LeishMANIAdb
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CULLIN_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CULLIN_2 domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
Q4Q6E0_LEIMA
TriTrypDb:
LmjF.31.1230 * , LMJLV39_310018800 * , LMJSD75_310018600 *
Length:
975

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 7

Expansion

Sequence features

Q4Q6E0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6E0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 255 259 PF00656 0.462
CLV_C14_Caspase3-7 297 301 PF00656 0.482
CLV_C14_Caspase3-7 612 616 PF00656 0.466
CLV_C14_Caspase3-7 694 698 PF00656 0.518
CLV_C14_Caspase3-7 722 726 PF00656 0.475
CLV_C14_Caspase3-7 850 854 PF00656 0.548
CLV_NRD_NRD_1 25 27 PF00675 0.469
CLV_NRD_NRD_1 261 263 PF00675 0.707
CLV_NRD_NRD_1 364 366 PF00675 0.452
CLV_NRD_NRD_1 808 810 PF00675 0.622
CLV_NRD_NRD_1 967 969 PF00675 0.467
CLV_PCSK_KEX2_1 261 263 PF00082 0.707
CLV_PCSK_KEX2_1 364 366 PF00082 0.452
CLV_PCSK_KEX2_1 428 430 PF00082 0.615
CLV_PCSK_KEX2_1 710 712 PF00082 0.405
CLV_PCSK_PC1ET2_1 428 430 PF00082 0.537
CLV_PCSK_PC1ET2_1 710 712 PF00082 0.405
CLV_PCSK_SKI1_1 188 192 PF00082 0.533
CLV_PCSK_SKI1_1 235 239 PF00082 0.473
CLV_PCSK_SKI1_1 286 290 PF00082 0.489
CLV_PCSK_SKI1_1 346 350 PF00082 0.450
CLV_PCSK_SKI1_1 608 612 PF00082 0.578
CLV_PCSK_SKI1_1 657 661 PF00082 0.422
CLV_PCSK_SKI1_1 750 754 PF00082 0.629
CLV_PCSK_SKI1_1 873 877 PF00082 0.385
DEG_APCC_DBOX_1 645 653 PF00400 0.431
DEG_APCC_DBOX_1 680 688 PF00400 0.501
DEG_APCC_DBOX_1 872 880 PF00400 0.429
DEG_MDM2_SWIB_1 124 132 PF02201 0.456
DEG_Nend_Nbox_1 1 3 PF02207 0.503
DOC_CDC14_PxL_1 522 530 PF14671 0.578
DOC_CKS1_1 109 114 PF01111 0.674
DOC_CKS1_1 311 316 PF01111 0.635
DOC_CKS1_1 822 827 PF01111 0.468
DOC_CYCLIN_RxL_1 229 240 PF00134 0.400
DOC_CYCLIN_yCln2_LP_2 164 170 PF00134 0.502
DOC_MAPK_DCC_7 646 654 PF00069 0.434
DOC_MAPK_FxFP_2 43 46 PF00069 0.442
DOC_MAPK_gen_1 556 563 PF00069 0.488
DOC_MAPK_gen_1 809 817 PF00069 0.571
DOC_MAPK_MEF2A_6 416 425 PF00069 0.572
DOC_MAPK_MEF2A_6 646 654 PF00069 0.434
DOC_PP1_RVXF_1 259 266 PF00149 0.475
DOC_PP1_SILK_1 905 910 PF00149 0.326
DOC_PP2B_LxvP_1 164 167 PF13499 0.591
DOC_PP2B_LxvP_1 392 395 PF13499 0.513
DOC_PP4_FxxP_1 148 151 PF00568 0.453
DOC_PP4_FxxP_1 311 314 PF00568 0.508
DOC_PP4_FxxP_1 43 46 PF00568 0.442
DOC_USP7_MATH_1 216 220 PF00917 0.480
