Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q6E7_LEIMA

TriTrypDb:

LmjF.31.1160 , LMJLV39_310018000 , LMJSD75_310017600

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005929	cilium	4	6
GO:0015630	microtubule cytoskeleton	6	2
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4Q6E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6E7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	480	484	PF00656	0.460
CLV_NRD_NRD_1	186	188	PF00675	0.528
CLV_NRD_NRD_1	22	24	PF00675	0.633
CLV_NRD_NRD_1	291	293	PF00675	0.479
CLV_NRD_NRD_1	339	341	PF00675	0.451
CLV_NRD_NRD_1	560	562	PF00675	0.582
CLV_PCSK_FUR_1	558	562	PF00082	0.575
CLV_PCSK_KEX2_1	129	131	PF00082	0.587
CLV_PCSK_KEX2_1	22	24	PF00082	0.681
CLV_PCSK_KEX2_1	248	250	PF00082	0.434
CLV_PCSK_KEX2_1	291	293	PF00082	0.554
CLV_PCSK_KEX2_1	339	341	PF00082	0.451
CLV_PCSK_KEX2_1	547	549	PF00082	0.480
CLV_PCSK_KEX2_1	558	560	PF00082	0.546
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.587
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.434
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.435
CLV_PCSK_SKI1_1	113	117	PF00082	0.583
CLV_PCSK_SKI1_1	120	124	PF00082	0.488
CLV_PCSK_SKI1_1	233	237	PF00082	0.486
CLV_PCSK_SKI1_1	268	272	PF00082	0.325
CLV_PCSK_SKI1_1	291	295	PF00082	0.465
CLV_PCSK_SKI1_1	457	461	PF00082	0.472
CLV_Separin_Metazoa	563	567	PF03568	0.558
DEG_APCC_DBOX_1	565	573	PF00400	0.563
DEG_APCC_DBOX_1	610	618	PF00400	0.438
DEG_SCF_FBW7_1	138	145	PF00400	0.629
DEG_SPOP_SBC_1	137	141	PF00917	0.551
DEG_SPOP_SBC_1	418	422	PF00917	0.518
DOC_CDC14_PxL_1	310	318	PF14671	0.444
DOC_CKS1_1	182	187	PF01111	0.465
DOC_CKS1_1	38	43	PF01111	0.664
DOC_CYCLIN_RxL_1	565	573	PF00134	0.563
DOC_MAPK_gen_1	520	529	PF00069	0.485
DOC_MAPK_MEF2A_6	120	128	PF00069	0.492
DOC_MIT_MIM_1	563	572	PF04212	0.565
DOC_PP1_RVXF_1	103	110	PF00149	0.546
DOC_PP2B_LxvP_1	214	217	PF13499	0.492
DOC_PP2B_LxvP_1	363	366	PF13499	0.535
DOC_USP7_MATH_1	11	15	PF00917	0.629
DOC_USP7_MATH_1	137	141	PF00917	0.624
DOC_USP7_MATH_1	217	221	PF00917	0.488
DOC_USP7_MATH_1	234	238	PF00917	0.296
DOC_USP7_MATH_1	426	430	PF00917	0.528
DOC_USP7_MATH_1	6	10	PF00917	0.661
DOC_USP7_MATH_1	68	72	PF00917	0.783
DOC_USP7_UBL2_3	188	192	PF12436	0.503
DOC_WW_Pin1_4	138	143	PF00397	0.653
DOC_WW_Pin1_4	181	186	PF00397	0.447
DOC_WW_Pin1_4	37	42	PF00397	0.666
DOC_WW_Pin1_4	422	427	PF00397	0.519
DOC_WW_Pin1_4	468	473	PF00397	0.475
LIG_14-3-3_CanoR_1	113	122	PF00244	0.546
LIG_14-3-3_CanoR_1	233	239	PF00244	0.453
LIG_14-3-3_CanoR_1	249	253	PF00244	0.287
LIG_14-3-3_CanoR_1	254	259	PF00244	0.427
LIG_14-3-3_CanoR_1	274	281	PF00244	0.279
LIG_14-3-3_CanoR_1	284	293	PF00244	0.388
LIG_14-3-3_CanoR_1	30	39	PF00244	0.605
LIG_14-3-3_CanoR_1	457	462	PF00244	0.474
LIG_14-3-3_CanoR_1	511	518	PF00244	0.480
LIG_14-3-3_CanoR_1	520	525	PF00244	0.411
LIG_14-3-3_CanoR_1	558	564	PF00244	0.624
LIG_14-3-3_CanoR_1	591	597	PF00244	0.569
LIG_Actin_WH2_2	234	250	PF00022	0.357
