SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6F7_LEIMA

TriTrypDb:

LmjF.31.1060 , LMJLV39_310016800 , LMJSD75_310016400

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q6F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6F7

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018026	peptidyl-lysine monomethylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.480
CLV_C14_Caspase3-7	239	243	PF00656	0.488
CLV_C14_Caspase3-7	297	301	PF00656	0.510
CLV_C14_Caspase3-7	352	356	PF00656	0.582
CLV_NRD_NRD_1	138	140	PF00675	0.240
CLV_NRD_NRD_1	218	220	PF00675	0.243
CLV_NRD_NRD_1	492	494	PF00675	0.500
CLV_NRD_NRD_1	533	535	PF00675	0.590
CLV_PCSK_KEX2_1	138	140	PF00082	0.240
CLV_PCSK_KEX2_1	211	213	PF00082	0.280
CLV_PCSK_KEX2_1	218	220	PF00082	0.236
CLV_PCSK_KEX2_1	492	494	PF00082	0.503
CLV_PCSK_KEX2_1	533	535	PF00082	0.644
CLV_PCSK_KEX2_1	80	82	PF00082	0.273
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.280
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.273
CLV_PCSK_PC7_1	214	220	PF00082	0.180
CLV_PCSK_SKI1_1	132	136	PF00082	0.273
CLV_PCSK_SKI1_1	27	31	PF00082	0.552
CLV_PCSK_SKI1_1	338	342	PF00082	0.379
CLV_PCSK_SKI1_1	365	369	PF00082	0.330
CLV_PCSK_SKI1_1	66	70	PF00082	0.403
CLV_PCSK_SKI1_1	76	80	PF00082	0.269
DEG_Nend_Nbox_1	1	3	PF02207	0.550
DOC_ANK_TNKS_1	261	268	PF00023	0.380
DOC_MAPK_DCC_7	327	336	PF00069	0.497
DOC_MAPK_gen_1	327	336	PF00069	0.580
DOC_MAPK_gen_1	76	86	PF00069	0.522
DOC_MAPK_HePTP_8	324	336	PF00069	0.480
DOC_MAPK_MEF2A_6	327	336	PF00069	0.497
DOC_MAPK_MEF2A_6	80	88	PF00069	0.482
DOC_MAPK_RevD_3	63	77	PF00069	0.382
DOC_PP2B_LxvP_1	86	89	PF13499	0.480
DOC_USP7_MATH_1	227	231	PF00917	0.534
DOC_USP7_MATH_1	253	257	PF00917	0.480
DOC_USP7_MATH_1	288	292	PF00917	0.548
DOC_USP7_MATH_1	409	413	PF00917	0.447
DOC_USP7_MATH_1	448	452	PF00917	0.480
DOC_USP7_MATH_1	48	52	PF00917	0.581
DOC_USP7_UBL2_3	359	363	PF12436	0.510
DOC_USP7_UBL2_3	76	80	PF12436	0.464
DOC_WW_Pin1_4	167	172	PF00397	0.438
DOC_WW_Pin1_4	446	451	PF00397	0.418
DOC_WW_Pin1_4	5	10	PF00397	0.517
DOC_WW_Pin1_4	515	520	PF00397	0.728
DOC_WW_Pin1_4	91	96	PF00397	0.542
LIG_14-3-3_CanoR_1	138	143	PF00244	0.438
LIG_14-3-3_CanoR_1	15	22	PF00244	0.488
LIG_14-3-3_CanoR_1	327	332	PF00244	0.527
LIG_14-3-3_CanoR_1	66	74	PF00244	0.438
LIG_Actin_WH2_2	50	68	PF00022	0.459
LIG_BIR_III_4	242	246	PF00653	0.380
LIG_BIR_III_4	25	29	PF00653	0.492
LIG_BIR_III_4	355	359	PF00653	0.480
LIG_eIF4E_1	173	179	PF01652	0.461
LIG_FHA_1	100	106	PF00498	0.509
LIG_FHA_1	249	255	PF00498	0.430
LIG_FHA_1	285	291	PF00498	0.446
LIG_FHA_1	426	432	PF00498	0.523
LIG_FHA_1	457	463	PF00498	0.480
LIG_FHA_1	85	91	PF00498	0.507
LIG_FHA_2	200	206	PF00498	0.423
LIG_FHA_2	92	98	PF00498	0.495
LIG_Integrin_RGD_1	437	439	PF01839	0.230
LIG_LIR_Gen_1	102	112	PF02991	0.430
LIG_LIR_Gen_1	127	135	PF02991	0.438
LIG_LIR_Gen_1	18	29	PF02991	0.456
LIG_LIR_Gen_1	449	458	PF02991	0.556
LIG_LIR_Nem_3	102	107	PF02991	0.452
LIG_LIR_Nem_3	127	131	PF02991	0.438
LIG_LIR_Nem_3	140	145	PF02991	0.438
LIG_LIR_Nem_3	170	176	PF02991	0.477
LIG_LIR_Nem_3	18	24	PF02991	0.464
LIG_LIR_Nem_3	449	455	PF02991	0.556
LIG_LIR_Nem_3	477	483	PF02991	0.367
LIG_LYPXL_S_1	172	176	PF13949	0.261
LIG_LYPXL_yS_3	173	176	PF13949	0.461
LIG_Pex14_1	224	228	PF04695	0.438
LIG_Pex14_1	536	540	PF04695	0.551
LIG_PTB_Apo_2	407	414	PF02174	0.522
LIG_PTB_Phospho_1	407	413	PF10480	0.491
LIG_SH2_CRK	128	132	PF00017	0.522
LIG_SH2_CRK	452	456	PF00017	0.508
LIG_SH2_CRK	485	489	PF00017	0.470