DOC_USP7_MATH_1 354 358 PF00917 0.516
DOC_USP7_MATH_1 402 406 PF00917 0.619
DOC_USP7_MATH_1 630 634 PF00917 0.450
DOC_USP7_MATH_1 752 756 PF00917 0.602
DOC_USP7_MATH_1 777 781 PF00917 0.770
DOC_USP7_MATH_2 736 742 PF00917 0.637
DOC_WW_Pin1_4 108 113 PF00397 0.622
DOC_WW_Pin1_4 310 315 PF00397 0.631
DOC_WW_Pin1_4 417 422 PF00397 0.586
DOC_WW_Pin1_4 578 583 PF00397 0.443
DOC_WW_Pin1_4 613 618 PF00397 0.530
DOC_WW_Pin1_4 818 823 PF00397 0.560
DOC_WW_Pin1_4 837 842 PF00397 0.459
LIG_14-3-3_CanoR_1 121 125 PF00244 0.623
LIG_14-3-3_CanoR_1 18 24 PF00244 0.489
LIG_14-3-3_CanoR_1 373 383 PF00244 0.381
LIG_14-3-3_CanoR_1 442 447 PF00244 0.740
LIG_14-3-3_CanoR_1 598 604 PF00244 0.394
LIG_14-3-3_CanoR_1 608 614 PF00244 0.471
LIG_14-3-3_CanoR_1 67 73 PF00244 0.494
LIG_14-3-3_CanoR_1 790 797 PF00244 0.600
LIG_14-3-3_CanoR_1 809 813 PF00244 0.595
LIG_14-3-3_CanoR_1 84 88 PF00244 0.584
LIG_14-3-3_CterR_2 973 975 PF00244 0.499
LIG_Actin_WH2_2 129 145 PF00022 0.530
LIG_Actin_WH2_2 600 616 PF00022 0.417
LIG_APCC_ABBA_1 624 629 PF00400 0.444
LIG_BRCT_BRCA1_1 242 246 PF00533 0.460
LIG_CaM_IQ_9 682 698 PF13499 0.473
LIG_Clathr_ClatBox_1 916 920 PF01394 0.378
LIG_DLG_GKlike_1 365 372 PF00625 0.393
LIG_EH_1 195 199 PF12763 0.512
LIG_EH_1 923 927 PF12763 0.418
LIG_eIF4E_1 325 331 PF01652 0.397
LIG_eIF4E_1 881 887 PF01652 0.461
LIG_FAT_LD_1 227 235 PF03623 0.389
LIG_FHA_1 109 115 PF00498 0.777
LIG_FHA_1 159 165 PF00498 0.552
LIG_FHA_1 172 178 PF00498 0.608
LIG_FHA_1 19 25 PF00498 0.522
LIG_FHA_1 305 311 PF00498 0.528
LIG_FHA_1 387 393 PF00498 0.473
LIG_FHA_1 418 424 PF00498 0.598
LIG_FHA_1 512 518 PF00498 0.628
LIG_FHA_1 54 60 PF00498 0.532
LIG_FHA_1 597 603 PF00498 0.366
LIG_FHA_1 640 646 PF00498 0.502
LIG_FHA_1 857 863 PF00498 0.520
LIG_FHA_1 912 918 PF00498 0.383
LIG_FHA_2 253 259 PF00498 0.453
LIG_FHA_2 295 301 PF00498 0.421
LIG_FHA_2 316 322 PF00498 0.501
LIG_FHA_2 452 458 PF00498 0.644
LIG_FHA_2 692 698 PF00498 0.524
LIG_FHA_2 720 726 PF00498 0.523
LIG_GBD_Chelix_1 226 234 PF00786 0.411
LIG_GBD_Chelix_1 326 334 PF00786 0.462
LIG_LIR_Apic_2 145 151 PF02991 0.520
LIG_LIR_Apic_2 40 46 PF02991 0.440
LIG_LIR_Apic_2 69 73 PF02991 0.516
LIG_LIR_Gen_1 123 132 PF02991 0.462
LIG_LIR_Gen_1 222 231 PF02991 0.440
LIG_LIR_Gen_1 236 246 PF02991 0.360
LIG_LIR_Gen_1 248 257 PF02991 0.361
LIG_LIR_Gen_1 460 470 PF02991 0.665
