Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6F4_LEIMA

TriTrypDb:

LmjF.31.1090 , LMJLV39_310017200 , LMJSD75_310016800

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6F4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.568
CLV_C14_Caspase3-7	369	373	PF00656	0.641
CLV_C14_Caspase3-7	5	9	PF00656	0.626
CLV_C14_Caspase3-7	563	567	PF00656	0.665
CLV_NRD_NRD_1	174	176	PF00675	0.643
CLV_NRD_NRD_1	194	196	PF00675	0.379
CLV_NRD_NRD_1	211	213	PF00675	0.535
CLV_NRD_NRD_1	519	521	PF00675	0.647
CLV_NRD_NRD_1	564	566	PF00675	0.676
CLV_NRD_NRD_1	576	578	PF00675	0.610
CLV_NRD_NRD_1	621	623	PF00675	0.587
CLV_PCSK_KEX2_1	173	175	PF00082	0.662
CLV_PCSK_KEX2_1	193	195	PF00082	0.380
CLV_PCSK_KEX2_1	210	212	PF00082	0.540
CLV_PCSK_KEX2_1	564	566	PF00082	0.664
CLV_PCSK_SKI1_1	103	107	PF00082	0.611
CLV_PCSK_SKI1_1	333	337	PF00082	0.638
CLV_PCSK_SKI1_1	521	525	PF00082	0.640
CLV_PCSK_SKI1_1	637	641	PF00082	0.576
DEG_APCC_DBOX_1	332	340	PF00400	0.597
DEG_APCC_DBOX_1	499	507	PF00400	0.582
DEG_COP1_1	417	426	PF00400	0.647
DEG_Nend_UBRbox_2	1	3	PF02207	0.581
DEG_SCF_TRCP1_1	36	42	PF00400	0.651
DEG_SPOP_SBC_1	371	375	PF00917	0.569
DEG_SPOP_SBC_1	540	544	PF00917	0.682
DOC_CDC14_PxL_1	449	457	PF14671	0.613
DOC_CKS1_1	167	172	PF01111	0.586
DOC_CKS1_1	315	320	PF01111	0.686
DOC_CYCLIN_RxL_1	518	527	PF00134	0.640
DOC_CYCLIN_yClb5_NLxxxL_5	330	336	PF00134	0.581
DOC_MAPK_DCC_7	333	341	PF00069	0.571
DOC_MAPK_gen_1	301	308	PF00069	0.567
DOC_MAPK_MEF2A_6	301	308	PF00069	0.659
DOC_MAPK_MEF2A_6	333	341	PF00069	0.571
DOC_MAPK_MEF2A_6	389	398	PF00069	0.595
DOC_MAPK_MEF2A_6	444	451	PF00069	0.628
DOC_PP2B_LxvP_1	421	424	PF13499	0.656
DOC_PP2B_LxvP_1	72	75	PF13499	0.577
DOC_PP4_FxxP_1	269	272	PF00568	0.657
DOC_USP7_MATH_1	239	243	PF00917	0.647
DOC_USP7_MATH_1	251	255	PF00917	0.592
DOC_USP7_MATH_1	281	285	PF00917	0.598
DOC_USP7_MATH_1	363	367	PF00917	0.581
DOC_USP7_MATH_1	371	375	PF00917	0.523
DOC_USP7_MATH_1	416	420	PF00917	0.667
DOC_USP7_MATH_1	424	428	PF00917	0.637
DOC_USP7_MATH_1	430	434	PF00917	0.615
DOC_USP7_MATH_1	462	466	PF00917	0.682
DOC_USP7_MATH_1	540	544	PF00917	0.682
DOC_USP7_MATH_1	545	549	PF00917	0.652
DOC_USP7_MATH_1	554	558	PF00917	0.588
DOC_WW_Pin1_4	160	165	PF00397	0.663
DOC_WW_Pin1_4	166	171	PF00397	0.611
DOC_WW_Pin1_4	18	23	PF00397	0.781
DOC_WW_Pin1_4	314	319	PF00397	0.591
DOC_WW_Pin1_4	350	355	PF00397	0.649
