Putative monoglyceride lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

monoglyceride lipase, putative

Species:

Leishmania major

UniProt:

Q4Q6E9_LEIMA

TriTrypDb:

LmjF.31.1140 , LMJLV39_310017800 , LMJSD75_310017400

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6E9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016298	lipase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0047372	acylglycerol lipase activity	5	7
GO:0052689	carboxylic ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.337
CLV_PCSK_SKI1_1	12	16	PF00082	0.485
CLV_PCSK_SKI1_1	266	270	PF00082	0.336
DOC_CKS1_1	13	18	PF01111	0.479
DOC_CKS1_1	204	209	PF01111	0.288
DOC_MAPK_gen_1	224	233	PF00069	0.264
DOC_MAPK_MEF2A_6	73	81	PF00069	0.337
DOC_PP1_RVXF_1	56	63	PF00149	0.285
DOC_PP4_FxxP_1	62	65	PF00568	0.337
DOC_USP7_MATH_1	129	133	PF00917	0.288
DOC_USP7_MATH_1	242	246	PF00917	0.327
DOC_USP7_UBL2_3	266	270	PF12436	0.313
DOC_WW_Pin1_4	12	17	PF00397	0.509
DOC_WW_Pin1_4	203	208	PF00397	0.288
LIG_AP2alpha_2	215	217	PF02296	0.377
LIG_APCC_ABBA_1	250	255	PF00400	0.358
LIG_BIR_II_1	1	5	PF00653	0.427
LIG_BIR_III_4	154	158	PF00653	0.288
LIG_BRCT_BRCA1_1	185	189	PF00533	0.356
LIG_BRCT_BRCA1_1	264	268	PF00533	0.285
LIG_BRCT_BRCA1_2	185	191	PF00533	0.356
LIG_BRCT_BRCA1_2	264	270	PF00533	0.313
LIG_EH1_1	139	147	PF00400	0.261
LIG_FHA_1	108	114	PF00498	0.337
LIG_FHA_1	204	210	PF00498	0.388
LIG_FHA_1	55	61	PF00498	0.404
LIG_KLC1_Yacidic_2	102	107	PF13176	0.337
LIG_LIR_Apic_2	203	207	PF02991	0.337
LIG_LIR_Gen_1	107	116	PF02991	0.286
LIG_LIR_Gen_1	125	134	PF02991	0.272
LIG_LIR_Gen_1	215	225	PF02991	0.334
LIG_LIR_Gen_1	71	81	PF02991	0.318
LIG_LIR_Gen_1	84	91	PF02991	0.200
LIG_LIR_Nem_3	107	112	PF02991	0.262
LIG_LIR_Nem_3	125	130	PF02991	0.369
LIG_LIR_Nem_3	156	161	PF02991	0.240
LIG_LIR_Nem_3	186	192	PF02991	0.356
LIG_LIR_Nem_3	215	221	PF02991	0.376
LIG_LIR_Nem_3	244	250	PF02991	0.305
LIG_LIR_Nem_3	71	77	PF02991	0.275
LIG_LIR_Nem_3	84	89	PF02991	0.231
LIG_MYND_1	23	27	PF01753	0.442
LIG_NRP_CendR_1	309	311	PF00754	0.398
LIG_PALB2_WD40_1	184	192	PF16756	0.264
LIG_PCNA_PIPBox_1	178	187	PF02747	0.288
LIG_PCNA_yPIPBox_3	205	213	PF02747	0.342
LIG_Pex14_2	184	188	PF04695	0.337
LIG_Pex14_2	40	44	PF04695	0.501
LIG_REV1ctd_RIR_1	266	274	PF16727	0.313
LIG_SH2_CRK	127	131	PF00017	0.317
LIG_SH2_CRK	13	17	PF00017	0.521
LIG_SH2_CRK	204	208	PF00017	0.337
LIG_SH2_CRK	218	222	PF00017	0.193
LIG_SH2_CRK	74	78	PF00017	0.261
LIG_SH2_GRB2like	218	221	PF00017	0.337
LIG_SH2_NCK_1	13	17	PF00017	0.505
LIG_SH2_NCK_1	218	222	PF00017	0.313
LIG_SH2_NCK_1	74	78	PF00017	0.377
