RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q6F9_LEIMA

TriTrypDb:

LmjF.31.1040 , LMJLV39_310016600 , LMJSD75_310016200

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6F9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.530
CLV_C14_Caspase3-7	382	386	PF00656	0.547
CLV_NRD_NRD_1	227	229	PF00675	0.532
CLV_NRD_NRD_1	244	246	PF00675	0.343
CLV_NRD_NRD_1	391	393	PF00675	0.477
CLV_NRD_NRD_1	472	474	PF00675	0.478
CLV_NRD_NRD_1	501	503	PF00675	0.523
CLV_NRD_NRD_1	554	556	PF00675	0.651
CLV_NRD_NRD_1	647	649	PF00675	0.462
CLV_PCSK_FUR_1	499	503	PF00082	0.517
CLV_PCSK_KEX2_1	227	229	PF00082	0.532
CLV_PCSK_KEX2_1	391	393	PF00082	0.477
CLV_PCSK_KEX2_1	471	473	PF00082	0.467
CLV_PCSK_KEX2_1	501	503	PF00082	0.504
CLV_PCSK_KEX2_1	519	521	PF00082	0.390
CLV_PCSK_KEX2_1	553	555	PF00082	0.652
CLV_PCSK_KEX2_1	647	649	PF00082	0.462
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.442
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.652
CLV_PCSK_SKI1_1	227	231	PF00082	0.566
CLV_PCSK_SKI1_1	654	658	PF00082	0.413
CLV_PCSK_SKI1_1	726	730	PF00082	0.450
DEG_APCC_DBOX_1	653	661	PF00400	0.412
DEG_COP1_1	9	19	PF00400	0.682
DEG_SIAH_1	24	32	PF03145	0.524
DEG_SPOP_SBC_1	206	210	PF00917	0.589
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.634
DOC_MAPK_DCC_7	553	562	PF00069	0.559
DOC_MAPK_FxFP_2	351	354	PF00069	0.607
DOC_MAPK_gen_1	391	398	PF00069	0.446
DOC_MAPK_gen_1	499	509	PF00069	0.476
DOC_MAPK_gen_1	553	562	PF00069	0.705
DOC_MAPK_MEF2A_6	150	157	PF00069	0.409
DOC_MAPK_MEF2A_6	553	562	PF00069	0.647
DOC_MAPK_MEF2A_6	654	663	PF00069	0.410
DOC_MAPK_RevD_3	489	502	PF00069	0.367
DOC_MAPK_RevD_3	541	555	PF00069	0.549
DOC_PP1_RVXF_1	724	731	PF00149	0.463
DOC_PP2B_LxvP_1	347	350	PF13499	0.631
DOC_PP4_FxxP_1	351	354	PF00568	0.607
DOC_PP4_FxxP_1	690	693	PF00568	0.389
DOC_USP7_MATH_1	206	210	PF00917	0.688
DOC_USP7_MATH_1	31	35	PF00917	0.580
DOC_USP7_MATH_1	339	343	PF00917	0.609
DOC_USP7_MATH_1	41	45	PF00917	0.593
DOC_USP7_MATH_1	515	519	PF00917	0.434
DOC_USP7_MATH_1	546	550	PF00917	0.622
DOC_USP7_MATH_1	561	565	PF00917	0.516
DOC_USP7_MATH_2	13	19	PF00917	0.590
DOC_WW_Pin1_4	155	160	PF00397	0.480
DOC_WW_Pin1_4	175	180	PF00397	0.329
DOC_WW_Pin1_4	202	207	PF00397	0.641
DOC_WW_Pin1_4	21	26	PF00397	0.579
DOC_WW_Pin1_4	355	360	PF00397	0.567
DOC_WW_Pin1_4	37	42	PF00397	0.488
DOC_WW_Pin1_4	48	53	PF00397	0.491
DOC_WW_Pin1_4	9	14	PF00397	0.802
LIG_14-3-3_CanoR_1	263	272	PF00244	0.483
LIG_14-3-3_CanoR_1	406	413	PF00244	0.473
LIG_14-3-3_CanoR_1	452	459	PF00244	0.401
LIG_Actin_WH2_2	359	376	PF00022	0.579
LIG_APCC_ABBA_1	687	692	PF00400	0.349
LIG_BIR_II_1	1	5	PF00653	0.835
LIG_BIR_III_2	476	480	PF00653	0.451
LIG_BIR_III_4	290	294	PF00653	0.542