DOC_WW_Pin1_4	400	405	PF00397	0.649
DOC_WW_Pin1_4	480	485	PF00397	0.659
DOC_WW_Pin1_4	511	516	PF00397	0.674
DOC_WW_Pin1_4	547	552	PF00397	0.699
DOC_WW_Pin1_4	91	96	PF00397	0.569
LIG_14-3-3_CanoR_1	103	112	PF00244	0.607
LIG_14-3-3_CanoR_1	137	141	PF00244	0.598
LIG_14-3-3_CanoR_1	212	220	PF00244	0.600
LIG_14-3-3_CanoR_1	240	244	PF00244	0.580
LIG_14-3-3_CanoR_1	309	313	PF00244	0.666
LIG_14-3-3_CanoR_1	325	332	PF00244	0.541
LIG_14-3-3_CanoR_1	385	393	PF00244	0.623
LIG_14-3-3_CanoR_1	420	424	PF00244	0.704
LIG_14-3-3_CanoR_1	535	539	PF00244	0.660
LIG_EH_1	49	53	PF12763	0.616
LIG_FHA_1	250	256	PF00498	0.584
LIG_FHA_1	309	315	PF00498	0.667
LIG_FHA_1	354	360	PF00498	0.622
LIG_FHA_1	434	440	PF00498	0.652
LIG_FHA_1	525	531	PF00498	0.653
LIG_FHA_1	59	65	PF00498	0.558
LIG_FHA_2	429	435	PF00498	0.754
LIG_Integrin_RGD_1	231	233	PF01839	0.644
LIG_Integrin_RGD_1	586	588	PF01839	0.702
LIG_Integrin_RGD_1	592	594	PF01839	0.653
LIG_LIR_Apic_2	268	272	PF02991	0.684
LIG_LIR_Apic_2	351	355	PF02991	0.647
LIG_LIR_Gen_1	106	114	PF02991	0.518
LIG_LIR_Gen_1	2	11	PF02991	0.597
LIG_LIR_Gen_1	403	412	PF02991	0.781
LIG_LIR_Gen_1	631	640	PF02991	0.561
LIG_LIR_Gen_1	94	105	PF02991	0.624
LIG_LIR_Nem_3	106	112	PF02991	0.521
LIG_LIR_Nem_3	179	185	PF02991	0.564
LIG_LIR_Nem_3	2	6	PF02991	0.612
LIG_LIR_Nem_3	217	223	PF02991	0.647
LIG_LIR_Nem_3	397	401	PF02991	0.720
LIG_LIR_Nem_3	403	409	PF02991	0.718
LIG_LIR_Nem_3	631	636	PF02991	0.554
LIG_LIR_Nem_3	94	100	PF02991	0.631
LIG_PCNA_yPIPBox_3	325	336	PF02747	0.645
LIG_Pex14_2	629	633	PF04695	0.555
LIG_REV1ctd_RIR_1	180	188	PF16727	0.544
LIG_SH2_CRK	220	224	PF00017	0.579
LIG_SH2_CRK	352	356	PF00017	0.646
LIG_SH2_NCK_1	352	356	PF00017	0.646
LIG_SH2_NCK_1	97	101	PF00017	0.659
LIG_SH2_STAT5	229	232	PF00017	0.604
LIG_SH2_STAT5	3	6	PF00017	0.624
LIG_SH2_STAT5	97	100	PF00017	0.664
LIG_SH3_2	147	152	PF14604	0.635
LIG_SH3_2	337	342	PF14604	0.653
LIG_SH3_2	551	556	PF14604	0.670
LIG_SH3_2	75	80	PF14604	0.574
LIG_SH3_3	144	150	PF00018	0.638
LIG_SH3_3	161	167	PF00018	0.538
LIG_SH3_3	220	226	PF00018	0.583
LIG_SH3_3	242	248	PF00018	0.582
LIG_SH3_3	270	276	PF00018	0.620
LIG_SH3_3	312	318	PF00018	0.644
LIG_SH3_3	334	340	PF00018	0.660
LIG_SH3_3	398	404	PF00018	0.647
LIG_SH3_3	448	454	PF00018	0.654
LIG_SH3_3	481	487	PF00018	0.636
LIG_SH3_3	488	494	PF00018	0.620
LIG_SH3_3	503	509	PF00018	0.554
LIG_SH3_3	548	554	PF00018	0.698
