Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q6F8_LEIMA

TriTrypDb:

LmjF.31.1050 , LMJLV39_310016700 , LMJSD75_310016300

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6F8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.578
CLV_NRD_NRD_1	202	204	PF00675	0.719
CLV_NRD_NRD_1	213	215	PF00675	0.595
CLV_NRD_NRD_1	262	264	PF00675	0.726
CLV_PCSK_FUR_1	199	203	PF00082	0.721
CLV_PCSK_KEX2_1	161	163	PF00082	0.678
CLV_PCSK_KEX2_1	199	201	PF00082	0.721
CLV_PCSK_KEX2_1	202	204	PF00082	0.689
CLV_PCSK_KEX2_1	213	215	PF00082	0.566
CLV_PCSK_KEX2_1	262	264	PF00082	0.697
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.678
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.697
CLV_PCSK_SKI1_1	137	141	PF00082	0.629
CLV_PCSK_SKI1_1	284	288	PF00082	0.713
DEG_SPOP_SBC_1	194	198	PF00917	0.594
DOC_CKS1_1	8	13	PF01111	0.698
DOC_MAPK_gen_1	135	143	PF00069	0.567
DOC_MAPK_gen_1	227	237	PF00069	0.612
DOC_PP1_RVXF_1	138	144	PF00149	0.566
DOC_PP2B_LxvP_1	349	352	PF13499	0.697
DOC_PP4_FxxP_1	8	11	PF00568	0.667
DOC_USP7_MATH_1	118	122	PF00917	0.718
DOC_USP7_MATH_1	253	257	PF00917	0.721
DOC_USP7_MATH_1	311	315	PF00917	0.711
DOC_USP7_MATH_1	323	327	PF00917	0.576
DOC_USP7_MATH_1	51	55	PF00917	0.706
DOC_USP7_MATH_1	82	86	PF00917	0.699
DOC_USP7_UBL2_3	278	282	PF12436	0.717
DOC_USP7_UBL2_3	284	288	PF12436	0.653
DOC_WW_Pin1_4	152	157	PF00397	0.629
DOC_WW_Pin1_4	277	282	PF00397	0.685
DOC_WW_Pin1_4	7	12	PF00397	0.695
LIG_14-3-3_CanoR_1	247	253	PF00244	0.604
LIG_14-3-3_CanoR_1	50	59	PF00244	0.671
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_FHA_1	340	346	PF00498	0.689
LIG_FHA_1	53	59	PF00498	0.667
LIG_FHA_2	239	245	PF00498	0.717
LIG_FHA_2	341	347	PF00498	0.571
LIG_FHA_2	8	14	PF00498	0.699
LIG_Integrin_isoDGR_2	245	247	PF01839	0.695
LIG_LIR_Apic_2	7	11	PF02991	0.665
LIG_PDZ_Class_1	382	387	PF00595	0.708
LIG_SH2_NCK_1	180	184	PF00017	0.668
LIG_SH2_STAP1	180	184	PF00017	0.668
LIG_SH3_3	138	144	PF00018	0.566
LIG_SH3_3	160	166	PF00018	0.707
LIG_SH3_3	171	177	PF00018	0.585
LIG_SH3_3	53	59	PF00018	0.789
LIG_SH3_3	97	103	PF00018	0.772
LIG_SH3_4	284	291	PF00018	0.707
LIG_Sin3_3	125	132	PF02671	0.556
LIG_TRAF2_1	256	259	PF00917	0.664
LIG_TRAF2_1	372	375	PF00917	0.695
MOD_CDK_SPK_2	277	282	PF00069	0.685
MOD_CDK_SPxxK_3	277	284	PF00069	0.686
MOD_CK1_1	238	244	PF00069	0.720
MOD_CK1_1	257	263	PF00069	0.720
MOD_CK1_1	54	60	PF00069	0.771
MOD_CK1_1	65	71	PF00069	0.686
MOD_CK2_1	118	124	PF00069	0.691
MOD_CK2_1	238	244	PF00069	0.716
MOD_CK2_1	253	259	PF00069	0.702
MOD_CK2_1	311	317	PF00069	0.706
MOD_CK2_1	35	41	PF00069	0.705
MOD_CK2_1	7	13	PF00069	0.696
MOD_Cter_Amidation	158	161	PF01082	0.712
MOD_Cter_Amidation	211	214	PF01082	0.729
MOD_Cter_Amidation	260	263	PF01082	0.596
MOD_GlcNHglycan	1	4	PF01048	0.686
MOD_GlcNHglycan	111	114	PF01048	0.817
MOD_GlcNHglycan	120	123	PF01048	0.653
MOD_GlcNHglycan	16	19	PF01048	0.524
MOD_GlcNHglycan	191	194	PF01048	0.603
MOD_GlcNHglycan	259	262	PF01048	0.727
MOD_GlcNHglycan	304	307	PF01048	0.711
MOD_GlcNHglycan	317	321	PF01048	0.588
MOD_GlcNHglycan	324	328	PF01048	0.505
MOD_GlcNHglycan	349	352	PF01048	0.695
MOD_GlcNHglycan	37	40	PF01048	0.721
MOD_GlcNHglycan	67	70	PF01048	0.664
MOD_GlcNHglycan	82	85	PF01048	0.576
MOD_GSK3_1	189	196	PF00069	0.578
MOD_GSK3_1	253	260	PF00069	0.817
MOD_GSK3_1	298	305	PF00069	0.703
MOD_GSK3_1	33	40	PF00069	0.726
MOD_GSK3_1	54	61	PF00069	0.742
MOD_LATS_1	60	66	PF00433	0.687
MOD_NEK2_1	35	40	PF00069	0.713
MOD_PIKK_1	215	221	PF00454	0.712
MOD_PIKK_1	238	244	PF00454	0.716
MOD_PIKK_1	254	260	PF00454	0.690
MOD_PIKK_1	311	317	PF00454	0.721
MOD_PKA_2	107	113	PF00069	0.704
MOD_PKA_2	14	20	PF00069	0.575
MOD_PKA_2	65	71	PF00069	0.716
MOD_Plk_2-3	340	346	PF00069	0.567
MOD_Plk_4	96	102	PF00069	0.672
MOD_ProDKin_1	152	158	PF00069	0.629
MOD_ProDKin_1	277	283	PF00069	0.685
MOD_ProDKin_1	7	13	PF00069	0.696
MOD_SUMO_for_1	372	375	PF00179	0.695
MOD_SUMO_rev_2	121	128	PF00179	0.680
MOD_SUMO_rev_2	328	337	PF00179	0.641
TRG_ER_diArg_1	106	109	PF00400	0.703
TRG_ER_diArg_1	199	202	PF00400	0.721
TRG_ER_diArg_1	213	215	PF00400	0.564
TRG_ER_KDEL_1	384	387	PF00810	0.707
TRG_NLS_MonoExtC_3	159	164	PF00514	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJY9	Leishmania donovani	84%	100%
A4I6M9	Leishmania infantum	85%	100%
E9B1Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%