CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

'Cold-shock' DNA-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q6C9_LEIMA

TriTrypDb:

LmjF.31.1340 , LMJLV39_310020400 , LMJSD75_310019900

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6C9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003677	DNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.602
CLV_NRD_NRD_1	237	239	PF00675	0.507
CLV_PCSK_KEX2_1	340	342	PF00082	0.433
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.433
DEG_COP1_1	270	280	PF00400	0.611
DEG_Nend_Nbox_1	1	3	PF02207	0.582
DEG_SPOP_SBC_1	162	166	PF00917	0.674
DEG_SPOP_SBC_1	167	171	PF00917	0.615
DOC_CKS1_1	396	401	PF01111	0.379
DOC_CYCLIN_yCln2_LP_2	25	28	PF00134	0.526
DOC_MAPK_gen_1	238	245	PF00069	0.550
DOC_MAPK_gen_1	394	402	PF00069	0.454
DOC_PP1_RVXF_1	423	429	PF00149	0.503
DOC_PP2B_LxvP_1	25	28	PF13499	0.526
DOC_PP2B_LxvP_1	281	284	PF13499	0.637
DOC_PP2B_LxvP_1	312	315	PF13499	0.525
DOC_PP4_FxxP_1	307	310	PF00568	0.704
DOC_PP4_MxPP_1	259	262	PF00568	0.556
DOC_SPAK_OSR1_1	427	431	PF12202	0.475
DOC_USP7_MATH_1	105	109	PF00917	0.541
DOC_USP7_MATH_1	141	145	PF00917	0.569
DOC_USP7_MATH_1	167	171	PF00917	0.550
DOC_USP7_MATH_1	284	288	PF00917	0.536
DOC_USP7_MATH_1	31	35	PF00917	0.530
DOC_USP7_MATH_1	373	377	PF00917	0.583
DOC_USP7_MATH_1	91	95	PF00917	0.741
DOC_WW_Pin1_4	109	114	PF00397	0.752
DOC_WW_Pin1_4	137	142	PF00397	0.723
DOC_WW_Pin1_4	191	196	PF00397	0.591
DOC_WW_Pin1_4	232	237	PF00397	0.644
DOC_WW_Pin1_4	369	374	PF00397	0.671
DOC_WW_Pin1_4	389	394	PF00397	0.583
DOC_WW_Pin1_4	395	400	PF00397	0.495
LIG_14-3-3_CanoR_1	30	39	PF00244	0.521
LIG_14-3-3_CanoR_1	319	325	PF00244	0.576
LIG_BRCT_BRCA1_1	156	160	PF00533	0.524
LIG_BRCT_BRCA1_1	303	307	PF00533	0.596
LIG_EVH1_1	314	318	PF00568	0.535
LIG_FHA_1	229	235	PF00498	0.503
LIG_FHA_1	352	358	PF00498	0.430
LIG_FHA_1	379	385	PF00498	0.603
LIG_FHA_1	417	423	PF00498	0.495
LIG_FHA_2	242	248	PF00498	0.667
LIG_FHA_2	384	390	PF00498	0.563
LIG_LIR_Apic_2	254	260	PF02991	0.637
LIG_LIR_Apic_2	304	310	PF02991	0.653
LIG_LIR_Apic_2	395	399	PF02991	0.384
LIG_LIR_Apic_2	51	57	PF02991	0.546
LIG_LIR_Nem_3	20	26	PF02991	0.524
LIG_LIR_Nem_3	333	338	PF02991	0.392
LIG_LIR_Nem_3	415	420	PF02991	0.529
LIG_MYND_1	24	28	PF01753	0.524
LIG_SH2_CRK	257	261	PF00017	0.677
LIG_SH2_CRK	396	400	PF00017	0.417
LIG_SH2_CRK	54	58	PF00017	0.588
LIG_SH2_CRK	6	10	PF00017	0.565
LIG_SH2_GRB2like	6	9	PF00017	0.589
LIG_SH2_NCK_1	257	261	PF00017	0.629
LIG_SH2_NCK_1	6	10	PF00017	0.499
LIG_SH2_STAP1	69	73	PF00017	0.537
LIG_SH2_STAT5	280	283	PF00017	0.644
LIG_SH3_1	257	263	PF00018	0.621
LIG_SH3_2	317	322	PF14604	0.615
LIG_SH3_3	192	198	PF00018	0.773
LIG_SH3_3	201	207	PF00018	0.525
LIG_SH3_3	21	27	PF00018	0.596
LIG_SH3_3	211	217	PF00018	0.571
LIG_SH3_3	257	263	PF00018	0.739
LIG_SH3_3	307	313	PF00018	0.714
LIG_SH3_3	314	320	PF00018	0.558
LIG_SH3_3	447	453	PF00018	0.558
LIG_SUMO_SIM_anti_2	354	362	PF11976	0.361
LIG_TRFH_1	23	27	PF08558	0.520