LIG_SH3_3	72	78	PF00018	0.572
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.643
LIG_TRAF2_1	426	429	PF00917	0.798
LIG_TRAF2_2	318	323	PF00917	0.672
LIG_UBA3_1	639	643	PF00899	0.559
LIG_WRC_WIRS_1	266	271	PF05994	0.661
LIG_WRC_WIRS_1	3	8	PF05994	0.747
LIG_WRC_WIRS_1	609	614	PF05994	0.588
LIG_WW_2	453	456	PF00397	0.618
LIG_WW_3	149	153	PF00397	0.630
MOD_CDC14_SPxK_1	21	24	PF00782	0.654
MOD_CDC14_SPxK_1	483	486	PF00782	0.659
MOD_CDC14_SPxK_1	553	556	PF00782	0.611
MOD_CDK_SPxK_1	18	24	PF00069	0.649
MOD_CDK_SPxK_1	480	486	PF00069	0.661
MOD_CDK_SPxK_1	550	556	PF00069	0.611
MOD_CDK_SPxxK_3	166	173	PF00069	0.587
MOD_CDK_SPxxK_3	314	321	PF00069	0.598
MOD_CDK_SPxxK_3	511	518	PF00069	0.686
MOD_CK1_1	10	16	PF00069	0.735
MOD_CK1_1	163	169	PF00069	0.603
MOD_CK1_1	234	240	PF00069	0.667
MOD_CK1_1	353	359	PF00069	0.649
MOD_CK1_1	365	371	PF00069	0.559
MOD_CK1_1	374	380	PF00069	0.536
MOD_CK1_1	381	387	PF00069	0.596
MOD_CK1_1	419	425	PF00069	0.683
MOD_CK1_1	433	439	PF00069	0.560
MOD_CK1_1	492	498	PF00069	0.749
MOD_CK1_1	534	540	PF00069	0.659
MOD_CK1_1	544	550	PF00069	0.611
MOD_CK1_1	557	563	PF00069	0.598
MOD_CK1_1	596	602	PF00069	0.629
MOD_CK2_1	110	116	PF00069	0.561
MOD_CK2_1	165	171	PF00069	0.692
MOD_CK2_1	374	380	PF00069	0.693
MOD_CK2_1	422	428	PF00069	0.765
MOD_Cter_Amidation	171	174	PF01082	0.668
MOD_DYRK1A_RPxSP_1	480	484	PF00069	0.566
MOD_GlcNHglycan	129	132	PF01048	0.556
MOD_GlcNHglycan	249	252	PF01048	0.663
MOD_GlcNHglycan	283	286	PF01048	0.684
MOD_GlcNHglycan	33	39	PF01048	0.677
MOD_GlcNHglycan	374	377	PF01048	0.750
MOD_GlcNHglycan	424	427	PF01048	0.672
MOD_GlcNHglycan	491	494	PF01048	0.649
MOD_GlcNHglycan	538	541	PF01048	0.671
MOD_GlcNHglycan	543	546	PF01048	0.647
MOD_GlcNHglycan	547	550	PF01048	0.624
MOD_GlcNHglycan	581	584	PF01048	0.611
MOD_GlcNHglycan	68	71	PF01048	0.655
MOD_GlcNHglycan	8	12	PF01048	0.762
MOD_GSK3_1	104	111	PF00069	0.496
MOD_GSK3_1	247	254	PF00069	0.667
MOD_GSK3_1	281	288	PF00069	0.672
MOD_GSK3_1	34	41	PF00069	0.664
MOD_GSK3_1	350	357	PF00069	0.666
MOD_GSK3_1	370	377	PF00069	0.691
MOD_GSK3_1	424	431	PF00069	0.646
MOD_GSK3_1	433	440	PF00069	0.612
MOD_GSK3_1	456	463	PF00069	0.635
MOD_GSK3_1	489	496	PF00069	0.679
MOD_GSK3_1	52	59	PF00069	0.508
MOD_GSK3_1	524	531	PF00069	0.658
MOD_GSK3_1	536	543	PF00069	0.570
MOD_GSK3_1	550	557	PF00069	0.586
MOD_GSK3_1	593	600	PF00069	0.694
MOD_GSK3_1	91	98	PF00069	0.566
