SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q6C8_LEIMA

TriTrypDb:

LmjF.31.1350 , LMJLV39_310020600 , LMJSD75_310020100

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6C8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.566
CLV_NRD_NRD_1	260	262	PF00675	0.674
CLV_NRD_NRD_1	396	398	PF00675	0.524
CLV_PCSK_FUR_1	278	282	PF00082	0.517
CLV_PCSK_KEX2_1	280	282	PF00082	0.511
CLV_PCSK_KEX2_1	396	398	PF00082	0.435
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.526
CLV_PCSK_SKI1_1	249	253	PF00082	0.789
CLV_PCSK_SKI1_1	304	308	PF00082	0.560
DEG_SPOP_SBC_1	161	165	PF00917	0.727
DOC_CDC14_PxL_1	295	303	PF14671	0.489
DOC_CKS1_1	58	63	PF01111	0.626
DOC_CYCLIN_yCln2_LP_2	478	481	PF00134	0.391
DOC_MAPK_HePTP_8	463	478	PF00069	0.614
DOC_MAPK_MEF2A_6	418	427	PF00069	0.471
DOC_PP1_RVXF_1	416	422	PF00149	0.480
DOC_PP2B_LxvP_1	230	233	PF13499	0.789
DOC_PP2B_LxvP_1	448	451	PF13499	0.711
DOC_PP2B_LxvP_1	477	480	PF13499	0.517
DOC_USP7_MATH_1	120	124	PF00917	0.580
DOC_USP7_MATH_1	14	18	PF00917	0.691
DOC_USP7_MATH_1	174	178	PF00917	0.672
DOC_USP7_MATH_1	201	205	PF00917	0.709
DOC_USP7_MATH_1	207	211	PF00917	0.661
DOC_USP7_MATH_1	22	26	PF00917	0.560
DOC_USP7_MATH_1	221	225	PF00917	0.679
DOC_USP7_MATH_1	329	333	PF00917	0.635
DOC_USP7_MATH_1	414	418	PF00917	0.514
DOC_USP7_MATH_1	48	52	PF00917	0.663
DOC_USP7_MATH_1	491	495	PF00917	0.770
DOC_WW_Pin1_4	191	196	PF00397	0.727
DOC_WW_Pin1_4	20	25	PF00397	0.776
DOC_WW_Pin1_4	239	244	PF00397	0.609
DOC_WW_Pin1_4	254	259	PF00397	0.808
DOC_WW_Pin1_4	321	326	PF00397	0.727
DOC_WW_Pin1_4	33	38	PF00397	0.730
DOC_WW_Pin1_4	395	400	PF00397	0.530
DOC_WW_Pin1_4	57	62	PF00397	0.673
LIG_14-3-3_CanoR_1	149	158	PF00244	0.525
LIG_14-3-3_CanoR_1	380	386	PF00244	0.578
LIG_Actin_WH2_2	381	398	PF00022	0.381
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_BIR_III_1	1	5	PF00653	0.629
LIG_BIR_III_2	326	330	PF00653	0.705
LIG_BIR_III_3	1	5	PF00653	0.629
LIG_BRCT_BRCA1_1	182	186	PF00533	0.807
LIG_CtBP_PxDLS_1	41	45	PF00389	0.560
LIG_eIF4E_1	295	301	PF01652	0.481
LIG_EVH1_1	230	234	PF00568	0.685
LIG_FHA_1	162	168	PF00498	0.729
LIG_FHA_1	212	218	PF00498	0.686
LIG_FHA_1	255	261	PF00498	0.792
LIG_FHA_1	292	298	PF00498	0.467
LIG_FHA_1	52	58	PF00498	0.741
LIG_FHA_2	173	179	PF00498	0.700
LIG_FHA_2	382	388	PF00498	0.506
LIG_FHA_2	494	500	PF00498	0.699
LIG_LIR_Gen_1	136	143	PF02991	0.731