LIG_BRCT_BRCA1_1	403	407	PF00533	0.465
LIG_BRCT_BRCA1_1	632	636	PF00533	0.555
LIG_EH1_1	460	468	PF00400	0.378
LIG_eIF4E_1	655	661	PF01652	0.408
LIG_FHA_1	21	27	PF00498	0.644
LIG_FHA_1	419	425	PF00498	0.447
LIG_FHA_1	444	450	PF00498	0.538
LIG_FHA_1	493	499	PF00498	0.481
LIG_FHA_1	51	57	PF00498	0.639
LIG_FHA_1	614	620	PF00498	0.535
LIG_FHA_1	640	646	PF00498	0.487
LIG_FHA_1	72	78	PF00498	0.457
LIG_FHA_2	189	195	PF00498	0.491
LIG_FHA_2	414	420	PF00498	0.418
LIG_GBD_Chelix_1	462	470	PF00786	0.410
LIG_Integrin_isoDGR_2	683	685	PF01839	0.437
LIG_LIR_Apic_2	688	693	PF02991	0.377
LIG_LIR_Gen_1	104	110	PF02991	0.535
LIG_LIR_Gen_1	487	496	PF02991	0.377
LIG_LIR_LC3C_4	194	199	PF02991	0.548
LIG_LIR_Nem_3	104	108	PF02991	0.535
LIG_LIR_Nem_3	266	271	PF02991	0.600
LIG_LIR_Nem_3	487	491	PF02991	0.370
LIG_LIR_Nem_3	649	655	PF02991	0.432
LIG_LIR_Nem_3	753	759	PF02991	0.448
LIG_NRBOX	419	425	PF00104	0.447
LIG_PCNA_PIPBox_1	455	464	PF02747	0.298
LIG_PCNA_yPIPBox_3	91	99	PF02747	0.535
LIG_PDZ_Class_2	765	770	PF00595	0.482
LIG_Pex14_1	120	124	PF04695	0.535
LIG_Pex14_2	731	735	PF04695	0.427
LIG_SH2_STAP1	170	174	PF00017	0.481
LIG_SH2_STAP1	631	635	PF00017	0.541
LIG_SH2_STAT5	105	108	PF00017	0.535
LIG_SH2_STAT5	139	142	PF00017	0.502
LIG_SH2_STAT5	655	658	PF00017	0.409
LIG_SH3_1	555	561	PF00018	0.644
LIG_SH3_2	145	150	PF14604	0.539
LIG_SH3_3	142	148	PF00018	0.625
LIG_SH3_3	295	301	PF00018	0.611
LIG_SH3_3	555	561	PF00018	0.644
LIG_SUMO_SIM_anti_2	194	201	PF11976	0.539
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.479
LIG_SUMO_SIM_par_1	194	201	PF11976	0.568
LIG_TRAF2_1	666	669	PF00917	0.430
LIG_UBA3_1	715	721	PF00899	0.342
LIG_WRC_WIRS_1	485	490	PF05994	0.461
LIG_WRC_WIRS_1	562	567	PF05994	0.651
MOD_CDC14_SPxK_1	158	161	PF00782	0.483
MOD_CDK_SPK_2	202	207	PF00069	0.641
MOD_CDK_SPxK_1	155	161	PF00069	0.485
MOD_CK1_1	18	24	PF00069	0.530
MOD_CK1_1	208	214	PF00069	0.585
MOD_CK1_1	3	9	PF00069	0.693
MOD_CK1_1	376	382	PF00069	0.619
MOD_CK1_1	418	424	PF00069	0.445
MOD_CK1_1	44	50	PF00069	0.631
MOD_CK1_1	518	524	PF00069	0.451
MOD_CK1_1	57	63	PF00069	0.534
MOD_CK1_1	622	628	PF00069	0.610
MOD_CK1_1	639	645	PF00069	0.355
MOD_CK1_1	64	70	PF00069	0.445
MOD_CK2_1	413	419	PF00069	0.423
MOD_CK2_1	570	576	PF00069	0.708
MOD_CK2_1	584	590	PF00069	0.602
MOD_CK2_1	69	75	PF00069	0.552
MOD_CK2_1	9	15	PF00069	0.805
MOD_GlcNHglycan	2	5	PF01048	0.823
MOD_GlcNHglycan	200	203	PF01048	0.652
MOD_GlcNHglycan	216	219	PF01048	0.639
MOD_GlcNHglycan	256	259	PF01048	0.590
MOD_GlcNHglycan	286	289	PF01048	0.635
MOD_GlcNHglycan	341	344	PF01048	0.623
MOD_GlcNHglycan	375	378	PF01048	0.610
MOD_GlcNHglycan	403	406	PF01048	0.466
MOD_GlcNHglycan	441	444	PF01048	0.587
MOD_GlcNHglycan	463	466	PF01048	0.376
