Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q6E5_LEIMA

TriTrypDb:

LmjF.31.1180 , LMJLV39_310018300 , LMJSD75_310018100

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q6E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6E5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0020037	heme binding	4	2
GO:0046906	tetrapyrrole binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.529
CLV_C14_Caspase3-7	41	45	PF00656	0.502
CLV_PCSK_KEX2_1	160	162	PF00082	0.662
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.632
CLV_PCSK_SKI1_1	40	44	PF00082	0.375
CLV_PCSK_SKI1_1	8	12	PF00082	0.319
DOC_CKS1_1	128	133	PF01111	0.596
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.287
DOC_MAPK_RevD_3	149	162	PF00069	0.437
DOC_PP2B_LxvP_1	133	136	PF13499	0.287
DOC_PP2B_LxvP_1	69	72	PF13499	0.576
DOC_USP7_MATH_1	111	115	PF00917	0.639
DOC_USP7_MATH_1	123	127	PF00917	0.624
DOC_USP7_MATH_1	28	32	PF00917	0.613
DOC_WW_Pin1_4	100	105	PF00397	0.640
DOC_WW_Pin1_4	127	132	PF00397	0.608
DOC_WW_Pin1_4	77	82	PF00397	0.665
DOC_WW_Pin1_4	93	98	PF00397	0.602
LIG_APCC_ABBA_1	34	39	PF00400	0.546
LIG_FHA_1	101	107	PF00498	0.697
LIG_FHA_1	128	134	PF00498	0.601
LIG_FHA_2	122	128	PF00498	0.673
LIG_LIR_Apic_2	15	19	PF02991	0.536
LIG_LIR_Gen_1	31	38	PF02991	0.535
LIG_LIR_Gen_1	43	53	PF02991	0.566
LIG_LIR_Nem_3	43	49	PF02991	0.518
LIG_NBox_RRM_1	134	144	PF00076	0.219
LIG_NRP_CendR_1	160	162	PF00754	0.627
LIG_REV1ctd_RIR_1	7	16	PF16727	0.516
LIG_SH2_PTP2	155	158	PF00017	0.400
LIG_SH2_SRC	16	19	PF00017	0.516
LIG_SH2_STAP1	67	71	PF00017	0.557
LIG_SH2_STAT5	155	158	PF00017	0.446
LIG_SH2_STAT5	16	19	PF00017	0.560
LIG_SH2_STAT5	22	25	PF00017	0.542
LIG_SH2_STAT5	37	40	PF00017	0.562
LIG_SH3_3	101	107	PF00018	0.611
LIG_SH3_3	125	131	PF00018	0.610
LIG_SH3_3	153	159	PF00018	0.476
LIG_SH3_3	75	81	PF00018	0.664
LIG_SUMO_SIM_anti_2	150	155	PF11976	0.260
LIG_TRAF2_1	81	84	PF00917	0.701
LIG_TYR_ITIM	153	158	PF00017	0.507
MOD_CDK_SPK_2	127	132	PF00069	0.608
MOD_CDK_SPK_2	93	98	PF00069	0.612
MOD_CK1_1	126	132	PF00069	0.657
MOD_CK2_1	121	127	PF00069	0.693
MOD_GSK3_1	117	124	PF00069	0.666
MOD_GSK3_1	73	80	PF00069	0.661
MOD_NEK2_1	147	152	PF00069	0.334
MOD_Plk_1	49	55	PF00069	0.642
MOD_Plk_1	73	79	PF00069	0.617
MOD_Plk_4	12	18	PF00069	0.574
MOD_ProDKin_1	100	106	PF00069	0.639
MOD_ProDKin_1	127	133	PF00069	0.608
MOD_ProDKin_1	77	83	PF00069	0.667
MOD_ProDKin_1	93	99	PF00069	0.601
TRG_ENDOCYTIC_2	155	158	PF00928	0.429
TRG_ENDOCYTIC_2	32	35	PF00928	0.516
TRG_ENDOCYTIC_2	7	10	PF00928	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ILC3	Leishmania donovani	31%	100%
A0A3S7WPP2	Leishmania donovani	30%	100%
A0A3S7X4E5	Leishmania donovani	89%	100%
A4HJ99	Leishmania braziliensis	69%	100%
A4HJA1	Leishmania braziliensis	30%	100%
A4HT20	Leishmania infantum	30%	100%
A4I6P4	Leishmania infantum	89%	100%
E9AGY1	Leishmania infantum	31%	100%
E9B1R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%