LIG_LIR_Gen_1 663 670 PF02991 0.405
LIG_LIR_Gen_1 671 682 PF02991 0.409
LIG_LIR_Gen_1 855 862 PF02991 0.596
LIG_LIR_Nem_3 123 127 PF02991 0.480
LIG_LIR_Nem_3 222 226 PF02991 0.454
LIG_LIR_Nem_3 240 245 PF02991 0.339
LIG_LIR_Nem_3 248 252 PF02991 0.338
LIG_LIR_Nem_3 258 263 PF02991 0.411
LIG_LIR_Nem_3 460 465 PF02991 0.674
LIG_LIR_Nem_3 580 586 PF02991 0.415
LIG_LIR_Nem_3 671 677 PF02991 0.454
LIG_LIR_Nem_3 855 860 PF02991 0.487
LIG_LIR_Nem_3 863 869 PF02991 0.426
LIG_LIR_Nem_3 920 926 PF02991 0.414
LIG_LIR_Nem_3 930 934 PF02991 0.395
LIG_LYPXL_yS_3 583 586 PF13949 0.414
LIG_MLH1_MIPbox_1 242 246 PF16413 0.460
LIG_Pex14_2 124 128 PF04695 0.454
LIG_Pex14_2 245 249 PF04695 0.377
LIG_Pex14_2 347 351 PF04695 0.439
LIG_PTB_Apo_2 193 200 PF02174 0.431
LIG_PTB_Apo_2 925 932 PF02174 0.418
LIG_Rb_LxCxE_1 936 957 PF01857 0.464
LIG_SH2_CRK 70 74 PF00017 0.464
LIG_SH2_NCK_1 70 74 PF00017 0.464
LIG_SH2_PTP2 866 869 PF00017 0.442
LIG_SH2_STAP1 242 246 PF00017 0.460
LIG_SH2_STAP1 272 276 PF00017 0.487
LIG_SH2_STAP1 39 43 PF00017 0.441
LIG_SH2_STAP1 413 417 PF00017 0.532
LIG_SH2_STAT3 184 187 PF00017 0.553
LIG_SH2_STAT3 634 637 PF00017 0.409
LIG_SH2_STAT5 325 328 PF00017 0.514
LIG_SH2_STAT5 379 382 PF00017 0.394
LIG_SH2_STAT5 39 42 PF00017 0.438
LIG_SH2_STAT5 587 590 PF00017 0.382
LIG_SH2_STAT5 70 73 PF00017 0.465
LIG_SH2_STAT5 856 859 PF00017 0.466
LIG_SH2_STAT5 866 869 PF00017 0.417
LIG_SH3_2 650 655 PF14604 0.399
LIG_SH3_3 104 110 PF00018 0.744
LIG_SH3_3 435 441 PF00018 0.726
LIG_SH3_3 514 520 PF00018 0.763
LIG_SH3_3 647 653 PF00018 0.446
LIG_SH3_3 819 825 PF00018 0.493
LIG_SUMO_SIM_par_1 284 292 PF11976 0.430
LIG_SUMO_SIM_par_1 418 426 PF11976 0.637
LIG_SUMO_SIM_par_1 609 616 PF11976 0.543
LIG_SUMO_SIM_par_1 640 648 PF11976 0.436
LIG_SUMO_SIM_par_1 884 890 PF11976 0.390
LIG_TRAF2_1 219 222 PF00917 0.503
LIG_TRAF2_1 534 537 PF00917 0.567
LIG_TRAF2_1 726 729 PF00917 0.621
LIG_TRAF2_1 816 819 PF00917 0.522
LIG_UBA3_1 610 614 PF00899 0.403
LIG_WRC_WIRS_1 246 251 PF05994 0.416
LIG_WRC_WIRS_1 257 262 PF05994 0.508
LIG_WRC_WIRS_1 408 413 PF05994 0.534
LIG_WRC_WIRS_1 87 92 PF05994 0.621
MOD_CDK_SPxxK_3 613 620 PF00069 0.512
MOD_CK1_1 17 23 PF00069 0.508
MOD_CK1_1 368 374 PF00069 0.454
MOD_CK1_1 375 381 PF00069 0.378
MOD_CK1_1 409 415 PF00069 0.729
MOD_CK1_1 478 484 PF00069 0.488
MOD_CK1_1 515 521 PF00069 0.626
MOD_CK1_1 52 58 PF00069 0.494
