Cilia- and flagella-associated protein 300

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4498), putative

Species:

Leishmania major

UniProt:

Q4Q6F3_LEIMA

TriTrypDb:

LmjF.31.1100 , LMJLV39_310017400 , LMJSD75_310017000

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005856	cytoskeleton	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q6F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6F3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.587
CLV_C14_Caspase3-7	21	25	PF00656	0.572
CLV_PCSK_KEX2_1	182	184	PF00082	0.408
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.468
CLV_PCSK_SKI1_1	102	106	PF00082	0.322
CLV_PCSK_SKI1_1	134	138	PF00082	0.508
CLV_PCSK_SKI1_1	157	161	PF00082	0.543
CLV_PCSK_SKI1_1	199	203	PF00082	0.337
CLV_PCSK_SKI1_1	251	255	PF00082	0.268
CLV_PCSK_SKI1_1	57	61	PF00082	0.456
CLV_Separin_Metazoa	144	148	PF03568	0.456
DEG_APCC_DBOX_1	156	164	PF00400	0.443
DEG_Nend_Nbox_1	1	3	PF02207	0.498
DOC_CYCLIN_RxL_1	99	106	PF00134	0.307
DOC_CYCLIN_yClb1_LxF_4	128	133	PF00134	0.357
DOC_PP1_RVXF_1	128	134	PF00149	0.375
DOC_PP4_FxxP_1	105	108	PF00568	0.465
DOC_USP7_MATH_1	14	18	PF00917	0.663
DOC_USP7_MATH_1	27	31	PF00917	0.296
DOC_USP7_MATH_1	7	11	PF00917	0.619
DOC_USP7_MATH_1	70	74	PF00917	0.570
DOC_USP7_MATH_1	83	87	PF00917	0.431
DOC_USP7_MATH_2	53	59	PF00917	0.489
DOC_WW_Pin1_4	68	73	PF00397	0.740
LIG_14-3-3_CanoR_1	134	143	PF00244	0.511
LIG_14-3-3_CanoR_1	57	64	PF00244	0.718
LIG_Actin_WH2_2	148	163	PF00022	0.403
LIG_APCC_ABBA_1	187	192	PF00400	0.558
LIG_BIR_III_2	24	28	PF00653	0.420
LIG_FHA_2	139	145	PF00498	0.371
LIG_FHA_2	165	171	PF00498	0.515
LIG_FHA_2	227	233	PF00498	0.556
LIG_FHA_2	306	312	PF00498	0.431
LIG_LIR_Apic_2	103	108	PF02991	0.455
LIG_LIR_Apic_2	47	53	PF02991	0.351
LIG_LIR_Gen_1	137	146	PF02991	0.375
LIG_LIR_Gen_1	261	272	PF02991	0.428
LIG_LIR_Gen_1	326	337	PF02991	0.583
LIG_LIR_Nem_3	137	143	PF02991	0.361
LIG_LIR_Nem_3	26	31	PF02991	0.591
LIG_LIR_Nem_3	261	267	PF02991	0.445
LIG_LIR_Nem_3	293	298	PF02991	0.545
LIG_LIR_Nem_3	326	332	PF02991	0.509
LIG_NBox_RRM_1	177	187	PF00076	0.302
LIG_SH2_CRK	28	32	PF00017	0.490
LIG_SH2_CRK	295	299	PF00017	0.441
LIG_SH2_CRK	329	333	PF00017	0.470
LIG_SH2_CRK	362	366	PF00017	0.428
LIG_SH2_CRK	50	54	PF00017	0.408
LIG_SH2_PTP2	364	367	PF00017	0.428
LIG_SH2_SRC	287	290	PF00017	0.452
LIG_SH2_STAT3	120	123	PF00017	0.420
LIG_SH2_STAT5	176	179	PF00017	0.428