LIG_Actin_WH2_2	260	276	PF00022	0.420
LIG_Actin_WH2_2	463	480	PF00022	0.485
LIG_Actin_WH2_2	497	515	PF00022	0.429
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BIR_III_4	282	286	PF00653	0.451
LIG_BRCT_BRCA1_1	374	378	PF00533	0.630
LIG_DLG_GKlike_1	254	261	PF00625	0.419
LIG_EVH1_2	152	156	PF00568	0.502
LIG_FHA_1	11	17	PF00498	0.639
LIG_FHA_1	121	127	PF00498	0.491
LIG_FHA_1	209	215	PF00498	0.436
LIG_FHA_1	32	38	PF00498	0.648
LIG_FHA_2	191	197	PF00498	0.504
LIG_FHA_2	234	240	PF00498	0.477
LIG_FHA_2	384	390	PF00498	0.510
LIG_FHA_2	458	464	PF00498	0.472
LIG_FHA_2	478	484	PF00498	0.260
LIG_FHA_2	84	90	PF00498	0.548
LIG_LIR_Apic_2	131	137	PF02991	0.588
LIG_LIR_Gen_1	208	218	PF02991	0.478
LIG_LIR_Gen_1	333	343	PF02991	0.328
LIG_LIR_Gen_1	351	361	PF02991	0.378
LIG_LIR_Gen_1	428	438	PF02991	0.438
LIG_LIR_Gen_1	500	510	PF02991	0.441
LIG_LIR_Gen_1	89	96	PF02991	0.611
LIG_LIR_Nem_3	208	213	PF02991	0.474
LIG_LIR_Nem_3	320	326	PF02991	0.449
LIG_LIR_Nem_3	333	338	PF02991	0.347
LIG_LIR_Nem_3	357	362	PF02991	0.365
LIG_LIR_Nem_3	413	419	PF02991	0.614
LIG_LIR_Nem_3	428	433	PF02991	0.374
LIG_LIR_Nem_3	483	489	PF02991	0.461
LIG_LIR_Nem_3	500	506	PF02991	0.284
LIG_LIR_Nem_3	89	93	PF02991	0.519
LIG_LYPXL_S_1	415	419	PF13949	0.669
LIG_LYPXL_yS_3	416	419	PF13949	0.667
LIG_SH2_CRK	134	138	PF00017	0.617
LIG_SH2_CRK	323	327	PF00017	0.482
LIG_SH2_CRK	90	94	PF00017	0.523
LIG_SH2_GRB2like	503	506	PF00017	0.447
LIG_SH2_PTP2	503	506	PF00017	0.447
LIG_SH2_STAP1	57	61	PF00017	0.631
LIG_SH2_STAT5	203	206	PF00017	0.327
LIG_SH2_STAT5	39	42	PF00017	0.760
LIG_SH2_STAT5	503	506	PF00017	0.447
LIG_SH2_STAT5	79	82	PF00017	0.575
LIG_SH3_3	379	385	PF00018	0.596
LIG_SH3_3	38	44	PF00018	0.756
LIG_SUMO_SIM_anti_2	157	164	PF11976	0.332
LIG_SUMO_SIM_anti_2	222	228	PF11976	0.470
LIG_SUMO_SIM_par_1	157	164	PF11976	0.332
LIG_SUMO_SIM_par_1	440	447	PF11976	0.489
LIG_SUMO_SIM_par_1	568	573	PF11976	0.590
LIG_TRAF2_1	96	99	PF00917	0.482
LIG_TRAF2_2	167	172	PF00917	0.526
LIG_TYR_ITIM	414	419	PF00017	0.682
LIG_TYR_ITIM	501	506	PF00017	0.457
LIG_UBA3_1	197	206	PF00899	0.475
LIG_WRC_WIRS_1	207	212	PF05994	0.464
MOD_CDK_SPxK_1	181	187	PF00069	0.457
MOD_CDK_SPxxK_3	181	188	PF00069	0.468
MOD_CK1_1	140	146	PF00069	0.689
MOD_CK1_1	220	226	PF00069	0.481
MOD_CK1_1	237	243	PF00069	0.298
MOD_CK1_1	257	263	PF00069	0.391
MOD_CK1_1	425	431	PF00069	0.574
MOD_CK1_1	442	448	PF00069	0.317
MOD_CK2_1	190	196	PF00069	0.509
MOD_CK2_1	233	239	PF00069	0.484
MOD_CK2_1	345	351	PF00069	0.443
MOD_CK2_1	399	405	PF00069	0.535
MOD_CK2_1	428	434	PF00069	0.517
MOD_CK2_1	457	463	PF00069	0.478
MOD_CK2_1	520	526	PF00069	0.500
MOD_CK2_1	83	89	PF00069	0.561
MOD_CK2_1	91	97	PF00069	0.440
MOD_GlcNHglycan	13	16	PF01048	0.604
MOD_GlcNHglycan	142	145	PF01048	0.706
MOD_GlcNHglycan	244	247	PF01048	0.465
MOD_GlcNHglycan	287	290	PF01048	0.453
MOD_GlcNHglycan	323	326	PF01048	0.468
MOD_GlcNHglycan	375	378	PF01048	0.539
MOD_GlcNHglycan	394	397	PF01048	0.564