MOD_CK1_1 755 761 PF00069 0.579
MOD_CK1_1 780 786 PF00069 0.557
MOD_CK1_1 788 794 PF00069 0.639
MOD_CK1_1 808 814 PF00069 0.497
MOD_CK1_1 821 827 PF00069 0.448
MOD_CK1_1 956 962 PF00069 0.406
MOD_CK2_1 1 7 PF00069 0.516
MOD_CK2_1 216 222 PF00069 0.441
MOD_CK2_1 315 321 PF00069 0.520
MOD_CK2_1 356 362 PF00069 0.436
MOD_CK2_1 375 381 PF00069 0.384
MOD_CK2_1 393 399 PF00069 0.554
MOD_CK2_1 451 457 PF00069 0.663
MOD_CK2_1 699 705 PF00069 0.436
MOD_CK2_1 808 814 PF00069 0.661
MOD_GlcNHglycan 242 245 PF01048 0.390
MOD_GlcNHglycan 327 330 PF01048 0.474
MOD_GlcNHglycan 399 403 PF01048 0.570
MOD_GlcNHglycan 665 668 PF01048 0.531
MOD_GlcNHglycan 740 743 PF01048 0.748
MOD_GlcNHglycan 787 790 PF01048 0.555
MOD_GlcNHglycan 798 801 PF01048 0.482
MOD_GlcNHglycan 848 852 PF01048 0.489
MOD_GlcNHglycan 956 959 PF01048 0.461
MOD_GSK3_1 14 21 PF00069 0.501
MOD_GSK3_1 229 236 PF00069 0.474
MOD_GSK3_1 252 259 PF00069 0.545
MOD_GSK3_1 282 289 PF00069 0.422
MOD_GSK3_1 3 10 PF00069 0.548
MOD_GSK3_1 300 307 PF00069 0.574
MOD_GSK3_1 368 375 PF00069 0.451
MOD_GSK3_1 398 405 PF00069 0.640
MOD_GSK3_1 412 419 PF00069 0.644
MOD_GSK3_1 45 52 PF00069 0.473
MOD_GSK3_1 511 518 PF00069 0.768
MOD_GSK3_1 53 60 PF00069 0.509
MOD_GSK3_1 609 616 PF00069 0.458
MOD_GSK3_1 734 741 PF00069 0.776
MOD_GSK3_1 751 758 PF00069 0.600
MOD_GSK3_1 780 787 PF00069 0.618
MOD_GSK3_1 837 844 PF00069 0.517
MOD_GSK3_1 856 863 PF00069 0.401
MOD_GSK3_1 949 956 PF00069 0.451
MOD_N-GLC_1 304 309 PF02516 0.574
MOD_N-GLC_1 315 320 PF02516 0.410
MOD_N-GLC_1 719 724 PF02516 0.432
MOD_N-GLC_1 729 734 PF02516 0.577
MOD_N-GLC_1 841 846 PF02516 0.402
MOD_N-GLC_1 860 865 PF02516 0.328
MOD_N-GLC_1 927 932 PF02516 0.399
MOD_NEK2_1 1 6 PF00069 0.495
MOD_NEK2_1 142 147 PF00069 0.458
MOD_NEK2_1 237 242 PF00069 0.444
MOD_NEK2_1 245 250 PF00069 0.377
MOD_NEK2_1 256 261 PF00069 0.470
MOD_NEK2_1 372 377 PF00069 0.467
MOD_NEK2_1 450 455 PF00069 0.668
MOD_NEK2_1 59 64 PF00069 0.450
MOD_NEK2_1 660 665 PF00069 0.367
MOD_NEK2_1 767 772 PF00069 0.644
MOD_NEK2_1 784 789 PF00069 0.613
MOD_NEK2_1 805 810 PF00069 0.675
MOD_NEK2_1 83 88 PF00069 0.634
MOD_NEK2_1 860 865 PF00069 0.399
MOD_NEK2_1 919 924 PF00069 0.359
MOD_NEK2_1 937 942 PF00069 0.470
MOD_NEK2_1 949 954 PF00069 0.398
MOD_NEK2_2 233 238 PF00069 0.411
MOD_NEK2_2 609 614 PF00069 0.405
MOD_PIKK_1 114 120 PF00454 0.534
MOD_PIKK_1 183 189 PF00454 0.560