LIG_WRC_WIRS_1	286	291	PF05994	0.579
LIG_WW_3	316	320	PF00397	0.553
MOD_CDK_SPK_2	389	394	PF00069	0.532
MOD_CDK_SPxK_1	232	238	PF00069	0.486
MOD_CDK_SPxxK_3	232	239	PF00069	0.495
MOD_CK1_1	100	106	PF00069	0.601
MOD_CK1_1	139	145	PF00069	0.608
MOD_CK1_1	154	160	PF00069	0.764
MOD_CK1_1	163	169	PF00069	0.602
MOD_CK1_1	209	215	PF00069	0.730
MOD_CK1_1	228	234	PF00069	0.503
MOD_CK1_1	246	252	PF00069	0.624
MOD_CK1_1	267	273	PF00069	0.588
MOD_CK1_1	276	282	PF00069	0.580
MOD_CK1_1	302	308	PF00069	0.647
MOD_CK1_1	33	39	PF00069	0.608
MOD_CK1_1	78	84	PF00069	0.745
MOD_CK2_1	149	155	PF00069	0.665
MOD_CK2_1	383	389	PF00069	0.569
MOD_GlcNHglycan	102	105	PF01048	0.622
MOD_GlcNHglycan	107	110	PF01048	0.579
MOD_GlcNHglycan	147	150	PF01048	0.743
MOD_GlcNHglycan	155	159	PF01048	0.544
MOD_GlcNHglycan	165	168	PF01048	0.619
MOD_GlcNHglycan	208	211	PF01048	0.679
MOD_GlcNHglycan	247	251	PF01048	0.653
MOD_GlcNHglycan	270	273	PF01048	0.737
MOD_GlcNHglycan	301	304	PF01048	0.678
MOD_GlcNHglycan	33	36	PF01048	0.569
MOD_GlcNHglycan	367	370	PF01048	0.682
MOD_GlcNHglycan	78	81	PF01048	0.681
MOD_GSK3_1	105	112	PF00069	0.677
MOD_GSK3_1	13	20	PF00069	0.579
MOD_GSK3_1	137	144	PF00069	0.641
MOD_GSK3_1	145	152	PF00069	0.713
MOD_GSK3_1	156	163	PF00069	0.499
MOD_GSK3_1	177	184	PF00069	0.574
MOD_GSK3_1	205	212	PF00069	0.661
MOD_GSK3_1	228	235	PF00069	0.610
MOD_GSK3_1	241	248	PF00069	0.597
MOD_GSK3_1	249	256	PF00069	0.586
MOD_GSK3_1	264	271	PF00069	0.637
MOD_GSK3_1	272	279	PF00069	0.619
MOD_GSK3_1	295	302	PF00069	0.600
MOD_GSK3_1	351	358	PF00069	0.463
MOD_GSK3_1	361	368	PF00069	0.555
MOD_GSK3_1	369	376	PF00069	0.609
MOD_GSK3_1	379	386	PF00069	0.686
MOD_GSK3_1	65	72	PF00069	0.689
MOD_N-GLC_1	105	110	PF02516	0.555
MOD_N-GLC_1	184	189	PF02516	0.642
MOD_N-GLC_1	377	382	PF02516	0.627
MOD_NEK2_1	160	165	PF00069	0.756
MOD_NEK2_1	188	193	PF00069	0.667
MOD_NEK2_1	200	205	PF00069	0.520
MOD_NEK2_1	225	230	PF00069	0.604
MOD_NEK2_1	301	306	PF00069	0.563
MOD_NEK2_1	351	356	PF00069	0.389
MOD_NEK2_1	377	382	PF00069	0.603
MOD_PIKK_1	264	270	PF00454	0.681
MOD_PIKK_1	33	39	PF00454	0.592
MOD_PKA_2	144	150	PF00069	0.647
MOD_PKA_2	75	81	PF00069	0.645
MOD_Plk_1	60	66	PF00069	0.639
MOD_Plk_2-3	241	247	PF00069	0.596
MOD_Plk_4	131	137	PF00069	0.625
MOD_Plk_4	276	282	PF00069	0.657
MOD_Plk_4	355	361	PF00069	0.403
MOD_ProDKin_1	109	115	PF00069	0.753
MOD_ProDKin_1	137	143	PF00069	0.720
MOD_ProDKin_1	191	197	PF00069	0.591
MOD_ProDKin_1	232	238	PF00069	0.649
MOD_ProDKin_1	369	375	PF00069	0.672
MOD_ProDKin_1	389	395	PF00069	0.571
MOD_SUMO_for_1	58	61	PF00179	0.588
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.525
TRG_ENDOCYTIC_2	335	338	PF00928	0.396
TRG_ER_diArg_1	425	428	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P654	Leptomonas seymouri	41%	84%
A0A3S7X4H1	Leishmania donovani	88%	86%
A4HJB7	Leishmania braziliensis	62%	88%
A4I6R0	Leishmania infantum	87%	86%
E9B1T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	87%