Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q6E3_LEIMA

TriTrypDb:

LmjF.31.1200 , LMJLV39_310018500 , LMJSD75_310018300

Length:

134

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q6E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6E3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0020037	heme binding	4	4
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.335
CLV_NRD_NRD_1	106	108	PF00675	0.320
CLV_NRD_NRD_1	128	130	PF00675	0.667
CLV_NRD_NRD_1	82	84	PF00675	0.365
CLV_NRD_NRD_1	95	97	PF00675	0.363
CLV_PCSK_FUR_1	103	107	PF00082	0.333
CLV_PCSK_KEX2_1	102	104	PF00082	0.375
CLV_PCSK_KEX2_1	105	107	PF00082	0.332
CLV_PCSK_KEX2_1	128	130	PF00082	0.572
CLV_PCSK_KEX2_1	95	97	PF00082	0.408
CLV_PCSK_PC7_1	102	108	PF00082	0.308
CLV_PCSK_SKI1_1	83	87	PF00082	0.355
CLV_PCSK_SKI1_1	96	100	PF00082	0.306
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.510
DOC_MAPK_MEF2A_6	13	21	PF00069	0.548
DOC_PP2B_LxvP_1	17	20	PF13499	0.500
LIG_14-3-3_CanoR_1	105	111	PF00244	0.473
LIG_14-3-3_CanoR_1	95	104	PF00244	0.561
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_eIF4E_1	12	18	PF01652	0.511
LIG_FHA_1	106	112	PF00498	0.468
LIG_FHA_1	13	19	PF00498	0.483
LIG_FHA_2	60	66	PF00498	0.541
LIG_LIR_Gen_1	5	12	PF02991	0.497
LIG_LIR_Gen_1	62	68	PF02991	0.688
LIG_LIR_LC3C_4	15	19	PF02991	0.477
LIG_LIR_Nem_3	5	10	PF02991	0.500
LIG_LIR_Nem_3	62	66	PF02991	0.668
LIG_SH2_GRB2like	38	41	PF00017	0.448
LIG_SH2_NCK_1	76	80	PF00017	0.529
LIG_SH2_PTP2	7	10	PF00017	0.491
LIG_SH2_STAT3	34	37	PF00017	0.448
LIG_SH2_STAT3	38	41	PF00017	0.448
LIG_SH2_STAT5	34	37	PF00017	0.448
LIG_SH2_STAT5	7	10	PF00017	0.503
LIG_TRAF2_1	62	65	PF00917	0.542
LIG_WRC_WIRS_1	60	65	PF05994	0.539
MOD_CK2_1	42	48	PF00069	0.444
MOD_CK2_1	59	65	PF00069	0.563
MOD_CK2_1	87	93	PF00069	0.610
MOD_GlcNHglycan	44	47	PF01048	0.311
MOD_GSK3_1	105	112	PF00069	0.458
MOD_N-GLC_1	50	55	PF02516	0.312
MOD_NEK2_1	50	55	PF00069	0.427
MOD_PKA_1	105	111	PF00069	0.438
MOD_PKA_2	105	111	PF00069	0.533
MOD_PKB_1	103	111	PF00069	0.560
MOD_Plk_4	106	112	PF00069	0.521
MOD_Plk_4	13	19	PF00069	0.516
MOD_Plk_4	3	9	PF00069	0.638
TRG_ENDOCYTIC_2	7	10	PF00928	0.491
TRG_ER_diArg_1	101	103	PF00400	0.565
TRG_ER_diArg_1	104	107	PF00400	0.562
TRG_ER_diArg_1	127	129	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U0	Leptomonas seymouri	57%	100%
A0A3Q8ICI2	Leishmania donovani	32%	100%
A0A3Q8IG43	Leishmania donovani	94%	100%
A4HJ98	Leishmania braziliensis	29%	88%
A4HJA1	Leishmania braziliensis	82%	100%
A4I6P3	Leishmania infantum	32%	100%
A4I6P6	Leishmania infantum	95%	100%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B1R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4Q6E6	Leishmania major	33%	91%
Q4QIU6	Leishmania major	30%	100%