LIG_SH2_STAP1	74	78	PF00017	0.320
LIG_SH2_STAT5	105	108	PF00017	0.261
LIG_SH2_STAT5	4	7	PF00017	0.505
LIG_SH2_STAT5	86	89	PF00017	0.318
LIG_SH3_2	190	195	PF14604	0.288
LIG_SH3_2	53	58	PF14604	0.487
LIG_SH3_3	17	23	PF00018	0.458
LIG_SH3_3	187	193	PF00018	0.460
LIG_SH3_3	277	283	PF00018	0.240
LIG_SH3_3	50	56	PF00018	0.534
MOD_CDK_SPxK_1	12	18	PF00069	0.486
MOD_CK1_1	132	138	PF00069	0.288
MOD_CK1_1	203	209	PF00069	0.386
MOD_CK1_1	219	225	PF00069	0.465
MOD_CK1_1	261	267	PF00069	0.264
MOD_CK1_1	271	277	PF00069	0.132
MOD_CK2_1	96	102	PF00069	0.332
MOD_GlcNHglycan	154	158	PF01048	0.302
MOD_GlcNHglycan	163	166	PF01048	0.229
MOD_GlcNHglycan	270	273	PF01048	0.375
MOD_GlcNHglycan	5	8	PF01048	0.554
MOD_GSK3_1	258	265	PF00069	0.373
MOD_N-GLC_1	219	224	PF02516	0.313
MOD_NEK2_1	122	127	PF00069	0.398
MOD_NEK2_1	138	143	PF00069	0.263
MOD_NEK2_1	145	150	PF00069	0.341
MOD_NEK2_1	168	173	PF00069	0.379
MOD_NEK2_1	177	182	PF00069	0.352
MOD_NEK2_1	262	267	PF00069	0.457
MOD_NEK2_1	268	273	PF00069	0.358
MOD_PIKK_1	129	135	PF00454	0.446
MOD_PIKK_1	183	189	PF00454	0.264
MOD_PIKK_1	242	248	PF00454	0.299
MOD_PK_1	73	79	PF00069	0.377
MOD_Plk_1	219	225	PF00069	0.313
MOD_Plk_4	132	138	PF00069	0.379
MOD_Plk_4	145	151	PF00069	0.406
MOD_Plk_4	264	270	PF00069	0.430
MOD_ProDKin_1	12	18	PF00069	0.505
MOD_ProDKin_1	203	209	PF00069	0.288
MOD_SUMO_rev_2	271	279	PF00179	0.339
TRG_DiLeu_BaEn_1	275	280	PF01217	0.192
TRG_DiLeu_BaEn_2	300	306	PF01217	0.384
TRG_ENDOCYTIC_2	127	130	PF00928	0.327
TRG_ENDOCYTIC_2	218	221	PF00928	0.375
TRG_ENDOCYTIC_2	74	77	PF00928	0.261
TRG_ENDOCYTIC_2	86	89	PF00928	0.261
TRG_ER_diArg_1	223	226	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	195	200	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ITL6	Bodo saltans	47%	96%
A0A3R7L576	Trypanosoma rangeli	50%	100%
A0A3S7X4B8	Leishmania donovani	96%	100%
A0QNZ7	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	32%	100%
A4HJ94	Leishmania braziliensis	84%	100%
A4I6N9	Leishmania infantum	95%	100%
C9ZM73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZWV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	99%
E9B1R1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O07427	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
O34705	Bacillus subtilis (strain 168)	27%	100%
O35678	Mus musculus	33%	100%
O94305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	82%
P07000	Escherichia coli (strain K12)	28%	91%
P59588	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	28%	91%
Q8R431	Rattus norvegicus	31%	100%
Q99685	Homo sapiens	33%	100%
Q9C942	Arabidopsis thaliana	23%	94%