MOD_PIKK_1 566 572 PF00454 0.462
MOD_PIKK_1 597 603 PF00454 0.384
MOD_PIKK_1 68 74 PF00454 0.465
MOD_PIKK_1 729 735 PF00454 0.690
MOD_PK_1 442 448 PF00069 0.625
MOD_PKA_2 120 126 PF00069 0.614
MOD_PKA_2 142 148 PF00069 0.485
MOD_PKA_2 17 23 PF00069 0.520
MOD_PKA_2 372 378 PF00069 0.481
MOD_PKA_2 387 393 PF00069 0.502
MOD_PKA_2 504 510 PF00069 0.796
MOD_PKA_2 597 603 PF00069 0.444
MOD_PKA_2 645 651 PF00069 0.462
MOD_PKA_2 66 72 PF00069 0.498
MOD_PKA_2 789 795 PF00069 0.621
MOD_PKA_2 808 814 PF00069 0.556
MOD_PKA_2 83 89 PF00069 0.585
MOD_Plk_1 304 310 PF00069 0.560
MOD_Plk_1 365 371 PF00069 0.475
MOD_Plk_1 406 412 PF00069 0.616
MOD_Plk_1 564 570 PF00069 0.377
MOD_Plk_1 639 645 PF00069 0.471
MOD_Plk_1 841 847 PF00069 0.415
MOD_Plk_1 919 925 PF00069 0.389
MOD_Plk_1 927 933 PF00069 0.430
MOD_Plk_2-3 895 901 PF00069 0.423
MOD_Plk_4 120 126 PF00069 0.501
MOD_Plk_4 142 148 PF00069 0.478
MOD_Plk_4 201 207 PF00069 0.616
MOD_Plk_4 237 243 PF00069 0.417
MOD_Plk_4 252 258 PF00069 0.460
MOD_Plk_4 375 381 PF00069 0.378
MOD_Plk_4 504 510 PF00069 0.603
MOD_Plk_4 660 666 PF00069 0.510
MOD_Plk_4 78 84 PF00069 0.585
MOD_Plk_4 841 847 PF00069 0.511
MOD_Plk_4 943 949 PF00069 0.384
MOD_ProDKin_1 108 114 PF00069 0.619
MOD_ProDKin_1 310 316 PF00069 0.640
MOD_ProDKin_1 417 423 PF00069 0.590
MOD_ProDKin_1 578 584 PF00069 0.445
MOD_ProDKin_1 613 619 PF00069 0.516
MOD_ProDKin_1 818 824 PF00069 0.545
MOD_ProDKin_1 837 843 PF00069 0.462
MOD_SUMO_rev_2 169 177 PF00179 0.491
MOD_SUMO_rev_2 278 288 PF00179 0.474
MOD_SUMO_rev_2 424 430 PF00179 0.629
MOD_SUMO_rev_2 961 971 PF00179 0.391
TRG_AP2beta_CARGO_1 671 681 PF09066 0.485
TRG_DiLeu_BaEn_1 78 83 PF01217 0.536
TRG_DiLeu_LyEn_5 606 611 PF01217 0.445
TRG_ENDOCYTIC_2 242 245 PF00928 0.466
TRG_ENDOCYTIC_2 583 586 PF00928 0.414
TRG_ENDOCYTIC_2 665 668 PF00928 0.474
TRG_ENDOCYTIC_2 866 869 PF00928 0.464
TRG_ENDOCYTIC_2 923 926 PF00928 0.499
TRG_ER_diArg_1 260 262 PF00400 0.566
TRG_ER_diArg_1 654 657 PF00400 0.427
TRG_Pf-PMV_PEXEL_1 261 266 PF00026 0.441
TRG_Pf-PMV_PEXEL_1 480 485 PF00026 0.540
TRG_Pf-PMV_PEXEL_1 636 640 PF00026 0.473

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5A0 Leptomonas seymouri 32% 100%
A0A3S7X4D3 Leishmania donovani 85% 100%
A4HJA6 Leishmania braziliensis 63% 100%
A4I6P9 Leishmania infantum 85% 100%
E9B1S1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS