Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q6E4_LEIMA

TriTrypDb:

LmjF.31.1190 , LMJLV39_310018400 , LMJSD75_310018200

Length:

130

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q6E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6E4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0020037	heme binding	4	3
GO:0046906	tetrapyrrole binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.610
CLV_NRD_NRD_1	39	41	PF00675	0.256
CLV_PCSK_KEX2_1	39	41	PF00082	0.256
CLV_PCSK_SKI1_1	46	50	PF00082	0.351
CLV_PCSK_SKI1_1	54	58	PF00082	0.288
CLV_PCSK_SKI1_1	71	75	PF00082	0.321
DEG_APCC_DBOX_1	70	78	PF00400	0.456
DOC_CYCLIN_RxL_1	65	78	PF00134	0.456
DOC_MAPK_gen_1	29	37	PF00069	0.456
DOC_MAPK_gen_1	67	76	PF00069	0.456
DOC_PIKK_1	78	86	PF02985	0.561
DOC_PP2B_LxvP_1	47	50	PF13499	0.491
DOC_USP7_MATH_1	5	9	PF00917	0.620
DOC_USP7_MATH_1	63	67	PF00917	0.537
LIG_14-3-3_CanoR_1	32	38	PF00244	0.497
LIG_FHA_1	28	34	PF00498	0.498
LIG_FHA_1	4	10	PF00498	0.617
LIG_FHA_2	11	17	PF00498	0.628
LIG_LIR_Apic_2	30	34	PF02991	0.510
LIG_PCNA_PIPBox_1	70	79	PF02747	0.531
LIG_SH2_CRK	31	35	PF00017	0.447
LIG_SH2_GRB2like	51	54	PF00017	0.487
LIG_SH2_STAP1	100	104	PF00017	0.573
LIG_SH2_STAT5	100	103	PF00017	0.548
LIG_SH3_3	6	12	PF00018	0.625
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.330
LIG_TRAF2_1	82	85	PF00917	0.552
MOD_CK1_1	110	116	PF00069	0.276
MOD_CK1_1	3	9	PF00069	0.675
MOD_CK1_1	98	104	PF00069	0.625
MOD_CK2_1	79	85	PF00069	0.598
MOD_N-GLC_2	103	105	PF02516	0.271
MOD_NEK2_1	77	82	PF00069	0.597
MOD_PIKK_1	54	60	PF00454	0.510
MOD_PIKK_1	95	101	PF00454	0.524
MOD_Plk_1	77	83	PF00069	0.559
MOD_Plk_2-3	79	85	PF00069	0.566
MOD_Plk_4	107	113	PF00069	0.305
MOD_Plk_4	33	39	PF00069	0.451
TRG_DiLeu_BaEn_1	84	89	PF01217	0.584
TRG_DiLeu_BaEn_4	84	90	PF01217	0.519
TRG_ER_diArg_1	38	40	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.260
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX76	Leptomonas seymouri	55%	92%
A0A0N1I3U0	Leptomonas seymouri	32%	98%
A0A3Q8ICI2	Leishmania donovani	38%	100%
A0A3Q8IGB7	Leishmania donovani	86%	100%
A0A3S7X4C9	Leishmania donovani	34%	100%
A4HJ97	Leishmania braziliensis	39%	100%
A4HJ98	Leishmania braziliensis	36%	100%
A4HJA0	Leishmania braziliensis	81%	100%
A4HJA1	Leishmania braziliensis	35%	99%
A4HJA2	Leishmania braziliensis	83%	100%
A4I6P2	Leishmania infantum	34%	100%
A4I6P3	Leishmania infantum	38%	100%
A4I6P5	Leishmania infantum	87%	100%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B1R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q6E6	Leishmania major	38%	100%