MOD_GlcNHglycan	405	409	PF01048	0.555
MOD_GlcNHglycan	446	449	PF01048	0.471
MOD_GlcNHglycan	486	489	PF01048	0.465
MOD_GlcNHglycan	528	532	PF01048	0.469
MOD_GlcNHglycan	572	575	PF01048	0.648
MOD_GlcNHglycan	69	73	PF01048	0.648
MOD_GlcNHglycan	8	11	PF01048	0.668
MOD_GlcNHglycan	93	96	PF01048	0.510
MOD_GSK3_1	109	116	PF00069	0.530
MOD_GSK3_1	136	143	PF00069	0.677
MOD_GSK3_1	173	180	PF00069	0.510
MOD_GSK3_1	208	215	PF00069	0.335
MOD_GSK3_1	233	240	PF00069	0.362
MOD_GSK3_1	400	407	PF00069	0.662
MOD_GSK3_1	418	425	PF00069	0.458
MOD_GSK3_1	438	445	PF00069	0.291
MOD_GSK3_1	478	485	PF00069	0.464
MOD_GSK3_1	493	500	PF00069	0.338
MOD_GSK3_1	586	593	PF00069	0.581
MOD_GSK3_1	6	13	PF00069	0.638
MOD_N-GLC_1	285	290	PF02516	0.432
MOD_NEK2_1	161	166	PF00069	0.355
MOD_NEK2_1	319	324	PF00069	0.451
MOD_NEK2_1	419	424	PF00069	0.573
MOD_NEK2_1	477	482	PF00069	0.481
MOD_NEK2_1	495	500	PF00069	0.302
MOD_NEK2_1	570	575	PF00069	0.647
MOD_NEK2_2	345	350	PF00069	0.442
MOD_PIKK_1	161	167	PF00454	0.497
MOD_PIKK_1	208	214	PF00454	0.475
MOD_PIKK_1	262	268	PF00454	0.471
MOD_PIKK_1	330	336	PF00454	0.413
MOD_PIKK_1	428	434	PF00454	0.471
MOD_PIKK_1	586	592	PF00454	0.584
MOD_PK_1	292	298	PF00069	0.443
MOD_PK_1	478	484	PF00069	0.465
MOD_PKA_1	248	254	PF00069	0.436
MOD_PKA_1	291	297	PF00069	0.516
MOD_PKA_1	559	565	PF00069	0.581
MOD_PKA_2	248	254	PF00069	0.436
MOD_PKA_2	273	279	PF00069	0.428
MOD_PKA_2	291	297	PF00069	0.327
MOD_PKA_2	559	565	PF00069	0.603
MOD_PKA_2	590	596	PF00069	0.586
MOD_Plk_1	130	136	PF00069	0.577
MOD_Plk_1	319	325	PF00069	0.457
MOD_Plk_1	439	445	PF00069	0.438
MOD_Plk_1	482	488	PF00069	0.460
MOD_Plk_4	222	228	PF00069	0.470
MOD_Plk_4	237	243	PF00069	0.318
MOD_Plk_4	383	389	PF00069	0.519
MOD_Plk_4	410	416	PF00069	0.625
MOD_Plk_4	439	445	PF00069	0.460
MOD_ProDKin_1	138	144	PF00069	0.652
MOD_ProDKin_1	181	187	PF00069	0.457
MOD_ProDKin_1	37	43	PF00069	0.666
MOD_ProDKin_1	422	428	PF00069	0.512
MOD_ProDKin_1	468	474	PF00069	0.475
MOD_SUMO_for_1	128	131	PF00179	0.492
MOD_SUMO_rev_2	117	122	PF00179	0.577
MOD_SUMO_rev_2	265	273	PF00179	0.321
TRG_DiLeu_BaEn_1	157	162	PF01217	0.336
TRG_DiLeu_BaEn_1	605	610	PF01217	0.482
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.534
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.559
TRG_ENDOCYTIC_2	323	326	PF00928	0.468
TRG_ENDOCYTIC_2	416	419	PF00928	0.679
TRG_ENDOCYTIC_2	503	506	PF00928	0.447
TRG_ENDOCYTIC_2	90	93	PF00928	0.527
TRG_ER_diArg_1	22	24	PF00400	0.536
TRG_ER_diArg_1	291	293	PF00400	0.479
TRG_ER_diArg_1	338	340	PF00400	0.453
TRG_ER_diArg_1	510	513	PF00400	0.434
TRG_ER_diArg_1	558	561	PF00400	0.580
TRG_ER_diArg_1	565	568	PF00400	0.530
TRG_NES_CRM1_1	266	277	PF08389	0.467
TRG_NES_CRM1_1	490	502	PF08389	0.490
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ISJ9	Leishmania donovani	91%	100%
A4HJ96	Leishmania braziliensis	71%	99%
A4I6P1	Leishmania infantum	91%	100%
E9B1R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%