Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q6E6_LEIMA

TriTrypDb:

LmjF.31.1170 , LMJLV39_310018200 , LMJSD75_310017700

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q6E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6E6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0020037	heme binding	4	4
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.564
CLV_PCSK_KEX2_1	76	78	PF00082	0.370
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.383
CLV_PCSK_SKI1_1	31	35	PF00082	0.252
CLV_PCSK_SKI1_1	40	44	PF00082	0.255
DOC_CYCLIN_yClb1_LxF_4	4	10	PF00134	0.444
DOC_MAPK_gen_1	89	97	PF00069	0.448
DOC_USP7_MATH_1	3	7	PF00917	0.614
DOC_USP7_MATH_1	49	53	PF00917	0.497
LIG_14-3-3_CanoR_1	89	99	PF00244	0.419
LIG_14-3-3_CterR_2	109	112	PF00244	0.353
LIG_Actin_WH2_2	95	111	PF00022	0.261
LIG_BIR_II_1	1	5	PF00653	0.555
LIG_BRCT_BRCA1_1	5	9	PF00533	0.487
LIG_deltaCOP1_diTrp_1	84	90	PF00928	0.554
LIG_TRAF2_1	45	48	PF00917	0.414
LIG_UBA3_1	34	40	PF00899	0.430
MOD_CK1_1	21	27	PF00069	0.389
MOD_CK2_1	64	70	PF00069	0.556
MOD_GlcNHglycan	1	4	PF01048	0.361
MOD_GlcNHglycan	66	69	PF01048	0.370
MOD_N-GLC_1	64	69	PF02516	0.318
MOD_NEK2_2	3	8	PF00069	0.501
MOD_PKA_2	90	96	PF00069	0.415
MOD_Plk_4	18	24	PF00069	0.441
TRG_DiLeu_BaEn_1	70	75	PF01217	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX76	Leptomonas seymouri	35%	79%
A0A0N1IH82	Leptomonas seymouri	76%	100%
A0A3Q8ICI2	Leishmania donovani	96%	100%
A0A3Q8IG43	Leishmania donovani	33%	84%
A0A3Q8IGB7	Leishmania donovani	36%	86%
A0A3Q8ILC3	Leishmania donovani	35%	91%
A0A3S7WPP2	Leishmania donovani	39%	91%
A0A3S7X4C9	Leishmania donovani	28%	93%
A4H4U1	Leishmania braziliensis	41%	92%
A4HJ97	Leishmania braziliensis	30%	93%
A4HJ98	Leishmania braziliensis	83%	100%
A4HJA0	Leishmania braziliensis	36%	86%
A4HT20	Leishmania infantum	39%	91%
A4I6P2	Leishmania infantum	28%	93%
A4I6P3	Leishmania infantum	96%	100%
A4I6P5	Leishmania infantum	37%	86%
A4I6P6	Leishmania infantum	34%	84%
E9ACS1	Leishmania major	37%	100%
E9AGY1	Leishmania infantum	35%	91%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	91%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	91%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	93%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B1R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	86%
E9B1R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	83%
Q4Q6E3	Leishmania major	33%	84%
Q4Q6E4	Leishmania major	38%	86%
Q4QIU6	Leishmania major	36%	91%
Q874I5	Candida tropicalis	37%	87%