LIG_LIR_Nem_3	136	142	PF02991	0.734
LIG_LIR_Nem_3	292	298	PF02991	0.465
LIG_LIR_Nem_3	387	392	PF02991	0.501
LIG_PDZ_Class_1	509	514	PF00595	0.517
LIG_SH2_CRK	139	143	PF00017	0.743
LIG_SH2_CRK	236	240	PF00017	0.816
LIG_SH2_CRK	288	292	PF00017	0.468
LIG_SH2_CRK	295	299	PF00017	0.472
LIG_SH2_CRK	392	396	PF00017	0.537
LIG_SH2_STAP1	236	240	PF00017	0.816
LIG_SH2_STAT3	104	107	PF00017	0.796
LIG_SH2_STAT5	104	107	PF00017	0.671
LIG_SH2_STAT5	127	130	PF00017	0.687
LIG_SH2_STAT5	372	375	PF00017	0.577
LIG_SH2_STAT5	91	94	PF00017	0.697
LIG_SH3_3	228	234	PF00018	0.684
LIG_SH3_3	237	243	PF00018	0.572
LIG_SH3_3	376	382	PF00018	0.472
LIG_SH3_3	408	414	PF00018	0.547
LIG_SH3_3	422	428	PF00018	0.511
LIG_SH3_3	95	101	PF00018	0.767
LIG_SH3_CIN85_PxpxPR_1	325	330	PF14604	0.735
LIG_SUMO_SIM_anti_2	475	480	PF11976	0.509
LIG_SUMO_SIM_par_1	40	46	PF11976	0.561
LIG_TRAF2_1	451	454	PF00917	0.606
LIG_TRFH_1	295	299	PF08558	0.470
LIG_TYR_ITIM	390	395	PF00017	0.518
LIG_UBA3_1	297	302	PF00899	0.462
LIG_WRC_WIRS_1	181	186	PF05994	0.679
LIG_WRC_WIRS_1	315	320	PF05994	0.572
LIG_WW_1	233	236	PF00397	0.811
MOD_CDK_SPxxK_3	254	261	PF00069	0.796
MOD_CDK_SPxxK_3	321	328	PF00069	0.732
MOD_CK1_1	12	18	PF00069	0.729
MOD_CK1_1	121	127	PF00069	0.702
MOD_CK1_1	130	136	PF00069	0.577
MOD_CK1_1	137	143	PF00069	0.551
MOD_CK1_1	165	171	PF00069	0.767
MOD_CK1_1	177	183	PF00069	0.609
MOD_CK1_1	185	191	PF00069	0.533
MOD_CK1_1	210	216	PF00069	0.745
MOD_CK1_1	224	230	PF00069	0.569
MOD_CK1_1	254	260	PF00069	0.730
MOD_CK1_1	314	320	PF00069	0.726
MOD_CK1_1	33	39	PF00069	0.713
MOD_CK1_1	332	338	PF00069	0.752
MOD_CK1_1	43	49	PF00069	0.707
MOD_CK1_1	507	513	PF00069	0.683
MOD_CK1_1	51	57	PF00069	0.587
MOD_CK2_1	172	178	PF00069	0.745
MOD_CK2_1	313	319	PF00069	0.739
MOD_CK2_1	395	401	PF00069	0.476
MOD_CK2_1	493	499	PF00069	0.701
MOD_GlcNHglycan	120	123	PF01048	0.775
MOD_GlcNHglycan	129	132	PF01048	0.621
MOD_GlcNHglycan	14	17	PF01048	0.771
MOD_GlcNHglycan	151	154	PF01048	0.738
MOD_GlcNHglycan	164	167	PF01048	0.591
MOD_GlcNHglycan	205	208	PF01048	0.664
MOD_GlcNHglycan	221	224	PF01048	0.741
MOD_GlcNHglycan	226	229	PF01048	0.740
MOD_GlcNHglycan	291	294	PF01048	0.406
MOD_GlcNHglycan	32	35	PF01048	0.633
MOD_GlcNHglycan	335	338	PF01048	0.653
MOD_GlcNHglycan	459	462	PF01048	0.564
MOD_GlcNHglycan	493	496	PF01048	0.775
MOD_GlcNHglycan	502	505	PF01048	0.665
