LeishMANIAdb
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Putative N-acyl-L-amino acid amidohydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative N-acyl-L-amino acid amidohydrolase
Gene product:
amidohydrolase, putative
Species:
Leishmania major
UniProt:
Q4Q6F0_LEIMA
TriTrypDb:
LmjF.31.1130 , LMJLV39_310017700 * , LMJSD75_310017300 *
Length:
405

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 48
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 20
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 28
NetGPI no yes: 0, no: 28
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6F0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6F0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 29
GO:0004046 aminoacylase activity 5 24
GO:0016787 hydrolase activity 2 29
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3 24
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4 24

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 253 257 PF00656 0.427
CLV_NRD_NRD_1 11 13 PF00675 0.485
CLV_NRD_NRD_1 236 238 PF00675 0.382
CLV_NRD_NRD_1 24 26 PF00675 0.432
CLV_PCSK_KEX2_1 11 13 PF00082 0.481
CLV_PCSK_KEX2_1 188 190 PF00082 0.237
CLV_PCSK_KEX2_1 236 238 PF00082 0.380
CLV_PCSK_KEX2_1 24 26 PF00082 0.432
CLV_PCSK_PC1ET2_1 188 190 PF00082 0.236
CLV_PCSK_SKI1_1 126 130 PF00082 0.418
CLV_PCSK_SKI1_1 140 144 PF00082 0.346
DOC_CYCLIN_RxL_1 123 131 PF00134 0.496
DOC_CYCLIN_RxL_1 134 147 PF00134 0.373
DOC_MAPK_gen_1 134 143 PF00069 0.369
DOC_MAPK_MEF2A_6 134 143 PF00069 0.441
DOC_MAPK_RevD_3 223 237 PF00069 0.384
DOC_PP1_RVXF_1 138 144 PF00149 0.441
DOC_USP7_MATH_1 100 104 PF00917 0.368
DOC_USP7_MATH_1 213 217 PF00917 0.306
DOC_USP7_MATH_1 252 256 PF00917 0.455
DOC_USP7_MATH_1 299 303 PF00917 0.255
DOC_USP7_MATH_2 345 351 PF00917 0.278
DOC_USP7_UBL2_3 389 393 PF12436 0.428
DOC_WW_Pin1_4 341 346 PF00397 0.514
LIG_14-3-3_CanoR_1 264 268 PF00244 0.442
LIG_BIR_III_2 89 93 PF00653 0.368
LIG_BIR_III_4 52 56 PF00653 0.562
LIG_BRCT_BRCA1_1 345 349 PF00533 0.403
LIG_FHA_1 123 129 PF00498 0.408
LIG_FHA_1 136 142 PF00498 0.380
LIG_FHA_1 180 186 PF00498 0.441
LIG_FHA_1 196 202 PF00498 0.423
LIG_FHA_2 396 402 PF00498 0.292
LIG_LIR_Gen_1 14 22 PF02991 0.376
LIG_LIR_Gen_1 255 265 PF02991 0.379
LIG_LIR_Gen_1 346 357 PF02991 0.420
LIG_LIR_Gen_1 54 63 PF02991 0.526
LIG_LIR_Nem_3 14 20 PF02991 0.584
LIG_LIR_Nem_3 255 261 PF02991 0.379
LIG_LIR_Nem_3 346 352 PF02991 0.408
LIG_LIR_Nem_3 54 60 PF02991 0.534
LIG_Pex14_1 305 309 PF04695 0.427
LIG_SH2_CRK 17 21 PF00017 0.370
LIG_SH2_CRK 258 262 PF00017 0.398
LIG_SH2_CRK 396 400 PF00017 0.292
LIG_SH2_NCK_1 258 262 PF00017 0.398
LIG_SH2_PTP2 360 363 PF00017 0.441
LIG_SH2_STAP1 17 21 PF00017 0.366
LIG_SH2_STAP1 309 313 PF00017 0.520
LIG_SH2_STAT5 26 29 PF00017 0.456
LIG_SH2_STAT5 360 363 PF00017 0.439
LIG_SH2_STAT5 43 46 PF00017 0.432
LIG_SUMO_SIM_anti_2 334 340 PF11976 0.260
LIG_SUMO_SIM_par_1 244 250 PF11976 0.374
LIG_SUMO_SIM_par_1 334 340 PF11976 0.430
LIG_TRAF2_1 145 148 PF00917 0.441
LIG_TRAF2_1 34 37 PF00917 0.486
LIG_TRAF2_1 92 95 PF00917 0.368
LIG_TYR_ITIM 394 399 PF00017 0.292
LIG_UBA3_1 174 178 PF00899 0.408
MOD_CK1_1 195 201 PF00069 0.389
MOD_CK1_1 254 260 PF00069 0.363