MOD_N-GLC_1	127	132	PF02516	0.553
MOD_N-GLC_1	176	181	PF02516	0.600
MOD_N-GLC_1	456	461	PF02516	0.591
MOD_N-GLC_1	566	571	PF02516	0.699
MOD_N-GLC_1	578	583	PF02516	0.600
MOD_N-GLC_2	118	120	PF02516	0.606
MOD_NEK2_1	308	313	PF00069	0.667
MOD_NEK2_1	39	44	PF00069	0.598
MOD_NEK2_1	45	50	PF00069	0.572
MOD_NEK2_1	52	57	PF00069	0.564
MOD_NEK2_1	528	533	PF00069	0.645
MOD_NEK2_1	558	563	PF00069	0.706
MOD_NEK2_1	58	63	PF00069	0.506
MOD_NEK2_1	7	12	PF00069	0.602
MOD_NEK2_2	251	256	PF00069	0.598
MOD_NEK2_2	265	270	PF00069	0.593
MOD_PIKK_1	271	277	PF00454	0.667
MOD_PIKK_1	308	314	PF00454	0.668
MOD_PIKK_1	325	331	PF00454	0.534
MOD_PIKK_1	354	360	PF00454	0.650
MOD_PIKK_1	58	64	PF00454	0.536
MOD_PIKK_1	98	104	PF00454	0.644
MOD_PKA_2	136	142	PF00069	0.599
MOD_PKA_2	239	245	PF00069	0.580
MOD_PKA_2	281	287	PF00069	0.655
MOD_PKA_2	294	300	PF00069	0.551
MOD_PKA_2	308	314	PF00069	0.639
MOD_PKA_2	384	390	PF00069	0.624
MOD_PKA_2	419	425	PF00069	0.652
MOD_PKA_2	534	540	PF00069	0.659
MOD_Plk_1	433	439	PF00069	0.583
MOD_Plk_1	456	462	PF00069	0.720
MOD_Plk_1	554	560	PF00069	0.690
MOD_Plk_1	565	571	PF00069	0.623
MOD_Plk_2-3	2	8	PF00069	0.746
MOD_Plk_4	119	125	PF00069	0.622
MOD_Plk_4	136	142	PF00069	0.521
MOD_Plk_4	2	8	PF00069	0.594
MOD_Plk_4	225	231	PF00069	0.586
MOD_Plk_4	294	300	PF00069	0.567
MOD_Plk_4	378	384	PF00069	0.639
MOD_ProDKin_1	160	166	PF00069	0.663
MOD_ProDKin_1	18	24	PF00069	0.785
MOD_ProDKin_1	314	320	PF00069	0.594
MOD_ProDKin_1	350	356	PF00069	0.650
MOD_ProDKin_1	400	406	PF00069	0.651
MOD_ProDKin_1	480	486	PF00069	0.661
MOD_ProDKin_1	511	517	PF00069	0.673
MOD_ProDKin_1	547	553	PF00069	0.700
MOD_ProDKin_1	91	97	PF00069	0.571
MOD_SUMO_rev_2	171	179	PF00179	0.642
TRG_DiLeu_BaEn_2	1	7	PF01217	0.595
TRG_ENDOCYTIC_2	220	223	PF00928	0.578
TRG_ENDOCYTIC_2	3	6	PF00928	0.646
TRG_ENDOCYTIC_2	472	475	PF00928	0.790
TRG_ENDOCYTIC_2	97	100	PF00928	0.664
TRG_ER_diArg_1	173	175	PF00400	0.662
TRG_ER_diArg_1	193	195	PF00400	0.380
TRG_ER_diArg_1	210	212	PF00400	0.476
TRG_ER_diArg_1	23	26	PF00400	0.663
TRG_NLS_Bipartite_1	173	194	PF00514	0.568
TRG_NLS_MonoExtC_3	189	194	PF00514	0.434
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	571	576	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4B7	Leishmania donovani	79%	100%
A4I6N3	Leishmania infantum	80%	95%
E9B1Q6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%