Biotin/lipoate protein ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

biotin/lipoate protein ligase-like protein

Species:

Leishmania major

UniProt:

Q4Q6F6_LEIMA

TriTrypDb:

LmjF.31.1070 , LMJLV39_310017000 , LMJSD75_310016600

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q6F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6F6

PDB structure(s): 6jhu_A , 7dbs_A

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	4	10
GO:0016874	ligase activity	2	12
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	10
GO:0018271	biotin-protein ligase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.412
CLV_PCSK_KEX2_1	223	225	PF00082	0.518
CLV_PCSK_KEX2_1	91	93	PF00082	0.418
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.567
CLV_PCSK_SKI1_1	163	167	PF00082	0.576
CLV_PCSK_SKI1_1	217	221	PF00082	0.552
CLV_PCSK_SKI1_1	92	96	PF00082	0.412
DEG_APCC_DBOX_1	91	99	PF00400	0.612
DOC_MAPK_DCC_7	75	84	PF00069	0.571
DOC_MAPK_gen_1	91	97	PF00069	0.612

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUD5	Leptomonas seymouri	70%	100%
A0A0S4JE29	Bodo saltans	35%	85%
A0A1X0P3B0	Trypanosomatidae	52%	100%
A0A3R7NY08	Trypanosoma rangeli	49%	100%
A0A3S7X4E1	Leishmania donovani	93%	100%
A4HJ88	Leishmania braziliensis	83%	100%
A4I6N1	Leishmania infantum	93%	100%
D0A8L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B1Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DNJ4	Trypanosoma cruzi	51%	100%

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