MOD_CK2_1 208 214 PF00069 0.396
MOD_CK2_1 31 37 PF00069 0.386
MOD_CK2_1 341 347 PF00069 0.475
MOD_CK2_1 395 401 PF00069 0.292
MOD_CK2_1 58 64 PF00069 0.394
MOD_GlcNHglycan 316 319 PF01048 0.438
MOD_GlcNHglycan 339 342 PF01048 0.374
MOD_GSK3_1 191 198 PF00069 0.434
MOD_GSK3_1 208 215 PF00069 0.312
MOD_GSK3_1 246 253 PF00069 0.440
MOD_GSK3_1 263 270 PF00069 0.447
MOD_GSK3_1 337 344 PF00069 0.470
MOD_GSK3_1 58 65 PF00069 0.570
MOD_NEK2_1 122 127 PF00069 0.308
MOD_NEK2_1 225 230 PF00069 0.441
MOD_NEK2_1 246 251 PF00069 0.426
MOD_NEK2_1 267 272 PF00069 0.398
MOD_NEK2_1 58 63 PF00069 0.393
MOD_PIKK_1 270 276 PF00454 0.506
MOD_PIKK_1 58 64 PF00454 0.394
MOD_PKA_2 263 269 PF00069 0.375
MOD_Plk_1 213 219 PF00069 0.517
MOD_Plk_1 309 315 PF00069 0.437
MOD_Plk_1 31 37 PF00069 0.518
MOD_Plk_4 181 187 PF00069 0.369
MOD_ProDKin_1 341 347 PF00069 0.514
MOD_SUMO_for_1 44 47 PF00179 0.332
TRG_DiLeu_BaLyEn_6 137 142 PF01217 0.407
TRG_ENDOCYTIC_2 17 20 PF00928 0.520
TRG_ENDOCYTIC_2 258 261 PF00928 0.398
TRG_ENDOCYTIC_2 297 300 PF00928 0.260
TRG_ENDOCYTIC_2 360 363 PF00928 0.435
TRG_ENDOCYTIC_2 396 399 PF00928 0.292
TRG_ER_diArg_1 11 13 PF00400 0.479
TRG_ER_diArg_1 23 25 PF00400 0.412
TRG_ER_diArg_1 236 238 PF00400 0.380
TRG_Pf-PMV_PEXEL_1 126 130 PF00026 0.400
TRG_Pf-PMV_PEXEL_1 140 144 PF00026 0.275
TRG_Pf-PMV_PEXEL_1 25 29 PF00026 0.475

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2N6 Leptomonas seymouri 74% 100%
A0A0N0P327 Leptomonas seymouri 27% 100%
A0A0N1IJE8 Leptomonas seymouri 47% 100%
A0A1X0NW20 Trypanosomatidae 47% 100%
A0A1X0NW36 Trypanosomatidae 46% 100%
A0A1X0NWQ6 Trypanosomatidae 42% 100%
A0A3Q8IBS0 Leishmania donovani 44% 100%
A0A3Q8IIH2 Leishmania donovani 96% 100%
A0A3Q8IJC1 Leishmania donovani 39% 92%
A0A3S7WW66 Leishmania donovani 44% 100%
A0A3S7WW80 Leishmania donovani 45% 75%
A0A422NTM4 Trypanosoma rangeli 44% 100%
A0AHD2 Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8) 29% 100%
A0RHZ2 Bacillus thuringiensis (strain Al Hakam) 31% 100%
A2RI06 Lactococcus lactis subsp. cremoris (strain MG1363) 28% 100%
A3CQT4 Streptococcus sanguinis (strain SK36) 29% 100%
A4HJ93 Leishmania braziliensis 82% 100%
A4HZ10 Leishmania infantum 44% 100%
A4HZ11 Leishmania infantum 44% 75%
A4I5G9 Leishmania infantum 39% 92%
A4I6N7 Leishmania infantum 96% 100%
A4I6N8 Leishmania infantum 82% 100%
A4ILT6 Geobacillus thermodenitrificans (strain NG80-2) 31% 100%
A4VY21 Streptococcus suis (strain 05ZYH33) 27% 100%
A4W4B4 Streptococcus suis (strain 98HAH33) 27% 100%
A5VJ57 Limosilactobacillus reuteri (strain DSM 20016) 26% 100%
A7GS08 Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) 31% 100%
A7Z433 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) 31% 100%
A8AUM0 Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288) 31% 100%
A8FCN2 Bacillus pumilus (strain SAFR-032) 30% 100%
A8YUT2 Lactobacillus helveticus (strain DPC 4571) 28% 100%
A9VUE2 Bacillus mycoides (strain KBAB4) 30% 100%
B1I9G2 Streptococcus pneumoniae (strain Hungary19A-6) 27% 100%
B1MZM9 Leuconostoc citreum (strain KM20) 28% 100%
B1YJ90 Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15) 31% 100%
B2G6M8 Limosilactobacillus reuteri (strain JCM 1112) 26% 100%