MOD_GlcNHglycan	78	81	PF01048	0.604
MOD_GSK3_1	10	17	PF00069	0.706
MOD_GSK3_1	121	128	PF00069	0.727
MOD_GSK3_1	130	137	PF00069	0.670
MOD_GSK3_1	161	168	PF00069	0.679
MOD_GSK3_1	18	25	PF00069	0.635
MOD_GSK3_1	180	187	PF00069	0.674
MOD_GSK3_1	201	208	PF00069	0.646
MOD_GSK3_1	235	242	PF00069	0.672
MOD_GSK3_1	329	336	PF00069	0.732
MOD_GSK3_1	341	348	PF00069	0.657
MOD_GSK3_1	42	49	PF00069	0.704
MOD_GSK3_1	491	498	PF00069	0.699
MOD_GSK3_1	500	507	PF00069	0.620
MOD_GSK3_1	53	60	PF00069	0.787
MOD_GSK3_1	76	83	PF00069	0.676
MOD_N-GLC_1	149	154	PF02516	0.644
MOD_NEK2_1	118	123	PF00069	0.722
MOD_NEK2_1	125	130	PF00069	0.605
MOD_NEK2_1	134	139	PF00069	0.519
MOD_NEK2_1	184	189	PF00069	0.694
MOD_NEK2_1	205	210	PF00069	0.593
MOD_NEK2_1	42	47	PF00069	0.785
MOD_PIKK_1	103	109	PF00454	0.553
MOD_PIKK_1	165	171	PF00454	0.696
MOD_PIKK_1	46	52	PF00454	0.700
MOD_PKA_2	329	335	PF00069	0.818
MOD_PKB_1	328	336	PF00069	0.705
MOD_Plk_1	177	183	PF00069	0.753
MOD_Plk_1	345	351	PF00069	0.703
MOD_Plk_2-3	433	439	PF00069	0.581
MOD_Plk_4	137	143	PF00069	0.652
MOD_Plk_4	235	241	PF00069	0.817
MOD_Plk_4	345	351	PF00069	0.635
MOD_Plk_4	53	59	PF00069	0.700
MOD_Plk_4	80	86	PF00069	0.683
MOD_ProDKin_1	191	197	PF00069	0.726
MOD_ProDKin_1	20	26	PF00069	0.776
MOD_ProDKin_1	239	245	PF00069	0.609
MOD_ProDKin_1	254	260	PF00069	0.797
MOD_ProDKin_1	321	327	PF00069	0.729
MOD_ProDKin_1	33	39	PF00069	0.731
MOD_ProDKin_1	395	401	PF00069	0.535
MOD_ProDKin_1	57	63	PF00069	0.674
MOD_SUMO_for_1	421	424	PF00179	0.490
MOD_SUMO_rev_2	335	344	PF00179	0.744
MOD_SUMO_rev_2	433	441	PF00179	0.576
TRG_DiLeu_BaEn_1	345	350	PF01217	0.539
TRG_DiLeu_BaEn_1	454	459	PF01217	0.577
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.482
TRG_ENDOCYTIC_2	139	142	PF00928	0.750
TRG_ENDOCYTIC_2	236	239	PF00928	0.819
TRG_ENDOCYTIC_2	288	291	PF00928	0.468
TRG_ENDOCYTIC_2	295	298	PF00928	0.465
TRG_ENDOCYTIC_2	303	306	PF00928	0.530
TRG_ENDOCYTIC_2	392	395	PF00928	0.529
TRG_ENDOCYTIC_2	471	474	PF00928	0.496
TRG_ER_diArg_1	395	397	PF00400	0.404
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.765

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J5	Leptomonas seymouri	38%	88%
A0A3Q8ICJ1	Leishmania donovani	87%	99%
A4HJB8	Leishmania braziliensis	59%	99%
A4HJX4	Leishmania braziliensis	55%	94%
A4I6R1	Leishmania infantum	87%	99%
E9B1T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	97%