LIG_SH2_NCK_1	115	119	PF00017	0.568
LIG_SH2_NCK_1	228	232	PF00017	0.522
LIG_SH2_NCK_1	476	480	PF00017	0.459
LIG_SH2_SRC	206	209	PF00017	0.447
LIG_SH2_SRC	281	284	PF00017	0.447
LIG_SH2_SRC	369	372	PF00017	0.508
LIG_SH2_STAP1	115	119	PF00017	0.480
LIG_SH2_STAP1	206	210	PF00017	0.447
LIG_SH2_STAP1	476	480	PF00017	0.357
LIG_SH2_STAP1	74	78	PF00017	0.522
LIG_SH2_STAT5	175	178	PF00017	0.438
LIG_SH2_STAT5	413	416	PF00017	0.455
LIG_SH2_STAT5	472	475	PF00017	0.412
LIG_SH2_STAT5	480	483	PF00017	0.289
LIG_SH3_3	120	126	PF00018	0.544
LIG_SH3_3	168	174	PF00018	0.458
LIG_SH3_3	194	200	PF00018	0.438
LIG_SH3_3	398	404	PF00018	0.563
LIG_SUMO_SIM_par_1	89	94	PF11976	0.380
MOD_CK1_1	127	133	PF00069	0.455
MOD_CK1_1	20	26	PF00069	0.441
MOD_CK1_1	268	274	PF00069	0.452
MOD_CK1_1	291	297	PF00069	0.476
MOD_CK1_1	4	10	PF00069	0.499
MOD_CK1_1	425	431	PF00069	0.512
MOD_CK1_1	518	524	PF00069	0.604
MOD_CK2_1	199	205	PF00069	0.423
MOD_CK2_1	424	430	PF00069	0.580
MOD_CK2_1	488	494	PF00069	0.580
MOD_GlcNHglycan	180	183	PF01048	0.322
MOD_GlcNHglycan	229	232	PF01048	0.325
MOD_GlcNHglycan	290	293	PF01048	0.301
MOD_GlcNHglycan	296	299	PF01048	0.289
MOD_GlcNHglycan	441	444	PF01048	0.272
MOD_GlcNHglycan	446	449	PF01048	0.257
MOD_GlcNHglycan	529	532	PF01048	0.394
MOD_GSK3_1	1	8	PF00069	0.512
MOD_GSK3_1	133	140	PF00069	0.599
MOD_GSK3_1	284	291	PF00069	0.496
MOD_GSK3_1	323	330	PF00069	0.457
MOD_GSK3_1	386	393	PF00069	0.538
MOD_GSK3_1	418	425	PF00069	0.583
MOD_GSK3_1	426	433	PF00069	0.500
MOD_GSK3_1	439	446	PF00069	0.462
MOD_GSK3_1	474	481	PF00069	0.365
MOD_GSK3_1	515	522	PF00069	0.633
MOD_GSK3_1	535	542	PF00069	0.492
MOD_N-GLC_1	409	414	PF02516	0.280
MOD_NEK2_1	1	6	PF00069	0.520
MOD_NEK2_1	254	259	PF00069	0.430
MOD_NEK2_1	42	47	PF00069	0.398
MOD_NEK2_1	468	473	PF00069	0.524
MOD_PK_1	474	480	PF00069	0.409
MOD_PKA_1	138	144	PF00069	0.427
MOD_PKA_2	137	143	PF00069	0.438
MOD_PKA_2	14	20	PF00069	0.506
MOD_PKA_2	456	462	PF00069	0.492
MOD_Plk_1	17	23	PF00069	0.577
MOD_Plk_1	268	274	PF00069	0.387
MOD_Plk_1	409	415	PF00069	0.483
MOD_Plk_1	466	472	PF00069	0.445
MOD_Plk_4	17	23	PF00069	0.577
MOD_Plk_4	390	396	PF00069	0.469
MOD_Plk_4	42	48	PF00069	0.422
MOD_Plk_4	468	474	PF00069	0.469
MOD_Plk_4	478	484	PF00069	0.292
MOD_Plk_4	496	502	PF00069	0.480
MOD_Plk_4	535	541	PF00069	0.496
MOD_ProDKin_1	167	173	PF00069	0.438
MOD_ProDKin_1	446	452	PF00069	0.418
MOD_ProDKin_1	5	11	PF00069	0.513
MOD_ProDKin_1	515	521	PF00069	0.726
MOD_ProDKin_1	91	97	PF00069	0.542
MOD_SUMO_rev_2	291	297	PF00179	0.468
TRG_DiLeu_BaEn_1	58	63	PF01217	0.393
TRG_DiLeu_BaEn_4	463	469	PF01217	0.455
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.480
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.522
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.447
TRG_ENDOCYTIC_2	128	131	PF00928	0.455
TRG_ENDOCYTIC_2	173	176	PF00928	0.455
TRG_ENDOCYTIC_2	281	284	PF00928	0.518
TRG_ENDOCYTIC_2	369	372	PF00928	0.539
TRG_ENDOCYTIC_2	452	455	PF00928	0.508
TRG_ENDOCYTIC_2	485	488	PF00928	0.468
TRG_ER_diArg_1	137	139	PF00400	0.572
TRG_ER_diArg_1	217	219	PF00400	0.435
TRG_ER_diArg_1	532	534	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM8	Leptomonas seymouri	51%	71%
A0A1X0NJ79	Trypanosomatidae	39%	95%
A0A3S7X4A8	Leishmania donovani	92%	100%
A4HJ86	Leishmania braziliensis	77%	71%
A4I6N0	Leishmania infantum	92%	100%
C9ZM67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	88%
E9B1Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BPH7	Trypanosoma cruzi	40%	86%