B2GC10 Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251) 29% 100%
B2IN14 Streptococcus pneumoniae (strain CGSP14) 27% 100%
B3W7E6 Lacticaseibacillus casei (strain BL23) 29% 100%
B5E3A3 Streptococcus pneumoniae serotype 19F (strain G54) 27% 100%
B7GIC0 Anoxybacillus flavithermus (strain DSM 21510 / WK1) 32% 100%
B7H6W7 Bacillus cereus (strain B4264) 30% 100%
B7HMV1 Bacillus cereus (strain AH187) 31% 100%
B7IVL7 Bacillus cereus (strain G9842) 31% 100%
B7JKV4 Bacillus cereus (strain AH820) 31% 100%
B8DEC3 Listeria monocytogenes serotype 4a (strain HCC23) 29% 100%
B8ZPL8 Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) 27% 100%
B9DVY6 Streptococcus uberis (strain ATCC BAA-854 / 0140J) 32% 100%
B9IW60 Bacillus cereus (strain Q1) 31% 100%
C0ZGH7 Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) 30% 100%
C1CAS3 Streptococcus pneumoniae (strain 70585) 27% 100%
C1CH24 Streptococcus pneumoniae (strain JJA) 27% 100%
C1CN42 Streptococcus pneumoniae (strain P1031) 27% 100%
C1CTZ9 Streptococcus pneumoniae (strain Taiwan19F-14) 28% 100%
C1EPZ4 Bacillus cereus (strain 03BB102) 31% 100%
C1L1T3 Listeria monocytogenes serotype 4b (strain CLIP80459) 30% 100%
C3LI46 Bacillus anthracis (strain CDC 684 / NRRL 3495) 31% 100%
C3P6Y7 Bacillus anthracis (strain A0248) 31% 100%
C5D827 Geobacillus sp. (strain WCH70) 31% 100%
C9ZIL8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
D5E0A1 Priestia megaterium (strain ATCC 12872 / QMB1551) 29% 100%
E9AGU3 Leishmania infantum 44% 100%
E9AIM3 Leishmania braziliensis 45% 100%
E9AIM4 Leishmania braziliensis 42% 90%
E9AIM5 Leishmania braziliensis 45% 100%
E9AUV6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AUV7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AUV8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9B0R7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B1R0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
O04373 Arabidopsis thaliana 34% 92%
O07598 Bacillus subtilis (strain 168) 32% 100%
O34916 Bacillus subtilis (strain 168) 31% 100%
O34980 Bacillus subtilis (strain 168) 39% 97%
O50173 Enterobacter agglomerans 27% 93%
O81641 Arabidopsis thaliana 34% 95%
P37112 Geobacillus stearothermophilus 39% 100%
P44765 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 24% 96%
P45493 Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) 37% 100%
P54955 Bacillus subtilis (strain 168) 38% 100%
P54968 Arabidopsis thaliana 33% 92%
P54969 Arabidopsis thaliana 35% 92%
P54970 Arabidopsis thaliana 34% 92%
P54983 Bacillus subtilis (strain 168) 30% 100%
P54984 Synechocystis sp. (strain PCC 6803 / Kazusa) 33% 100%
P55663 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 28% 100%
P58156 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 41% 100%
P77357 Escherichia coli (strain K12) 25% 93%
P80092 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 41% 100%
Q032G8 Lactococcus lactis subsp. cremoris (strain SK11) 28% 100%
Q03CW2 Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441) 29% 100%
Q03HT1 Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) 26% 100%
Q03IN1 Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) 27% 100%
Q03YE3 Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y) 29% 100%
