THO complex subunit 7

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6C7_LEIMA

TriTrypDb:

LmjF.31.1360 , LMJLV39_310020700 , LMJSD75_310020200

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6C7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.395
CLV_C14_Caspase3-7	378	382	PF00656	0.428
CLV_NRD_NRD_1	148	150	PF00675	0.569
CLV_NRD_NRD_1	202	204	PF00675	0.545
CLV_NRD_NRD_1	330	332	PF00675	0.555
CLV_NRD_NRD_1	337	339	PF00675	0.506
CLV_NRD_NRD_1	77	79	PF00675	0.470
CLV_PCSK_KEX2_1	148	150	PF00082	0.576
CLV_PCSK_KEX2_1	202	204	PF00082	0.533
CLV_PCSK_KEX2_1	251	253	PF00082	0.498
CLV_PCSK_KEX2_1	291	293	PF00082	0.623
CLV_PCSK_KEX2_1	330	332	PF00082	0.620
CLV_PCSK_KEX2_1	336	338	PF00082	0.559
CLV_PCSK_KEX2_1	77	79	PF00082	0.426
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.466
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.561
CLV_PCSK_SKI1_1	149	153	PF00082	0.569
CLV_PCSK_SKI1_1	31	35	PF00082	0.483
DEG_APCC_DBOX_1	229	237	PF00400	0.525
DOC_CKS1_1	60	65	PF01111	0.482
DOC_MAPK_MEF2A_6	190	198	PF00069	0.397
DOC_MAPK_MEF2A_6	358	366	PF00069	0.558
DOC_PP4_FxxP_1	219	222	PF00568	0.508
DOC_USP7_MATH_1	107	111	PF00917	0.351
DOC_USP7_MATH_1	222	226	PF00917	0.431
DOC_USP7_MATH_1	297	301	PF00917	0.721
DOC_USP7_MATH_1	313	317	PF00917	0.650
DOC_USP7_MATH_1	323	327	PF00917	0.669
DOC_USP7_MATH_1	96	100	PF00917	0.512
DOC_USP7_UBL2_3	195	199	PF12436	0.520
DOC_WW_Pin1_4	26	31	PF00397	0.531
DOC_WW_Pin1_4	59	64	PF00397	0.482
LIG_14-3-3_CanoR_1	117	125	PF00244	0.469
LIG_14-3-3_CanoR_1	184	194	PF00244	0.468
LIG_14-3-3_CanoR_1	240	247	PF00244	0.482
LIG_14-3-3_CanoR_1	65	70	PF00244	0.454
LIG_Actin_WH2_2	194	210	PF00022	0.486
LIG_Actin_WH2_2	250	267	PF00022	0.440
LIG_BIR_II_1	1	5	PF00653	0.426
LIG_BRCT_BRCA1_1	43	47	PF00533	0.442
LIG_DLG_GKlike_1	65	73	PF00625	0.447
LIG_FHA_1	119	125	PF00498	0.431
LIG_FHA_1	186	192	PF00498	0.483
LIG_FHA_2	288	294	PF00498	0.601
LIG_LIR_Nem_3	416	421	PF02991	0.525
LIG_Pex14_2	215	219	PF04695	0.501
LIG_SH3_3	319	325	PF00018	0.482
LIG_SH3_3	60	66	PF00018	0.478
LIG_SUMO_SIM_par_1	126	133	PF11976	0.469
LIG_WRC_WIRS_1	97	102	PF05994	0.529
MOD_CDK_SPK_2	26	31	PF00069	0.428
MOD_CDK_SPxK_1	59	65	PF00069	0.481
MOD_CK1_1	332	338	PF00069	0.446
MOD_CK2_1	239	245	PF00069	0.609
MOD_CK2_1	26	32	PF00069	0.438
MOD_GlcNHglycan	138	141	PF01048	0.527
MOD_GlcNHglycan	142	145	PF01048	0.630
MOD_GlcNHglycan	299	302	PF01048	0.660
MOD_GlcNHglycan	399	402	PF01048	0.504
MOD_GlcNHglycan	49	52	PF01048	0.556
MOD_GSK3_1	136	143	PF00069	0.605
MOD_GSK3_1	297	304	PF00069	0.707
MOD_GSK3_1	332	339	PF00069	0.491
MOD_GSK3_1	39	46	PF00069	0.482
MOD_GSK3_1	65	72	PF00069	0.456
MOD_NEK2_1	160	165	PF00069	0.644
MOD_NEK2_1	247	252	PF00069	0.465
MOD_NEK2_1	270	275	PF00069	0.559
MOD_NEK2_1	41	46	PF00069	0.487
MOD_NEK2_1	69	74	PF00069	0.438
MOD_NEK2_2	96	101	PF00069	0.512
MOD_PIKK_1	239	245	PF00454	0.564
MOD_PKA_1	336	342	PF00069	0.551
MOD_PKA_2	118	124	PF00069	0.574
MOD_PKA_2	239	245	PF00069	0.455
MOD_PKA_2	247	253	PF00069	0.405
MOD_PKA_2	329	335	PF00069	0.669
MOD_PKA_2	336	342	PF00069	0.591
MOD_Plk_4	277	283	PF00069	0.522
MOD_ProDKin_1	26	32	PF00069	0.535
MOD_ProDKin_1	59	65	PF00069	0.481
MOD_SUMO_for_1	257	260	PF00179	0.431
MOD_SUMO_rev_2	192	201	PF00179	0.509
MOD_SUMO_rev_2	250	259	PF00179	0.529
MOD_SUMO_rev_2	381	390	PF00179	0.617
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.430
TRG_ER_diArg_1	201	203	PF00400	0.630
TRG_ER_diArg_1	336	338	PF00400	0.588
TRG_ER_diArg_1	76	78	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXL4	Leptomonas seymouri	40%	100%
A0A3S7X4F2	Leishmania donovani	91%	100%
A0A422NZ65	Trypanosoma rangeli	30%	100%
A4HJB9	Leishmania braziliensis	73%	100%
A4I6R2	Leishmania infantum	91%	100%
C9ZWT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B1T4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%