LIG_SH2_STAT5	287	290	PF00017	0.438
LIG_SH2_STAT5	362	365	PF00017	0.428
LIG_SH3_3	3	9	PF00018	0.321
LIG_SH3_3	66	72	PF00018	0.758
LIG_TRAF2_1	258	261	PF00917	0.470
LIG_TRAF2_1	308	311	PF00917	0.470
LIG_TRAF2_1	318	321	PF00917	0.446
LIG_TYR_ITIM	360	365	PF00017	0.438
LIG_WRC_WIRS_1	56	61	PF05994	0.541
MOD_CDK_SPxxK_3	68	75	PF00069	0.487
MOD_CK1_1	370	376	PF00069	0.456
MOD_CK1_1	71	77	PF00069	0.574
MOD_CK2_1	100	106	PF00069	0.358
MOD_CK2_1	138	144	PF00069	0.376
MOD_CK2_1	20	26	PF00069	0.539
MOD_CK2_1	221	227	PF00069	0.571
MOD_CK2_1	255	261	PF00069	0.517
MOD_CK2_1	305	311	PF00069	0.525
MOD_CK2_1	333	339	PF00069	0.469
MOD_CK2_1	55	61	PF00069	0.647
MOD_GlcNHglycan	10	13	PF01048	0.694
MOD_GlcNHglycan	15	19	PF01048	0.661
MOD_GlcNHglycan	240	243	PF01048	0.527
MOD_GlcNHglycan	273	276	PF01048	0.391
MOD_GlcNHglycan	323	326	PF01048	0.349
MOD_GlcNHglycan	64	67	PF01048	0.612
MOD_GlcNHglycan	85	88	PF01048	0.516
MOD_GSK3_1	134	141	PF00069	0.484
MOD_GSK3_1	14	21	PF00069	0.471
MOD_GSK3_1	51	58	PF00069	0.584
MOD_GSK3_1	70	77	PF00069	0.623
MOD_N-GLC_2	361	363	PF02516	0.228
MOD_NEK2_1	100	105	PF00069	0.300
MOD_NEK2_1	236	241	PF00069	0.638
MOD_NEK2_1	298	303	PF00069	0.531
MOD_NEK2_2	344	349	PF00069	0.542
MOD_PKA_2	138	144	PF00069	0.500
MOD_PKA_2	74	80	PF00069	0.643
MOD_PKB_1	49	57	PF00069	0.446
MOD_Plk_1	333	339	PF00069	0.528
MOD_Plk_2-3	164	170	PF00069	0.644
MOD_Plk_2-3	192	198	PF00069	0.396
MOD_Plk_2-3	228	234	PF00069	0.688
MOD_Plk_2-3	55	61	PF00069	0.538
MOD_Plk_4	121	127	PF00069	0.671
MOD_Plk_4	333	339	PF00069	0.465
MOD_Plk_4	344	350	PF00069	0.450
MOD_Plk_4	372	378	PF00069	0.470
MOD_ProDKin_1	68	74	PF00069	0.742
TRG_ENDOCYTIC_2	264	267	PF00928	0.428
TRG_ENDOCYTIC_2	28	31	PF00928	0.495
TRG_ENDOCYTIC_2	295	298	PF00928	0.443
TRG_ENDOCYTIC_2	329	332	PF00928	0.540
TRG_ENDOCYTIC_2	362	365	PF00928	0.428
TRG_NES_CRM1_1	192	204	PF08389	0.384
TRG_NES_CRM1_1	293	306	PF08389	0.576
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.252
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P369	Leptomonas seymouri	54%	100%
A0A0S4JGK6	Bodo saltans	30%	100%
A0A1X0NJZ3	Trypanosomatidae	32%	97%
A0A3S7X4F5	Leishmania donovani	93%	100%
A0A422NQV4	Trypanosoma rangeli	38%	100%
A4HJ90	Leishmania braziliensis	79%	100%
A4I6N4	Leishmania infantum	93%	100%
C9ZM71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B1Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5DGC7	Trypanosoma cruzi	39%	96%