Q04FS2 Oenococcus oeni (strain ATCC BAA-331 / PSU-1) 29% 100%
Q04I78 Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 27% 100%
Q1WUQ7 Ligilactobacillus salivarius (strain UCC118) 27% 100%
Q2FH40 Staphylococcus aureus (strain USA300) 29% 100%
Q2FYN6 Staphylococcus aureus (strain NCTC 8325 / PS 47) 29% 100%
Q2YY21 Staphylococcus aureus (strain bovine RF122 / ET3-1) 28% 100%
Q49XK0 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 27% 100%
Q4L6A3 Staphylococcus haemolyticus (strain JCSC1435) 26% 100%
Q4Q7G6 Leishmania major 37% 100%
Q4QCM4 Leishmania major 44% 98%
Q4QCM5 Leishmania major 44% 100%
Q4QCM6 Leishmania major 44% 100%
Q5FKR0 Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) 26% 100%
Q5HG22 Staphylococcus aureus (strain COL) 29% 100%
Q5HPE4 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 27% 100%
Q5L145 Geobacillus kaustophilus (strain HTA426) 32% 100%
Q5LXY3 Streptococcus thermophilus (strain CNRZ 1066) 27% 100%
Q5M2I5 Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) 27% 100%
Q5N8F2 Oryza sativa subsp. japonica 36% 89%
Q5WF94 Alkalihalobacillus clausii (strain KSM-K16) 29% 100%
Q5Z678 Oryza sativa subsp. japonica 32% 79%
Q635U8 Bacillus cereus (strain ZK / E33L) 31% 100%
Q65K84 Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) 32% 100%
Q6G9G3 Staphylococcus aureus (strain MSSA476) 29% 100%
Q6GH10 Staphylococcus aureus (strain MRSA252) 28% 100%
Q6HEI5 Bacillus thuringiensis subsp. konkukian (strain 97-27) 32% 100%
Q6LAN3 Listeria ivanovii 30% 100%
Q721F4 Listeria monocytogenes serotype 4b (strain F2365) 30% 100%
Q731Y6 Bacillus cereus (strain ATCC 10987 / NRS 248) 31% 100%
Q7A5P6 Staphylococcus aureus (strain N315) 29% 100%
Q7XUA8 Oryza sativa subsp. japonica 36% 95%
Q819J6 Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) 30% 100%
Q81MQ3 Bacillus anthracis 31% 100%
Q836H7 Enterococcus faecalis (strain ATCC 700802 / V583) 29% 100%
Q84XG9 Oryza sativa subsp. indica 34% 92%
Q851L5 Oryza sativa subsp. japonica 37% 97%
Q851L6 Oryza sativa subsp. japonica 36% 98%
Q88V24 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 29% 100%
Q8CSM6 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 27% 100%
Q8DN55 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 27% 100%
Q8DVY6 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) 27% 100%
Q8ERA3 Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831) 33% 100%
Q8GGD4 Corynebacterium striatum 31% 100%
Q8H3C7 Oryza sativa subsp. japonica 37% 92%
Q8H3C8 Oryza sativa subsp. japonica 37% 91%
Q8H3C9 Oryza sativa subsp. japonica 37% 89%
Q8NWS3 Staphylococcus aureus (strain MW2) 29% 100%
Q8S9S4 Oryza sativa subsp. japonica 34% 92%
Q8VYX0 Arabidopsis thaliana 35% 87%
Q8Y8A0 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) 29% 100%
Q92D10 Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) 30% 100%
Q97NE7 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 27% 100%
Q99U87 Staphylococcus aureus (strain Mu50 / ATCC 700699) 29% 100%
Q9CIS4 Lactococcus lactis subsp. lactis (strain IL1403) 28% 100%
Q9K9H9 Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 30% 100%
Q9SWX9 Arabidopsis thaliana 34% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS