PF00069	0.519
MOD_ProDKin_1	362	368	PF00069	0.593
MOD_ProDKin_1	392	398	PF00069	0.647
MOD_ProDKin_1	438	444	PF00069	0.602
MOD_ProDKin_1	445	451	PF00069	0.578
MOD_ProDKin_1	467	473	PF00069	0.620
MOD_ProDKin_1	492	498	PF00069	0.548
MOD_ProDKin_1	5	11	PF00069	0.571
MOD_SUMO_for_1	175	178	PF00179	0.485
MOD_SUMO_rev_2	736	746	PF00179	0.610
TRG_DiLeu_BaEn_1	178	183	PF01217	0.461
TRG_DiLeu_BaEn_1	763	768	PF01217	0.440
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.612
TRG_DiLeu_BaLyEn_6	624	629	PF01217	0.347
TRG_ENDOCYTIC_2	114	117	PF00928	0.600
TRG_ENDOCYTIC_2	221	224	PF00928	0.352
TRG_ENDOCYTIC_2	238	241	PF00928	0.352
TRG_ENDOCYTIC_2	315	318	PF00928	0.444
TRG_ENDOCYTIC_2	453	456	PF00928	0.625
TRG_ENDOCYTIC_2	584	587	PF00928	0.373
TRG_ENDOCYTIC_2	715	718	PF00928	0.577
TRG_ENDOCYTIC_2	837	840	PF00928	0.533
TRG_ER_diArg_1	179	182	PF00400	0.464
TRG_ER_diArg_1	222	225	PF00400	0.352
TRG_ER_diArg_1	253	255	PF00400	0.312
TRG_ER_diArg_1	768	770	PF00400	0.413
TRG_NES_CRM1_1	585	598	PF08389	0.436
TRG_NES_CRM1_1	646	660	PF08389	0.401
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P425	Leptomonas seymouri	57%	98%
A0A3S7X4F6	Leishmania donovani	92%	100%
A4HJ83	Leishmania braziliensis	79%	100%
A4I6M7	Leishmania infantum	92%	100%
E9B1Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%