MOD_GlcNHglycan	621	625	PF01048	0.760
MOD_GlcNHglycan	676	679	PF01048	0.548
MOD_GlcNHglycan	723	726	PF01048	0.510
MOD_GSK3_1	15	22	PF00069	0.559
MOD_GSK3_1	198	205	PF00069	0.633
MOD_GSK3_1	208	215	PF00069	0.583
MOD_GSK3_1	335	342	PF00069	0.549
MOD_GSK3_1	37	44	PF00069	0.559
MOD_GSK3_1	401	408	PF00069	0.468
MOD_GSK3_1	439	446	PF00069	0.576
MOD_GSK3_1	48	55	PF00069	0.588
MOD_GSK3_1	57	64	PF00069	0.544
MOD_GSK3_1	620	627	PF00069	0.730
MOD_N-GLC_1	175	180	PF02516	0.519
MOD_N-GLC_1	57	62	PF02516	0.618
MOD_N-GLC_1	637	642	PF02516	0.386
MOD_N-GLC_1	721	726	PF02516	0.511
MOD_N-GLC_2	260	262	PF02516	0.574
MOD_NEK2_1	19	24	PF00069	0.588
MOD_NEK2_1	373	378	PF00069	0.614
MOD_NEK2_1	401	406	PF00069	0.457
MOD_NEK2_1	426	431	PF00069	0.462
MOD_NEK2_1	619	624	PF00069	0.614
MOD_NEK2_1	69	74	PF00069	0.564
MOD_NEK2_1	735	740	PF00069	0.390
MOD_NEK2_1	77	82	PF00069	0.367
MOD_OFUCOSY	261	267	PF10250	0.545
MOD_PIKK_1	379	385	PF00454	0.591
MOD_PIKK_1	418	424	PF00454	0.445
MOD_PIKK_1	451	457	PF00454	0.441
MOD_PIKK_1	50	56	PF00454	0.639
MOD_PIKK_1	518	524	PF00454	0.572
MOD_PIKK_1	740	746	PF00454	0.457
MOD_PKA_2	373	379	PF00069	0.617
MOD_PKA_2	405	411	PF00069	0.484
MOD_PKA_2	451	457	PF00069	0.412
MOD_PKA_2	69	75	PF00069	0.552
MOD_PKA_2	749	755	PF00069	0.463
MOD_Plk_1	188	194	PF00069	0.482
MOD_Plk_1	418	424	PF00069	0.445
MOD_Plk_1	57	63	PF00069	0.616
MOD_Plk_1	600	606	PF00069	0.572
MOD_Plk_1	613	619	PF00069	0.532
MOD_Plk_1	648	654	PF00069	0.438
MOD_Plk_1	726	732	PF00069	0.439
MOD_Plk_4	15	21	PF00069	0.560
MOD_Plk_4	41	47	PF00069	0.633
MOD_Plk_4	492	498	PF00069	0.473
MOD_Plk_4	547	553	PF00069	0.637
MOD_Plk_4	561	567	PF00069	0.517
MOD_Plk_4	570	576	PF00069	0.567
MOD_Plk_4	64	70	PF00069	0.635
MOD_Plk_4	669	675	PF00069	0.337
MOD_Plk_4	726	732	PF00069	0.439
MOD_Plk_4	763	769	PF00069	0.453
MOD_ProDKin_1	155	161	PF00069	0.485
MOD_ProDKin_1	175	181	PF00069	0.328
MOD_ProDKin_1	202	208	PF00069	0.643
MOD_ProDKin_1	21	27	PF00069	0.578
MOD_ProDKin_1	355	361	PF00069	0.560
MOD_ProDKin_1	37	43	PF00069	0.488
MOD_ProDKin_1	48	54	PF00069	0.491
MOD_ProDKin_1	9	15	PF00069	0.805
MOD_SUMO_rev_2	585	594	PF00179	0.550
TRG_DiLeu_BaEn_1	15	20	PF01217	0.562
TRG_DiLeu_BaEn_1	419	424	PF01217	0.441
TRG_DiLeu_BaEn_1	692	697	PF01217	0.479
TRG_DiLeu_BaLyEn_6	742	747	PF01217	0.451
TRG_ENDOCYTIC_2	105	108	PF00928	0.535
TRG_ENDOCYTIC_2	122	125	PF00928	0.420
TRG_ENDOCYTIC_2	139	142	PF00928	0.341
TRG_ER_diArg_1	106	109	PF00400	0.535
TRG_ER_diArg_1	227	229	PF00400	0.545
TRG_ER_diArg_1	470	473	PF00400	0.458
TRG_ER_diArg_1	498	501	PF00400	0.632
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IET1	Leishmania donovani	89%	100%
A4I6M8	Leishmania infantum	89%	100%
E9B1Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%